Functional brain stem circuits for control of nose motion.

Abstract:

:Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. We studied the premotor control of this motion. We used replication-competent rabies virus to transsynaptically label inputs to the deflector nasi muscle and find putative premotor labeling throughout the parvocellular, intermediate, and gigantocellular reticular formations, as well as the trigeminal nuclei, pontine reticular formation, midbrain reticular formation, red nucleus, and superior colliculus. Two areas with extensive labeling were analyzed for their impact on nose movement. One area is in the reticular formation caudal to the facial motor nucleus and is denoted the nose retrofacial area. The second is in the caudal part of the intermediate reticular region near the oscillator for whisking (the nose IRt). Functionally, we find that optogenetic activation of glutamatergic cells in both areas drives deflection of the nose. Ablation of cells in the nose retrofacial area, but not the nose IRt, impairs movement of the nose in response to the presentation of odorants but otherwise leaves movement unaffected. These data suggest that the nose retrofacial area is a conduit for a sensory-driven orofacial motor action. Furthermore, we find labeling of neurons that are immediately upstream of premotor neurons in the preBötzinger complex that presumably synchronizes a small, rhythmic component of nose motion to breathing. NEW & NOTEWORTHY We identify two previously undescribed premotor areas in the medulla that control deflection of the nose. This includes a pathway for directed motion of the nose in response to an odorant.

journal_name

J Neurophysiol

authors

Kurnikova A,Deschênes M,Kleinfeld D

doi

10.1152/jn.00608.2018

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

205-217

issue

1

eissn

0022-3077

issn

1522-1598

journal_volume

121

pub_type

杂志文章
  • Dendritic spikes and their influence on extracellular calcium signaling.

    abstract::Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular calcium, which has motivated recent computational work that employs such fluctuations in an info...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1329

    authors: Wiest MC,Eagleman DM,King RD,Montague PR

    更新日期:2000-03-01 00:00:00

  • Path perturbation detection tasks reduce MSTd neuronal self-movement heading responses.

    abstract::We presented optic flow and real movement heading stimuli while recording MSTd neuronal activity. Monkeys were alternately engaged in three tasks: visual detection of optic flow heading perturbations, vestibular detection of real movement heading perturbations, and auditory detection of brief tones. Push-button RTs we...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00958.2016

    authors: Page WK,Duffy CJ

    更新日期:2018-01-01 00:00:00

  • Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.

    abstract::Respiratory depression is a therapy-limiting side effect of opioid analgesics, yet our understanding of the brain circuits mediating this potentially lethal outcome remains incomplete. Here we studied the contribution of the rostral ventromedial medulla (RVM), a region long implicated in pain modulation and homeostati...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00563.2012

    authors: Phillips RS,Cleary DR,Nalwalk JW,Arttamangkul S,Hough LB,Heinricher MM

    更新日期:2012-11-01 00:00:00

  • Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.

    abstract::The temporal lobe is well known for its oscillatory activity associated with exploration, navigation, and learning. Intrinsic membrane potential oscillations (MPOs) and resonance of stellate cells (SCs) in layer II of the entorhinal cortex are thought to contribute to network oscillations and thereby to the encoding o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00743.2011

    authors: Boehlen A,Henneberger C,Heinemann U,Erchova I

    更新日期:2013-01-01 00:00:00

  • Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release.

    abstract::Activity-dependent developmental maturation of the neocortical network is thought to involve the stabilization and potentiation of immature synapses. In particular, N-methyl-d-aspartate (NMDA) receptor-dependent long-term plasticity that is expressed presynaptically appears to be crucial for the selection of functiona...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00018.2006

    authors: Walz C,Jüngling K,Lessmann V,Gottmann K

    更新日期:2006-12-01 00:00:00

  • Ultrastructural analysis of ectopic synaptic boutons arising from peripherally regenerated primary afferent fibers.

    abstract::The central axons of peripherally regenerated Abeta primary sensory neurons were impaled in the dorsal columns of alpha-chloralose-anesthetized cats 9-12 mo after axotomy. The adequate peripheral stimulus was determined, and the afferent fibers intracellularly stimulated while simultaneously recording the resulting co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.4.1636

    authors: Koerber HR,Mirnics K,Kavookjian AM,Light AR

    更新日期:1999-04-01 00:00:00

  • Summation of motor unit tensions in the tibialis posterior muscle of the cat under isometric and nonisometric conditions.

    abstract::1. The tension produced by the combined stimulation of two to four single motor units of the cat tibialis posterior muscle was compared with the algebraic sum of the tensions produced by each individual motor unit. Comparisons were made under isometric conditions and during imposed changes in muscle length. 2. Under i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.6.1838

    authors: Powers RK,Binder MD

    更新日期:1991-12-01 00:00:00

  • Processing of retinal and extraretinal signals for memory-guided saccades during smooth pursuit.

    abstract::It is an essential feature for the visual system to keep track of self-motion to maintain space constancy. Therefore the saccadic system uses extraretinal information about previous saccades to update the internal representation of memorized targets, an ability that has been identified in behavioral and electrophysiol...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00543.2004

    authors: Blohm G,Missal M,Lefèvre P

    更新日期:2005-03-01 00:00:00

  • Antidromic activity in visual radiation during evoked cortical responses.

    abstract::1. Antidromic stimulation of the visual radiation of cats has been used to investigate the possibility that some of the activity in principal geniculate cells following an optic tract stimulus is antidromic. Single spikes were selected from two classes of poststimulus activity to condition the antidromic test spike--t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1977.40.1.9

    authors: Rosen AD,Vastola EF

    更新日期:1977-01-01 00:00:00

  • Signal transmission in the catfish retina. IV. Transmission to ganglion cells.

    abstract::1. To characterize the temporal dynamic responses of ganglion cells and to define the possible inputs giving rise to their responses in catfish retina, we recorded the ganglion cell responses evoked by 1) a step of light presented in the dark, 2) an incremental and decremental step from a background illumination, and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.6.1307

    authors: Sakai HM,Naka K

    更新日期:1987-12-01 00:00:00

  • Selective effects of light exposure on distribution of motility in the chick embryo at E18.

    abstract::It is well established that orderly patterns of motor neuron activity, muscle recruitment, and limb movement are generated in chicks during motility by embryonic day (E)9, the midpoint in embryonic development. However, our recent work suggests that some attributes of motility, such as the rhythm of repetitive limb mo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00393.2003

    authors: Bradley NS,Jahng DY

    更新日期:2003-09-01 00:00:00

  • Effects of impulse frequency, PTP, and temperature on responses elicited in large populations of motoneurons by impulses in single Ia-fibers.

    abstract::Excitatory postsynaptic potentials (EPSPs) were evoked in large populations of motoneurons by impulses in single Ia- and group II fibers and recorded from L7 and S1 ventral roots by means of a sucrose-gap technique and spike-triggered averaging, as previously described (33, 34). Factors known to influence conduction a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.5.1045

    authors: Lüscher H,Ruenzel PW,Henneman E

    更新日期:1983-11-01 00:00:00

  • Deficits in anticipatory inhibition of postural muscle activity associated with load release while standing in individuals with spastic diplegic cerebral palsy.

    abstract::This study aimed to determine whether individuals with spastic diplegic cerebral palsy (SDCP) have deficits in anticipatory inhibition of postural muscle activity. Nine individuals with SDCP (SDCP group, 3 female and 6 male, 13-24 yr of age) and nine age- and sex-matched individuals without disability (control group) ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00253.2012

    authors: Tomita H,Fukaya Y,Totsuka K,Tsukahara Y

    更新日期:2013-04-01 00:00:00

  • Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells.

    abstract::Whole cell voltage-clamp techniques were employed to characterize the sodium (Na) conductances in acutely dissociated, mature guinea-pig cerebellar Purkinje cells. Three phenomenological components were noted: two inactivating and a persistent component (I(P)(Na). All exhibited similar sensitivities to tetrodotoxin (T...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.3.1167

    authors: Kay AR,Sugimori M,Llinás R

    更新日期:1998-09-01 00:00:00

  • Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern.

    abstract::Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative r...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00046.2003

    authors: Schaefer AT,Larkum ME,Sakmann B,Roth A

    更新日期:2003-06-01 00:00:00

  • Increased calcium current in carotid body glomus cells following in vivo acclimatization to chronic hypoxia.

    abstract::1. Rat pups were gestated and born in normoxia (inspired O2 pressure 149 mmHg) or chronic hypoxia (insured O2 pressure 80 mmHg) to test whether chronic hypoxia alters carotid body glomus cell calcium currents. Carotid bodies were removed from 5- to 8-day-old-pups under halothane anesthesia, at which time blood hematoc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.3.1880

    authors: Hempleman SC

    更新日期:1996-09-01 00:00:00

  • The effects of microstimulation of the dorsomedial frontal cortex on saccade latency.

    abstract::Neural regions in the dorsomedial frontal cortex (DMFC), including the supplementary eye field (SEF) and the presupplementary motor area (pre-SMA), are likely candidates for generating top-down control of saccade target selection. To investigate this, we applied electrical microstimulation to these structures while sa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00119.2007

    authors: Yang SN,Heinen SJ,Missal M

    更新日期:2008-04-01 00:00:00

  • Activity in V4 reflects the direction, but not the latency, of saccades during visual search.

    abstract::We constantly make eye movements to bring objects of interest onto the fovea for more detailed processing. Activity in area V4, a prestriate visual area, is enhanced at the location corresponding to the target of an eye movement. However, the precise role of activity in V4 in relation to these saccades and the modulat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00898.2009

    authors: Gee AL,Ipata AE,Goldberg ME

    更新日期:2010-10-01 00:00:00

  • Spatiotemporal patterns of dorsal root-evoked network activity in the neonatal rat spinal cord: optical and intracellular recordings.

    abstract::Spatiotemporal patterns of dorsal root-evoked potentials were studied in transverse slices of the rat spinal cord by monitoring optical signals from a voltage-sensitive dye with multiple-photodiode optic camera. Typically, dorsal root stimulation generated two basic waveforms of voltage images: dual-component images c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00209.2005

    authors: Ziskind-Conhaim L,Redman S

    更新日期:2005-09-01 00:00:00

  • Evolution of motor memory during the seconds after observation of motor error.

    abstract::When a movement results in error, the nervous system amends the motor commands that generate the subsequent movement. Here we show that this adaptation depends not just on error, but also on passage of time between the two movements. We observed that subjects learned a reaching task faster, i.e., with fewer trials, wh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01281.2006

    authors: Huang VS,Shadmehr R

    更新日期:2007-06-01 00:00:00

  • Morphological identification of physiologically characterized afferents innervating the turtle posterior crista.

    abstract::The turtle posterior crista consists of two hemicristae. Each hemicrista extends from the planum semilunatum to the nonsensory torus and includes a central zone (CZ) surrounded by a peripheral zone (PZ). Type I and type II hair cells are found in the CZ and are innervated by calyx, dimorphic and bouton afferents. Only...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1202

    authors: Brichta AM,Goldberg JM

    更新日期:2000-03-01 00:00:00

  • Mixed slip-trip perturbation training for improving reactive responses in people with chronic stroke.

    abstract::This study determined the effect of mixed (slip- and trip-like stance perturbation) training on reactive responses in people with chronic stroke (PwCS) and examined modulation of their reactive responses on higher intensity perturbations posttraining (scaling). Twelve PwCS were exposed to consecutive blocks of treadmi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00671.2019

    authors: Dusane S,Bhatt T

    更新日期:2020-07-01 00:00:00

  • Influence of biases in numerical magnitude allocation on human prosocial decision making.

    abstract::Over the past decade neuroscientific research has attempted to probe the neurobiological underpinnings of human prosocial decision making. Such research has almost ubiquitously employed tasks such as the dictator game or similar variations (i.e., ultimatum game). Considering the explicit numerical nature of such tasks...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00372.2017

    authors: Arshad Q,Nigmatullina Y,Siddiqui S,Franka M,Mediratta S,Ramachandaran S,Lobo R,Malhotra PA,Roberts RE,Bronstein AM

    更新日期:2017-12-01 00:00:00

  • Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses.

    abstract::Activation of metabotropic glutamate receptors (mGluRs), which are coupled to G proteins, has important roles in certain forms of synaptic plasticity including corticostriatal long-term depression (LTD). In the present study, extracellular field potential and whole cell voltage-clamp recording techniques were used to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.5.2405

    authors: Sung KW,Choi S,Lovinger DM

    更新日期:2001-11-01 00:00:00

  • Weakly modulated spike trains: significance, precision, and correction for sample size.

    abstract::Many single-unit electrophysiological studies of visual cortex have investigated strong evoked responses to simple stimuli such as oriented gratings. Experiments involving other types of stimuli, such as natural scenes, higher-order features, and surface brightness, produce single-unit responses that are more difficul...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00420.2001

    authors: Hung CP,Ramsden BM,Roe AW

    更新日期:2002-05-01 00:00:00

  • Structure-function relationships in the primate superior colliculus. II. Morphological identity of presaccadic neurons.

    abstract::1. Microelectrodes filled with horseradish peroxidase (HRP) were inserted in the superior colliculus (SC) of alert squirrel monkeys. Spontaneous eye movements were monitored in the dark during recording and intraaxonal injection of fibers carrying presaccadic signals. 2. Analysis of the relationship between neuronal a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.1.263

    authors: Moschovakis AK,Karabelas AB,Highstein SM

    更新日期:1988-07-01 00:00:00

  • Inhibitory-excitatory synaptic balance is shifted toward increased excitation in magnocellular neurosecretory cells of heart failure rats.

    abstract::Despite the well-established contribution of neurohumoral activation to morbidity and mortality in heart failure (HF) patients, relatively little is known about the underlying central nervous system mechanisms. In this study, we aimed to determine whether changes in GABAergic inhibitory and glutamatergic excitatory sy...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00218.2011

    authors: Potapenko ES,Biancardi VC,Florschutz RM,Ryu PD,Stern JE

    更新日期:2011-09-01 00:00:00

  • Differences in inhibitory synaptic input between layer II-III and layer V neurons of the cat neocortex.

    abstract::1. The goal of this study was to compare the relative effectiveness of intrinsic inhibitory synaptic inputs in different layers of the cat motor cortex. Postsynaptic potentials (PSPs) were evoked in neurons located in the superficial (layer II-III) or deep layers (layer V) by local extracellular stimulation in vitro. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.3.1149

    authors: van Brederode JF,Spain WJ

    更新日期:1995-09-01 00:00:00

  • Consolidation of visuomotor adaptation memory with consistent and noisy environments.

    abstract::Our understanding of how we learn and retain motor behaviors is still limited. For instance, there is conflicting evidence as to whether the memory of a learned visuomotor perturbation consolidates; i.e., the motor memory becomes resistant to interference from learning a competing perturbation over time. Here, we soug...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00178.2016

    authors: Maeda RS,McGee SE,Marigold DS

    更新日期:2017-01-01 00:00:00

  • Target size matters: target errors contribute to the generalization of implicit visuomotor learning.

    abstract::The process of sensorimotor adaptation is considered to be driven by errors. While sensory prediction errors, defined as the difference between the planned and the actual movement of the cursor, drive implicit learning processes, target errors (e.g., the distance of the cursor from the target) are thought to drive exp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00830.2015

    authors: Reichenthal M,Avraham G,Karniel A,Shmuelof L

    更新日期:2016-08-01 00:00:00