Abstract:
:Spatiotemporal patterns of dorsal root-evoked potentials were studied in transverse slices of the rat spinal cord by monitoring optical signals from a voltage-sensitive dye with multiple-photodiode optic camera. Typically, dorsal root stimulation generated two basic waveforms of voltage images: dual-component images consisting of fast, spike-like signal followed by a slow signal in the dorsal horn, and small, slow signals in the ventral horn. To qualitatively relate the optical signals to membrane potentials, whole cell recordings were combined with measurements of light absorption in the area around the soma. The slow optical signals correlated closely with subthreshold postsynaptic potentials in all regions of the cord. The spike-like component was not associated with postsynaptic action potentials, suggesting that the fast signal was generated by presynaptic action potentials. Firing in a single neuron could not be detected optically, implying that local voltage images originated from synchronously activated neuronal ensembles. Blocking glutamatergic synaptic transmission inhibited excitatory postsynaptic potentials (EPSPs) and significantly reduced the slow optical signals, indicating that they were mediated by glutamatergic synapses. Suppressing glycine-mediated inhibition increased the amplitude of both optical signals and EPSPs, while blocking GABA(A) receptor-mediated synapses, increased the amplitude and time course of EPSPs and prolonged the duration of voltage images in larger areas of the slice. The close correlation between evoked EPSPs and their respective local voltage images shows the advantage of the high temporal resolution optical system in measuring both the spatiotemporal dynamics of segmental network excitation and integrated potentials of neuronal ensembles at identified sites.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Ziskind-Conhaim L,Redman Sdoi
10.1152/jn.00209.2005subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1952-61issue
3eissn
0022-3077issn
1522-1598pii
00209.2005journal_volume
94pub_type
杂志文章abstract::1. Neurons in the ventral intraparietal area (VIP) are known to respond to translating random dot patterns. Such responses can be explained on the basis of the input of the middle temporal area (MT) to this area. Anatomic evidence has shown that VIP receives input from the dorsal part of the medial superior temporal a...
journal_title:Journal of neurophysiology
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pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1152/jn.00812.2005
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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更新日期:1999-07-01 00:00:00
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更新日期:2008-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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