Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells.

abstract：:1. Whole-cell recordings were performed on acutely isolated pyramidal neurons from rat sensorimotor cortex 2 to 21 days postnatal to study the expression of a tetrodotoxin (TTX) sensitive, voltage dependent, persistent Na+ current (INaP) during different stages of postnatal development. 2. INaP was activated positive ...

journal_title：Journal of neurophysiology

authors： Alzheimer C,Schwindt PC,Crill WE

更新日期：1993-01-01 00:00:00

abstract：:In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...

journal_title：Journal of neurophysiology

authors： Warren TL,Tumer EC,Charlesworth JD,Brainard MS

更新日期：2011-10-01 00:00:00

abstract：:The development of synaptic interconnections between the cerebellum and inferior olive, the sole source of climbing fibers, could contribute to the ontogeny of certain forms of motor learning (e.g., eyeblink conditioning). Purkinje cell complex spikes are produced exclusively by climbing fibers and exhibit short- and ...

journal_title：Journal of neurophysiology

authors： Nicholson DA,Freeman JH Jr

更新日期：2003-10-01 00:00:00

abstract：:Liolaemus lizards were explored to ascertain whether they would make an amenable model to study single-cell electrophysiology of neurons in the vomeronasal organ (VNO). Despite a rich array of chemosensory-related behaviors chronicled for this genus, no anatomical or functional data exist for the VNO, the organ mediat...

journal_title：Journal of neurophysiology

authors： Labra A,Brann JH,Fadool DA

更新日期：2005-10-01 00:00:00

abstract：:1. The alignment of the pupillary axes and of the visual axes has been measured in 23 normally reared cats ranging in age from 14 days to adulthood. 2. In agreement with a previous report, we find that pupillary divergence, as measured from photographs, tends to decrease during the first 2 mo of life. 3. The angle bet...

journal_title：Journal of neurophysiology

authors： Olson CR,Freeman RD

更新日期：1978-07-01 00:00:00

abstract：:1. We study the propagation and dynamics of spindle waves in thalamic slices by developing and analyzing a model of reciprocally coupled populations of excitatory thalamocortical (TC) neurons and inhibitory thalamic reticular (RE) neurons. 2. Each TC neuron has three intrinsic ionic currents: a low-threshold T-type Ca...

journal_title：Journal of neurophysiology

authors： Golomb D,Wang XJ,Rinzel J

更新日期：1996-02-01 00:00:00

abstract：:The functional role of sensory input to the motor cortex was studied by interrupting two major input pathways. One was the dorsal column, which sends the input directly through the thalamus to the motor cortex, and the other was the sensory cortex, which transfers its input through association fibers. Removal of the s...

journal_title：Journal of neurophysiology

authors： Asanuma H,Arissian K

更新日期：1984-08-01 00:00:00

abstract：:The ventrolateral preoptic nucleus (VLPO) is a key nucleus involved in the homeostatic regulation of sleep-wakefulness. Little is known, however, about the cellular mechanisms underlying its role in sleep regulation and how the neurotransmitters, such as GABA and noradrenaline (NA), are involved. In the present study ...

journal_title：Journal of neurophysiology

authors： Matsuo S,Jang IS,Nabekura J,Akaike N

更新日期：2003-03-01 00:00:00

abstract：:Changes in the environment require rapid modification or inhibition of ongoing behavior. We used the stop-signal paradigm and intracranial recordings to investigate response preparation, inhibition, and monitoring of task-relevant information. Electrocorticographic data were recorded in eight patients with electrodes ...

journal_title：Journal of neurophysiology

authors： Fonken YM,Rieger JW,Tzvi E,Crone NE,Chang E,Parvizi J,Knight RT,Krämer UM

更新日期：2016-04-01 00:00:00

abstract：:To investigate the nature of the visuomotor transformation, previous studies have used pointing tasks and examined how adaptation to a spatially localized mismatch between vision and proprioception generalizes across the workspace. Whereas some studies found extensive spatial generalization of single-point remapping, ...

journal_title：Journal of neurophysiology

authors： Malfait N,Henriques DY,Gribble PL

更新日期：2008-01-01 00:00:00

abstract：:The dendritic tree of layer 5 (L5) pyramidal neurons spans the neocortical layers, allowing the integration of intra- and extracortical synaptic inputs. Here we investigate the postnatal development of the integrative properties of rat L5 pyramidal neurons using simultaneous whole cell recording from the soma and dist...

journal_title：Journal of neurophysiology

authors： Atkinson SE,Williams SR

更新日期：2009-08-01 00:00:00

abstract：:1. The induction of long-term weakening of synaptic transmission in rat hippocampal slices was examined in CA1 synapses during cholinergic modulation. 2. Bath application of the cholinergic agonist carbachol (50 microM) activated an oscillation of the local field potential in the theta-frequency range (5-12 Hz), terme...

journal_title：Journal of neurophysiology

authors： Huerta PT,Lisman JE

更新日期：1996-02-01 00:00:00

abstract：:Frequency facilitation is a process whereby neurosecretion increases as a function of stimulation frequency during repetitive synaptic activity. To examine the physiological basis underlying facilitation, we have estimated the frequency dependence of the synaptic parameters n (number of units capable of responding to ...

journal_title：Journal of neurophysiology

authors： Worden MK,Bykhovskaia M,Hackett JT

更新日期：1997-07-01 00:00:00

abstract：:Visual object information is conveyed from V1 to area TE along the ventral visual pathway with increasing receptive field (RF) sizes. The RFs of TE neurons are known to be large, but it is largely unknown how large RFs are shaped along the ventral visual pathway. In this study, we addressed this question in two aspect...

journal_title：Journal of neurophysiology

authors： Obara K,O'Hashi K,Tanifuji M

更新日期：2017-10-01 00:00:00

abstract：:Subacute and chronic changes in tonic GABAergic inhibition occur in human and experimental epilepsy. Less is known about how tonic inhibition is modulated over shorter time frames (seconds). We measured endogenous tonic GABA currents from cultured rat hippocampal neurons to evaluate how they are affected by 1) transie...

journal_title：Journal of neurophysiology

authors： Ransom CB,Tao W,Wu Y,Spain WJ,Richerson GB

更新日期：2013-02-01 00:00:00

abstract：:1. Serotonergic modulation of a hyperpolarization-activated inward current, Ih, and a calcium-dependent outward current, Io(Ca), was examined in the dorsal gastric (DG) motor neuron, with the use of intracellular recording techniques in an isolated preparation of the crab stomatogastric ganglion (STG). 2. Hyperpolariz...

journal_title：Journal of neurophysiology

authors： Kiehn O,Harris-Warrick RM

更新日期：1992-08-01 00:00:00

abstract：:Plantar cutaneous afferent transmission is critical for recovery of locomotion in spinalized animals, whereas a phase-dependent reflex modulation is apparent during fictive or real locomotion. In nine people with a chronic spinal cord injury (SCI) the effects of foot sole stimulation on the soleus H-reflex and tibiali...

journal_title：Journal of neurophysiology

authors： Knikou M

更新日期：2010-03-01 00:00:00

abstract：:Synaptic plasticity can last from a fraction of a second to weeks depending on how it was induced. The mechanisms that underlie short-, intermediate-, and long-term plasticity have been intensively studied at central synapses of both vertebrates and invertebrates; however, peripheral plasticity has not received as muc...

journal_title：Journal of neurophysiology

authors： Fox LE,Lloyd PE

更新日期：2002-04-01 00:00:00

abstract：:1. The effects of D-O-phosphoserine (DOS) were examined on proximal neurons in the superfused mudpuppy retinal-eyecup preparation by measuring their synaptically evoked whole-cell currents with the use of patch-clamp electrodes. 2. DOS reduced the light-evoked excitatory postsynaptic potentials (EPSPs) of amacrine and...

journal_title：Journal of neurophysiology

authors： Coleman PA,Miller RF

更新日期：1989-08-01 00:00:00

abstract：:The problem of how the hippocampus encodes both spatial and nonspatial information at the cellular network level remains largely unresolved. Spatial memory is widely modeled through the theoretical framework of attractor networks, but standard computational models can only represent spaces that are much smaller than t...

journal_title：Journal of neurophysiology

authors： Hedrick KR,Zhang K

更新日期：2016-08-01 00:00:00

abstract：:Cell-surface glutamate transporters are essential for the proper function of early cortical networks because their dysfunction induces seizures in the newborn rat in vivo. We have now analyzed the consequences of their inhibition by DL-TBOA on the activity of the developing CA1 rat hippocampal network in vitro. DL-TBO...

journal_title：Journal of neurophysiology

authors： Cattani AA,Bonfardin VD,Represa A,Ben-Ari Y,Aniksztejn L

更新日期：2007-10-01 00:00:00

abstract：:Thalamic relay neurons express high levels of T-type Ca(2+) channels, which support the generation of robust burst discharges. This intrinsically mediated form of phasic spike firing is thought to be critical in the generation of slow (3-4 Hz) synchronous oscillatory activity of absence epilepsy. Recordings made from ...

journal_title：Journal of neurophysiology

authors： Porcello DM,Smith SD,Huguenard JR

更新日期：2003-01-01 00:00:00

abstract：:Mechanisms that could mitigate the effects of hypoxia on neuronal signaling are incompletely understood. We show that axonal performance of a locust visual interneuron varied depending on oxygen availability. To induce hypoxia, tracheae supplying the thoracic nervous system were surgically lesioned and action potentia...

journal_title：Journal of neurophysiology

authors： Money TG,Sproule MK,Cross KP,Robertson RM

更新日期：2016-09-01 00:00:00

abstract：:Peroneal motoneurons were recorded intracellularly in anesthetized cats during sustained submaximal contractions of peroneus brevis muscle (PB) elicited by repetitive electrical stimulation of motor axons in the distal portion of cut ventral root filaments. Mechanical stimulation of the territory innervated by the sup...

journal_title：Journal of neurophysiology

authors： Perrier JF,Lamotte D'Incamps B,Kouchtir-Devanne N,Jami L,Zytnicki D

更新日期：2000-06-01 00:00:00

abstract：:Humans engage in many daily activities that rely on working memory, the ability to hold and sequence information temporarily to accomplish a task. We focus on the process of working memory, based on circuit mechanisms for attending to relevant signals and suppressing irrelevant stimuli. We discuss that connections cri...

journal_title：Journal of neurophysiology

authors： Barbas H,Wang J,Joyce MKP,García-Cabezas MÁ

更新日期：2018-11-01 00:00:00

abstract：:1. Noxious stimuli have been shown to produce a diffuse inhibition of nociresponsive neurons in the spinal and trigeminal dorsal horns. The present study sought to extend these electrophysiological studies of diffuse noxious inhibitory controls (DNIC) by determining the effect of a spatially remote noxious stimulus on...

journal_title：Journal of neurophysiology

authors： Morgan MM,Heinricher MM,Fields HL

更新日期：1994-09-01 00:00:00

abstract：:A plaid pattern is formed when two sinusoidal gratings of different orientations are added together. Previous work has shown that V1 neurons selectively encode the direction and orientation of the component gratings in a moving plaid but not the direction of the plaid itself (Movshon et al. 1985). We recorded the resp...

journal_title：Journal of neurophysiology

authors： Tinsley CJ,Webb BS,Barraclough NE,Vincent CJ,Parker A,Derrington AM

更新日期：2003-08-01 00:00:00

abstract：:Synaptic dynamics comprise a variety of interacting processes acting on a wide range of time scales. This enables a synapse to perform a large array of computations, from temporal and spatial filtering to associative learning. In this study, we describe how changing synaptic gain via long-term plasticity can act to sh...

journal_title：Journal of neurophysiology

authors： Lewis JE,Maler L

更新日期：2004-02-01 00:00:00

abstract：:Several previous studies have shown the existence of Up and Down states and have linked their magnitude (e.g., depolarization level) to the size of sensory-evoked responses. Here, we studied how the temporal dynamics of such states influence the sensory-evoked response to vibrissa deflection. Under alpha-chloralose an...

journal_title：Journal of neurophysiology

authors： Haslinger R,Ulbert I,Moore CI,Brown EN,Devor A

更新日期：2006-09-01 00:00:00

abstract：:The pacemaker current of a bursting neuron of Helix pomatia was investigated using voltage-clamp and pressure-injection techniques. In the steady state the net membrane current was zero near threshold of the action potential at -45 mV. Negative to this potential the membrane current was inward and steady. During burst...

journal_title：Journal of neurophysiology

authors： Swandulla D,Lux HD

更新日期：1985-12-01 00:00:00