Frontal and motor cortex contributions to response inhibition: evidence from electrocorticography.

Abstract:

:Changes in the environment require rapid modification or inhibition of ongoing behavior. We used the stop-signal paradigm and intracranial recordings to investigate response preparation, inhibition, and monitoring of task-relevant information. Electrocorticographic data were recorded in eight patients with electrodes covering frontal, temporal, and parietal cortex, and time-frequency analysis was used to examine power differences in the beta (13-30 Hz) and high-gamma bands (60-180 Hz). Over motor cortex, beta power decreased, and high-gamma power increased during motor preparation for both go trials (Go) and unsuccessful stops (US). For successful stops (SS), beta increased, and high-gamma was reduced, indexing the cancellation of the prepared response. In the middle frontal gyrus (MFG), stop signals elicited a transient high-gamma increase. The MFG response occurred before the estimated stop-signal reaction time but did not distinguish between SS and US trials, likely signaling attention to the salient stop stimulus. A postresponse high-gamma increase in MFG was stronger for US compared with SS and absent in Go, supporting a role in behavior monitoring. These results provide evidence for differential contributions of frontal subregions to response inhibition, including motor preparation and inhibitory control in motor cortex and cognitive control and action evaluation in lateral prefrontal cortex.

journal_name

J Neurophysiol

authors

Fonken YM,Rieger JW,Tzvi E,Crone NE,Chang E,Parvizi J,Knight RT,Krämer UM

doi

10.1152/jn.00708.2015

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

2224-36

issue

4

eissn

0022-3077

issn

1522-1598

pii

jn.00708.2015

journal_volume

115

pub_type

杂志文章
  • Fiber architecture and histochemistry in the cat neck muscle, biventer cervicis.

    abstract::1. Biventer cervicis (BC) is an anatomically complex muscle that is divided by tendinous inscriptions into five in-series compartments of motor units. We have analyzed the fiber architecture and fiber-type composition of these different compartments using microdissection and histochemical methods. 2. BC narrows as it ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.1.46

    authors: Richmond FJ,Armstrong JB

    更新日期:1988-07-01 00:00:00

  • Motion mechanisms in macaque MT.

    abstract::The macaque middle temporal area (MT) is exquisitely sensitive to visual motion and there is a large amount of evidence that neural activity in MT is tightly correlated with the perception of motion. The mechanisms by which MT neurons achieve their directional selectivity, however, have received considerably less atte...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00473.2004

    authors: Krekelberg B,Albright TD

    更新日期:2005-05-01 00:00:00

  • Breathing frequency changes at the onset of stepping in human infants.

    abstract::Breathing frequency increases at the onset of movement in a wide rage of mammals including adult humans. Moreover, the magnitude of increase in the rate of breathing appears related to the rate of the rhythmic movement. We determined whether human infants show the same type of response when supported to step on a trea...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00868.2007

    authors: Noah JA,Boliek C,Lam T,Yang JF

    更新日期:2008-03-01 00:00:00

  • Electrotonic architecture of cat gamma motoneurons.

    abstract::1. Experimental measures of input resistance, RN, and responses to brief hyperpolarizing current pulses were obtained in identified gamma-motoneurons in pentobarbital-anesthetized cats using conventional sharp micropipettes. The same cells were subsequently injected with horseradish peroxidase and completely reconstru...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.5.2302

    authors: Burke RE,Fyffe RE,Moschovakis AK

    更新日期:1994-11-01 00:00:00

  • Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity.

    abstract::Trimming all but two whiskers in adult rats produces a predictable change in cortical cell-evoked responses characterized by increased responsiveness to the two intact whiskers and decreased responsiveness to the trimmed whiskers. This type of synaptic plasticity in rat somatic sensory cortex, called "whisker pairing ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.6.3216

    authors: Sachdev RN,Lu SM,Wiley RG,Ebner FF

    更新日期:1998-06-01 00:00:00

  • Effects of agonists and antagonists of NMDA and ACh receptors on plasticity of bat auditory system elicited by fear conditioning.

    abstract::In big brown bats, tone-specific plastic changes [best frequency (BF) shifts] of cortical and collicular neurons can be evoked by auditory fear conditioning, repetitive acoustic stimuli or cortical electric stimulation. It has been shown that acetylcholine (ACh) plays an important role in evoking large long-term corti...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00112.2005

    authors: Ji W,Suga N,Gao E

    更新日期:2005-08-01 00:00:00

  • Nicotinic receptors modulate olfactory bulb external tufted cells via an excitation-dependent inhibitory mechanism.

    abstract::Olfactory bulb (OB) glomeruli, the initial sites of synaptic processing of odor information, exhibit high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. The role of glomerular nAChRs in olfactory processing, however, remains to be elucidated...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00865.2012

    authors: D'Souza RD,Parsa PV,Vijayaraghavan S

    更新日期:2013-10-01 00:00:00

  • P2 receptor-mediated signaling in spherical bushy cells of the mammalian cochlear nucleus.

    abstract::Purinoreceptors of the P2 family contribute strongly to signaling in the cochlea, but little is known about the effects of purinergic neurotransmission in the central auditory system. Here we examine P2 receptor-mediated signaling in the large spherical bushy cells (SBCs) of Mongolian gerbils around the onset of acous...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00186.2009

    authors: Milenkovic I,Rinke I,Witte M,Dietz B,Rübsamen R

    更新日期:2009-09-01 00:00:00

  • Spatiotemporal distribution of location and object effects in reach-to-grasp kinematics.

    abstract::In reaching to grasp an object, the arm transports the hand to the intended location as the hand shapes to grasp the object. Prior studies that tracked arm endpoint and grip aperture have shown that reaching and grasping, while proceeding in parallel, are interdependent to some degree. Other studies of reaching and gr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00686.2015

    authors: Rouse AG,Schieber MH

    更新日期:2015-12-01 00:00:00

  • Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin.

    abstract::1. Activation of neurokinin receptors contributes to the excitation of many dorsal horn neurons by cutaneous sensory stimuli, particularly noxious stimuli. In the present study we investigate the role of neurokinin receptors in the activation of primate spinothalamic tract (STT) neurons by cutaneous mechanical stimuli...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.4.1464

    authors: Dougherty PM,Palecek J,Palecková V,Willis WD

    更新日期:1994-10-01 00:00:00

  • Quantitative characterization of ceruleospinal inhibition of nociceptive transmission in the rat.

    abstract::A total of 51 dorsal horn units responsive to heat were isolated and their receptive fields characterized (i.e., response properties and adequate stimuli determined) in pentobarbital-anesthetized, paralyzed rats. In 39 of the 51 units, the descending inhibition of heat-evoked activity produced by focal electrical stim...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.5.1397

    authors: Jones SL,Gebhart GF

    更新日期:1986-11-01 00:00:00

  • Frequency-dependent regulation of afferent transmission in the feeding circuitry of Aplysia.

    abstract::During rhythmic behaviors, sensori-motor transmission is often regulated so that there are phasic changes in afferent input to follower neurons. We study this type of regulation in the feeding circuit of Aplysia. We characterize effects of the B4/5 interneurons on transmission from the mechanoafferent B21 to the radul...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00786.2003

    authors: Evans CG,Jing J,Proekt A,Rosen SC,Cropper EC

    更新日期:2003-12-01 00:00:00

  • Binocular 3D otolith-ocular reflexes: responses of normal chinchillas to tilt and translation.

    abstract::Head rotation, translation, and tilt with respect to a gravitational field elicit reflexive eye movements that partially stabilize images of Earth-fixed objects on the retinas of humans and other vertebrates. Compared with the angular vestibulo-ocular reflex, responses to translation and tilt, collectively called the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00882.2018

    authors: Hageman KN,Chow MR,Roberts D,Della Santina CC

    更新日期:2020-01-01 00:00:00

  • Fibrinogen-cellular prion protein complex formation on astrocytes.

    abstract::Traumatic brain injury (TBI) is one of the most common neurological disorders causing memory reduction, particularly short-term memory (STM). We showed that, during TBI-induced inflammation, increased blood content of fibrinogen (Fg) enhanced vascular protein transcytosis and deposition of extravasated Fg in vasculo-a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00224.2020

    authors: Charkviani M,Muradashvili N,Sulimai N,Lominadze D

    更新日期:2020-08-01 00:00:00

  • A transthalamic olfactory pathway to orbitofrontal cortex in the monkey.

    abstract::1. Evoked potentials restricted to the magnocellular portion of the mediodorsal nucleus (MDmc) of the thalamus were recorded after stimulation of the olfactory bulb (OB) and the posterior orbital cortex of the frontal lobe (OFC). Potentials evoked by stimulation of OB were probably trans-synaptically elicited, while p...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1980.43.1.69

    authors: Yarita H,Iino M,Tanabe T,Kogure S,Takagi SF

    更新日期:1980-01-01 00:00:00

  • Modulation of pursuit eye movements by stimulation of cortical areas MT and MST.

    abstract::1. Many cells in the superior temporal sulcus (STS) of the monkey that represent the foveal region of the visual field discharge during pursuit eye movements. Damage to these areas produces a deficit in the maintenance of pursuit eye movements when the target towards the side of the brain with the lesion. In the prese...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.62.1.31

    authors: Komatsu H,Wurtz RH

    更新日期:1989-07-01 00:00:00

  • Linear and nonlinear components of human electroretinogram.

    abstract::We compared electroretinographic (ERG) responses to uniform-field and a variety of pattern stimuli using both transient and steady-state analyses. Evidence is provided that for all of these stimuli, the peak at high temporal frequencies in the steady-state response corresponds to the fast wave of the transient respons...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.51.5.952

    authors: Baker CL Jr,Hess RF

    更新日期:1984-05-01 00:00:00

  • Transduction and adaptation in spider slit sense organ mechanoreceptors.

    abstract::1. Mechanoreceptor neurons in spider (Cupiennlus salei) slit sense organ were examined by intracellular current- and voltageclarry recordings. Steps and pseudorandomly modulated displacement stimuli were delivered to the mechanosensitive cuticular slits. The resulting responses were used to determine the response dyna...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.6.2513

    authors: Juusola M,French AS

    更新日期:1995-12-01 00:00:00

  • Decision making by urgency gating: theory and experimental support.

    abstract::It is often suggested that decisions are made when accumulated sensory information reaches a fixed accuracy criterion. This is supported by many studies showing a gradual build up of neural activity to a threshold. However, the proposal that this build up is caused by sensory accumulation is challenged by findings tha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01071.2011

    authors: Thura D,Beauregard-Racine J,Fradet CW,Cisek P

    更新日期:2012-12-01 00:00:00

  • Single and population coding of taste in the gustatory cortex of awake mice.

    abstract::Electrophysiological analysis has revealed much about the broad coding and neural ensemble dynamics that characterize gustatory cortical (GC) taste processing in awake rats and about how these dynamics relate to behavior. With regard to mice, however, data concerning cortical taste coding have largely been restricted ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00357.2019

    authors: Levitan D,Lin JY,Wachutka J,Mukherjee N,Nelson SB,Katz DB

    更新日期:2019-10-01 00:00:00

  • Modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C.

    abstract::Voltage-gated Na+ channels (VGSC) are transmembrane proteins that are essential for the initiation and propagation of action potentials in neuronal excitability. Because neurons express a mixture of Na+ channel isoforms and protein kinase C (PKC) isozymes, the nature of which channel is being regulated by which PKC is...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00676.2003

    authors: Vijayaragavan K,Boutjdir M,Chahine M

    更新日期:2004-04-01 00:00:00

  • Discharge patterns of neurons in the ventral nucleus of the lateral lemniscus of the unanesthetized rabbit.

    abstract::The ventral nucleus of the lateral lemniscus (VNLL) is a major auditory nucleus that sends a large projection to the inferior colliculus. Despite its prominence, the responses of neurons in the VNLL have not been extensively studied. Previous studies in nonecholocating species have used anesthesia, which is known to a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.3.1097

    authors: Batra R,Fitzpatrick DC

    更新日期:1999-09-01 00:00:00

  • Sensitive response to low-frequency cochlear distortion products in the auditory midbrain.

    abstract::During auditory stimulation with several frequency components, distortion products (DPs) are generated as byproduct of nonlinear cochlear amplification. After generated, DP energy is reemitted into the ear channel where it can be measured as DP otoacoustic emission (DPOAE), and it also induces an excitatory response a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90805.2008

    authors: Abel C,Kössl M

    更新日期:2009-03-01 00:00:00

  • Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex.

    abstract::In vitro whole cell patch-clamp recordings of stellate cells in layer II of medial entorhinal cortex show a subthreshold membrane potential resonance in response to a sinusoidal current injection of varying frequency. Physiological recordings from awake behaving animals show that neurons in layer II medial entorhinal ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00492.2009

    authors: Heys JG,Giocomo LM,Hasselmo ME

    更新日期:2010-07-01 00:00:00

  • Direction-selective adaptation in simple and complex cells in cat striate cortex.

    abstract::1. The selectivity of adaptation to unidirectional motion was examined in neurons of the cat striate cortex. Following prolonged stimulation with a unidirectional high-contrast grating, the responsivity of cortical neurons was reduced. In many units this decrease was restricted to the direction of prior stimulation. T...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.59.4.1314

    authors: Marlin SG,Hasan SJ,Cynader MS

    更新日期:1988-04-01 00:00:00

  • Neural processes associated with antisaccade task performance investigated with event-related FMRI.

    abstract::One of the hallmarks of cognitive control is the suppression of prepotent but inappropriate responses. Here we used event-related functional MRI to measure functional brain activation during a stimulus-response incompatibility task. Subjects were instructed before a stimulus appeared either to look at the stimulus (pr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00471.2004

    authors: Ford KA,Goltz HC,Brown MR,Everling S

    更新日期:2005-07-01 00:00:00

  • Long-term expression of two interacting motor pattern-generating networks in the stomatogastric system of freely behaving lobster.

    abstract::Rhythmic movements of the gastric mill and pyloric regions of the crustacean foregut are controlled by two stomatogastric neuronal networks that have been intensively studied in vitro. By using electromyographic recordings from the European lobster, Homarus gammarus, we have monitored simultaneously the motor activity...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.3.1396

    authors: Clemens S,Combes D,Meyrand P,Simmers J

    更新日期:1998-03-01 00:00:00

  • Risky business: disambiguating ambiguity-related responses in the brain.

    abstract::Previous functional MRI studies reported neural correlates of risk and ambiguity based on behavioral economic theories. A recent study controlled for uncertainty by adding noise to information of an impending aversive event and demonstrated brain areas that did not track the degree of uncertainty: the activation peake...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00406.2009

    authors: O'Neill M,Kobayashi S

    更新日期:2009-08-01 00:00:00

  • Multisensory enhancement in the optic tectum of the barn owl: spike count and spike timing.

    abstract::Temporal and spatial correlations between auditory and visual stimuli facilitate the perception of unitary events and improve behavioral responses. However, it is not clear how combined visual and auditory information is processed in single neurons. Here we studied responses of multisensory neurons in the barn owl's o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91193.2008

    authors: Zahar Y,Reches A,Gutfreund Y

    更新日期:2009-05-01 00:00:00

  • Zinc downmodulates thf GABAc receptor current in cone horizontal cells acutely isolated from the catfish retina.

    abstract::1. We studied the effect of zinc on the gamma-aminobutyric acid-C (GABAC) receptor in acutely isolated catfish cone horizontal cells using the whole cell patch-clamp technique. 2. GABA activates the GABAC receptor with a half-activation concentration (EC50) of 2.99 microM. The Hill coefficient is 1.32. Desensitization...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.2.916

    authors: Dong CJ,Werblin FS

    更新日期:1995-02-01 00:00:00