Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity.

abstract：:Although fluorescence microscopy has proven to be one of the most powerful tools in biology, its application to the intact animal has been limited to imaging several hundred micrometers below the surface. The rest of the animal has eluded investigation at the microscopic level without excising tissue or performing ext...

journal_title：Journal of neurophysiology

authors： Levene MJ,Dombeck DA,Kasischke KA,Molloy RP,Webb WW

更新日期：2004-04-01 00:00:00

abstract：:Seizures may cause brain damage due to mechanisms initiated by excessive excitatory synaptic transmission. One such mechanism is the activation of death-promoting intracellular cascades by the influx and the perturbed homeostasis of Ca2+. The neuroprotective effects of preventing the entry of Ca2+ from voltage-depende...

journal_title：Journal of neurophysiology

authors： Pelletier MR,Wadia JS,Mills LR,Carlen PL

更新日期：1999-06-01 00:00:00

abstract：:In this study, the representation of taste in the orbitofrontal cortex was investigated to determine whether or not a pleasant and an aversive taste have distinct or overlapping representations in this region. The pleasant stimulus used was sweet taste (1 M glucose), and the unpleasant stimulus was salt taste (0.1 M N...

journal_title：Journal of neurophysiology

authors： O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F

更新日期：2001-03-01 00:00:00

abstract：:Cutaneous application of painful radiant heat laser pulses evokes potentials (laser-evoked potentials) that can be recorded from scalp or intracranial electrodes. We have now tested the hypothesis that the response of thalamic neurons to a cutaneous laser stimulus occurs at latencies predicted by the conduction delay ...

journal_title：Journal of neurophysiology

authors： Kobayashi K,Winberry J,Liu CC,Treede RD,Lenz FA

更新日期：2009-05-01 00:00:00

abstract：:Evidence for a persistent Na+ current (I(NaP)) in the apical dendrite of neocortical neurons was sought with the use of fluorescence imaging to measure changes in intradendritic Na+ concentration. Neurons in neocortical brain slices were filled iontophoretically through an intracellular recording microelectrode with t...

journal_title：Journal of neurophysiology

authors： Mittmann T,Linton SM,Schwindt P,Crill W

更新日期：1997-08-01 00:00:00

abstract：:Experience-dependent modification in the electrical properties of central neurons is a form of intrinsic plasticity that occurs during development and has been observed following behavioral learning. We report a novel form of intrinsic plasticity in hippocampal CA1 pyramidal neurons mediated by the KV7/KCNQ and CaV1/L...

journal_title：Journal of neurophysiology

authors： Wu WW,Chan CS,Surmeier DJ,Disterhoft JF

更新日期：2008-10-01 00:00:00

abstract：:Previous research has described kinetic characteristics of treadmill steps in very stable steppers, in cross-sectional designs. In this study we examined, longitudinally, muscle activation patterns during treadmill stepping, without practice, in 12 healthy infants at 1, 6, and 12 mo of age. We assessed lateral gastroc...

journal_title：Journal of neurophysiology

authors： Teulier C,Sansom JK,Muraszko K,Ulrich BD

更新日期：2012-08-01 00:00:00

abstract：:The temporal lobe is well known for its oscillatory activity associated with exploration, navigation, and learning. Intrinsic membrane potential oscillations (MPOs) and resonance of stellate cells (SCs) in layer II of the entorhinal cortex are thought to contribute to network oscillations and thereby to the encoding o...

journal_title：Journal of neurophysiology

authors： Boehlen A,Henneberger C,Heinemann U,Erchova I

更新日期：2013-01-01 00:00:00

abstract：:An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded...

journal_title：Journal of neurophysiology

authors： Compte A,Constantinidis C,Tegner J,Raghavachari S,Chafee MV,Goldman-Rakic PS,Wang XJ

更新日期：2003-11-01 00:00:00

abstract：:Microglia constitute ~10-20% of glial cells in the adult human brain. They are the resident phagocytic immune cells of the central nervous system and play an integral role as first responders during inflammation. Microglia are commonly classified as "HM" (homeostatic), "M1" (classically activated proinflammatory), or ...

journal_title：Journal of neurophysiology

authors： von Maydell D,Jorfi M

更新日期：2019-10-01 00:00:00

abstract：:Synapsin is a synaptic vesicle-associated protein implicated in the regulation of vesicle trafficking and transmitter release, but its role in heterosynaptic plasticity remains elusive. Moreover, contradictory results have obscured the contribution of synapsin to homosynaptic plasticity. We previously reported that th...

journal_title：Journal of neurophysiology

authors： Fioravante D,Liu RY,Netek AK,Cleary LJ,Byrne JH

更新日期：2007-12-01 00:00:00

abstract：:Recent advances in recording and computing hardware have enabled laboratories to record the electrical activity of multiple brain regions simultaneously. Lagging behind these technical advances, however, are the methods needed to rapidly produce microdrives and head-caps that can flexibly accommodate different recordi...

journal_title：Journal of neurophysiology

authors： Headley DB,DeLucca MV,Haufler D,Paré D

更新日期：2015-04-01 00:00:00

abstract：:Changes to cerebral miRNA expression have been implicated in the progression of Alzheimer's disease (AD), as miRNAs that regulate the expression of gene products involved in amyloid beta (Aβ) processing, such as BACE1, are dysregulated in those that suffer from AD. Exercise training improves cognition and reduces BACE...

journal_title：Journal of neurophysiology

authors： Dungan CM,Valentino T,Vechetti IJ Jr,Zdunek CJ,Murphy MP,Lin AL,McCarthy JJ,Peterson CA

更新日期：2020-12-01 00:00:00

abstract：:1. Less than two segments of the cervical spinal cord of the mudpuppy (Necturus maculatus) is sufficient to generate a locomotor rhythm with application of N-methyl-D-aspartic acid (NMDA). We have recorded intracellularly from rhythmically active interneurons in these segments and classified them according to their ph...

journal_title：Journal of neurophysiology

authors： Wheatley M,Jovanović K,Stein RB,Lawson V

更新日期：1994-06-01 00:00:00

abstract：:Voluntary and stimulus-driven shifts of attention can modulate the representation of behaviorally relevant stimuli in early areas of visual cortex. In turn, attended items are processed faster and more accurately, facilitating the selection of appropriate behavioral responses. Information processing is also strongly i...

journal_title：Journal of neurophysiology

authors： Serences JT,Saproo S

更新日期：2010-07-01 00:00:00

abstract：:1. Visual interneurons tuned to the motion of small objects are found in many animal species and are assumed to be the neuronal basis of figure-ground discrimination by relative motion. A well-examined example is the FD1-cell in the third visual neuropil of blowflies. This cell type responds best to motion of small ob...

journal_title：Journal of neurophysiology

authors： Warzecha AK,Egelhaaf M,Borst A

更新日期：1993-02-01 00:00:00

abstract：:1. Teased axon recordings were made from 167 spontaneously active A beta- and A delta-afferents that ended in sciatic nerve end neuromas of 6-12 days standing. When challenged with a standard bolus of systemically applied adrenaline, 100 (60%) responded, either with an increase in baseline firing frequency (excitation...

journal_title：Journal of neurophysiology

authors： Chen Y,Michaelis M,Janig W,Devor M

更新日期：1996-12-01 00:00:00

abstract：:1. Voltage-dependent Na+ conductances were studied in small (18-25 microns diam) adult rat dorsal root ganglion (DRG) neurons with the use of the whole cell patch-clamp technique. Na+ currents were also recorded from larger (44-50 microns diam) neurons and compared with those of the small neurons. 2. The predominant N...

journal_title：Journal of neurophysiology

authors： Rizzo MA,Kocsis JD,Waxman SG

更新日期：1994-12-01 00:00:00

abstract：:1. The vibratory response to two-tone stimuli was measured in the basilar membrane of the chinchilla cochlea by means of the Mössbauer technique or laser velocimetry. Measurements were made at sites with characteristic frequency (CF, the frequency at which an auditory structure is most sensitive) of 7-10 kHz, located ...

journal_title：Journal of neurophysiology

authors： Ruggero MA,Robles L,Rich NC

更新日期：1992-10-01 00:00:00

abstract：:The development of synaptic interconnections between the cerebellum and inferior olive, the sole source of climbing fibers, could contribute to the ontogeny of certain forms of motor learning (e.g., eyeblink conditioning). Purkinje cell complex spikes are produced exclusively by climbing fibers and exhibit short- and ...

journal_title：Journal of neurophysiology

authors： Nicholson DA,Freeman JH Jr

更新日期：2003-10-01 00:00:00

abstract：:The human motor system regulates arm mechanics to produce stable postures during interactions with different physical environments. This occurs partly via involuntary mechanisms, including stretch reflexes. Previous single-joint studies demonstrated enhanced reflex sensitivity during interactions with compliant enviro...

journal_title：Journal of neurophysiology

authors： Perreault EJ,Chen K,Trumbower RD,Lewis G

更新日期：2008-05-01 00:00:00

abstract：:Working memory (WM) for sensory-based information about individual objects and their locations appears to involve interactions between lateral prefrontal and sensory cortexes. The mechanisms and representations for maintenance of more abstract, nonsensory information in WM are unknown, particularly whether such active...

journal_title：Journal of neurophysiology

authors： Ikkai A,Blacker KJ,Lakshmanan BM,Ewen JB,Courtney SM

更新日期：2014-10-15 00:00:00

abstract：:1. Intracellular and extracellular recordings were obtained from ganglion cells in the rabbit retina. The effect of N-methyl-DL-aspartate (NMDLA) and N-methyl-D-aspartate (NMDA) antagonists were studied with the use of a perfusion method for drug application. 2. NMDLA excited all ganglion cell types and caused a chara...

journal_title：Journal of neurophysiology

authors： Massey SC,Miller RF

更新日期：1990-01-01 00:00:00

abstract：:We compared electroretinographic (ERG) responses to uniform-field and a variety of pattern stimuli using both transient and steady-state analyses. Evidence is provided that for all of these stimuli, the peak at high temporal frequencies in the steady-state response corresponds to the fast wave of the transient respons...

journal_title：Journal of neurophysiology

authors： Baker CL Jr,Hess RF

更新日期：1984-05-01 00:00:00

abstract：:Pharmacological modulation of gamma-aminobutyric acid-A (GABAA) receptors can provide important information on the types of subunits composing these receptors. In recombinant studies, zinc more potently inhibits alphabeta subunits compared with the alphabetagamma combination, whereas modulation by nanomolar concentrat...

journal_title：Journal of neurophysiology

authors： Defazio T,Hablitz JJ

更新日期：1998-10-01 00:00:00

abstract：:Rhythm generation by the gastric motor network in the stomatogastric ganglion (STG) of the lobster Homarus gammarus is controlled by modulatory projection neurons from rostral commissural ganglia (CoGs); blocking action potential conduction in these inputs to the STG of a stomatogastric nervous system in vitro rapidly...

journal_title：Journal of neurophysiology

authors： Faumont S,Simmers J,Meyrand P

更新日期：1998-11-01 00:00:00

abstract：:1. The antidromic compound action potential (ACAP) of the auditory nerve was evoked by shocks to the auditory nerve root and recorded at the round window of the cochlea in anesthetized guinea pigs. The goal of this study was to determine the characteristics of the ACAP and compare these characteristics with those of t...

journal_title：Journal of neurophysiology

authors： Brown MC

更新日期：1994-05-01 00:00:00

abstract：:In many rhythmic neuronal networks that operate in a wide range of frequencies, the time of neuronal firing relative to the cycle period (the phase) is invariant. This invariance suggests that when frequency changes, firing time is precisely adjusted either by intrinsic or synaptic mechanisms. We study the maintenance...

journal_title：Journal of neurophysiology

authors： Manor Y,Bose A,Booth V,Nadim F

更新日期：2003-11-01 00:00:00

abstract：:1. Eleven adult cats were trained to stop inspiration in response to a conditioning stimulus. The conditioning stimuli were presented at the onset of inspiration at intervals of approximately 20-30 s. Intratracheal pressures, diaphragmatic activity, and the extracellular activity of single medullary respiratory neuron...

journal_title：Journal of neurophysiology

authors： Orem J

更新日期：1989-11-01 00:00:00

abstract：:Dopamine neurons in freely moving rats often fire behaviorally relevant high-frequency bursts, but depolarization block limits the maximum steady firing rate of dopamine neurons in vitro to ∼10 Hz. Using a reduced model that faithfully reproduces the sodium current measured in these neurons, we show that adding an add...

journal_title：Journal of neurophysiology

authors： Qian K,Yu N,Tucker KR,Levitan ES,Canavier CC

更新日期：2014-12-01 00:00:00