Maintenance of relational information in working memory leads to suppression of the sensory cortex.

Abstract:

:Working memory (WM) for sensory-based information about individual objects and their locations appears to involve interactions between lateral prefrontal and sensory cortexes. The mechanisms and representations for maintenance of more abstract, nonsensory information in WM are unknown, particularly whether such actively maintained information can become independent of the sensory information from which it was derived. Previous studies of WM for individual visual items found increased electroencephalogram (EEG) alpha (8-13 Hz) power over posterior electrode sites, which appears to correspond to the suppression of cortical areas that represent irrelevant sensory information. Here, we recorded EEG while participants performed a visual WM task that involved maintaining either concrete spatial coordinates or abstract relational information. Maintenance of relational information resulted in higher alpha power in posterior electrodes. Furthermore, lateralization of alpha power due to a covert shift of attention to one visual hemifield was marginally weaker during storage of relational information than during storage of concrete information. These results suggest that abstract relational information is maintained in WM differently from concrete, sensory representations and that during maintenance of abstract information, posterior sensory regions become task irrelevant and are thus suppressed.

journal_name

J Neurophysiol

authors

Ikkai A,Blacker KJ,Lakshmanan BM,Ewen JB,Courtney SM

doi

10.1152/jn.00134.2014

subject

Has Abstract

pub_date

2014-10-15 00:00:00

pages

1903-15

issue

8

eissn

0022-3077

issn

1522-1598

pii

jn.00134.2014

journal_volume

112

pub_type

杂志文章
  • Spatial attention enhances the selective integration of activity from area MT.

    abstract::Distinguishing which of the many proposed neural mechanisms of spatial attention actually underlies behavioral improvements in visually guided tasks has been difficult. One attractive hypothesis is that attention allows downstream neural circuits to selectively integrate responses from the most informative sensory neu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00949.2011

    authors: Masse NY,Herrington TM,Cook EP

    更新日期:2012-09-01 00:00:00

  • Population response profiles in early visual cortex are biased in favor of more valuable stimuli.

    abstract::Voluntary and stimulus-driven shifts of attention can modulate the representation of behaviorally relevant stimuli in early areas of visual cortex. In turn, attended items are processed faster and more accurately, facilitating the selection of appropriate behavioral responses. Information processing is also strongly i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01090.2009

    authors: Serences JT,Saproo S

    更新日期:2010-07-01 00:00:00

  • Evoked responses of the dentate gyrus during seizures in developing gerbils with inherited epilepsy.

    abstract::When they are 1-2 mo old, domesticated Mongolian gerbils begin having initially mild seizures which become more severe with age. To evaluate the development of this increasing seizure severity, we obtained field potential responses of the dentate gyrus to paired-pulse stimulation of the perforant path during seizures....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.2.783

    authors: Buckmaster PS,Wong EH

    更新日期:2002-08-01 00:00:00

  • Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus.

    abstract::Inhibition is presumed to play an important role in gustatory processing in the rostral nucleus of the solitary tract (rNST). One source of inhibition, GABA, is abundant within the nucleus and comes both from local, intrasolitary sources and from outside the nucleus. In addition to the receptor-mediated effects of GAB...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00168.2016

    authors: Chen Z,Travers SP,Travers JB

    更新日期:2016-08-01 00:00:00

  • Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons.

    abstract::The lability of the responses of mammalian central neurons to gamma-aminobutyric acid (GABA) was studied using neurons acutely dissociated from the CA1 region of the adult guinea pig hippocampus as a model system. GABA was applied to the neuronal somata by pressure ejection and the resulting current (IGABA) recorded u...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.1.1

    authors: Huguenard JR,Alger BE

    更新日期:1986-07-01 00:00:00

  • Uncertainty and invariance in the human visual cortex.

    abstract::The way in which input noise perturbs the behavior of a system depends on the internal processing structure of the system. In visual psychophysics, there is a long tradition of using external noise methods (i.e., adding noise to visual stimuli) as tools for system identification. Here, we demonstrate that external noi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01367.2005

    authors: Tjan BS,Lestou V,Kourtzi Z

    更新日期:2006-09-01 00:00:00

  • The quantal component of synaptic transmission from sensory hair cells to the vestibular calyx.

    abstract::Spontaneous and stimulus-evoked excitatory postsynaptic currents (EPSCs) were recorded in calyx nerve terminals from the turtle vestibular lagena to quantify key attributes of quantal transmission at this synapse. On average, EPSC events had a magnitude of ∼ 42 pA, a rise time constant of τ(0) ∼ 229 μs, decayed to bas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00055.2015

    authors: Highstein SM,Mann MA,Holstein GR,Rabbitt RD

    更新日期:2015-06-01 00:00:00

  • Inhibition and facilitation of different nocifensor reflexes by spatially remote noxious stimuli.

    abstract::1. Noxious stimuli have been shown to produce a diffuse inhibition of nociresponsive neurons in the spinal and trigeminal dorsal horns. The present study sought to extend these electrophysiological studies of diffuse noxious inhibitory controls (DNIC) by determining the effect of a spatially remote noxious stimulus on...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.3.1152

    authors: Morgan MM,Heinricher MM,Fields HL

    更新日期:1994-09-01 00:00:00

  • Large gaze shift generation while standing: the role of the vestibular system.

    abstract::The functional significance of vestibular information for the generation of gaze shifts is controversial and less well established than the vestibular contribution to gaze stability. In this study, we asked seven bilaterally avestibular patients to execute voluntary, whole body pivot turns to visual targets up to 180°...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00343.2019

    authors: Anastasopoulos D,Ziavra N,Bronstein AM

    更新日期:2019-11-01 00:00:00

  • Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

    abstract::The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory perception, motor control, arousal, attention, learning, and memory. Here we investigate the mechanisms by which ACh affects neocortical pyramidal neurons in adult mice. Stimulation of cholinergic axons activated muscarinic and nicotinic...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00716.2014

    authors: Hedrick T,Waters J

    更新日期:2015-04-01 00:00:00

  • Optogenetic fMRI sheds light on the neural basis of the BOLD signal.

    abstract::Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neuro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00535.2010

    authors: Palmer HS

    更新日期:2010-10-01 00:00:00

  • Expression of motor learning in the response of the primate vestibuloocular reflex pathway to electrical stimulation.

    abstract::1. The vestibuloocular reflex (VOR) undergoes long-term adaptive changes in the presence of persistent retinal image motion during head turns. Previous experiments using natural stimuli have provided evidence that the VOR is subserved by parallel pathways, including some that are modified during learning and some that...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.67.6.1493

    authors: Broussard DM,Brontë-Stewart HM,Lisberger SG

    更新日期:1992-06-01 00:00:00

  • Generation and coordination of heartbeat timing oscillation in the medicinal leech. II. Intersegmental coordination.

    abstract::1. A network of four pairs of interneurons, HN(1)-HN(4), times the heartbeat of the medicinal leech. The following model accounts for the stable phase relationships in the network and the network's response to perturbation, entrainment, and stimulation. 2. There are two centers of oscillation, one the HN(3) pair in th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.49.3.627

    authors: Peterson EL

    更新日期:1983-03-01 00:00:00

  • Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia.

    abstract::1. Plasticity at the connections between sensory neurons and their follower cells in Aplysia has been used extensively as a model system to examine mechanisms of simple forms of learning. Earlier studies have concluded that serotonin (5-HT) is a key modulatory transmitter and that it exerts its short-term actions via ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.2.643

    authors: Sugita S,Goldsmith JR,Baxter DA,Byrne JH

    更新日期:1992-08-01 00:00:00

  • The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network.

    abstract::The spinal network coordinating locomotion is comprised of a core of glutamate and glycine interneurons. This network is modulated by several transmitter systems including spinal GABA interneurons. The purpose of this study is to explore the contribution of GABAergic neurons to the regulation of locomotor burst freque...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00233.2004

    authors: Schmitt DE,Hill RH,Grillner S

    更新日期:2004-10-01 00:00:00

  • Modulatory effect of substance P to the brain stem locomotor command in lampreys.

    abstract::Substance P initiates locomotion when injected in the brain stem of mammals. This study examined the possible role of this peptide on the supraspinal locomotor command system in lampreys. Substance P was bath applied or locally injected into an in vitro isolated brain stem, and the effects of the drug were examined on...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00401.2004

    authors: Brocard F,Bardy C,Dubuc R

    更新日期:2005-04-01 00:00:00

  • Reference frames for spinal proprioception: kinematics based or kinetics based?

    abstract::This second paper of the series deals with another issue regarding sensorimotor representations in the CNS that has received much attention, namely the relative weighting of kinematic and kinetic representations. The question we address here is the contribution of muscle tension afferent information in dorsal spinocer...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.5.2946

    authors: Bosco G,Poppele RE

    更新日期:2000-05-01 00:00:00

  • A method for generating precise temporal patterns of retinal spiking using prosthetic stimulation.

    abstract::The goal of retinal prosthetic devices is to generate meaningful visual information in patients that have lost outer retinal function. To accomplish this, these devices should generate patterns of ganglion cell activity that closely resemble the spatial and temporal components of those patterns that are normally elici...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00849.2005

    authors: Fried SI,Hsueh HA,Werblin FS

    更新日期:2006-02-01 00:00:00

  • 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus.

    abstract::The suprachiasmatic nucleus (SCN) receives a dense serotonergic innervation that modulates photic input to the SCN via serotonin 1B (5-HT1B) presynaptic receptors on retinal glutamatergic terminals. However, the majority of 5-HT1B binding sites in the SCN are located on nonretinal terminals and most axonal terminals i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00770.2004

    authors: Bramley JR,Sollars PJ,Pickard GE,Dudek FE

    更新日期:2005-06-01 00:00:00

  • Preferential correlations of a medullary neuron's activity to different sympathetic outflows as revealed by partial coherence analysis.

    abstract::1. In vagotomized, paralyzed, decerebrate cats, simultaneous recordings were taken from one or more sympathetic nerves [cervical sympathetic (CS), inferior cardiac (IC), splanchnic (SP)] and from medullary neurons in vasomotor-related regions. Coherence analyses were used to ascertain the presence of sympathetic rhyth...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.1.474

    authors: Cohen MI,Yu Q,Huang WX

    更新日期:1995-07-01 00:00:00

  • Hemispheric differences in the relationship between corticomotor excitability changes following a fine-motor task and motor learning.

    abstract::Motor performance induces a postexercise increase in corticomotor excitability that may be associated with motor learning. We investigated whether there are hemispheric differences in the extent and/or time course of changes in corticomotor excitability following a manipulation task (Purdue pegboard) and their relatio...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00595.2003

    authors: Garry MI,Kamen G,Nordstrom MA

    更新日期:2004-04-01 00:00:00

  • Retinotopic organization of lateral eye input to Limulus brain.

    abstract::1. The retinotopic organization of retinal inputs from the lateral eye of Limulus to the optic ganglia of the brain was determined from microelectrode recordings of nerve impulses. 2. The central connections of the natural subunits of the lateral optic nerve were determined using cobalt impregnation of cut axons. 3. C...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.48.2.505

    authors: Chamberlain SC,Barlow RB Jr

    更新日期:1982-08-01 00:00:00

  • Functional properties of neurons in the primate tongue primary motor cortex during swallowing.

    abstract::Recent studies conducted in our laboratory have suggested that the tongue primary motor cortex (i.e., tongue-MI) plays a critical role in the control of voluntary tongue movements in the primate. However, the possible involvement of tongue-MI in semiautomatic tongue movements, such as those in swallowing, remains unkn...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.3.1516

    authors: Martin RE,Murray GM,Kemppainen P,Masuda Y,Sessle BJ

    更新日期:1997-09-01 00:00:00

  • The motor inhibitory system operating during active sleep is tonically suppressed by GABAergic mechanisms during other states.

    abstract::The present study was undertaken to explore the neuronal mechanisms responsible for muscle atonia that occurs after the microinjection of bicuculline into the nucleus pontis oralis (NPO). Specifically, we wished to test the hypothesis that motoneurons are postsynaptically inhibited after the microinjection of bicucull...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.4.1908

    authors: Xi MC,Morales FR,Chase MH

    更新日期:2001-10-01 00:00:00

  • Inhibition of bradykinin-induced plasma extravasation produced by noxious cutaneous and visceral stimuli and its modulation by vagal activity.

    abstract::Intrathecally applied nicotine reduces bradykinin-induced plasma extravasation (BK-induced PE) in the rat knee joint. This depression is mediated by the hypothalamo-pituitary-adrenal (HPA) axis and is enhanced by interruption of impulse traffic in afferents of the abdominal vagus nerve. Like intrathecal nicotine, elec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.3.1285

    authors: Miao FJ,Jänig W,Green PG,Levine JD

    更新日期:1997-09-01 00:00:00

  • Rapid acquisition of novel interface control by small ensembles of arbitrarily selected primary motor cortex neurons.

    abstract::Pioneering studies demonstrated that novel degrees of freedom could be controlled individually by directly encoding the firing rate of single motor cortex neurons, without regard to each neuron's role in controlling movement of the native limb. In contrast, recent brain-computer interface work has emphasized decoding ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00373.2013

    authors: Law AJ,Rivlis G,Schieber MH

    更新日期:2014-09-15 00:00:00

  • Pathway mechanism for excitatory and inhibitory control in working memory.

    abstract::Humans engage in many daily activities that rely on working memory, the ability to hold and sequence information temporarily to accomplish a task. We focus on the process of working memory, based on circuit mechanisms for attending to relevant signals and suppressing irrelevant stimuli. We discuss that connections cri...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00936.2017

    authors: Barbas H,Wang J,Joyce MKP,García-Cabezas MÁ

    更新日期:2018-11-01 00:00:00

  • Antidromic activity in visual radiation during evoked cortical responses.

    abstract::1. Antidromic stimulation of the visual radiation of cats has been used to investigate the possibility that some of the activity in principal geniculate cells following an optic tract stimulus is antidromic. Single spikes were selected from two classes of poststimulus activity to condition the antidromic test spike--t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1977.40.1.9

    authors: Rosen AD,Vastola EF

    更新日期:1977-01-01 00:00:00

  • Serotonin and forskolin increase an inwardly rectifying potassium conductance in cultured identified Aplysia neurons.

    abstract::1. The effect of serotonin (5-HT) and forskolin on an inwardly rectifying K+ conductance (IKR) was studied using voltage-clamp techniques in several identified Aplysia neurons isolated and maintained in primary cell culture. 2. Inward rectification was observed in the current-voltage relationship of the identified neu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.5.909

    authors: Lotshaw DP,Levitan IB

    更新日期:1987-11-01 00:00:00

  • Activation of a lobster motor rhythm-generating network by disinhibition of permissive modulatory inputs.

    abstract::Rhythm generation by the gastric motor network in the stomatogastric ganglion (STG) of the lobster Homarus gammarus is controlled by modulatory projection neurons from rostral commissural ganglia (CoGs); blocking action potential conduction in these inputs to the STG of a stomatogastric nervous system in vitro rapidly...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.5.2776

    authors: Faumont S,Simmers J,Meyrand P

    更新日期:1998-11-01 00:00:00