Abstract:
:1. The antidromic compound action potential (ACAP) of the auditory nerve was evoked by shocks to the auditory nerve root and recorded at the round window of the cochlea in anesthetized guinea pigs. The goal of this study was to determine the characteristics of the ACAP and compare these characteristics with those of the orthodromic, sound-evoked compound action potential (CAP). 2. The ACAP consists of an initial complex of a positive peak (p1) followed by a negative peak (n1). In contrast, the CAP consists of a negative peak (N1) followed by a positive peak (P1). These differences in waveform are likely due to the differences in conduction direction, antidromic for the ACAP vs. orthodromic for the CAP. 3. After the initial complex, the ACAP has a second complex of peaks (p2, n2) at a latency of approximately 1 ms; this complex is much smaller in amplitude than the initial complex (p1, n1). It is likely that the initial ACAP complex reflects firing of auditory-nerve fibers whereas the second complex reflects firing of neurons further centrally, perhaps in the cochlear nucleus, that are activated by orthodromic firing of auditory-nerve fibers. 4. Experiments with shock pairs are consistent with the idea that for auditory nerve fibers, the absolute refractory period is < 0.5 ms, and the relative refractory period is between 0.5 and at least 5 ms. 5. Experiments with click-shock pairs indicate that a shock interferes with the response to a click when the click and shock are given at about the same time.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Brown MCdoi
10.1152/jn.1994.71.5.1826subject
Has Abstractpub_date
1994-05-01 00:00:00pages
1826-34issue
5eissn
0022-3077issn
1522-1598journal_volume
71pub_type
杂志文章abstract::The objective of this project was to examine the influence of stimulus waveform and frequency on extracellular stimulation of neurons with their cell bodies near the electrode (local cells) and fibers of passage in the CNS. Detailed computer-based models of CNS cells and axons were developed that accurately reproduced...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.88.4.1592
更新日期:2002-10-01 00:00:00
abstract::Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2811
更新日期:1997-11-01 00:00:00
abstract::1. The discharges from individual Golgi tendon organs of peroneus tertius and brevis muscles were recorded in anesthetized cats. Responses to unfused isometric contractions of single motor units and combinations of motor units were compared with responses to contractions eliciting muscle shortening (i.e., shortening c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.59.5.1510
更新日期:1988-05-01 00:00:00
abstract::The cardiac ganglion (CG) of Homarus americanus is a central pattern generator that consists of two oscillatory groups of neurons: "small cells" (SCs) and "large cells" (LCs). We have shown that SCs and LCs begin their bursts nearly simultaneously but end their bursts at variable phases. This variability contrasts wit...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01010.2012
更新日期:2013-05-01 00:00:00
abstract::Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular dri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00437.2018
更新日期:2019-02-01 00:00:00
abstract::A mathematical model is developed for simulation of action potential propagation through a single branch point of a myelinated nerve fiber with a parent branch bifurcating into two identical daughter branches. This model is based on a previously published multi-layer compartmental model for single unbranched myelinate...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.1.197
更新日期:2001-01-01 00:00:00
abstract::Motor imagery (MI) is a promising rehabilitation technique that has received significant interest for use in persons with multiple sclerosis (MS). Through alterations in neural networks, MI has the potential to improve measures of walking speed, walking distance, and fatigue in people with MS. Further research is requ...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00291.2018
更新日期:2019-02-01 00:00:00
abstract::Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01107.2006
更新日期:2007-08-01 00:00:00
abstract::We introduce a new method to unveil the network connectivity among dozens of neurons in brain slice preparations. While synaptic inputs were whole cell recorded from given postsynaptic neurons, the spatiotemporal firing patterns of presynaptic neuron candidates were monitored en masse with functional multineuron calci...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00012.2009
更新日期:2009-07-01 00:00:00
abstract::Paw-shake responses (PSRs) were evoked by wrapping masking tape around the hind-paw in nine cats spinalized at the T12 level either at 2 or 12 wk of age or as young adults (10-12 mo). Electromyographic responses of ankle extensors (LG and SOL) and one ankle flexor (TA) were recorded through the 6th mo after cord trans...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.51.4.680
更新日期:1984-04-01 00:00:00
abstract::The present study was an examination of state-dependent functional connectivity during spontaneous activity between the piriform cortex and its upstream and downstream connections. Rats were anesthetized with urethan and allowed to spontaneously cycle between fast- and slow-wave states similar to fast- and slow-wave s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00711.2010
更新日期:2010-12-01 00:00:00
abstract::Prefrontal cortex (PFC) dopamine D1/5 receptors modulate long- and short-term neuronal plasticity that may contribute to cognitive functions. Synergistic to synaptic strength modulation, direct postsynaptic D1/5 receptor activation also modulates voltage-dependent ionic currents that regulate spike firing, thus alteri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00317.2006
更新日期:2007-03-01 00:00:00
abstract::Recent experimental findings suggest that there may be rich physiological information embedded within the power spectrum of neurophysiological recordings, which, in addition to power in specific oscillatory frequencies, can be extracted with the appropriate model. This article reviews previous empirical and modeling r...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00722.2015
更新日期:2016-02-01 00:00:00
abstract::The primate posterior thalamus has been proposed to contribute to pain sensation, but its precise role is unclear. This is in part because spinothalamic tract (STT) neurons that project to the posterior thalamus have received little attention. In this study, antidromic mapping was used to identify individual STT neuro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90810.2008
更新日期:2008-10-01 00:00:00
abstract::AMPA-type glutamate receptors are normally Ca(2+) impermeable due to the expression of the GluR2 receptor subunit. By using GluR2 null mice we were able to detect miniature synaptic Ca(2+) transients (MSCTs) associated with AMPA-type receptor-mediated miniature synaptic currents at single synapses in primary cortical ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.88.1.29
更新日期:2002-07-01 00:00:00
abstract::Previous research has described kinetic characteristics of treadmill steps in very stable steppers, in cross-sectional designs. In this study we examined, longitudinally, muscle activation patterns during treadmill stepping, without practice, in 12 healthy infants at 1, 6, and 12 mo of age. We assessed lateral gastroc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01037.2011
更新日期:2012-08-01 00:00:00
abstract::Neurons in the inferior colliculus (IC) process acoustic information converging from inputs from almost all nuclei of the auditory brain stem. Despite its importance in auditory processing, little is known about the distribution of ion currents in IC neurons, namely the hyperpolarization-activated current Ih. This cur...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00375.2003
更新日期:2003-12-01 00:00:00
abstract::Breathing frequency increases at the onset of movement in a wide rage of mammals including adult humans. Moreover, the magnitude of increase in the rate of breathing appears related to the rate of the rhythmic movement. We determined whether human infants show the same type of response when supported to step on a trea...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00868.2007
更新日期:2008-03-01 00:00:00
abstract::Recent findings indicate that monkeys can report their confidence in perceptual decisions and that this information is encoded in neurons involved in making decisions, including the lateral intraparietal area (LIP) and the supplementary eye field (SEF). A key issue to consider when studying confidence is that decision...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00152.2018
更新日期:2018-11-01 00:00:00
abstract::The role of the nitric oxide (NO)-cGMP signaling cascade in modulation of peripheral nociception is controversial. Although behavioral studies have suggested both pro- and anti-nociceptive effects, little is known about the direct action of this signaling cascade on primary afferent nociceptive neurons that mediate th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00058.2004
更新日期:2004-08-01 00:00:00
abstract::Responses have been recorded from primary endings of muscle spindles in the cat soleus muscle. Changes in spindle responsiveness were measured following a period of conditioning that consisted of a series of rapid stretches or of tetanic ventral root stimulation. In the testing procedure the response of a single spind...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.56.2.451
更新日期:1986-08-01 00:00:00
abstract::To understand the contribution of the human presupplementary motor area (pre-SMA) in sequential motor behavior, we performed a series of finger key-press experiments. Experiment 1 revealed that each subject had a spontaneous tendency to organize or "chunk" a long sequence into shorter components. We hypothesized that ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00651.2003
更新日期:2004-02-01 00:00:00
abstract::Motor behavior often occurs in environments with multiple goal options that can vary during the ongoing action. We explored this situation by requiring subjects to select between different target options during an ongoing reach. During split trials the original target was replaced with a left and a right flanking targ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00336.2020
更新日期:2020-10-01 00:00:00
abstract::Precisely synchronized neuronal activity has been commonly observed in the mammalian visual pathway. Spike timing correlations in the lateral geniculate nucleus (LGN) often take the form of phase synchronized oscillations in the high gamma frequency range. To study the relations between oscillatory activity, synchrony...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01000.2009
更新日期:2010-12-01 00:00:00
abstract::GSG1L is an AMPA receptor (AMPAR) auxiliary subunit that regulates AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its physiological roles in other types of neurons remain to be characterized. Here, we investigated the role of GSG1L in hippocampal dentate granule cells and found that GSG1...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00307.2016
更新日期:2017-01-01 00:00:00
abstract::Synaptic dynamics comprise a variety of interacting processes acting on a wide range of time scales. This enables a synapse to perform a large array of computations, from temporal and spatial filtering to associative learning. In this study, we describe how changing synaptic gain via long-term plasticity can act to sh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00856.2003
更新日期:2004-02-01 00:00:00
abstract::Over the past decade neuroscientific research has attempted to probe the neurobiological underpinnings of human prosocial decision making. Such research has almost ubiquitously employed tasks such as the dictator game or similar variations (i.e., ultimatum game). Considering the explicit numerical nature of such tasks...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00372.2017
更新日期:2017-12-01 00:00:00
abstract::We studied the effects of horizontal smooth pursuit on the ocular responses to brief vertical perturbations of textured backgrounds in humans. When the subject was fixating on a stationary target, a brief vertical perturbation of the background elicited a small tracking response. When the subject was pursuing a target...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00430.2009
更新日期:2009-09-01 00:00:00
abstract::Interaural time differences (ITDs) conveyed by the modulated envelopes of high-frequency sounds can serve as a cue for localizing a sound source. Klein-Hennig et al. (J Acoust Soc Am 129: 3856, 2011) demonstrated the envelope attack (the rate at which stimulus energy in the envelope increases) and the duration of the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01048.2015
更新日期:2017-10-01 00:00:00
abstract::Using CFos-EGFP transgenic mice (P6-P12), we targeted persistent inward current (PIC) in the spinal interneurons activated by locomotion. Following a locomotor task, whole cell patch-clamp recordings were obtained from ventral EGFP+ neurons in spinal cord slices (200-250 μm from T₁₃-L₄). PIC was recorded by a family o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01111.2009
更新日期:2010-04-01 00:00:00