Hyperpolarization-activated current (Ih) in the inferior colliculus: distribution and contribution to temporal processing.

Abstract:

:Neurons in the inferior colliculus (IC) process acoustic information converging from inputs from almost all nuclei of the auditory brain stem. Despite its importance in auditory processing, little is known about the distribution of ion currents in IC neurons, namely the hyperpolarization-activated current Ih. This current, as shown in neurons of the auditory brain stem, contributes to the precise analysis of temporal information. Distribution and properties of the Ih current and its contribution to membrane properties and synaptic integration were examined by current- and voltage-clamp recordings obtained from IC neurons in acute slices of rats (P17-P19). Based on firing patterns to positive current injection, three basic response types were distinguished: onset, adapting, and sustained firing neurons. Onset and adapting cells showed an Ih-dependent depolarizing sag and had a more depolarized resting membrane potential and lower input resistance than sustained neurons. Ih amplitudes were largest in onset, medium in adapting, and small in sustained neurons. Ih activation kinetics was voltage dependent in all neurons and faster in onset and adapting compared with sustained neurons. Injecting trains of simulated synaptic currents into the neurons or evoking inhibitory postsynaptic potentials (IPSPs) by stimulating the lemniscal tract showed that Ih reduced temporal summation of excitatory and inhibitory potentials in onset but not in sustained neurons. Blocking Ih also abolished afterhyperpolarization and rebound spiking. These results suggest that, in a large proportion of IC cells, namely the onset and adapting neurons, Ih improves precise temporal processing and contributes to the temporal analysis of input patterns.

journal_name

J Neurophysiol

authors

Koch U,Grothe B

doi

10.1152/jn.00375.2003

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

3679-87

issue

6

eissn

0022-3077

issn

1522-1598

pii

00375.2003

journal_volume

90

pub_type

杂志文章
  • Mechanisms of pattern generation underlying swimming in Tritonia. IV. Gating of central pattern generator.

    abstract::Swimming behavior in the marine mollusc Tritonia diomedea is episodic, consisting of a series of alternating dorsal and ventral flexions initiated by a brief sensory stimulus. The swim motor pattern is generated by a network formed of four groups of premotor interneurons: cerebral cell 2 (C2), dorsal swim interneurons...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.2.466

    authors: Getting PA,Dekin MS

    更新日期:1985-02-01 00:00:00

  • NMDA-dependent currents in granule cells of the dentate gyrus contribute to induction but not permanence of kindling.

    abstract::Single-electrode voltage-clamp techniques and bath application of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) were used to study the time course of seizure-induced alterations in NMDA-dependent synaptic currents in granule cells of the dentate gyrus in hippocampal slices f...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.2.564

    authors: Sayin,Rutecki P,Sutula T

    更新日期:1999-02-01 00:00:00

  • Ca2+/calmodulin-dependent protein kinase regulates GABA-activated Cl- current in cockroach dorsal unpaired median neurons.

    abstract::We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in symmetrical chloride solutions. All DUM neurons voltage-clamped at -50 mV displayed inward currents (I(GABA)) when 10(...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.87.6.2972

    authors: Alix P,Grolleau F,Hue B

    更新日期:2002-06-01 00:00:00

  • In CA1 hippocampal neurons, the redox state of NMDA receptors determines LTP expressed by NMDA but not by AMPA receptors.

    abstract::1. Using extracellular recording techniques in the CA1 region of the rat hippocampus, we have evaluated the effects of the redox reagents 5,5O-dithiobis-2-nitrobenzoic acid (DTNB) and tris (carboxyethyl) phosphine (TCEP) on long-term potentiation (LTP) expressed by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.6.2612

    authors: Gozlan H,Khazipov R,Diabira D,Ben-Ari Y

    更新日期:1995-06-01 00:00:00

  • Modulation of pursuit eye movements by stimulation of cortical areas MT and MST.

    abstract::1. Many cells in the superior temporal sulcus (STS) of the monkey that represent the foveal region of the visual field discharge during pursuit eye movements. Damage to these areas produces a deficit in the maintenance of pursuit eye movements when the target towards the side of the brain with the lesion. In the prese...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.62.1.31

    authors: Komatsu H,Wurtz RH

    更新日期:1989-07-01 00:00:00

  • Differential impairment of individuated finger movements in humans after damage to the motor cortex or the corticospinal tract.

    abstract::The purpose of this study was to quantify the long-term loss of independent finger movements in humans with lesions relatively restricted to motor cortex or corticospinal tract. We questioned whether damage to the motor cortex or corticospinal tract would permanently affect the ability to move each finger to the same ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00130.2003

    authors: Lang CE,Schieber MH

    更新日期:2003-08-01 00:00:00

  • Changes in the control of arm position, movement, and thalamic discharge during local inactivation in the globus pallidus of the monkey.

    abstract::1. To examine the effect of disruption of basal ganglia output on limb stability and movement, muscimol was injected into the internal globus pallidus (GPi) of monkeys trained to make arm movements to visible or remembered targets in a two-dimensional workspace. 2. Injections of as little as 0.25 micrograms muscimol a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.3.1087

    authors: Inase M,Buford JA,Anderson ME

    更新日期:1996-03-01 00:00:00

  • Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. I. Gaze dysmetria.

    abstract::The cerebellar control of orienting behavior toward visual targets was studied in the head-unrestrained cat by analyzing the deficits of saccadic gaze shifts after unilateral injection of muscimol in the caudal part of the fastigial nucleus (cFN). Gaze shifts are rendered strongly inaccurate by muscimol cFN inactivati...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.4.1942

    authors: Goffart L,Pélisson D

    更新日期:1998-04-01 00:00:00

  • Individuals with cerebellar degeneration show similar adaptation deficits with large and small visuomotor errors.

    abstract::The cerebellum has long been recognized to play an important role in motor adaptation. Individuals with cerebellar ataxia exhibit impaired learning in visuomotor adaptation tasks such as prism adaptation and force field learning. Both types of tasks involve the adjustment of an internal model to compensate for an exte...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00654.2011

    authors: Schlerf JE,Xu J,Klemfuss NM,Griffiths TL,Ivry RB

    更新日期:2013-02-01 00:00:00

  • Desensitization-resistant and -sensitive GPCR-mediated inhibition of GABA release occurs by Ca2+-dependent and -independent mechanisms at a hypothalamic synapse.

    abstract::Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor (GABABR...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00535.2015

    authors: Pennock RL,Hentges ST

    更新日期:2016-06-01 00:00:00

  • Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy.

    abstract::1. Single-unit recordings were made, under moderate gaseous anesthesia (33% O2-66% N2O + 0.5/0.6% halothane), in the ventrobasal (VB) thalamic complex of rats (n = 42) with a mononeuropathy created 2-3 wk beforehand, by four loose ligatures around the common sciatic nerve. Before the recording session, three behaviora...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.64.5.1537

    authors: Guilbaud G,Benoist JM,Jazat F,Gautron M

    更新日期:1990-11-01 00:00:00

  • Diffusion, not uptake, limits glycine concentration in the synaptic cleft.

    abstract::1. The question of whether active uptake limits the duration of action of the inhibitory transmitter glycine has been addressed in vivo at inhibitory synapses on the goldfish Mauthner (M) cell. The kinetics of inhibitory postsynaptic potentials and inhibitory postsynaptic currents (IPSCs) evoked antidromically and by ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.4.1738

    authors: Titmus MJ,Korn H,Faber DS

    更新日期:1996-04-01 00:00:00

  • Pain enhances functional connectivity of a brain network evoked by performance of a cognitive task.

    abstract::Experimental and clinical evidence indicates that pain can affect cognitive processes, but the cortical networks involved in pain-cognition interactions are unclear. In this study, we determined the effect of pain on the activity of cortical areas involved in cognition acting as a whole (i.e., a network). Subjects und...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01210.2006

    authors: Seminowicz DA,Davis KD

    更新日期:2007-05-01 00:00:00

  • Cooperative mechanisms between leg joints of Carausius morosus I. Nonspiking interneurons that contribute to interjoint coordination.

    abstract::Three nonspiking interneurons are described in this paper that influence the activity of the motor neurons of three muscles of the proximal leg joints of the stick insect. Interneurons were recorded and stained intracellularly by glass microelectrodes; motor neurons were recorded extracellularly with oil-hook electrod...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.6.2964

    authors: Brunn DE

    更新日期:1998-06-01 00:00:00

  • PAD and PAH response patterns of group Ia- and Ib-fibers to cutaneous and descending inputs in the cat spinal cord.

    abstract::The characteristics of the primary afferent depolarization (PAD) of Ia- and Ib-fibers generated by segmental and descending inputs have been analyzed in the spinal cord of anesthetized cats. The PAD was inferred from the changes produced by conditioning inputs on the intraspinal stimulus current required to produce a ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.4.987

    authors: Rudomin P,Solodkin M,Jiménez I

    更新日期:1986-10-01 00:00:00

  • Group I metabotropic glutamate receptors are differentially expressed by two populations of olfactory bulb granule cells.

    abstract::In the main olfactory bulb, several populations of granule cells (GCs) can be distinguished based on the soma location either superficially, interspersed with mitral cells within the mitral cell layer (MCL), or deeper, within the GC layer (GCL). Little is known about the physiological properties of superficial GCs (sG...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01202.2006

    authors: Heinbockel T,Hamilton KA,Ennis M

    更新日期:2007-04-01 00:00:00

  • Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. II. Loss of functional connectivity with motoneurons.

    abstract::Regeneration of a cut muscle nerve fails to restore the stretch reflex, and the companion paper to this article [Alvarez FJ, Titus-Mitchell HE, Bullinger KL, Kraszpulski M, Nardelli P, Cope TC. J Neurophysiol (August 10, 2011). doi:10.1152/jn.01095.2010] suggests an important central contribution from substantial and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01097.2010

    authors: Bullinger KL,Nardelli P,Pinter MJ,Alvarez FJ,Cope TC

    更新日期:2011-11-01 00:00:00

  • Comparison of the inhibitory response to tendon and cutaneous afferent stimulation in the human lower limb.

    abstract::A powerful early inhibition is seen in triceps surae after transcutaneous electrical stimulation of the Achilles tendon [tendon electrical stimulation (TES)]. The aim of the present study was to confirm results from surface electromyogram (SEMG) recordings that the inhibition is not wholly or partly due to stimulation...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00751.2011

    authors: Rogasch NC,Burne JA,Türker KS

    更新日期:2012-01-01 00:00:00

  • Postnatal development of electrical activity in the locus ceruleus.

    abstract::1. A method for adapting a standard stereotaxic frame for use with neonatal rats as young as postnatal day 1 (PD 1) was devised, and single-unit extracellular recordings were obtained from neurons in the locus ceruleus (LC) in urethan-anesthetized rats during different stages in development from PD 1 to PD 34. 2. The ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.3.510

    authors: Nakamura S,Kimura F,Sakaguchi T

    更新日期:1987-09-01 00:00:00

  • The spread of attention across features of a surface.

    abstract::Contrasting theories of visual attention have emphasized selection by spatial location, individual features, and whole objects. We used functional magnetic resonance imaging to ask whether and how attention to one feature of an object spreads to other features of the same object. Subjects viewed two spatially superimp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00828.2012

    authors: Ernst ZR,Boynton GM,Jazayeri M

    更新日期:2013-11-01 00:00:00

  • Linking express saccade occurance to stimulus properties and sensorimotor integration in the superior colliculus.

    abstract::Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00047.2015

    authors: Marino RA,Levy R,Munoz DP

    更新日期:2015-08-01 00:00:00

  • Eye position effects in monkey cortex. I. Visual and pursuit-related activity in extrastriate areas MT and MST.

    abstract::We studied the effect of eye position on visual and pursuit-related activity in neurons in the superior temporal sulcus of the macaque monkey. Altogether, 109 neurons from the middle temporal area (area MT) and the medial superior temporal area (area MST) were tested for influence of eye position on their stimulus-dri...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.2.944

    authors: Bremmer F,Ilg UJ,Thiele A,Distler C,Hoffmann KP

    更新日期:1997-02-01 00:00:00

  • Concept of neuron types in gustation in the rat.

    abstract::1. In taste neurophysiology, from Pfaffmann's (49, 50) pioneering work until the present, the possibility of types of neurons corresponding in some sense with the "primary" taste qualities of Henning (33) has been entertained: recently types of gustatory neurons in peripheral nerves have been established according to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1979.42.5.1390

    authors: Woolston DC,Erickson RP

    更新日期:1979-09-01 00:00:00

  • Differential modulation by copper and zinc of P2X2 and P2X4 receptor function.

    abstract::Differential Modulation by Copper and Zinc of P2X2 and P2X4 Receptor Function. The modulation by Cu2+ and Zn2+ of P2X2 and P2X4 receptors expressed in Xenopus oocytes was studied with the two-electrode, voltage-clamp technique. In oocytes expressing P2X2 receptors, both Cu2+ and Zn2+, in the concentration range 1-130 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.5.2088

    authors: Xiong K,Peoples RW,Montgomery JP,Chiang Y,Stewart RR,Weight FF,Li C

    更新日期:1999-05-01 00:00:00

  • A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates.

    abstract::A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00625.2011

    authors: Feingold J,Desrochers TM,Fujii N,Harlan R,Tierney PL,Shimazu H,Amemori K,Graybiel AM

    更新日期:2012-04-01 00:00:00

  • Perception of simulated local shapes using active and passive touch.

    abstract::This study reexamined the perceptual equivalence of active and passive touch using a computer-controlled force-feedback device. Nine subjects explored a 6 x 10-cm workspace, with the index finger resting on a mobile flat plate, and experienced simulated Gaussian ridges and troughs (width, 15 mm; amplitude, 0.5 to 4.5 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00043.2009

    authors: Smith AM,Chapman CE,Donati F,Fortier-Poisson P,Hayward V

    更新日期:2009-12-01 00:00:00

  • Responses of primate spinothalamic tract neurons to electrical stimulation of hindlimb peripheral nerves.

    abstract::The responses of spinothalamic tract neurons were studied by extra- and intracellular recordings from the lumbosacral spinal cord in anesthetized rhesus monkeys (Macaca mulatta). The neurons were identified by antidromic activation from the contralateral diencephalon. They were then classified by the mildest form of m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1975.38.1.132

    authors: Foreman RD,Applebaum AE,Beall JE,Trevino DL,Willis WD

    更新日期:1975-01-01 00:00:00

  • Explaining autism spectrum disorders: central coherence vs. predictive coding theories.

    abstract::In this article, we review a recent paper by Stevenson et al. (J Neurosci 34: 691-697, 2014). This paper illustrates the need to present different forms of stimuli in order to characterize the perceptual abilities of people with autism spectrum disorder (ASD). Furthermore, we will discuss their behavioral results and ...

    journal_title:Journal of neurophysiology

    pub_type: 评论,杂志文章

    doi:10.1152/jn.00242.2014

    authors: Chan JS,Naumer MJ

    更新日期:2014-12-01 00:00:00

  • Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation.

    abstract::Parkinson's disease is associated with altered neural activity in the motor cortex. Chronic high-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in suppressing parkinsonian motor symptoms and modulates cortical activity. However, the anatomical pathways responsible for STN DBS-medi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00862.2017

    authors: Kumaravelu K,Oza CS,Behrend CE,Grill WM

    更新日期:2018-08-01 00:00:00

  • Subject-specific muscle synergies in human balance control are consistent across different biomechanical contexts.

    abstract::The musculoskeletal redundancy of the body provides multiple solutions for performing motor tasks. We have proposed that the nervous system solves this unconstrained problem through the recruitment of motor modules or functional muscle synergies that map motor intention to action. Consistent with this hypothesis, we s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00960.2009

    authors: Torres-Oviedo G,Ting LH

    更新日期:2010-06-01 00:00:00