Abstract:
:Single-electrode voltage-clamp techniques and bath application of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) were used to study the time course of seizure-induced alterations in NMDA-dependent synaptic currents in granule cells of the dentate gyrus in hippocampal slices from kindled and normal rats. In agreement with previous studies, granule cells from kindled rats examined within 1 wk after the last of 3 or 30-35 generalized tonic-clonic (class V) seizures demonstrated an increase in the NMDA receptor-dependent component of the perforant path-evoked synaptic current. Within 1 wk of the last kindled seizure, NMDA-dependent charge transfer underlying the perforant path-evoked current was increased by 63-111% at a holding potential of -30 mV. In contrast, the NMDA-dependent component of the perforant-evoked current in granule cells examined at 2.5-3 mo after the last of 3 or 90-120 class V seizures did not differ from age-matched controls. Because the seizure-induced increases in NMDA-dependent synaptic currents declined toward control values during a time course of 2.5-3 mo, increases in NMDA-dependent synaptic transmission cannot account for the permanent susceptibility to evoked and spontaneous seizures induced by kindling. The increase in NMDA receptor-dependent transmission was associated with the induction of kindling but was not responsible for the maintenance of the kindled state. The time course of alterations in NMDA-dependent synaptic current and the dependence of the progression of kindling and kindling-induced mossy fiber sprouting on repeated NMDA receptor activation are consistent with the possibility that the NMDA receptor is part of a transmembrane signaling pathway that induces long-term cellular alterations and circuit remodeling in response to repeated seizures, but is not required for permanent seizure susceptibility in circuitry altered by kindling.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Sayin,Rutecki P,Sutula Tdoi
10.1152/jn.1999.81.2.564subject
Has Abstractpub_date
1999-02-01 00:00:00pages
564-74issue
2eissn
0022-3077issn
1522-1598journal_volume
81pub_type
杂志文章abstract::1. Single motor axons innervating human toe extensor muscles were selectively stimulated through a tungsten microelectrode inserted percutaneously into the peroneal nerve. Twitch and tetanic forces were measured from a strain gauge over the proximal phalanx of the toe generating the greatest force. Twitch data were ob...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.1996.75.6.2509
更新日期:1996-06-01 00:00:00
abstract::Multiple studies have demonstrated that brain-derived neurotrophic factor (BDNF) is a potent modulator of neuronal structure and function in the hippocampus. However, the majority of studies to date have relied on the application of recombinant BDNF. We herein report that endogenous BDNF, released via theta burst stim...
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pub_type: 杂志文章
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journal_title:Journal of neurophysiology
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更新日期:2002-06-01 00:00:00
abstract::1. Horizontal cells were enzymatically and mechanically dissociated from the white perch (Roccus americana) retina and voltage clamped using patch electrodes. Steady-state current-voltage (I-V) relationships of solitary horizontal cells were determined by changing the membrane potential in a rampwise fashion. 2. The I...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.4.1322
更新日期:1988-10-01 00:00:00
abstract::Are behaviors that rely on common muscles and motoneurons generated by separate or overlapping groups of pattern-generating neurons? This question was investigated for the three forms of scratching in immobilized, spinal turtles. Individual neurons were recorded extracellularly from the gray matter through most of the...
journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.4.1960
更新日期:1999-04-01 00:00:00
abstract::Flexible behavior requires the ability to delay a response until it is appropriate. This can be achieved by holding either a sensory or a motor representation online. Here we assess whether maintenance of sensory or motor material drives the motor system to different functional states, as indexed by alterations of cor...
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pub_type: 杂志文章
doi:10.1152/jn.01005.2006
更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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更新日期:1997-02-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00370.2002
更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1152/jn.90551.2008
更新日期:2008-12-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00542.2005
更新日期:2005-10-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.63.5.1060
更新日期:1990-05-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.3.1202
更新日期:2001-09-01 00:00:00
abstract::1. Neuronlike differentiation of Y-79 retinoblastoma was chemically induced in vitro, by plating the cells onto a poly-D-lysine and laminin substrate. The changes in voltage-dependent conductances after 48-72 h were examined with the whole-cell tight-seal and the perforated-patch recording techniques. 2. Although outw...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.70.4.1487
更新日期:1993-10-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.4.1913
更新日期:1997-10-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.3.961
更新日期:1992-09-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.6.1236
更新日期:1976-11-01 00:00:00