Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons.

abstract：:Procedural skill learning requires iterative comparisons between feedback of self-generated motor output and a goal sensorimotor pattern. In juvenile songbirds, neural representations of both self-generated behaviors (each bird's own immature song) and the goal motor pattern (each bird's adult tutor song) are essentia...

journal_title：Journal of neurophysiology

authors： Yuan RC,Bottjer SW

更新日期：2019-02-01 00:00:00

abstract：:Tissue injury in early life can produce distinctive effects on pain processing, but little is known about the underlying neural mechanisms. Neonatal inflammation modulates excitatory synapses in spinal nociceptive circuits, but it is unclear whether this results directly from altered afferent input. Here we investigat...

journal_title：Journal of neurophysiology

authors： Li J,Walker SM,Fitzgerald M,Baccei ML

更新日期：2009-10-01 00:00:00

abstract：:Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their ...

journal_title：Journal of neurophysiology

authors： Sturm JJ,Weisz CJ

更新日期：2015-11-01 00:00:00

abstract：:We investigated whether heptanol and other long-chain alcohols that are known to block gap junctions interfere with the generation or the propagation of spreading depression (SD). Waves of SD were triggered by micro-injection of concentrated KCl solution in stratum (s.) radiatum of CA1 of rat hippocampal tissue slices...

journal_title：Journal of neurophysiology

authors： Largo C,Tombaugh GC,Aitken PG,Herreras O,Somjen GG

更新日期：1997-01-01 00:00:00

abstract：:We studied the temporal behavior and tuning properties of medial superior temporal (MST) neurons in response to constant flow-field stimulation and continuously changing flow-field stimulation (transitions), which were obtained by morphing one flow field into another. During transitions, the flow fields resembled the ...

journal_title：Journal of neurophysiology

authors： Paolini M,Distler C,Bremmer F,Lappe M,Hoffmann KP

更新日期：2000-08-01 00:00:00

abstract：:Direct electrical coupling between neurons can be the result of both electrotonic current transfer through gap junctions and extracellular fields. Intracellular recordings from CA1 pyramidal neurons of rat hippocampal slices showed two different types of small-amplitude coupling potentials: short-duration (5 ms) bipha...

journal_title：Journal of neurophysiology

authors： Vigmond EJ,Perez Velazquez JL,Valiante TA,Bardakjian BL,Carlen PL

更新日期：1997-12-01 00:00:00

abstract：:Natural visual scenes are cluttered. In such scenes, many objects in the periphery can be crowded, blocked from identification, simply because of the dense array of clutter. Outside of the fovea, crowding constitutes the fundamental limitation on object recognition and is thought to arise from the limited resolution o...

journal_title：Journal of neurophysiology

authors： Fischer J,Whitney D

更新日期：2011-09-01 00:00:00

abstract：:In contrast to hand movements, the existence of a neural representation of saccade kinematics is unclear. Saccade kinematics is typically thought to be specified by motor error/desired displacement and generated by brain stem circuits that are not penetrable to voluntary control. We studied the influence of instructed...

journal_title：Journal of neurophysiology

authors： Gopal A,Jana S,Murthy A

更新日期：2017-09-01 00:00:00

abstract：:Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now descr...

journal_title：Journal of neurophysiology

authors： Brown MR,El-Hassar L,Zhang Y,Alvaro G,Large CH,Kaczmarek LK

更新日期：2016-07-01 00:00:00

abstract：:Studies on generalization show the nature of how learning is encoded in the brain. Previous studies have shown rather limited generalization of dynamics learning across changes in movement direction, a finding that is consistent with the idea that learning is primarily local. In contrast, studies show a broader patter...

journal_title：Journal of neurophysiology

authors： Mattar AA,Ostry DJ

更新日期：2010-07-01 00:00:00

abstract：:Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key functional microcircuits within layer 2/3 of mouse primary...

journal_title：Journal of neurophysiology

authors： Avermann M,Tomm C,Mateo C,Gerstner W,Petersen CC

更新日期：2012-06-01 00:00:00

abstract：:1. R2 and LPl1 are homologous giant cholinergic neurons in the nervous system of Aplysia with overlapping and almost symmetrical axonal trees extending over most of the body wall. In spite of much experimental study, the behavioral role of the cells has remained unknown. 2. After intrasomatic injection of R2 and LPl1 ...

journal_title：Journal of neurophysiology

authors： Rayport SG,Ambron RT,Babiarz J

更新日期：1983-04-01 00:00:00

abstract：:Despite its widespread use, high-resolution imaging with multiphoton microscopy to record neuronal signals in vivo is limited to the surface of brain tissue because of limited light penetration. Moreover, most imaging studies do not simultaneously record electrical neural activity, which is, however, crucial to unders...

journal_title：Journal of neurophysiology

authors： Hirai Y,Nishino E,Ohmori H

更新日期：2015-06-01 00:00:00

abstract：:Working memory (WM) for sensory-based information about individual objects and their locations appears to involve interactions between lateral prefrontal and sensory cortexes. The mechanisms and representations for maintenance of more abstract, nonsensory information in WM are unknown, particularly whether such active...

journal_title：Journal of neurophysiology

authors： Ikkai A,Blacker KJ,Lakshmanan BM,Ewen JB,Courtney SM

更新日期：2014-10-15 00:00:00

abstract：:1. The horizontal eye movements induced by acceleration along the interaural axis were recorded from five monkeys (Macaca mulatta) by the use of the electromagnetic search-coil technique. Animals sat on a sled that was moved briefly in darkness along a linear track (bell-shaped acceleration profile: peak, 400 mm/s2; d...

journal_title：Journal of neurophysiology

authors： Schwarz U,Miles FA

更新日期：1991-09-01 00:00:00

abstract：:1. High-voltage-activated Ca2+ currents [ICa(HVA)] were studied in immunolabeled mouse retinal ganglion neurons (RGNs) to elucidate channel-specific components and their developmental changes in vitro. 2. Neurons were dissociated at postnatal day 5. RGNs were selected for electrophysiological measurements by vital lab...

journal_title：Journal of neurophysiology

authors： Rothe T,Grantyn R

更新日期：1994-11-01 00:00:00

abstract：:We explored how contour information in primary visual cortex might be embedded in the simultaneous activity of multiple cells recorded with a 100-electrode array. Synchronous activity in cat visual cortex was more selective and predictable in discriminating between drifting grating and concentric ring stimuli than cha...

journal_title：Journal of neurophysiology

authors： Samonds JM,Zhou Z,Bernard MR,Bonds AB

更新日期：2006-04-01 00:00:00

abstract：:The timing of brief stationary sounds has been shown to alter the perceived speed of visual apparent motion (AM), presumably by altering the perceived timing of the individual frames of the AM stimuli and/or the duration of the interstimulus intervals (ISIs) between those frames. To investigate the neural correlates o...

journal_title：Journal of neurophysiology

authors： Kafaligonul H,Albright TD,Stoner GR

更新日期：2018-09-01 00:00:00

abstract：:Particular types of amacrine cells of the vertebrate retina show oscillatory membrane potentials (OMPs) in response to light stimulation. Historically it has been thought the oscillations arose as a result of circuit properties. In a previous study we found that in some amacrine cells, the ability to oscillate was an ...

journal_title：Journal of neurophysiology

authors： Vigh J,Solessio E,Morgans CW,Lasater EM

更新日期：2003-07-01 00:00:00

abstract：:The brain's ability to integrate information from different senses is acquired only after extensive sensory experience. However, whether early life experience instantiates a general integrative capacity in multisensory neurons or one limited to the particular cross-modal stimulus combinations to which one has been exp...

journal_title：Journal of neurophysiology

authors： Xu J,Yu L,Stanford TR,Rowland BA,Stein BE

更新日期：2015-02-01 00:00:00

abstract：:Although fluorescence microscopy has proven to be one of the most powerful tools in biology, its application to the intact animal has been limited to imaging several hundred micrometers below the surface. The rest of the animal has eluded investigation at the microscopic level without excising tissue or performing ext...

journal_title：Journal of neurophysiology

authors： Levene MJ,Dombeck DA,Kasischke KA,Molloy RP,Webb WW

更新日期：2004-04-01 00:00:00

abstract：:To explore neural mechanisms how olfactory information is processed in the brain and finally converted into behavior, it would be useful to have isolated whole brains that include both olfactory organs and motor output. In the present study, we identified an in vitro index of odor-evoked behavior in the terrestrial mo...

journal_title：Journal of neurophysiology

authors： Inoue T,Inokuma Y,Watanabe S,Kirino Y

更新日期：2004-01-01 00:00:00

abstract：:Hypocretin-1 and -2 (Hcrt-1 and -2, also called orexin-A and -B) are newly identified neuropeptides synthesized by hypothalamic neurons. Defects in the Hcrt system underlie the sleep disorder narcolepsy, which is characterized by sleep fragmentation and the involuntary loss of muscle tone called cataplexy. Hcrt neuron...

journal_title：Journal of neurophysiology

authors： Peever JH,Lai YY,Siegel JM

更新日期：2003-05-01 00:00:00

abstract：:We report the first optical recordings of action potentials, in single trials, from one or a few (approximately 1-2 microm) mammalian nerve terminals in an intact in vitro preparation, the mouse neurohypophysis. The measurements used two-photon excitation along the "blue" edge of the two-photon absorption spectrum of ...

journal_title：Journal of neurophysiology

authors： Fisher JA,Barchi JR,Welle CG,Kim GH,Kosterin P,Obaid AL,Yodh AG,Contreras D,Salzberg BM

更新日期：2008-03-01 00:00:00

abstract：:1. GABAergic mechanisms in the midbrain periaqueductal gray (PAG) have been proposed to control the activity of descending antinociceptive systems and defensive behavior. Here, the effect of neuronal disinhibition by gamma-aminobutyric acid (GABAA) receptor blockade at midbrain sites on spinal neuronal responses to no...

journal_title：Journal of neurophysiology

authors： Sandkühler J,Willmann E,Fu QG

更新日期：1991-01-01 00:00:00

abstract：:Epiretinal implants for the blind are designed to stimulate surviving retinal neurons, thus bypassing the diseased photoreceptor layer. Single-unit or multielectrode recordings from isolated animal retina are commonly used to inform the design of these implants. However, such electrical recordings provide limited info...

journal_title：Journal of neurophysiology

authors： Weitz AC,Behrend MR,Lee NS,Klein RL,Chiodo VA,Hauswirth WW,Humayun MS,Weiland JD,Chow RH

更新日期：2013-04-01 00:00:00

abstract：:1. The responses of onset units in the cochlear nucleus of the anesthetized guinea pig have been measured to single tones, two-tone complexes, and broadband noise (BBN; 20-kHz bandwidth). The onset units were subdivided into three groups, onset-I (OnI), onset-L (OnL), and onset-C (OnC), on the basis of a decision tree...

journal_title：Journal of neurophysiology

authors： Winter IM,Palmer AR

更新日期：1995-01-01 00:00:00

abstract：:1. The present study was designed to determine the effects of microstimulation of the medullary reticular formation (MRF) on the locomotor activity of the cat in the absence of phasic afferent feedback from the limbs. To this end, both short (33 ms) and long (200 ms) trains of stimuli (trains of 0.2-ms pulses at 330 H...

journal_title：Journal of neurophysiology

authors： Perreault MC,Rossignol S,Drew T

更新日期：1994-01-01 00:00:00

abstract：:The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparations provide an unparalleled opportunity to observe and control neural circuits. To investigate how neural circuits produce behavior, these m...

journal_title：Journal of neurophysiology

authors： Sanders JI,Kepecs A

更新日期：2012-12-01 00:00:00

abstract：:Rewards in the natural environment are rarely predicted with complete certainty. Uncertainty relating to future rewards has typically been defined as the variance of the potential outcomes. However, the asymmetry of predicted reward distributions, known as skewness, constitutes a distinct but neuroscientifically under...

journal_title：Journal of neurophysiology

authors： Burke CJ,Tobler PN

更新日期：2011-11-01 00:00:00