Abstract:
:Recent studies have reported that human subjects show varying degrees of ability to use contextual cues to recall the motor skills required to compensate for different dynamic external force fields during arm movements. In particular, the subjects showed little or no ability to use color cues to adjust motor outputs in anticipation of the perturbing fields after limited periods of training that were sufficient to learn to compensate for the fields themselves. This is unexpected since humans and monkeys can use color cues to perform a wide range of visuomotor tasks. Here we show that a monkey with extensive practice compensating for viscous fields in an elbow-movement task can use associated color cues to adjust motor output in anticipation of an impending field before physically encountering it.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Krouchev NI,Kalaska JFdoi
10.1152/jn.00779.2002subject
Has Abstractpub_date
2003-02-01 00:00:00pages
1165-75issue
2eissn
0022-3077issn
1522-1598journal_volume
89pub_type
杂志文章abstract::Two monkeys were trained to point to targets and to retrieve fruit bits from a Kluver board, bottles, and tubes. Once proficient in the tasks, the macaques underwent aseptic surgical implantation of a recording chamber over the cerebellar nuclei on the side of their preferred hand. After recovery from surgery, a serie...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.2.537
更新日期:1998-02-01 00:00:00
abstract::Iontophoresis of glutamate at sites on the apical dendrite 278-555 microm from the somata of rat neocortical pyramidal neurons evoked low-threshold, small, slow spikes and/or large, fast spikes in 71% of recorded cells. The amplitude of the small, slow spikes recorded at the soma averaged 9.1 mV, and their apparent th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.5.2466
更新日期:1997-05-01 00:00:00
abstract::We recorded single-unit activity of 25 units in the parafoveal representation of macaque V1 to transient appearance of sinusoidal gratings. Gratings were systematically varied in spatial phase and in one or two of the following: contrast, spatial frequency, and orientation. Individual responses were compared based on ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.2.554
更新日期:1998-08-01 00:00:00
abstract::Thalamic intralaminar and medial nuclei participate mainly in affective and motivational aspects of pain processing. Unique to the present study were identification and characterization of spontaneously active neurons in the central lateral nucleus (CL) of the intralaminar thalamus, which were found to respond only to...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90985.2008
更新日期:2009-07-01 00:00:00
abstract::We have previously shown that control subjects use two distinct temporal strategies when stepping on an inclined surface during walking: one for level and 10 degrees surfaces and another for 20 and 30 degrees surfaces. These two temporal strategies were characterized by systematic shifts in the timing of muscle activi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.2.759
更新日期:2001-02-01 00:00:00
abstract::Because the subthalamic nucleus (STN) acts as a driving force of the basal ganglia, it is important to know how the activities of STN neurons are regulated. Previously, we have reported that a subset of STN neurons generates a plateau potential in a voltage-dependent manner. These plateau potentials can be evoked only...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00508.2003
更新日期:2004-07-01 00:00:00
abstract::We previously reported that neurons in the mediodorsal thalamic nucleus (MD) are topographically organized and express spatial and nonspatial coding properties similar to those of the prefrontal areas with which they are connected. In the course of mapping the dorsal thalamus, we also studied neurons in a subset of th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00969.2003
更新日期:2005-01-01 00:00:00
abstract::1. Two subtypes of astrocytes that expressed distinctly different ion channel complements were identified in primary cultures from rat spinal cord and hippocampus using whole cell patch-clamp techniques. One population of cells expressed voltage-activated Na+ currents and displayed outwardly rectifying I-V relationshi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.1.626
更新日期:1996-07-01 00:00:00
abstract::We have investigated potential mechanisms by which exercise can promote changes in neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (BDNF), ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00152.2002
更新日期:2002-11-01 00:00:00
abstract::In the Aplysia mechanoafferent B21, afferent transmission is in part regulated via the control of active spike propagation. When B21 is peripherally activated at its resting membrane potential, spikes fail to propagate to an output process, and afferent transmission does not occur. In this report, we show that the pro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01341.2006
更新日期:2007-04-01 00:00:00
abstract::The last few years have seen an increase in the variety of in vivo experiments used for studying cerebellar physiological mechanisms. A combination of ketamine and xylazine has become a particularly popular form of anesthesia. However, because nonanesthetized control conditions are lacking in these experiments, so far...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00057.2007
更新日期:2007-09-01 00:00:00
abstract::Several models exist for explaining primary visual cortex (V1) orientation tuning. The modified feedforward model (MFM) and the recurrent model (RM) are major examples. We have implemented these two models, at the same level of detail, alongside a few newer variations, and thoroughly compared their receptive-field str...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00015.2005
更新日期:2006-07-01 00:00:00
abstract::Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na(+)-gated nonselective cation channel. The Na(+)-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagon...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00990.2004
更新日期:2005-03-01 00:00:00
abstract::Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding neuronal computation. Here, we describe a system that allows high-channel-count recordings from a small volume of neuronal tissue using a lightweight signal multiplexing headstage that permits...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00785.2013
更新日期:2014-03-01 00:00:00
abstract::Cutaneous reflexes evoked in the muscles of the arms with electrical stimulation of nerves of the foot ("interlimb reflexes") are observed during walking. These reflexes have been suggested to coordinate the actions of the legs and arms when walking is disturbed. Recently, we showed that cutaneous reflexes evoked in t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00746.2006
更新日期:2006-12-01 00:00:00
abstract::Thalamic relay neurons express high levels of T-type Ca(2+) channels, which support the generation of robust burst discharges. This intrinsically mediated form of phasic spike firing is thought to be critical in the generation of slow (3-4 Hz) synchronous oscillatory activity of absence epilepsy. Recordings made from ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00667.2002
更新日期:2003-01-01 00:00:00
abstract::To examine the functional interactions between the color and form pathways in the primate visual cortex, we have examined the functional connectivity between pairs of color oriented and nonoriented V1 and V2 neurons in Macaque monkeys. Optical imaging maps for color selectivity, orientation preference, and ocular domi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.5.2719
更新日期:1999-11-01 00:00:00
abstract::Neurons integrate subthreshold inputs in a frequency-dependent manner. For sinusoidal stimuli, response amplitudes thus vary with stimulus frequency. Neurons in entorhinal cortex show two types of such resonance behavior: stellate cells in layer II exhibit a prominent peak in the resonance profile at stimulus frequenc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01116.2003
更新日期:2004-07-01 00:00:00
abstract::In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00311.2011
更新日期:2011-10-01 00:00:00
abstract::Sciatic nerve section (axotomy) increases the excitability of rat dorsal root ganglion (DRG) neurons. The changes in Ca2+ currents, K+ currents, Ca2+ sensitive K+ current, and hyperpolarization-activated cation current (I(H)) that may be associated with this effect were examined by whole cell recording. Axotomy affect...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.2.644
更新日期:2001-02-01 00:00:00
abstract::Paired-pulse transcranial magnetic stimulation (TMS) can be used to examine intracortical inhibition in primary motor cortex (M1), termed short-interval intracortical inhibition (SICI). To our knowledge, SICI has only been demonstrated in contralateral motor evoked potentials (MEPs). Ipsilateral MEPs (iMEPs) are assum...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01139.2015
更新日期:2016-03-01 00:00:00
abstract::Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01107.2006
更新日期:2007-08-01 00:00:00
abstract::Seconds-scale network states, affecting many neurons within a network, modulate neural activity by complementing fast integration of neuron-specific inputs that arrive in the milliseconds before spiking. Nonrhythmic subthreshold dynamics at intermediate timescales, however, are less well characterized. We found, using...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00116.2017
更新日期:2017-08-01 00:00:00
abstract::Using intrinsic signal optical imaging (ISI), we have shown previously that the point spread of evoked activity in the rat barrel cortex in response to single-whisker stimulation encompasses a surprisingly large area. Given that our typical stimulation consists of five deflections at 5 Hz, the large area of evoked act...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.2.692
更新日期:1999-02-01 00:00:00
abstract::The auditory frequency-following response (FFR) reflects synchronized and phase-locked activity along the auditory pathway in response to sound. Although FFRs were historically thought to reflect subcortical activity, recent evidence suggests an auditory cortex contribution as well. Here we present electrophysiologica...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00112.2019
更新日期:2019-08-01 00:00:00
abstract::In this study, we examined the effect of arachidonic acid (AA) on the BK alpha-subunit with or without beta-subunits expressed in Xenopus oocytes. In excised patches, AA potentiated the hSlo-alpha current and slowed inactivation only when beta2/3 subunit was co-expressed. The beta2-subunit-dependent modulation by AA p...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00700.2006
更新日期:2007-01-01 00:00:00
abstract::Pharmacological modulation of gamma-aminobutyric acid-A (GABAA) receptors can provide important information on the types of subunits composing these receptors. In recombinant studies, zinc more potently inhibits alphabeta subunits compared with the alphabetagamma combination, whereas modulation by nanomolar concentrat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.4.1670
更新日期:1998-10-01 00:00:00
abstract::Foot drop is very common among people with chronic incomplete spinal cord injury (SCI) and likely stems from SCI that disturbs the corticospinal activation of the ankle dorsiflexor tibialis anterior (TA). Thus, if one can recover or increase the corticospinal excitability reduced by SCI, motor function recovery may be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00557.2018
更新日期:2019-03-01 00:00:00
abstract::Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2811
更新日期:1997-11-01 00:00:00
abstract::We performed a whole-body mapping study of the effect of unilateral muscle vibration, eliciting spindle Ia firing, on the control of standing and walking in humans. During quiet stance, vibration applied to various muscles of the trunk-neck system and of the lower limb elicited a significant tilt in whole body postura...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00764.2006
更新日期:2007-01-01 00:00:00