Transfer function of the rhesus macaque oculomotor system for small-amplitude slow motion trajectories.

Abstract:

:Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Two male rhesus macaque monkeys tracked a spot moving sinusoidally, but slowly, along the horizontal or vertical direction. Maximum target displacement in the motion trajectory was 30 min arc (0.5°), and we varied the temporal frequency of target motion from 0.2 to 5 Hz. We obtained an oculomotor "transfer function" by measuring smooth eye velocity gain (relative to target velocity) as a function of frequency, similar to past work with large-amplitude pursuit. Monkey eye velocities as slow as those observed during slow ocular drifts were clearly target motion driven. Moreover, as with large-amplitude smooth pursuit, eye velocity gain varied with temporal frequency. However, unlike with large-amplitude pursuit, exhibiting low-pass behavior, small-amplitude motion tracking was band pass, with the best ocular movement gain occurring at ~0.8-1 Hz. When oblique directions were tested, we found that the horizontal component of pursuit gain was larger than the vertical component. Our results provide a catalog of the control abilities of the monkey oculomotor system for slow target motions, and they also support the notion that smooth fixational ocular drifts are controllable. This has implications for neural investigations of drift control and the image-motion consequences of drifts on visual coding in early visual areas. NEW & NOTEWORTHY We studied the efficacy of monkey smooth pursuit eye movements for very slow target velocities. Pursuit was impaired for sinusoidal motions of frequency less than ~0.8-1 Hz. Nonetheless, eye trajectory was still sinusoidally modulated, even at velocities lower than those observed during gaze fixation with slow ocular drifts. Our results characterize the slow control capabilities of the monkey oculomotor system and provide a basis for future understanding of the neural mechanisms for slow ocular drifts.

journal_name

J Neurophysiol

authors

Skinner J,Buonocore A,Hafed ZM

doi

10.1152/jn.00437.2018

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

513-529

issue

2

eissn

0022-3077

issn

1522-1598

journal_volume

121

pub_type

杂志文章
  • Cortical mechanisms underlying tactile discrimination in the monkey. I. Role of primary somatosensory cortex in passive texture discrimination.

    abstract::1. The discharge patterns of 359 single neurons in the hand representation of primary somatosensory cortex (SI) of two monkeys (Macaca mulatta) were recorded during the performance of a passive texture discrimination task with the contralateral hand (104 in area 3b, 149 in area 1, and 106 in area 2). Three nyloprint s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.5.3382

    authors: Tremblay F,Ageranioti-Bélanger SA,Chapman CE

    更新日期:1996-11-01 00:00:00

  • Long-latency and voluntary responses to an arm displacement can be rapidly attenuated by perturbation offset.

    abstract::Feedback control of our limbs must account for the unexpected offset of mechanical perturbations. Here we examine the evoked activity of elbow flexor and extensor muscles to torque pulses lasting 22-152 ms and how torque offset impacts activity in the long-latency (45-100 ms) and voluntary epochs (120-180 ms). For eac...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01139.2009

    authors: Kurtzer I,Pruszynski JA,Scott SH

    更新日期:2010-06-01 00:00:00

  • Effects of a compression garment on sensory feedback transmission in the human upper limb.

    abstract::Compression apparel is popular in both medical and sport performance settings. Perceived benefits are suggested to include changes in sensory feedback transmission caused by activation of mechanoreceptors. However, little is known about effects of compression apparel on sensorimotor control. Our purpose was to mechani...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00581.2017

    authors: Barss TS,Pearcey GEP,Munro B,Bishop JL,Zehr EP

    更新日期:2018-07-01 00:00:00

  • Synaptic transmission from the supratrigeminal region to jaw-closing and jaw-opening motoneurons in developing rats.

    abstract::The supratrigeminal region (SupV) receives abundant orofacial sensory inputs and descending inputs from the cortical masticatory area and contains premotor neurons that target the trigeminal motor nucleus (MoV). Thus it is possible that the SupV is involved in controlling jaw muscle activity via sensory inputs during ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01145.2007

    authors: Nakamura S,Inoue T,Nakajima K,Moritani M,Nakayama K,Tokita K,Yoshida A,Maki K

    更新日期:2008-10-01 00:00:00

  • Effects of caudate microstimulation on spontaneous and purposive saccades.

    abstract::Electrical stimulation has been delivered to the basal ganglia (BG) to treat intractable symptoms of a variety of clinical disorders. However, it is still unknown how such treatments improve behavioral symptoms. A difficulty of this problem is that artificial signals created by electrical stimulation interact with int...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00046.2013

    authors: Watanabe M,Munoz DP

    更新日期:2013-07-01 00:00:00

  • GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons.

    abstract::GSG1L is an AMPA receptor (AMPAR) auxiliary subunit that regulates AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its physiological roles in other types of neurons remain to be characterized. Here, we investigated the role of GSG1L in hippocampal dentate granule cells and found that GSG1...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00307.2016

    authors: Mao X,Gu X,Lu W

    更新日期:2017-01-01 00:00:00

  • Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion.

    abstract::Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.5.2811

    authors: Crawford JD,Guitton D

    更新日期:1997-11-01 00:00:00

  • Contribution of voltage-gated Ca2+ channels to homosynaptic long-term depression in the CA1 region in vitro.

    abstract::Homosynaptic long-term depression (LTD) of synaptic efficacy was induced in field excitatory postsynaptic potentials by administration of 900 pulses at either 1 or 3 Hz in 2- to 3-wk-old Sprague-Dawley rats. The stimulation was administered via a bipolar stimulating electrode placed immediately adjacent to the recordi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.3.1651

    authors: Christie BR,Schexnayder LK,Johnston D

    更新日期:1997-03-01 00:00:00

  • Analysis of postural motoneuron activity in crayfish abdomen. I. Coordination by premotoneuron connections.

    abstract::The activity of the crayfish abdominal postural motoneurons and their associated neurons (the accessory neuron(s) and the MRO(1)) were examined with the aid of techniques for the analysis of simultaneously recorded spike trains. A means of reliably identifying the spikes of the individual motoneurons based on their re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1975.38.2.313

    authors: Sokolove PG,Tatton WG

    更新日期:1975-03-01 00:00:00

  • Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals.

    abstract::Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding neuronal computation. Here, we describe a system that allows high-channel-count recordings from a small volume of neuronal tissue using a lightweight signal multiplexing headstage that permits...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00785.2013

    authors: Berényi A,Somogyvári Z,Nagy AJ,Roux L,Long JD,Fujisawa S,Stark E,Leonardo A,Harris TD,Buzsáki G

    更新日期:2014-03-01 00:00:00

  • Synaptic events and discharge patterns of cochlear nucleus cells. I. Steady-frequency tone bursts.

    abstract::Unitary discharge patterns (peristimulus time histograms or PSTH) and synaptic events were studies with intracellular recording techniques in 164 cat cochlear nucleus cells to steady-frequency tone bursts 250 ms in duration. There were four response types defined on the basis of the shape of the discharge patterns to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1976.39.1.162

    authors: Britt R,Starr A

    更新日期:1976-01-01 00:00:00

  • Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus.

    abstract::Experiments in both conscious and anesthetized animals indicate that intrathecal (i.t.) strychnine (STR; glycine receptor antagonist) produces acute, reversible allodynia, as evidenced by inappropriate behavioral and autonomic responses to cutaneous tactile stimuli. Although STR is known to produce disinhibition of af...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.2.628

    authors: Sherman SE,Luo L,Dostrovsky JO

    更新日期:1997-08-01 00:00:00

  • Phasic and tonic cell types in the zebra finch auditory caudal mesopallium.

    abstract::The caudal mesopallium (CM) is a cortical-level area in the songbird auditory pathway where selective, invariant responses to familiar songs emerge. To characterize the cell types that perform this computation, we made whole cell recordings from brain slices in juvenile zebra finches ( Taeniopygia guttata) of both sex...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00694.2017

    authors: Chen AN,Meliza CD

    更新日期:2018-03-01 00:00:00

  • Windup of flexion reflexes in chronic human spinal cord injury: a marker for neuronal plateau potentials?

    abstract::The physiological basis of flexion spasms in individuals after spinal cord injury (SCI) may involve alterations in the properties of spinal neurons in the flexion reflex pathways. We hypothesize that these changes would be manifested as progressive increases in reflex response with repetitive stimulus application (i.e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00979.2001

    authors: Hornby TG,Rymer WZ,Benz EN,Schmit BD

    更新日期:2003-01-01 00:00:00

  • The effect of noise on CaMKII activation in a dendritic spine during LTP induction.

    abstract::Activation of calcium-calmodulin dependent protein kinase II (CaMKII) during induction of long-term potentiation (LTP) is a series of complicated stochastic processes that are affected by noise. There are two main sources of noise affecting CaMKII activation within a dendritic spine. One is the noise associated with s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91235.2008

    authors: Zeng S,Holmes WR

    更新日期:2010-04-01 00:00:00

  • The human brain representation of odor identification.

    abstract::Odor identification (OI) tests are increasingly used clinically as biomarkers for Alzheimer's disease and schizophrenia. The aim of this study was to directly compare the neuronal correlates to identified odors vs. nonidentified odors. Seventeen females with normal olfactory function underwent a functional magnetic re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01036.2010

    authors: Kjelvik G,Evensmoen HR,Brezova V,Håberg AK

    更新日期:2012-07-01 00:00:00

  • Three-independent-compartment chamber to study in vitro commissural synapses.

    abstract::We describe a novel chamber in which the two intact neonatal rat hippocampi and the commissural fibers are placed in three independent compartments separated by latex membranes and perfused selectively with different solutions. A set of control tests showed that the compartments are well isolated: 1) methylene blue or...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.2.921

    authors: Khazipov R,Desfreres L,Khalilov I,Ben-Ari Y

    更新日期:1999-02-01 00:00:00

  • Nucleus Z: a somatosensory relay to motor thalamus.

    abstract::1. It was the aim of this study to show that nucleus Z of the cat medulla acts as a relay between the spinal cord and the ventral lateral (VL) nucleus of the motor thalamus. For this purpose, extracellular recordings were made from neurons that were antidromically identified by stimulation in the rostral thalamus, par...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.5.1607

    authors: Mackel R,Miyashita E

    更新日期:1993-05-01 00:00:00

  • Ionic mechanisms underlying tonic and burst firing behavior in subfornical organ neurons: a combined experimental and modeling study.

    abstract::Subfornical organ (SFO) neurons exhibit heterogeneity in current expression and spiking behavior, where the two major spiking phenotypes appear as tonic and burst firing. Insight into the mechanisms behind this heterogeneity is critical for understanding how the SFO, a sensory circumventricular organ, integrates and s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00340.2018

    authors: Medlock L,Shute L,Fry M,Standage D,Ferguson AV

    更新日期:2018-11-01 00:00:00

  • Hyperpolarization-activated current (Ih) in the inferior colliculus: distribution and contribution to temporal processing.

    abstract::Neurons in the inferior colliculus (IC) process acoustic information converging from inputs from almost all nuclei of the auditory brain stem. Despite its importance in auditory processing, little is known about the distribution of ion currents in IC neurons, namely the hyperpolarization-activated current Ih. This cur...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00375.2003

    authors: Koch U,Grothe B

    更新日期:2003-12-01 00:00:00

  • Neurotransmitter regulation of the heart in the nudibranch Archidoris montereyensis.

    abstract::1. The heart of the nudibranch mollusc Archidoris montereyensis is uniquely responsive to regulation by identifiable cardiac motor neurons. The neurotransmitters mediating the strong excitatory and inhibitory actions of the neurons are unknown. 2. In this study we developed an infused, in vitro preparation of the Arch...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.4.1639

    authors: Wiens BL,Brownell PH

    更新日期:1995-10-01 00:00:00

  • Developmental modulation of the temporal relationship between brain and behavior.

    abstract::Humans and songbirds shape learned vocalizations during a sensorimotor sensitive period or "babbling" phase. The brain mechanisms that underlie the shaping of vocalizations by sensory feedback are not known. We examined song behavior and brain activity in zebra finches during singing as they actively shaped their song...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00907.2006

    authors: Crandall SR,Aoki N,Nick TA

    更新日期:2007-01-01 00:00:00

  • Frequency-dependent interaural delays in the medial superior olive: implications for interaural cochlear delays.

    abstract::Neurons in the medial superior olive (MSO) are tuned to the interaural time difference (ITD) of sound arriving at the two ears. MSO neurons evoke a strongest response at their best delay (BD), at which the internal delay between bilateral inputs to MSO matches the external ITD. We performed extracellular recordings in...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00131.2011

    authors: Day ML,Semple MN

    更新日期:2011-10-01 00:00:00

  • Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy.

    abstract::Formation of local excitatory circuits may contribute to epileptogenesis. We tested the hypothesis that epileptogenesis is associated with increased recurrent excitation in the hippocampal CA1 area of rats with kainate-induced epilepsy. Whole cell recordings were obtained during focal flash photolysis of caged glutama...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00131.2004

    authors: Shao LR,Dudek FE

    更新日期:2004-09-01 00:00:00

  • Role of cAMP in the short-term modulation of a neuromuscular system in aplysia.

    abstract::Neuromuscular synapses in buccal muscle I3a of Aplysia are modulated by the small cardioactive peptide (SCP), a peptide cotransmitter that is intrinsic to the motor neurons, and by serotonin (5-HT) released from modulatory neurons that are extrinsic to the motor circuit. Although the modulation of excitatory junction ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1567

    authors: Fox LE,Lloyd PE

    更新日期:2000-03-01 00:00:00

  • Massively parallel recording of unit and local field potentials with silicon-based electrodes.

    abstract::Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00116.2003

    authors: Csicsvari J,Henze DA,Jamieson B,Harris KD,Sirota A,Barthó P,Wise KD,Buzsáki G

    更新日期:2003-08-01 00:00:00

  • Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy.

    abstract::1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor antagonists bicuculline or picrotoxin. 2. The voltage-sensitive dye RH 41...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.4.1756

    authors: Sutor B,Hablitz JJ,Rucker F,ten Bruggencate G

    更新日期:1994-10-01 00:00:00

  • Possible network interactions indicated by bilaterally coherent fast rhythms in expiratory recurrent laryngeal nerve discharges.

    abstract::1. In a search for correlated fast rhythms in recurrent laryngeal (RL) expiratory (E) activities, we performed spectral and coherence analysis on bilateral RL nerve discharges in 54 midcollicular decerebrate, paralyzed cats. 2. Inspiratory (I) RL activities showed in almost all cases high-frequency oscillations (HFO, ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.5.2192

    authors: Huang WX,Christakos CN,Cohen MI,He Q

    更新日期:1993-11-01 00:00:00

  • Delayed excitatory connections in the flight system of the locust.

    abstract::1. Synaptic interactions between identified neurons in the flight system of the locust were investigated by the use of standard intracellular recording and staining techniques. The intent was to determine the distribution and functional significance of delayed excitatory connections, which have been previously describ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.5.1150

    authors: Robertson RM

    更新日期:1991-05-01 00:00:00

  • Receptive-field properties of rat ventral posterior medial neurons before and after selective kainic acid lesions of the trigeminal brain stem complex.

    abstract::Single neurons were recorded from the ventral posteromedial thalamic nucleus (VPM) of urethan-anesthetized rats. Six of these animals were intact, 28 sustained kainic acid (KA) lesions of trigeminal nucleus principalis (PrV), and 9 received similar lesions of trigeminal subnucleus interpolaris (SpVi). Four animals sus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.5.1577

    authors: Rhoades RW,Belford GR,Killackey HP

    更新日期:1987-05-01 00:00:00