Transfer function of the rhesus macaque oculomotor system for small-amplitude slow motion trajectories.


:Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Two male rhesus macaque monkeys tracked a spot moving sinusoidally, but slowly, along the horizontal or vertical direction. Maximum target displacement in the motion trajectory was 30 min arc (0.5°), and we varied the temporal frequency of target motion from 0.2 to 5 Hz. We obtained an oculomotor "transfer function" by measuring smooth eye velocity gain (relative to target velocity) as a function of frequency, similar to past work with large-amplitude pursuit. Monkey eye velocities as slow as those observed during slow ocular drifts were clearly target motion driven. Moreover, as with large-amplitude smooth pursuit, eye velocity gain varied with temporal frequency. However, unlike with large-amplitude pursuit, exhibiting low-pass behavior, small-amplitude motion tracking was band pass, with the best ocular movement gain occurring at ~0.8-1 Hz. When oblique directions were tested, we found that the horizontal component of pursuit gain was larger than the vertical component. Our results provide a catalog of the control abilities of the monkey oculomotor system for slow target motions, and they also support the notion that smooth fixational ocular drifts are controllable. This has implications for neural investigations of drift control and the image-motion consequences of drifts on visual coding in early visual areas. NEW & NOTEWORTHY We studied the efficacy of monkey smooth pursuit eye movements for very slow target velocities. Pursuit was impaired for sinusoidal motions of frequency less than ~0.8-1 Hz. Nonetheless, eye trajectory was still sinusoidally modulated, even at velocities lower than those observed during gaze fixation with slow ocular drifts. Our results characterize the slow control capabilities of the monkey oculomotor system and provide a basis for future understanding of the neural mechanisms for slow ocular drifts.


J Neurophysiol


Skinner J,Buonocore A,Hafed ZM




Has Abstract


2019-02-01 00:00:00












  • Inhibition [corrected] of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx.

    abstract::We investigated the cellular mechanism underlying presynaptic regulation of olfactory receptor neuron (ORN) input to the mouse olfactory bulb using optical-imaging techniques that selectively report activity in the ORN presynaptic terminal. First, we loaded ORNs with calcium-sensitive dye and imaged stimulus-evoked ca...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Wachowiak M,McGann JP,Heyward PM,Shao Z,Puche AC,Shipley MT

    更新日期:2005-10-01 00:00:00

  • Scene segmentation and attention in primate cortical areas V1 and V2.

    abstract::The responses of many neurons in primary visual cortex are modulated by stimuli outside the classical receptive field in ways that may contribute to integrative processes like scene segmentation. To explore this issue, single-unit neuronal responses were recorded in monkey cortical areas V1 and V2 to visual stimuli co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Marcus DS,Van Essen DC

    更新日期:2002-11-01 00:00:00

  • Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern.

    abstract::Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative r...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Schaefer AT,Larkum ME,Sakmann B,Roth A

    更新日期:2003-06-01 00:00:00

  • Blink-perturbed saccades in monkey. II. Superior colliculus activity.

    abstract::Trigeminal reflex blinks evoked near the onset of a saccade cause profound spatial-temporal perturbations of the saccade that are typically compensated in mid-flight. This paper investigates the influence of reflex blinks on the discharge properties of saccade-related burst neurons (SRBNs) in intermediate and deep lay...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Goossens HH,Van Opstal AJ

    更新日期:2000-06-01 00:00:00

  • Spatial bias in estimating the position of visual and proprioceptive targets.

    abstract::When people match an unseen hand to a visual or proprioceptive target, they make both variable and systematic (bias) errors. Variance is a well-established factor in behavior, but the origin and implications of bias, and its connection to variance, are poorly understood. Eighty healthy adults matched their unseen righ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Liu Y,Sexton BM,Block HJ

    更新日期:2018-05-01 00:00:00

  • Sensitivity to temporal modulation rate and spectral bandwidth in the human auditory system: fMRI evidence.

    abstract::Hierarchical models of auditory processing often posit that optimal stimuli, i.e., those eliciting a maximal neural response, will increase in bandwidth and decrease in modulation rate as one ascends the auditory neuraxis. Here, we tested how bandwidth and modulation rate interact at several loci along the human centr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Overath T,Zhang Y,Sanes DH,Poeppel D

    更新日期:2012-04-01 00:00:00

  • Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices.

    abstract::The mechanisms of irregular firing of spontaneous action potentials in neurons from the rat suprachiasmatic nucleus (SCN) were studied in hypothalamic slices using cell-attached and whole cell recording. The firing pattern of spontaneous action potentials could be divided into regular and irregular, based on the inter...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Kononenko NI,Dudek FE

    更新日期:2004-01-01 00:00:00

  • Neural coupling between homologous muscles during bimanual tasks: effects of visual and somatosensory feedback.

    abstract::While the effects of sensory feedback on bimanual tasks have been studied extensively at two ends of the motor control hierarchy, the cortical and behavioral levels, much less is known about how it affects the intermediate levels, including neural control of homologous muscle groups. We investigated the effects of som...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Nguyen HB,Lee SW,Harris-Love ML,Lum PS

    更新日期:2017-02-01 00:00:00

  • Muscle spindles in human tibialis anterior encode muscle fascicle length changes.

    abstract::Muscle spindles provide exquisitely sensitive proprioceptive information regarding joint position and movement. Through passively driven length changes in the muscle-tendon unit (MTU), muscle spindles detect joint rotations because of their in-parallel mechanical linkage to muscle fascicles. In human microneurography ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Day J,Bent LR,Birznieks I,Macefield VG,Cresswell AG

    更新日期:2017-04-01 00:00:00

  • Orientation sensitivity of the cat assessed from evoked potentials: central and peripheral contributions.

    abstract::To estimate contour-orientation sensitivity of the cat and the degree to which precortical processing contributes to such estimates, the amplitude of visually evoked potentials (VEP) recorded from the visual cortex of cats in response to a visual stimulus (S2) presented at various intervals after presentation of anoth...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Tootle JS,Berkley MA

    更新日期:1985-05-01 00:00:00

  • Inhibition of lobster olfactory receptor cells by an odor-activated potassium conductance.

    abstract::1. Whole cell current-clamp recordings show that odors not only depolarize but may also hyperpolarize lobster olfactory receptor cells. Odor-evoked hyperpolarizations occurred in 36% of 178 receptor cells examined. Cell-attached recordings of action potentials followed by current-clamp recordings in the same cell indi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Michel WC,McClintock TS,Ache BW

    更新日期:1991-03-01 00:00:00

  • Low-voltage-activated calcium current does not regulate the firing behavior in paired mechanosensory neurons with different adaptation properties.

    abstract::Low-voltage-activated Ca(2+) currents (LVA-I(Ca)) are believed to perform several roles in neurons such as lowering the threshold for action potentials, promoting burst firing and oscillatory behavior, and enhancing synaptic excitation. They also may allow rapid increases in intracellular Ca(2+) concentration. We disc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Sekizawa SI,French AS,Torkkeli PH

    更新日期:2000-02-01 00:00:00

  • Neuronal density determines network connectivity and spontaneous activity in cultured hippocampus.

    abstract::The effects of neuronal density on morphological and functional attributes of the evolving networks were studied in cultured dissociated hippocampal neurons. Plating at different densities affected connectivity among the neurons, such that sparse networks exhibited stronger synaptic connections between pairs of record...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Ivenshitz M,Segal M

    更新日期:2010-08-01 00:00:00

  • Inaudible high-frequency sounds affect brain activity: hypersonic effect.

    abstract::Although it is generally accepted that humans cannot perceive sounds in the frequency range above 20 kHz, the question of whether the existence of such "inaudible" high-frequency components may affect the acoustic perception of audible sounds remains unanswered. In this study, we used noninvasive physiological measure...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章


    authors: Oohashi T,Nishina E,Honda M,Yonekura Y,Fuwamoto Y,Kawai N,Maekawa T,Nakamura S,Fukuyama H,Shibasaki H

    更新日期:2000-06-01 00:00:00

  • The neural bases of different levels of action understanding.

    abstract::Many have recently questioned whether all levels of actions understanding, from lower kinematic levels to the higher goal or intention levels of action understanding, are processed in the action observation network (a network of neurons that are active during action execution and observation). A recent study by Wurm a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Marneweck M,Vallence AM

    更新日期:2016-03-01 00:00:00

  • Electrophysiological evidence for vasopressin V(1) receptors on neonatal motoneurons, premotor and other ventral horn neurons.

    abstract::Prominent arginine-vasopressin (AVP) binding and AVP V(1) type receptors are expressed early in the developing rat spinal cord. We sought to characterize their influence on neural excitability by using patch-clamp techniques to record AVP-induced responses from a population of motoneurons and interneurons in neonatal ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Oz M,Kolaj M,Renaud LP

    更新日期:2001-09-01 00:00:00

  • Effects of an experimental arthritis on the sensory properties of fine articular afferent units.

    abstract::An acute experimental arthritis was induced in the right knee joint of adult cats anesthetized with chloralose, and the activity of single fine afferent units of the medial articular nerve was recorded from filaments of the saphenous nerve. All units included in this study were sensitive to local mechanical probing of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Schaible HG,Schmidt RF

    更新日期:1985-11-01 00:00:00

  • Strength-duration relationship for extracellular neural stimulation: numerical and analytical models.

    abstract::The strength-duration relationship for extracellular stimulation is often assumed to be similar to the classical intracellular stimulation model, with a slope asymptotically approaching 1/τ at pulse durations shorter than chronaxy. We modeled extracellular neural stimulation numerically and analytically for several ce...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Boinagrov D,Loudin J,Palanker D

    更新日期:2010-10-01 00:00:00

  • Global electrosensory oscillations enhance directional responses of midbrain neurons in eigenmannia.

    abstract::Eigenmannia, a genus of weakly electric fish, exhibits a specialized behavior known as the jamming avoidance response (JAR). The JAR results in a categorical difference between Eigenmannia that are in groups of conspecifics and those that are alone. Fish in groups exhibit the JAR behavior and thereby experience ongoin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Ramcharitar JU,Tan EW,Fortune ES

    更新日期:2006-11-01 00:00:00

  • Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.

    abstract::Studies on animals have shown that noise-induced hearing loss is followed by an increase of spontaneous firing at several stages of the central auditory system. This central hyperactivity has been suggested to underpin the perception of tinnitus. It was shown that decreasing cochlear activity can abolish the noise-ind...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Noreña AJ,Mulders WH,Robertson D

    更新日期:2015-01-01 00:00:00

  • Effects of GABA receptor antagonists on retinal glycine receptors and on homomeric glycine receptor alpha subunits.

    abstract::Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists block...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Wang P,Slaughter MM

    更新日期:2005-06-01 00:00:00

  • Distribution of functional glutamate and GABA receptors on hippocampal pyramidal cells and interneurons.

    abstract::The distribution of functional neurotransmitter receptors is an important determinant of neuronal information processing. To map the location of functional glutamate and GABA receptors on individual hippocampal neurons, we photolyzed "caged" glutamate and GABA while measuring the electrical currents resulting from act...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Pettit DL,Augustine GJ

    更新日期:2000-07-01 00:00:00

  • Response properties of neurons in primary somatosensory cortex of owl monkeys reflect widespread spatiotemporal integration.

    abstract::Receptive fields of neurons in somatosensory area 3b of monkeys are typically described as restricted to part of a single digit or palm pad. However, such neurons are likely involved in integrating stimulus information from across the hand. To evaluate this possibility, we recorded from area 3b neurons in anesthetized...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Reed JL,Qi HX,Zhou Z,Bernard MR,Burish MJ,Bonds AB,Kaas JH

    更新日期:2010-04-01 00:00:00

  • Slow brain potential and oscillatory EEG manifestations of impaired temporal preparation in Parkinson's disease.

    abstract::Performance in behavioral tasks is influenced by temporal expectations shaped by the temporal structure of the task. Such implicit temporal preparation is reflected in slow brain potentials and electroencephalographic oscillations and is attributed to interval timing mechanisms that probably depend on intact basal gan...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Praamstra P,Pope P

    更新日期:2007-11-01 00:00:00

  • Wiener kernels of chinchilla auditory-nerve fibers: verification using responses to tones, clicks, and noise and comparison with basilar-membrane vibrations.

    abstract::Responses to tones, clicks, and noise were recorded from chinchilla auditory-nerve fibers (ANFs). The responses to noise were analyzed by computing the zeroth-, first-, and second-order Wiener kernels (h0, h1, and h2). The h1s correctly predicted the frequency tuning and phases of responses to tones of ANFs with low c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Temchin AN,Recio-Spinoso A,van Dijk P,Ruggero MA

    更新日期:2005-06-01 00:00:00

  • Cat hindlimb motoneurons during locomotion. I. Destination, axonal conduction velocity, and recruitment threshold.

    abstract::Fine flexible wire microelectrodes chronically implanted in the fifth lumbar ventral root (L5 VR) of 17 cats rendered stable records of the natural discharge patterns of 164 individual axons during locomotion on a treadmill. Fifty-one out of 164 axons were identified as motoneurons projecting to the anterior thigh mus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hoffer JA,Loeb GE,Marks WB,O'Donovan MJ,Pratt CA,Sugano N

    更新日期:1987-02-01 00:00:00

  • MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia.

    abstract::Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both M...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Sun JH,Yang B,Donnelly DF,Ma C,LaMotte RH

    更新日期:2006-11-01 00:00:00

  • Circuit feedback increases activity level of a circuit input through interactions with intrinsic properties.

    abstract::Central pattern generator (CPG) motor circuits underlying rhythmic behaviors provide feedback to the projection neuron inputs that drive these circuits. This feedback elicits projection neuron bursting linked to CPG rhythms. The brief periodic interruptions in projection neuron activity in turn influence CPG output, g...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Blitz DM

    更新日期:2017-08-01 00:00:00

  • Disparity selectivity of neurons in monkey inferior temporal cortex.

    abstract::The inferior temporal cortex (IT) of the monkey, a final stage in the ventral visual pathway, has been known to process information on two-dimensional (2-D) shape, color, and texture. On the other hand, the dorsal visual pathway leading to the posterior parietal cortex has been known to process information on location...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Uka T,Tanaka H,Yoshiyama K,Kato M,Fujita I

    更新日期:2000-07-01 00:00:00

  • Contribution of primate magnocellular red nucleus to timing of hand preshaping during reaching to grasp.

    abstract::Magnocellular red nucleus (RNm) is involved in controlling goal-directed limb movements such as reaching to grasp. We tested two hypotheses related to RNm's role in controlling reach-to-grasp movements. One hypothesis is that forelimb RNm neurons are grasp specific, and the other is that they specify the timing of met...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Van Kan PL,McCurdy ML

    更新日期:2002-03-01 00:00:00