Activation of a lobster motor rhythm-generating network by disinhibition of permissive modulatory inputs.

Abstract:

:Rhythm generation by the gastric motor network in the stomatogastric ganglion (STG) of the lobster Homarus gammarus is controlled by modulatory projection neurons from rostral commissural ganglia (CoGs); blocking action potential conduction in these inputs to the STG of a stomatogastric nervous system in vitro rapidly renders the gastric network silent. However, exposure of the CoGs to low Ca2+ saline to block chemical synapses activates a spontaneously silent gastric network or enhances an ongoing gastric rhythm. A similar permissive effect was observed when picrotoxin was also superfused on these ganglia. We conclude that in the CoGs continuous synaptic inhibition is exerted on modulatory projection neuron(s) and that release from this inhibition allows strong activation of the gastric network.

journal_name

J Neurophysiol

authors

Faumont S,Simmers J,Meyrand P

doi

10.1152/jn.1998.80.5.2776

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

2776-80

issue

5

eissn

0022-3077

issn

1522-1598

journal_volume

80

pub_type

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