Abstract:
:1. The goal of this study was to compare the relative effectiveness of intrinsic inhibitory synaptic inputs in different layers of the cat motor cortex. Postsynaptic potentials (PSPs) were evoked in neurons located in the superficial (layer II-III) or deep layers (layer V) by local extracellular stimulation in vitro. Electrophysiological properties and intracellular filling indicated that the recorded neurons were pyramidal cells. 2. The shape and time course of the evoked PSPs differed. Layer II-III cells showed stereotyped triphasic PSPs consisting of a fast excitatory PSP (fEPSP) and a fast and slow inhibitory PSP (fIPSP and sIPSP, respectively). PSPs in layer V cells, in contrast, were much more variable, mainly depolarizing at resting membrane potential, and lacked a hyperpolarizing IPSP in 84% of neurons tested at rest. 3. Blockade of glutaminergic neurotransmission with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonovaleric acid (AP5) revealed that fIPSPs could be evoked in all layer V cells by local stimulation of the superficial or deep layers, even in those that showed small or no IPSPs in control perfusate. Small (< 1 mV) isolated sIPSPs were evoked in only one-fifth of layer V cells when the deep layers were stimulated, and in about one-half of the layer V cells when the superficial layers were stimulated. In layer II-III cells, stimulation of the superficial layers always resulted in fIPSP-sIPSP combinations. No IPSPs could be evoked in layer II-III neurons by stimulating the deep layers after glutaminergic blockade. Selective blockade of gamma-aminobutyric acid-A (GABAA) or GABAB receptor-mediated neurotransmission showed that in both cell types fIPSPs were due to GABAA receptor stimulation, whereas sIPSPs were mediated by GABAB receptors. 4. Isolated fIPSPs were recorded in perfusate containing CNQX, AP5, and the GABAB antagonist CGP 35348. The rise and decay times of the fIPSPs in layer II-III cells were significantly longer than those in layer V cells. Rise and decay times normalized for differences in membrane time constant were not significantly different, however, suggesting that the intrinsic membrane properties of the postsynaptic membrane account for the difference in time course of the fIPSPs in these two cell types. 5. Selective blockade of the inward rectifier current Ih with extracellular Cs+ showed that this conductance functions to shorten and attenuate fIPSPs in layer V cells. In contrast, Ih is absent or small in layer II-III cells, and, consequently, Cs+ had little or no effect on the fIPSPs evoked in these cells.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
van Brederode JF,Spain WJdoi
10.1152/jn.1995.74.3.1149subject
Has Abstractpub_date
1995-09-01 00:00:00pages
1149-66issue
3eissn
0022-3077issn
1522-1598journal_volume
74pub_type
杂志文章abstract::Humans quickly and sophisticatedly correct their movements in response to changes in the world, such as when reaching to a target that abruptly changes its location. The vigor of these movement corrections is time-dependent, increasing if the time left to make the correction decreases, which can be explained by optima...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00616.2018
更新日期:2019-09-01 00:00:00
abstract::1. Monkeys were trained to react to an arm perturbation according to an instruction delivered prior to the perturbation. There were two possible instructions (push or pull), and monkeys learned to respond accordingly regardless of the direction (push or pull) of the triggering perturbation. 2. Pyramidal tract neurons ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.5.1069
更新日期:1976-09-01 00:00:00
abstract::Animal survival in the forest, and human success on the sports field, often depend on the ability to seize a target on the fly. All bodies fall at the same rate in the gravitational field, but the corresponding retinal motion varies with apparent viewing distance. How then does the brain predict time-to-collision unde...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00889.2007
更新日期:2008-04-01 00:00:00
abstract::Fine flexible wire microelectrodes chronically implanted in the fifth lumbar ventral root (L5 VR) of 17 cats rendered stable records of the natural discharge patterns of 164 individual axons during locomotion on a treadmill. Fifty-one out of 164 axons were identified as motoneurons projecting to the anterior thigh mus...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.2.510
更新日期:1987-02-01 00:00:00
abstract::Dopaminergic modulation of neuronal networks in the dorsolateral prefrontal cortex (PFC) is believed to play an important role in information processing during working memory tasks in both humans and nonhuman primates. To understand the basic cellular mechanisms that underlie these actions of dopamine (DA), we have in...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.6.2799
更新日期:2000-12-01 00:00:00
abstract::We have used the rat hippocampal slice preparation as a model system for studying the epileptogenic consequences of a reduction in neuronal Na+-K+ pump activity. The cardiac glycosides (CGs) strophanthidin and dihydroouabain were used to inhibit the pump. These drugs had readily reversible effects, provided they were ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.2.496
更新日期:1987-02-01 00:00:00
abstract::Studying adaptation to Coriolis perturbations of arm movements has advanced our understanding of motor control and learning. We have now applied this paradigm to two-dimensional postural sway. We measured how subjects (n = 8) standing at the center of a fully enclosed rotating room who made voluntary anterior-posterio...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00606.2018
更新日期:2019-06-01 00:00:00
abstract::1. We used transcranial magnetic stimulation (TMS) to study the role of plastic changes of the human motor system in the acquisition of new fine motor skills. We mapped the cortical motor areas targeting the contralateral long finger flexor and extensor muscles in subjects learning a one-handed, five-finger exercise o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.3.1037
更新日期:1995-09-01 00:00:00
abstract::1. The graded, synaptic potentials of first-order visual interneurons (lamina monopolar cells) were examined with intracellular recordings. The spatiotemporal properties were characterized with drifting sine wave gratings and annuli. 2. Annulus-elicited inhibition is maximal for annulus-test pulse intervals of approxi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.6.2168
更新日期:1994-06-01 00:00:00
abstract::The purpose of these studies was to determine the role of gracile nucleus and the effects of l-arginine-derived nitric oxide (NO) synthesis in the nucleus on the cardiovascular responses to electroacupuncture (EA) stimulation of "Zusanli" (ST36). Arterial blood pressure and heart rate were monitored during EA stimulat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00170.2003
更新日期:2003-08-01 00:00:00
abstract::Spinal neurons undergo large cyclic membrane potential oscillations during fictive locomotion in lamprey. It was investigated whether these oscillations were due only to synaptically driven excitatory and inhibitory potentials or if voltage-dependent inward conductances also contribute to the depolarizing phase by usi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.87.6.2676
更新日期:2002-06-01 00:00:00
abstract::The contributions of the hyperpolarization-activated current, I(h), to generation of rhythmic activities are well described for various central neurons, particularly in thalamocortical circuits. In the present study, we investigated effects of a general anesthetic, propofol, on native I(h) in neurons of thalamus and c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00389.2005
更新日期:2005-12-01 00:00:00
abstract::Odor identification (OI) tests are increasingly used clinically as biomarkers for Alzheimer's disease and schizophrenia. The aim of this study was to directly compare the neuronal correlates to identified odors vs. nonidentified odors. Seventeen females with normal olfactory function underwent a functional magnetic re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01036.2010
更新日期:2012-07-01 00:00:00
abstract::In common with other sensory cortices, the mammalian primary auditory cortex (AI) demonstrates the capacity for large-scale reorganization following many experimental situations. For example, training animals in frequency-discrimination tasks has been shown to result in an increase in cortical frequency representation...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.4.1555
更新日期:2001-10-01 00:00:00
abstract::When sudden environmental stimuli signaling threat occur in the portion of space surrounding the body (defensive peripersonal space), defensive responses are enhanced. Recently Bisio et al. (Bisio A, Garbarini F, Biggio M, Fossataro C, Ruggeri P, Bove M. J Neurosci 37: 2415-2424, 2017) showed that a marker of defensiv...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00316.2017
更新日期:2017-10-01 00:00:00
abstract::1. Receptive fields (RFs) of neurons in the primary somatosensory (SI) cortex were defined before, during, and after electrical stimulation of myelinated fibers in the dorsal cutaneous branch of the ulnar nerve in adult pentobarbital sodium-anesthetized cats. 2. This stimulation resulted in an approximately threefold ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.63.5.1213
更新日期:1990-05-01 00:00:00
abstract::The plant-derived insecticides have introduced a new concept in insecticide research. In response to insect attacks, some plants can release volatile sulfur compounds such as dimethyl disulfide (DMDS) in the atmosphere, which are lethal for the generalist insects. We demonstrate that DMDS induced an uncommon complex n...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01096.2002
更新日期:2003-07-01 00:00:00
abstract::An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00949.2002
更新日期:2003-11-01 00:00:00
abstract::1. Whole-cell recordings were performed on acutely isolated pyramidal neurons from rat sensorimotor cortex 2 to 21 days postnatal to study the expression of a tetrodotoxin (TTX) sensitive, voltage dependent, persistent Na+ current (INaP) during different stages of postnatal development. 2. INaP was activated positive ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.1.290
更新日期:1993-01-01 00:00:00
abstract::1. Cellular properties were studied before and after bath application of the dihydropyridine L-type calcium channel antagonist nimodipine in aging and young rabbit hippocampal CA1 pyramidal cells in vitro. Various concentrations of nimodipine, ranging from 10 nM to 10 microM, were tested to investigate age- and concen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.6.2100
更新日期:1992-12-01 00:00:00
abstract::We previously reported that neurons in the mediodorsal thalamic nucleus (MD) are topographically organized and express spatial and nonspatial coding properties similar to those of the prefrontal areas with which they are connected. In the course of mapping the dorsal thalamus, we also studied neurons in a subset of th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00969.2003
更新日期:2005-01-01 00:00:00
abstract::Little is known about the substrates for the large-scale shifts in the cortical representation produced by limb amputation. Subcortical changes likely contribute to the cortical remodeling, yet there is little data regarding the extent and pattern of reorganization in thalamus after such a massive deafferentation. Mor...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.5.3154
更新日期:2000-05-01 00:00:00
abstract::We studied the effects of fatigue of the index finger on indices of force variability in discrete and rhythmic accurate force production tasks performed by the index finger and by all four fingers pressing in parallel. An increase in the variance of the force produced by the fatigued index finger was expected. We hypo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00077.2010
更新日期:2010-06-01 00:00:00
abstract::A key element of walking is the coordinated interplay of multiple limbs to achieve a stable locomotor pattern that is adapted to the environment. We investigated intersegmental coordination of walking in the stick insect, Carausius morosus by examining the influence a single stepping leg has on the motoneural activity...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00291.2007
更新日期:2007-09-01 00:00:00
abstract::We have studied how rewards modulate the occurrence of microsaccades by manipulating the size of an expected reward and the location of the cue that sets the expectations for future reward. We found an interaction between the size of the reward and the location of the cue. When monkeys fixated on a cue that signaled t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00401.2015
更新日期:2015-11-01 00:00:00
abstract::The neuronal mechanisms that contribute to tactile perception were studied using single-unit recordings from the cutaneous hand representation of primate primary (S1) and secondary (S2) somatosensory cortex. This study followed up on our recent observation that S1 and S2 neurons developed a sustained change in dischar...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91121.2008
更新日期:2009-05-01 00:00:00
abstract::The discharge patterns of single units in the ventral cochlear nucleus (VCN) of anesthetized guinea pigs were examined in response to iterated rippled noise (IRN) as a function of the IRN delay (which determines the IRN pitch) and the IRN sound level. Delays were varied over five octaves in half-octave steps, and soun...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.3.1206
更新日期:2001-03-01 00:00:00
abstract::1. R2 and LPl1 are homologous giant cholinergic neurons in the nervous system of Aplysia with overlapping and almost symmetrical axonal trees extending over most of the body wall. In spite of much experimental study, the behavioral role of the cells has remained unknown. 2. After intrasomatic injection of R2 and LPl1 ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.49.4.864
更新日期:1983-04-01 00:00:00
abstract::One of the critical factors in determining network behavior of neurons is the influence of local circuit connections among interneurons. The short-term synaptic plasticity and the subtype of presynaptic calcium channels used at local circuit connections of inhibitory interneurons in CA1 were investigated using dual wh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00831.2010
更新日期:2011-03-01 00:00:00
abstract::Whereas Kvbeta2 subunits modulate potassium current properties carried by Kv1 channel complexes in heterologous systems, little is known about the contributions of Kvbeta2 subunits to native potassium channel function. Using antisense approaches and in situ recordings from Xenopus embryo spinal cord neurons, we tested...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90667.2008
更新日期:2008-10-01 00:00:00