CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.

Abstract:

:One of the critical factors in determining network behavior of neurons is the influence of local circuit connections among interneurons. The short-term synaptic plasticity and the subtype of presynaptic calcium channels used at local circuit connections of inhibitory interneurons in CA1 were investigated using dual whole-cell recordings combined with biocytin and double immunofluorescence labeling in acute slices of P18- to 21-day-old rat stratum radiatum (SR) and stratum lacunosum molecular (SLM). Two forms of temporally distinct synaptic facilitation were observed among interneuron connections involving presynaptic cholecystokinin (CCK)-positive cells in SR, frequency-dependent facilitation, and a delayed onset of release (45-80 ms) with subsequent facilitation (DORF). Inhibition at both these synapses was under tonic cannabinoid-type 1 (CB1) receptor activity. DORF synapses did not display conventional release-dependent properties; however, blocking CB1 receptors with antagonist AM-251 (10 μM) altered the synaptic transmission to frequency-dependent depression with a fast onset of release (2-4 ms). Presynaptic CCK-negative interneurons in SLM elicited inhibitory postsynaptic potentials (IPSPs) insensitive to CB1 receptor pharmacology displayed frequency-dependent depression. Release of GABA at facilitating synapses was solely mediated via N-type presynaptic calcium channels, whereas depressing synapses utilized P/Q-type channels. These data reveal two distinct models of neurotransmitter release patterns among interneuron circuits that correlate with the subtype of presynaptic calcium channel. These data suggest that endocannabinoids act via CB1 receptors to selectively modulate N-type calcium channels to alter signal transmission.

journal_name

J Neurophysiol

authors

Ali AB

doi

10.1152/jn.00831.2010

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

1051-62

issue

3

eissn

0022-3077

issn

1522-1598

pii

jn.00831.2010

journal_volume

105

pub_type

杂志文章
  • Postural adjustments for online corrections of arm movements in standing humans.

    abstract::The aim of this study was to investigate how humans correct ongoing arm movements while standing. Specifically, we sought to understand whether the postural adjustments in the legs required for online corrections of arm movements are predictive or rely on feedback from the moving limb. To answer this question we measu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00944.2010

    authors: Leonard JA,Gritsenko V,Ouckama R,Stapley PJ

    更新日期:2011-05-01 00:00:00

  • The raccoon lateral cervical nucleus: a single-unit analysis.

    abstract::1. Properties of 90 lateral cervical nucleus (LCN) neurons responsive to light tactile stimulation of ipsilateral body surfaces were examined in pentobarbital sodium-anesthetized raccoons. Peripheral receptive fields (RFs) of 60 of these lay totally or partially on glabrous skin of the forepaw. There were 71 neurons a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.6.1411

    authors: Simone DA,Pubols BH Jr

    更新日期:1991-06-01 00:00:00

  • Sensorimotor control of the trunk in sitting sway referencing.

    abstract::We developed a sway-referenced system for sitting to highlight the role of vestibular and visual contributions to trunk control. Motor control was investigated by measuring trunk kinematics in the frontal plane while manipulating visual availability and introducing a concurrent cognitive task. We examined motor learni...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00330.2017

    authors: Goodworth AD,Tetreault K,Lanman J,Klidonas T,Kim S,Saavedra S

    更新日期:2018-07-01 00:00:00

  • Responsiveness to D-glucose in neurosecretory cells of crustaceans.

    abstract::1. An electrophysiological study of the D-glucose sensitivity of X-organ (XO) neurosecretory cell bodies in crayfish was carried out with the use of microelectrodes, perforated, and cell-attached patch-clamp techniques. 2. Glucose depolarizes the membrane potential of XO cells in a concentration-dependent manner. 3. D...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.2.758

    authors: García E,Benítez A,Onetti CG

    更新日期:1993-08-01 00:00:00

  • Fatigue and motor redundancy: adaptive increase in finger force variance in multi-finger tasks.

    abstract::We studied the effects of fatigue of the index finger on indices of force variability in discrete and rhythmic accurate force production tasks performed by the index finger and by all four fingers pressing in parallel. An increase in the variance of the force produced by the fatigued index finger was expected. We hypo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00077.2010

    authors: Singh T,Varadhan SK,Zatsiorsky VM,Latash ML

    更新日期:2010-06-01 00:00:00

  • Effects of hypothalamic stimulation on activity of dorsomedial medulla neurons that respond to subdiaphragmatic vagal stimulation.

    abstract::1. Effects of hypothalamic stimulation on activity of dorsomedial medulla neurons that responded to subdiaphragmatic vagal stimulation were investigated in urethan-anesthetized rats. 2. Extracellular recordings were made from 231 neurons in the nucleus of the tractus solitarius (NTS) that fired repetitively in respons...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.4.655

    authors: Nishimura H,Oomura Y

    更新日期:1987-10-01 00:00:00

  • Role of retinal slip in the prediction of target motion during smooth and saccadic pursuit.

    abstract::Visual tracking of moving targets requires the combination of smooth pursuit eye movements with catch-up saccades. In primates, catch-up saccades usually take place only during pursuit initiation because pursuit gain is close to unity. This contrasts with the lower and more variable gain of smooth pursuit in cats, whe...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.2.550

    authors: de Brouwer S,Missal M,Lefèvre P

    更新日期:2001-08-01 00:00:00

  • Dynamics of stimulus-evoked spike timing correlations in the cat lateral geniculate nucleus.

    abstract::Precisely synchronized neuronal activity has been commonly observed in the mammalian visual pathway. Spike timing correlations in the lateral geniculate nucleus (LGN) often take the form of phase synchronized oscillations in the high gamma frequency range. To study the relations between oscillatory activity, synchrony...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01000.2009

    authors: Ito H,Maldonado PE,Gray CM

    更新日期:2010-12-01 00:00:00

  • Human frontoparietal cortex represents behaviorally relevant target status based on abstract object features.

    abstract::Searching for items that are useful given current goals, or "target" recognition, requires observers to flexibly attend to certain object properties at the expense of others. This could involve focusing on the identity of an object while ignoring identity-preserving transformations such as changes in viewpoint or focu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00015.2019

    authors: Henderson M,Serences JT

    更新日期:2019-04-01 00:00:00

  • Na+-activated K+ current contributes to postexcitatory hyperpolarization in neocortical intrinsically bursting neurons.

    abstract::The ionic mechanisms underlying the termination of action-potential (AP) bursts and postburst afterhyperpolarization (AHP) in intrinsically bursting (IB) neocortical neurons were investigated by performing intracellular recordings in thin slices of rat sensorimotor cortex. The blockade of Ca(2+)-activated K(+) current...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00695.2002

    authors: Franceschetti S,Lavazza T,Curia G,Aracri P,Panzica F,Sancini G,Avanzini G,Magistretti J

    更新日期:2003-04-01 00:00:00

  • Response properties of single units in the dorsal nucleus of the lateral lemniscus of decerebrate cats.

    abstract::The dorsal nucleus of the lateral lemniscus (DNLL) receives afferent inputs from many brain stem nuclei and, in turn, is a major source of inhibitory inputs to the inferior colliculus (IC). The goal of this study was to characterize the monaural and binaural response properties of neurons in the DNLL of unanesthetized...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00451.2007

    authors: Davis KA,Lomakin O,Pesavento MJ

    更新日期:2007-09-01 00:00:00

  • Molecular identity, ontogeny, and cAMP modulation of the hyperpolarization-activated current in vestibular ganglion neurons.

    abstract::Properties, developmental regulation, and cAMP modulation of the hyperpolarization-activated current (I(h)) were investigated by the whole cell patch-clamp technique in vestibular ganglion neurons of the rat at two postnatal stages (P7-10 and P25-28). In addition, by RT-PCR and immunohistochemistry the identity and di...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00337.2012

    authors: Almanza A,Luis E,Mercado F,Vega R,Soto E

    更新日期:2012-10-01 00:00:00

  • Photic-induced sensitization: acquisition of an augmenting spike-wave response in the adult rat through repeated strobe exposure.

    abstract::It is well established that patterns of sensory input can affect neuroplastic changes during early development. The scope and consequences of experience-dependent plasticity in the adult are less well understood. We studied the possibility that repeated exposure to trains of stroboscopic stimuli could induce a sensiti...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00724.2005

    authors: Uhlrich DJ,Manning KA,O'Laughlin ML,Lytton WW

    更新日期:2005-12-01 00:00:00

  • Growth factors mobilize multiple pools of KCa channels in developing parasympathetic neurons: role of ADP-ribosylation factors and related proteins.

    abstract::In developing ciliary ganglion (CG) neurons, movement of functional large-conductance (BK type) Ca(2+)-activated K+ (K(Ca)) channels to the cell surface is stimulated by the endogenous growth factors TGF(beta)1 and beta-neuregulin-1 (NRG1). Here we show that a brief NRG1 treatment (0.5-1.5 h) mobilizes K(Ca) channels ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00296.2005

    authors: Chae KS,Oh KS,Dryer SE

    更新日期:2005-08-01 00:00:00

  • Evidence for automatic on-line adjustments of hand orientation during natural reaching movements to stationary targets.

    abstract::Control of the spatial orientation of the hand is an important component of reaching and grasping movements. We studied the contribution of vision and proprioception to the perception and control of hand orientation in orientation-matching and letter-posting tasks. In the orientation-matching task, subjects aligned a ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00980.2007

    authors: Gosselin-Kessiby N,Messier J,Kalaska JF

    更新日期:2008-04-01 00:00:00

  • Implications of plan-based generalization in sensorimotor adaptation.

    abstract::Generalization is a fundamental aspect of behavior, allowing for the transfer of knowledge from one context to another. The details of this transfer are thought to reveal how the brain represents what it learns. Generalization has been a central focus in studies of sensorimotor adaptation, and its pattern has been wel...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00974.2016

    authors: McDougle SD,Bond KM,Taylor JA

    更新日期:2017-07-01 00:00:00

  • Can proprioceptive training improve motor learning?

    abstract::Recent work has investigated the link between motor learning and sensory function in arm movement control. A number of findings are consistent with the idea that motor learning is associated with systematic changes to proprioception (Haith A, Jackson C, Mial R, Vijayakumar S. Adv Neural Inf Process Syst 21: 593-600, 2...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00122.2012

    authors: Wong JD,Kistemaker DA,Chin A,Gribble PL

    更新日期:2012-12-01 00:00:00

  • Two types of local interneurons are distinguished by morphology, intrinsic membrane properties, and functional connectivity in the moth antennal lobe.

    abstract::Neurons in the silkmoth antennal lobe (AL) are well characterized in terms of their morphology and odor-evoked firing activity. However, their intrinsic electrical properties including voltage-gated ionic currents and synaptic connectivity remain unclear. To address this, whole cell current- and voltage-clamp recordin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00050.2015

    authors: Tabuchi M,Dong L,Inoue S,Namiki S,Sakurai T,Nakatani K,Kanzaki R

    更新日期:2015-11-01 00:00:00

  • Encoding of eye position in the goldfish horizontal oculomotor neural integrator.

    abstract::Monocular organization of the goldfish horizontal neural integrator was studied during spontaneous scanning saccadic and fixation behaviors. Analysis of neuronal firing rates revealed a population of ipsilateral (37%), conjugate (59%), and contralateral (4%) eye position neurons. When monocular optokinetic stimuli wer...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00313.2010

    authors: Debowy O,Baker R

    更新日期:2011-02-01 00:00:00

  • Differences in inhibitory synaptic input between layer II-III and layer V neurons of the cat neocortex.

    abstract::1. The goal of this study was to compare the relative effectiveness of intrinsic inhibitory synaptic inputs in different layers of the cat motor cortex. Postsynaptic potentials (PSPs) were evoked in neurons located in the superficial (layer II-III) or deep layers (layer V) by local extracellular stimulation in vitro. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.3.1149

    authors: van Brederode JF,Spain WJ

    更新日期:1995-09-01 00:00:00

  • Octopamine stabilizes conduction reliability of an unmyelinated axon during hypoxic stress.

    abstract::Mechanisms that could mitigate the effects of hypoxia on neuronal signaling are incompletely understood. We show that axonal performance of a locust visual interneuron varied depending on oxygen availability. To induce hypoxia, tracheae supplying the thoracic nervous system were surgically lesioned and action potentia...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00354.2016

    authors: Money TG,Sproule MK,Cross KP,Robertson RM

    更新日期:2016-09-01 00:00:00

  • Path perturbation detection tasks reduce MSTd neuronal self-movement heading responses.

    abstract::We presented optic flow and real movement heading stimuli while recording MSTd neuronal activity. Monkeys were alternately engaged in three tasks: visual detection of optic flow heading perturbations, vestibular detection of real movement heading perturbations, and auditory detection of brief tones. Push-button RTs we...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00958.2016

    authors: Page WK,Duffy CJ

    更新日期:2018-01-01 00:00:00

  • Retention and generalizability of balance recovery response adaptations from trip perturbations across the adult life span.

    abstract::For human locomotion, varying environments require adjustments of the motor system. We asked whether age affects gait balance recovery adaptation, its retention over months, and the transfer of adaptation to an untrained reactive balance task. Healthy adults (26 young, 27 middle-aged, and 25 older; average ages 24, 52...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00380.2019

    authors: König M,Epro G,Seeley J,Potthast W,Karamanidis K

    更新日期:2019-11-01 00:00:00

  • Is equilibrium point control feasible for fast goal-directed single-joint movements?

    abstract::Several types of equilibrium point (EP) controllers have been proposed for the control of posture and movement. EP controllers are appealing from a computational perspective because they do not require solving the "inverse dynamic problem" (i.e., computation of the torques required to move a system along a desired tra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00983.2005

    authors: Kistemaker DA,Van Soest AJ,Bobbert MF

    更新日期:2006-05-01 00:00:00

  • Low-voltage activated calcium currents increase in basal forebrain neurons from aged rats.

    abstract::1. Whole cell patch-clamp recordings were made of low-voltage-activated (LVA) calcium (Ca2+) currents using 2 mM barium (Ba2+) as charge carrier. Acutely dissociated neurons from medial septum (MS) and the nucleus of the diagonal band (nDB) were examined in young adult (1-3 mo) and aged (24-26 mo) Fischer 344 rats. 2....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.2.876

    authors: Murchison D,Griffith WH

    更新日期:1995-08-01 00:00:00

  • Large-scale recording of thalamocortical circuits: in vivo electrophysiology with the two-dimensional electronic depth control silicon probe.

    abstract::Recording simultaneous activity of a large number of neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the in vivo performance of a recently developed electrophysiological recording system comprising a two-dimensional, multi-shank, high-density silicon probe...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00318.2016

    authors: Fiáth R,Beregszászi P,Horváth D,Wittner L,Aarts AA,Ruther P,Neves HP,Bokor H,Acsády L,Ulbert I

    更新日期:2016-11-01 00:00:00

  • Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain.

    abstract::The tail and paws in rodents are heat exchangers involved in the maintenance of core body temperature (T(core)). They are also the most widely used target organs to study acute or chronic "models" of pain. We describe the fluctuations of vasomotor tone in the tail and paws in conditions of thermal neutrality and the c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00721.2013

    authors: El Bitar N,Pollin B,Karroum E,Pincedé I,Mouraux A,Le Bars D

    更新日期:2014-11-01 00:00:00

  • Mechanisms for shaping receptive field in monkey area TE.

    abstract::Visual object information is conveyed from V1 to area TE along the ventral visual pathway with increasing receptive field (RF) sizes. The RFs of TE neurons are known to be large, but it is largely unknown how large RFs are shaped along the ventral visual pathway. In this study, we addressed this question in two aspect...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00348.2017

    authors: Obara K,O'Hashi K,Tanifuji M

    更新日期:2017-10-01 00:00:00

  • Activity of primate V1 cortical neurons during blinks.

    abstract::Every time we blink our eyes, the image on the retina goes almost completely dark. And yet we hardly notice these interruptions, even though an external darkening is startling. Intuitively it would seem that if our perception is continuous, then the neuronal activity on which our perceptions are based should also be c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.5.2691

    authors: Gawne TJ,Martin JM

    更新日期:2000-11-01 00:00:00

  • Stiffness of cat soleus muscle and tendon during activation of part of muscle.

    abstract::Experiments have been carried out on the soleus muscle and its tendon in the anesthetized cat. Measurements of isometric tension and muscle stiffness were made during contraction of whole or part of the muscle in response to stimulation of ventral root filaments. In an attempt to determine the distribution of tension ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.52.3.459

    authors: Proske U,Morgan DL

    更新日期:1984-09-01 00:00:00