Evidence that REM sleep is controlled by the activation of brain stem pedunculopontine tegmental kainate receptor.

Abstract:

:Glutamate, the neurotransmitter, enhances rapid-eye-movement (REM) sleep when microinjected into the brain stem pedunculopontine tegmentum (PPT) of the cat and rat. Glutamate and its various receptors are normally present in the PPT cholinergic cell compartment. The aim of this study was to identify which specific receptor(s) in the cholinergic cell compartment of the PPT are involved in glutamate-induced-REM sleep. To identify these glutamate-induced REM-sleep-generating receptor(s) in the PPT cholinergic cell compartment, specific receptors were pharmacologically blocked differentially by localized pretreatment of specific glutamate receptor antagonists; glutamate was then microinjected into the PPT cholinergic cell compartment while quantifying the effects on REM sleep in freely moving chronically instrumented rats. The results demonstrate that when kainate receptors were blocked by pretreatment with a kainate-specific receptor antagonist, microinjection of glutamate was unable to induce REM sleep. Pharmacological blockade of specific N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors was unable to block glutamate-microinjection-induced-REM sleep. These findings suggest, for the first time, that the activation of kainate receptors within the cholinergic cell compartment of the PPT is an essential portion of the mechanism for the generation of glutamate-induced REM sleep in the rat.

journal_name

J Neurophysiol

authors

Datta S

doi

10.1152/jn.00763.2001

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

1790-8

issue

4

eissn

0022-3077

issn

1522-1598

journal_volume

87

pub_type

杂志文章
  • Potentiation in the first visual synapse of the fly compound eye.

    abstract::In the first visual synapse of the insect compound eye, both the presynaptic and postsynaptic signals are graded, nonspiking changes in membrane voltage. The synapse exhibits tonic transmitter release (even in dark) and strong adaptation to long-lasting light backgrounds, leading to changes also in the dynamics of sig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2103

    authors: Uusitalo RO,Weckström M

    更新日期:2000-04-01 00:00:00

  • Forebrain pathway for auditory space processing in the barn owl.

    abstract::The forebrain plays an important role in many aspects of sound localization behavior. Yet, the forebrain pathway that processes auditory spatial information is not known for any species. Using standard anatomic labeling techniques, we used a "top-down" approach to trace the flow of auditory spatial information from an...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.2.891

    authors: Cohen YE,Miller GL,Knudsen EI

    更新日期:1998-02-01 00:00:00

  • Existence in the nucleus incertus of the cat of horizontal-eye-movement-related neurons projecting to the cerebellar flocculus.

    abstract::1. Properties of nucleus incertus (NIC) neurons projecting to the cerebellar flocculus were studied in alert cats by using chronic unit and eye movement recording and antidromic activation. Projection of these neurons onto the flocculus was verified with retrograde transport of horseradish peroxidase after injections ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.3.1367

    authors: Cheron G,Saussez S,Gerrits N,Godaux E

    更新日期:1995-09-01 00:00:00

  • Optimization of rhythmic behaviors by modulation of the neuromuscular transform.

    abstract::We conclude our study of the properties and the functional role of the neuromuscular transform (NMT). The NMT is an input-output relation that formalizes the processes by which patterns of motor neuron firing are transformed to muscle contractions. Because the NMT acts as a dynamic, nonlinear, and modifiable filter, t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.1.260

    authors: Brezina V,Orekhova IV,Weiss KR

    更新日期:2000-01-01 00:00:00

  • Exploratory movements determine cue weighting in haptic length perception of handheld rods.

    abstract::In the present study, we sought to unravel how exploratory movements affect length perception of rods that are held in and wielded by hand. We manipulated the mechanical rod properties--mass (m), first moment of mass distribution (M), major principal moment of inertia (I(1))--individually, allowing us to assess the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01029.2009

    authors: Debats NB,van de Langenberg RW,Kingma I,Smeets JB,Beek PJ

    更新日期:2010-11-01 00:00:00

  • Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences.

    abstract::Two of the biggest health problems facing us today are addiction to nicotine and the increased prevalence of obesity. Interestingly, nicotine attenuates obesity, but the underlying mechanism is not clear. Here we address the hypothesis that if weight-reducing actions of nicotine are mediated by anorexigenic proopiomel...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00740.2010

    authors: Huang H,Xu Y,van den Pol AN

    更新日期:2011-09-01 00:00:00

  • GAT-3 transporters regulate inhibition in the neocortex.

    abstract::The role of GAT-3 transporters in regulating GABA(A) receptor-mediated inhibition was examined in the rat neocortex using an in vitro slice preparation. Pharmacologically isolated GABA(A) receptor-mediated responses were recorded from layer V neocortical pyramidal cells, and the effects of SNAP-5114, a GAT-3 GABA tran...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00420.2005

    authors: Kinney GA

    更新日期:2005-12-01 00:00:00

  • Single-unit stability using chronically implanted multielectrode arrays.

    abstract::The use of chronic intracortical multielectrode arrays has become increasingly prevalent in neurophysiological experiments. However, it is not obvious whether neuronal signals obtained over multiple recording sessions come from the same or different neurons. Here, we develop a criterion to assess single-unit stability...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90920.2008

    authors: Dickey AS,Suminski A,Amit Y,Hatsopoulos NG

    更新日期:2009-08-01 00:00:00

  • Tissue resistance changes and the profile of synchronized neuronal activity during ictal events in the low-calcium model of epilepsy.

    abstract::Population spikes vary in size during prolonged epileptic ("ictal") discharges, indicating variations in neuronal synchronization. Here we investigate the role of changes in tissue electrical resistivity in this process. We used the rat hippocampal slice, low-Ca(2+) model of epilepsy and measured changes in pyramidal ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00123.2004

    authors: Fox JE,Bikson M,Jefferys JG

    更新日期:2004-07-01 00:00:00

  • LFP power spectra in V1 cortex: the graded effect of stimulus contrast.

    abstract::We recorded local field potentials (LFPs) and single-unit activity simultaneously in the macaque primary visual cortex (V1) and studied their responses to drifting sinusoidal gratings that were chosen to be "optimal" for the single units. Over all stimulus conditions, the LFP spectra have much greater power in the low...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00919.2004

    authors: Henrie JA,Shapley R

    更新日期:2005-07-01 00:00:00

  • Spike coding during locomotor network activity in ventrally located neurons in the isolated spinal cord from neonatal rat.

    abstract::To characterize spike coding in spinal neurons during rhythmic locomotor activity, we recorded from individual cells in the lumbar spinal cord of neonatal rats by using the on-cell patch-clamp technique. Locomotor activity was induced by N-methyl-D aspartate (NMDA) and 5-hydroxytryptamine (5-HT) and monitored by ventr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.5.2825

    authors: Raastad M,Kiehn O

    更新日期:2000-05-01 00:00:00

  • Excitatory actions of ventral root stimulation during network activity generated by the disinhibited neonatal mouse spinal cord.

    abstract::To further understand the excitatory effects of motoneurons on spinal network function, we investigated the entrainment of disinhibited rhythms by ventral root (VR) stimulation in the neonatal mouse spinal cord. A brief train of stimuli applied to a VR triggered bursting reliably in 31/32 experiments. The same roots t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90740.2008

    authors: Bonnot A,Chub N,Pujala A,O'Donovan MJ

    更新日期:2009-06-01 00:00:00

  • Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+.

    abstract::1. The effects of the di- and trivalent trace metal cations, Pb2+, Zn2+, and Al3+, on voltage-activated calcium channel currents recorded from cultured rat dorsal root ganglion neurons were determined. 2. All three cations blocked transient and sustained components of the voltage-gated calcium channel currents elicite...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.4.1491

    authors: Büsselberg D,Platt B,Michael D,Carpenter DO,Haas HL

    更新日期:1994-04-01 00:00:00

  • Mechanoafferent neuron with an inexcitable somatic region: consequences for the regulation of spike propagation and afferent transmission.

    abstract::In the Aplysia mechanoafferent B21, afferent transmission is in part regulated via the control of active spike propagation. When B21 is peripherally activated at its resting membrane potential, spikes fail to propagate to an output process, and afferent transmission does not occur. In this report, we show that the pro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01341.2006

    authors: Evans CG,Ludwar BCh,Cropper EC

    更新日期:2007-04-01 00:00:00

  • Temporal evolution of "automatic gain-scaling".

    abstract::The earliest neural response to a mechanical perturbation, the short-latency stretch response (R1: 20-45 ms), is known to exhibit "automatic gain-scaling" whereby its magnitude is proportional to preperturbation muscle activity. Because gain-scaling likely reflects an intrinsic property of the motoneuron pool (via the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00085.2009

    authors: Pruszynski JA,Kurtzer I,Lillicrap TP,Scott SH

    更新日期:2009-08-01 00:00:00

  • Impact of cortical plasticity on information signaled by populations of neurons in the cerebral cortex.

    abstract::The performance of neural codes to represent attributes of sensory signals has been evaluated in the vertebrate peripheral and central nervous system. Here, we determine how information signaled by populations of neurons is modified by plasticity. Suprathreshold neuronal responses from a large number of neurons were r...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01001.2010

    authors: Pita-Almenar JD,Ranganathan GN,Koester HJ

    更新日期:2011-09-01 00:00:00

  • Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.

    abstract::Tissue injury in early life can produce distinctive effects on pain processing, but little is known about the underlying neural mechanisms. Neonatal inflammation modulates excitatory synapses in spinal nociceptive circuits, but it is unclear whether this results directly from altered afferent input. Here we investigat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00520.2009

    authors: Li J,Walker SM,Fitzgerald M,Baccei ML

    更新日期:2009-10-01 00:00:00

  • Motor cortex activation induced by a mirror: evidence from lateralized readiness potentials.

    abstract::Similar motor regions are activated during voluntarily executed or observed movements. We investigated whether observing movements of one's own hand through a mirror will generate activations in the cortical motor regions of both the moving and nonmoving hands. Using the lateralized readiness potential (LRP), an elect...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90260.2008

    authors: Touzalin-Chretien P,Dufour A

    更新日期:2008-07-01 00:00:00

  • Increase in Purkinje cell gain associated with naturally activated climbing fiber input.

    abstract::These experiments were designed to test the hypothesis that climbing fiber inputs evoked by a peripheral stimulus increase the responsiveness of Purkinje cells to mossy fiber inputs. This hypothesis was based on a previous series of observations demonstrating that spontaneous climbing fiber inputs are associated with ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.1.205

    authors: Ebner TJ,Yu QX,Bloedel JR

    更新日期:1983-07-01 00:00:00

  • Signal delay and input synchronization in passive dendritic structures.

    abstract::1. A novel approach for analyzing transients in passive structures called "the method of moments" is introduced. It provides, as a special case, an analytic method for calculating the time delay and speed of propagation of electrical signals in any passive dendritic tree without the need for numerical simulations. 2. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.5.2066

    authors: Agmon-Snir H,Segev I

    更新日期:1993-11-01 00:00:00

  • Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.

    abstract::Intense itch and urge to scratch are the major symptoms of many chronic skin ailments, which are increasingly common. Vicious itch-scratch cycles are readily established and may diminish quality of life for those afflicted. We investigated peripheral and central processing of two types of itch sensation elicited by sk...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00070.2006

    authors: Leknes SG,Bantick S,Willis CM,Wilkinson JD,Wise RG,Tracey I

    更新日期:2007-01-01 00:00:00

  • Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills.

    abstract::1. We used transcranial magnetic stimulation (TMS) to study the role of plastic changes of the human motor system in the acquisition of new fine motor skills. We mapped the cortical motor areas targeting the contralateral long finger flexor and extensor muscles in subjects learning a one-handed, five-finger exercise o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.3.1037

    authors: Pascual-Leone A,Nguyet D,Cohen LG,Brasil-Neto JP,Cammarota A,Hallett M

    更新日期:1995-09-01 00:00:00

  • Effects of mitochondrion on calcium transients at intact presynaptic terminals depend on frequency of nerve firing.

    abstract::The rate and the total amount of Ca2+ elevation in the presynaptic terminals of bullfrog sympathetic ganglia depend on the firing frequency of the terminals. Carbonyl cyanide m-chlorophenylhydrazone (CCCP), a mitochondrial uncoupler, was used for testing whether mitochondrial Ca2+ uptake is one of the mechanisms that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.186

    authors: Peng YY

    更新日期:1998-07-01 00:00:00

  • Characterization of GABAA receptor function in human temporal cortical neurons.

    abstract::1. Surgically resected tissue from the tip of the human temporal lobe of seven patients undergoing temporal lobectomy was employed to study functional properties of GABAergic inhibition mediated through activation of GABAA receptors, using patch-clamp recording techniques in acutely isolated neurons and in slices of h...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.4.1458

    authors: Gibbs JW 3rd,Zhang YF,Kao CQ,Holloway KL,Oh KS,Coulter DA

    更新日期:1996-04-01 00:00:00

  • Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus.

    abstract::1. Whole-cell patch-clamp recordings of excitatory postsynaptic currents (EPSCs) were made from guinea pig hippocampal CA1 pyramidal cells. The sensitivity of paired pulse facilitation (PPF) and EPSC variance to changes in synaptic transmission was investigated and the results were compared with the changes in these p...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.4.1451

    authors: Manabe T,Wyllie DJ,Perkel DJ,Nicoll RA

    更新日期:1993-10-01 00:00:00

  • β-Adrenergic modulation of spontaneous spatiotemporal activity patterns and synchrony in hyperexcitable hippocampal circuits.

    abstract::A description of healthy and pathological brain dynamics requires an understanding of spatiotemporal patterns of neural activity and characteristics of its propagation between interconnected circuits. However, the structure and modulation of the neural activation maps underlying these patterns and their propagation re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00708.2011

    authors: Hazra A,Rosenbaum R,Bodmann B,Cao S,Josić K,Žiburkus J

    更新日期:2012-07-01 00:00:00

  • Choline acts as agonist and blocker for Aplysia cholinergic synapses.

    abstract::Several identified neurons of the Aplysia buccal ganglia respond to choline. Iontophoretic applications of either choline or acetylcholine (ACh) to voltage-clamped inhibitory follower neurons produce similar currents. Peak amplitudes of choline responses were 10-100% of ACh responses on the same cell. Choline currents...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.51.1.1

    authors: Gardner D,Ruff RL,White RL

    更新日期:1984-01-01 00:00:00

  • Epileptiform activity in the dentate gyrus during low-calcium perfusion and exposure to transient electric fields.

    abstract::1. The dentate gyrus fails to develop epileptiform activity in many experimental models of epilepsy, including the in vitro low-Ca2+ model. Although manipulating the K+ concentration or osmolality of normal low-Ca2+ perfusion mediums can enhance the propensity of the dentate gyrus to develop seizure activity, the spec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.1.388

    authors: Richardson TL,O'Reilly CN

    更新日期:1995-07-01 00:00:00

  • Spatial vision in strabismic cats.

    abstract::Contrast thresholds for detection of stationary and flickering gratings were measured behaviorally for each eye of cats raised with induced convergent strabismus. The performance of the deviating eye was inferior to that of the nondeviating eye when test patterns were stationary. Flicker served to reduce the performan...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.1.287

    authors: Holopigian K,Blake R

    更新日期:1983-07-01 00:00:00

  • Responses of single facial taste fibers in the sea catfish, Arius felis, to amino acids.

    abstract::1. Taste buds in catfish are found not only within the oropharyngeal cavity, as in mammals, but are also located along the external body surface of the animal from the barbels and lips to the caudal fin. Because these taste buds are innervated by the facial (cranial VII) nerve, the extraoral taste system of catfish is...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.1.247

    authors: Michel W,Caprio J

    更新日期:1991-07-01 00:00:00