Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes.

abstract：:The neuronal mechanism which gives rise to the synchronization of motor-unit discharges has been inferred from an analysis of the interspike intervals of individual motor-unit discharges recorded from the soleus muscle. The motor units were divided into two groups on the basis of characteristic changes in their spike ...

journal_title：Journal of neurophysiology

authors： Mori S

更新日期：1975-07-01 00:00:00

abstract：:The excitotoxic theory of Parkinson's disease (PD) hypothesizes that a pathophysiological degeneration of dopaminergic neurons stems from neural hyperactivity at early stages of disease, leading to mitochondrial stress and cell death. Recent research has harnessed the visual system of Drosophila PD models to probe thi...

journal_title：Journal of neurophysiology

authors： Himmelberg MM,West RJH,Elliott CJH,Wade AR

更新日期：2018-03-01 00:00:00

abstract：:Neuromuscular synapses in buccal muscle I3a of Aplysia are modulated by the small cardioactive peptide (SCP), a peptide cotransmitter that is intrinsic to the motor neurons, and by serotonin (5-HT) released from modulatory neurons that are extrinsic to the motor circuit. Although the modulation of excitatory junction ...

journal_title：Journal of neurophysiology

authors： Fox LE,Lloyd PE

更新日期：2000-03-01 00:00:00

abstract：:Neuron loss, axon sprouting, and the formation of new synaptic circuits have been hypothesized to contribute to seizures in temporal lobe epilepsy (TLE). Using the kainate-treated rat, we examined how alterations in the density of CA1 pyramidal cells and interneurons, and subsequent sprouting of CA1 pyramidal cell axo...

journal_title：Journal of neurophysiology

authors： Smith BN,Dudek FE

更新日期：2001-01-01 00:00:00

abstract：:In this study we analyzed transient voltage-activated K+ currents (IA) of projection neurons and local interneurons in the antennal lobe of the cockroach Periplaneta americana The antennal lobe is the first synaptic processing station for olfactory information in insects. Local interneurons are crucial for computing o...

journal_title：Journal of neurophysiology

authors： Paeger L,Bardos V,Kloppenburg P

更新日期：2017-05-01 00:00:00

abstract：:1. To analyze the selectivity and the sparseness of firing to visual stimuli of single neurons in the primate temporal cortical visual area, neuronal responses were measured to a set of 68 visual stimuli in macaques performing a visual fixation task. The population of neurons analyzed had responses that occurred prima...

journal_title：Journal of neurophysiology

authors： Rolls ET,Tovee MJ

更新日期：1995-02-01 00:00:00

abstract：:Whole cell patch-clamp recordings were used to investigate the contribution of transient, low-threshold calcium currents (I(T)) to firing properties of hamster spinal dorsal horn neurons. I(T) was widely, though not uniformly, expressed by cells in Rexed's laminae I-IV and correlated with the pattern of action potenti...

journal_title：Journal of neurophysiology

authors： Ku WH,Schneider SP

更新日期：2011-11-01 00:00:00

abstract：:Twenty-four slowly adapting type 1 (SA1) and 26 rapidly adapting (RA) cutaneous mechanoreceptive afferents in the rhesus monkey were studied with an array of independently controlled, punctate probes that covered an entire fingerpad. Each afferent had a receptive field (RF) on a single fingerpad and was studied at 73 ...

journal_title：Journal of neurophysiology

authors： Vega-Bermudez F,Johnson KO

更新日期：1999-06-01 00:00:00

abstract：:With experience, an object can become behaviorally relevant and thereby quickly attract our interest when presented in a visual scene. A likely site of these learning effects is anterior inferior temporal (aIT) cortex, where neurons are thought to participate in the filtering of irrelevant information out of complex v...

journal_title：Journal of neurophysiology

authors： Jagadeesh B,Chelazzi L,Mishkin M,Desimone R

更新日期：2001-07-01 00:00:00

abstract：:1. A variety of pharmacological tests indicate that the neuromuscular junction between the salivary burster neuron (SB) and the salivary duct muscle (SD) in the terrestrial mollusk Limax maximus is cholinergic. These include the effects of curare, atropine, and hexamethonium. 2. Exogenously applied choline can act bot...

journal_title：Journal of neurophysiology

authors： Barry SR,Gelperin A

更新日期：1982-08-01 00:00:00

abstract：:Sensory cortical neurons display substantial receptive field dynamics during and after persistent sensory drive. Because a cell's response properties are determined by the inputs it receives, receptive field dynamics are likely to involve changes in the relative efficacy of different inputs to the cell. To test this h...

journal_title：Journal of neurophysiology

authors： Kohn A,Metz C,Tommerdahl MA,Whitsel BL

更新日期：2002-12-01 00:00:00

abstract：:1. Some scientists reported that the simple spike (SS) activity was transiently depressed after climbing fiber input, but others reported that predominant population of Purkinje cells increased their SS activity after the complex spike (CS). In the present study, SS activity after spontaneous CS was compared before an...

journal_title：Journal of neurophysiology

authors： Sato Y,Miura A,Fushiki H,Kawasaki T

更新日期：1993-04-01 00:00:00

abstract：:Depolarization-induced suppression of inhibition (DSI) is a form of retrograde signaling at GABAergic synapses that is initiated by the calcium- and depolarization-dependent release of endocannabinoids from postsynaptic neurons. In the neocortex, pyramidal neurons (PNs) appear to use DSI as a mechanism for regulating ...

journal_title：Journal of neurophysiology

authors： Fortin DA,Trettel J,Levine ES

更新日期：2004-10-01 00:00:00

abstract：:Following stepping in-place on the surface of a rotating circular treadmill, a subject attempting to step in-place or walk in a straight line across the floor without vision will rotate relative to space. This adaptation, termed podokinetic after-rotation (PKAR), transfers to backward walking following forward walking...

journal_title：Journal of neurophysiology

authors： Earhart GM,Melvill Jones G,Horak FB,Block EW,Weber KD,Fletcher WA

更新日期：2002-02-01 00:00:00

abstract：:The contributions of the hyperpolarization-activated current, I(h), to generation of rhythmic activities are well described for various central neurons, particularly in thalamocortical circuits. In the present study, we investigated effects of a general anesthetic, propofol, on native I(h) in neurons of thalamus and c...

journal_title：Journal of neurophysiology

authors： Chen X,Shu S,Bayliss DA

更新日期：2005-12-01 00:00:00

abstract：:Coupled oscillatory activity recorded between sensorimotor regions of the basal ganglia-thalamocortical loop is thought to reflect information transfer relevant to movement. A neuronal firing-rate model of basal ganglia-thalamocortical circuitry, however, has dominated thinking about basal ganglia function for the pas...

journal_title：Journal of neurophysiology

authors： Lipski WJ,Wozny TA,Alhourani A,Kondylis ED,Turner RS,Crammond DJ,Richardson RM

更新日期：2017-09-01 00:00:00

abstract：:In rats, forelimb movements are evoked from two cortical regions, the caudal and rostral forelimb areas (CFA and RFA, respectively). These areas are densely interconnected and RFA induces complex and powerful modulations of CFA outputs. CFA and RFA also have interhemispheric connections, and these areas from both hemi...

journal_title：Journal of neurophysiology

authors： Touvykine B,Elgbeili G,Quessy S,Dancause N

更新日期：2020-04-01 00:00:00

abstract：:Using intrinsic signal optical imaging (ISI), we have shown previously that the point spread of evoked activity in the rat barrel cortex in response to single-whisker stimulation encompasses a surprisingly large area. Given that our typical stimulation consists of five deflections at 5 Hz, the large area of evoked act...

journal_title：Journal of neurophysiology

authors： Polley DB,Chen-Bee CH,Frostig RD

更新日期：1999-02-01 00:00:00

abstract：:The problem of how the nervous system fuses sensory information from multiple modalities for upright stance control remains largely unsolved. It is well established that the visual, vestibular, and somatosensory modalities provide position and rate (e.g., velocity, acceleration) information for estimation of body dyna...

journal_title：Journal of neurophysiology

authors： Jeka J,Kiemel T,Creath R,Horak F,Peterka R

更新日期：2004-10-01 00:00:00

abstract：:Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key functional microcircuits within layer 2/3 of mouse primary...

journal_title：Journal of neurophysiology

authors： Avermann M,Tomm C,Mateo C,Gerstner W,Petersen CC

更新日期：2012-06-01 00:00:00

abstract：:Sleep disturbances are prevalent in clinical anxiety, but it remains unclear whether they are cause and/or consequence of this condition. Fear conditioning constitutes a valid laboratory model for the acquisition of normal and pathological anxiety. To explore the relationship between disturbed sleep and anxiety in mor...

journal_title：Journal of neurophysiology

authors： Peters AC,Blechert J,Sämann PG,Eidner I,Czisch M,Spoormaker VI

更新日期：2014-09-15 00:00:00

abstract：:Working memory (WM) performance is impaired by the presence of external interference. Accordingly, more efficient processing of intervening stimuli with practice may lead to enhanced WM performance. To explore the role of practice on the impact that interference has on WM performance, we studied young adults with elec...

journal_title：Journal of neurophysiology

authors： Berry AS,Zanto TP,Rutman AM,Clapp WC,Gazzaley A

更新日期：2009-09-01 00:00:00

abstract：:Mechanisms that could mitigate the effects of hypoxia on neuronal signaling are incompletely understood. We show that axonal performance of a locust visual interneuron varied depending on oxygen availability. To induce hypoxia, tracheae supplying the thoracic nervous system were surgically lesioned and action potentia...

journal_title：Journal of neurophysiology

authors： Money TG,Sproule MK,Cross KP,Robertson RM

更新日期：2016-09-01 00:00:00

abstract：:1. Less than two segments of the cervical spinal cord of the mudpuppy (Necturus maculatus) is sufficient to generate a locomotor rhythm with application of N-methyl-D-aspartic acid (NMDA). We have recorded intracellularly from rhythmically active interneurons in these segments and classified them according to their ph...

journal_title：Journal of neurophysiology

authors： Wheatley M,Jovanović K,Stein RB,Lawson V

更新日期：1994-06-01 00:00:00

abstract：:Rats typically employ 4- to 12-Hz "whisking" movements of their vibrissae during tactile exploration. The intentional sampling of signals in this frequency range suggests that neural processing of tactile information may be differentially engaged in this bandwidth. We examined action potential responses in rat primary...

journal_title：Journal of neurophysiology

authors： Garabedian CE,Jones SR,Merzenich MM,Dale A,Moore CI

更新日期：2003-09-01 00:00:00

abstract：:A lamprey maintains the dorsal-side-up orientation due to the activity of postural control system driven by vestibular input. Visual input can affect the body orientation: illumination of one eye evokes ipsilateral roll tilt. An important element of the postural network is the reticulospinal (RS) neurons transmitting ...

journal_title：Journal of neurophysiology

authors： Deliagina TG,Fagerstedt P

更新日期：2000-02-01 00:00:00

abstract：:Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now descr...

journal_title：Journal of neurophysiology

authors： Brown MR,El-Hassar L,Zhang Y,Alvaro G,Large CH,Kaczmarek LK

更新日期：2016-07-01 00:00:00

abstract：:Previous behavioral work has shown the existence of both anticipatory and reactive grip force responses to predictable load perturbations, but how the brain implements anticipatory control remains unclear. Here we recorded electroencephalographs while participants were subjected to predictable and unpredictable extern...

journal_title：Journal of neurophysiology

authors： Kourtis D,Kwok HF,Roach N,Wing AM,Praamstra P

更新日期：2008-02-01 00:00:00

abstract：:Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K+ current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K+ ions were investigated in vitro with the whole cell patch-cla...

journal_title：Journal of neurophysiology

authors： Pelz C,Jander J,Rosenboom H,Hammer M,Menzel R

更新日期：1999-04-01 00:00:00

abstract：:To trigger action potentials in neurons, most investigators use electrical or chemical stimulation. Here we describe an optical stimulation method based on semi-synthetic light-activated ion channels. These SPARK (synthetic photoisomerizable azobenzene-regulated K(+)) channels consist of a synthetic azobenzene-contain...

journal_title：Journal of neurophysiology

authors： Chambers JJ,Banghart MR,Trauner D,Kramer RH

更新日期：2006-11-01 00:00:00