Abstract:
:1. Receptive fields (RFs) of neurons in the primary somatosensory (SI) cortex were defined before, during, and after electrical stimulation of myelinated fibers in the dorsal cutaneous branch of the ulnar nerve in adult pentobarbital sodium-anesthetized cats. 2. This stimulation resulted in an approximately threefold increase of SI multiunit RF sizes. Substantial changes were first recorded within 1-2 h of stimulation. RFs typically enlarged continuously over a several-hour stimulation period, then stabilized. 3. RF-area increases were observed within both the forepaw and hindpaw representational zones in the SI cortex contralateral to the stimulated forepaw nerve. RF sizes did not increase in the ipsilateral SI body surface representation or in sham-stimulation control animals. 4. Preliminary studies indicate that stimulation-induced changes can be halted and often reversed by the intravenous administration of the opiate antagonist naloxone. 5. These observations suggest a global naloxone-sensitive modulatory system that operates on large-diameter afferent inputs in the cat somatosensory system. The increases in RF size occur under nerve-stimulation conditions similar to those that result in the generation of widespread analgesia (Chung et al. 1984a,b; Gamble and Milne 1986; Toda and Ichioka 1978).
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Recanzone GH,Allard TT,Jenkins WM,Merzenich MMdoi
10.1152/jn.1990.63.5.1213subject
Has Abstractpub_date
1990-05-01 00:00:00pages
1213-25issue
5eissn
0022-3077issn
1522-1598journal_volume
63pub_type
杂志文章abstract::Voltage-sensitive dye activity within the thin, unfoliated turtle cerebellar cortex (Cb) was recorded in vitro during eighth cranial nerve (nVIII) stimulation. Short latency responses were localized to the middle of the lateral edges of both ipsilateral and contralateral Cb [vestibulocerebellum (vCb)]. Even with a sev...
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00262.2004
更新日期:2004-10-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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