Motor signatures in autism spectrum disorder: the importance of variability.

abstract：:Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, is caused by loss of the fragile X mental retardation protein (FMRP). FMRP is a negative regulator of local mRNA translation downstream of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation. In the absence of FMRP there is...

journal_title：Journal of neurophysiology

authors： Auerbach BD,Bear MF

更新日期：2010-08-01 00:00:00

abstract：:The median nerve N20 and P22 SEP components constitute the initial response of the primary somatosensory cortex to somatosensory stimulation of the upper extremity. Knowledge of the underlying generators is important both for basic understanding of the initial sequence of cortical activation and to identify landmarks ...

journal_title：Journal of neurophysiology

authors： Baumgärtner U,Vogel H,Ohara S,Treede RD,Lenz FA

更新日期：2010-12-01 00:00:00

abstract：:A lamprey maintains the dorsal-side-up orientation due to the activity of postural control system driven by vestibular input. Visual input can affect the body orientation: illumination of one eye evokes ipsilateral roll tilt. An important element of the postural network is the reticulospinal (RS) neurons transmitting ...

journal_title：Journal of neurophysiology

authors： Deliagina TG,Fagerstedt P

更新日期：2000-02-01 00:00:00

abstract：:Previous studies have described maturational changes in GABAergic inhibitory synaptic transmission in the rodent somatosensory cortex during the early postnatal period. To determine whether alterations in the functional properties of synaptically localized GABA(A) receptors (GABA(A)Rs) contribute to development of inh...

journal_title：Journal of neurophysiology

authors： Dunning DD,Hoover CL,Soltesz I,Smith MA,O'Dowd DK

更新日期：1999-12-01 00:00:00

abstract：:Upon prolonged viewing of a sinusoidal grating, the visual system is selectively desensitized to the spatial frequency of the grating, while the sensitivity to other spatial frequencies remains largely unaffected. This technique, known as pattern adaptation, has been so central to the psychophysical study of the mecha...

journal_title：Journal of neurophysiology

authors： Hegdé J

更新日期：2009-10-01 00:00:00

abstract：:An initial overload of intracellular Ca2+ plays a critical role in the delayed death of hippocampal CA1 neurons that die a few days after transient ischemia. Without direct evidence, the prevailing hypothesis has been that Ca2+ overload may recur until cell death. Here, we report the first measurements of intracellula...

journal_title：Journal of neurophysiology

authors： Connor JA,Razani-Boroujerdi S,Greenwood AC,Cormier RJ,Petrozzino JJ,Lin RC

更新日期：1999-01-01 00:00:00

abstract：:1. Previous studies indicate that after transection of the rostral spinal cord, larval lamprey begin to recover locomotor behavior 2 wk posttransection and recovery is complete at approximately 8 wk. To examine the mechanisms underlying behavioral recovery after spinal cord transection, in the present study the time c...

journal_title：Journal of neurophysiology

authors： McClellan AD

更新日期：1994-08-01 00:00:00

abstract：:Previous research has described kinetic characteristics of treadmill steps in very stable steppers, in cross-sectional designs. In this study we examined, longitudinally, muscle activation patterns during treadmill stepping, without practice, in 12 healthy infants at 1, 6, and 12 mo of age. We assessed lateral gastroc...

journal_title：Journal of neurophysiology

authors： Teulier C,Sansom JK,Muraszko K,Ulrich BD

更新日期：2012-08-01 00:00:00

abstract：:Control of the spatial orientation of the hand is an important component of reaching and grasping movements. We studied the contribution of vision and proprioception to the perception and control of hand orientation in orientation-matching and letter-posting tasks. In the orientation-matching task, subjects aligned a ...

journal_title：Journal of neurophysiology

authors： Gosselin-Kessiby N,Messier J,Kalaska JF

更新日期：2008-04-01 00:00:00

abstract：:Interplexiform (IP) cells are a long-neglected group of retinal neurons the function of which is yet to be determined. Anatomical study indicates that IP cells are located in the inner nuclear layer, juxtaposed with the third-order neurons. However, the synaptic transmission of IP cells in the inner retina is poorly u...

journal_title：Journal of neurophysiology

authors： Jiang Z,Shen W

更新日期：2010-02-01 00:00:00

abstract：:The mechanisms underlying the depression of evoked fast excitatory postsynaptic currents (EPSCs) following superfusion with medium deprived of oxygen and glucose (in vitro ischemia) for a 4-min period in hippocampal CA1 neurons were investigated in rat brain slices. The amplitude of evoked fast EPSCs decreased by 85 +...

journal_title：Journal of neurophysiology

authors： Tanaka E,Yasumoto S,Hattori G,Niiyama S,Matsuyama S,Higashi H

更新日期：2001-09-01 00:00:00

abstract：:Humans quickly and sophisticatedly correct their movements in response to changes in the world, such as when reaching to a target that abruptly changes its location. The vigor of these movement corrections is time-dependent, increasing if the time left to make the correction decreases, which can be explained by optima...

journal_title：Journal of neurophysiology

authors： Oostwoud Wijdenes L,van Beers RJ,Medendorp WP

更新日期：2019-09-01 00:00:00

abstract：:We examined which motor areas would participate in the coding of a simple opposition of the thumb triggered by auditory, somatosensory and visual signals. We tested which motor areas might be active in response to all three modalities, which motor structures would be activated specifically in response to each modality...

journal_title：Journal of neurophysiology

authors： Naito E,Kinomura S,Geyer S,Kawashima R,Roland PE,Zilles K

更新日期：2000-03-01 00:00:00

abstract：:1. We present a new mathematical description of the complete distribution of electrical responses to stochastic synaptic activity (quantal analysis) that is intended as a model of experiments on central neuronal synapses. Unlike previous treatments, this distribution is calculated for each instant after the release of...

journal_title：Journal of neurophysiology

authors： Blum KI,Idiart MA

更新日期：1994-09-01 00:00:00

abstract：:We investigated if visual direction-selective neurons in the pretectal area (APT) of goldfish (Carassius auratus auratus) preferred visual stimuli resulting from rotations around axes corresponding to the best responsive axes of the semicircular canals [optic flow that is consistent to a maximal activation of the hori...

journal_title：Journal of neurophysiology

authors： Masseck OA,Hoffmann KP

更新日期：2009-11-01 00:00:00

abstract：:The countermanding saccade task has been used in many studies to investigate the neural mechanisms that underlie the decision to execute or restrain rapid eye movements. In this task, the presentation of a saccade target is sometimes followed by the appearance of a stop cue that indicates that the subject should cance...

journal_title：Journal of neurophysiology

authors： Walton MM,Gandhi NJ

更新日期：2006-10-01 00:00:00

abstract：:The neurons in the intermediate layers of the monkey superior colliculus (SC) that discharge before saccadic eye movements can be divided into at least two types, burst and buildup neurons, and the differences in their characteristics are compatible with different functional contributions of the two cell types. It has...

journal_title：Journal of neurophysiology

authors： Aizawa H,Wurtz RH

更新日期：1998-04-01 00:00:00

abstract：:1. The intersegmental coordination during undulatory locomotion in lamprey is characterized by a constant phase lag between consecutive segments, that is, the ratio between the intersegmental time lag and the cycle duration remains constant. It is shown that the spinal 5-HT (serotonin) system can, in a graded fashion,...

journal_title：Journal of neurophysiology

authors： Matsushima T,Grillner S

更新日期：1992-06-01 00:00:00

abstract：:Trigeminal reflex blinks evoked near the onset of a saccade cause profound spatial-temporal perturbations of the saccade that are typically compensated in mid-flight. This paper investigates the influence of reflex blinks on the discharge properties of saccade-related burst neurons (SRBNs) in intermediate and deep lay...

journal_title：Journal of neurophysiology

authors： Goossens HH,Van Opstal AJ

更新日期：2000-06-01 00:00:00

abstract：:Field potential recording was used to investigate properties of synaptic transmission and long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in both hippocampal slices of mutant mice in which the alpha-subunit of the olfactory cyclic nucleotide-gated channel (alpha3/OCNC)1 was rendered null and also in s...

journal_title：Journal of neurophysiology

authors： Parent A,Schrader K,Munger SD,Reed RR,Linden DJ,Ronnett GV

更新日期：1998-06-01 00:00:00

abstract：:Interneuron precursors transplanted into visual cortex induce network plasticity during their heterochronic maturation. Such plasticity can have a significant impact on the function of the animal and is normally present only during a brief critical period in early postnatal development. Elucidating the synaptic and ph...

journal_title：Journal of neurophysiology

authors： Larimer P,Spatazza J,Stryker MP,Alvarez-Buylla A,Hasenstaub AR

更新日期：2017-07-01 00:00:00

abstract：:Over the past 3 decades, various algorithms used to decompose the electromyographic (EMG) signal into its constituent motor unit action potentials (MUAPs) have been reported. All are limited to decomposing EMG signals from isometric contraction. In this report, we describe a successful approach to decomposing the surf...

journal_title：Journal of neurophysiology

authors： De Luca CJ,Chang SS,Roy SH,Kline JC,Nawab SH

更新日期：2015-03-15 00:00:00

abstract：:Behavioral and neural findings demonstrate that animals can locate low-frequency sounds along the azimuth by detecting microsecond interaural time differences (ITDs). Information about ITDs is also available in the amplitude modulations (i.e., envelope) of high-frequency sounds. Since medial superior olivary (MSO) neu...

journal_title：Journal of neurophysiology

authors： Gai Y,Kotak VC,Sanes DH,Rinzel J

更新日期：2014-08-15 00:00:00

abstract：:We have investigated potential mechanisms by which exercise can promote changes in neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (BDNF), ...

journal_title：Journal of neurophysiology

authors： Gómez-Pinilla F,Ying Z,Roy RR,Molteni R,Edgerton VR

更新日期：2002-11-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and is often refractory to antiepileptic medications. The medial entorhinal area (MEA) is affected in TLE but mechanisms underlying hyperexcitability of MEA neurons require further elucidation. Previous studies suggest that inputs from the pres...

journal_title：Journal of neurophysiology

authors： Abbasi S,Kumar SS

更新日期：2015-11-01 00:00:00

abstract：:The neuronal mechanism which gives rise to the synchronization of motor-unit discharges has been inferred from an analysis of the interspike intervals of individual motor-unit discharges recorded from the soleus muscle. The motor units were divided into two groups on the basis of characteristic changes in their spike ...

journal_title：Journal of neurophysiology

authors： Mori S

更新日期：1975-07-01 00:00:00

abstract：:The central auditory system has traditionally been divided into lemniscal and nonlemniscal pathways leading from the midbrain through the thalamus to the cortex. This view has served as an organizing principle for studying, modeling, and understanding the encoding of sound within the brain. However, there is evidence ...

journal_title：Journal of neurophysiology

authors： Straka MM,Schmitz S,Lim HH

更新日期：2014-08-15 00:00:00

abstract：:Tinnitus is a phantom auditory perception without an external sound source and is one of the most common public health concerns that impair the quality of life of many individuals. However, its neural mechanisms remain unclear. We herein examined population-level frequency tuning in the auditory cortex of unilateral t...

journal_title：Journal of neurophysiology

authors： Sekiya K,Takahashi M,Murakami S,Kakigi R,Okamoto H

更新日期：2017-03-01 00:00:00

abstract：:Thalamocortical neurons integrate sensory and cortical activity and are regulated by input from inhibitory neurons in the thalamic reticular nucleus. Evidence suggests that during bursts of action potentials, dendritic calcium transients are seen throughout the dendritic tree of thalamocortical cells. Here, we review ...

journal_title：Journal of neurophysiology

authors： Hulme SR,Connelly WM

更新日期：2014-11-01 00:00:00

abstract：:The properties of the vestibuloocular reflex (VOR) when the axis of rotation is behind the eyes and fixation of a near target is required were studied in the monkey. The magnitude of VOR gain in each eye was found to be above 1.0 and near the ideal value for stabilizing a retinal image. Evidence that this large VOR ga...

journal_title：Journal of neurophysiology

authors： Viirre E,Tweed D,Milner K,Vilis T

更新日期：1986-08-01 00:00:00