Abstract:
:The discharge patterns of single units in the ventral cochlear nucleus (VCN) of anesthetized guinea pigs were examined in response to iterated rippled noise (IRN) as a function of the IRN delay (which determines the IRN pitch) and the IRN sound level. Delays were varied over five octaves in half-octave steps, and sound levels were varied over a 30- or 50-dB range in steps of 5 dB. Neural responses were analyzed in terms of first-order and all-order inter-spike intervals (ISIs). The IRN quasi-periodicity was preserved in the all-order ISIs for most units independent of unit type or best frequency (BF). A deterioration of the temporal all-order code was found, however, when the neural response was influenced by inhibition. The IRN quasi-periodicity was also preserved in first-order ISIs for a limited range of IRN delays and levels. Sustained Chopper units (CS) in the VCN responded with very regular ISIs when the IRN delay corresponded to the unit's chopping period; i.e., the unit showed an increased proportion of intervals corresponding to the IRN delay (interval enhancement) relative to an equal-level, white-noise stimulation. This interval enhancement has a band-pass characteristic with a peak corresponding to the chopping period. Moreover, for CS units in rate saturation, the chopping period, and thus the interval enhancement to the IRN, did not vary with level. Units classified as onset-chopper also show a band-pass interval enhancement to the IRN stimuli; however, they show more level-dependent changes than CS units. Primary-like (PL) units also show level-dependent changes in their ability to code the IRN pitch in first-order intervals. The range of delays where PL units showed interval enhancement was broader and extended to shorter delays. Based on these findings, it is suggested that CS units may play an important role in pitch processing in that they transform a higher-order interval code into a first-order interval place code. Their limited dynamic range together with the preservation of the temporal stimulus features in saturation may serve as a physiological basis for the perceived level independence of pitch.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Wiegrebe L,Winter IMdoi
10.1152/jn.2001.85.3.1206subject
Has Abstractpub_date
2001-03-01 00:00:00pages
1206-19issue
3eissn
0022-3077issn
1522-1598journal_volume
85pub_type
杂志文章abstract::1. Properties of 90 lateral cervical nucleus (LCN) neurons responsive to light tactile stimulation of ipsilateral body surfaces were examined in pentobarbital sodium-anesthetized raccoons. Peripheral receptive fields (RFs) of 60 of these lay totally or partially on glabrous skin of the forepaw. There were 71 neurons a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.6.1411
更新日期:1991-06-01 00:00:00
abstract::The blood oxygen level-dependent (BOLD) functional magnetic resonance imaging signal arises as a consequence of changes in blood flow and oxygen usage that in turn are modulated by changes in neural activity. Much attention has been given to both theoretical and experimental aspects of the energetics but not to the ne...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00352.2017
更新日期:2018-03-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) is a noninvasive tool used to probe cognitive and affective processes. Although fMRI provides indirect measures of neural activity, the advent of fMRI has allowed for1) the corroboration of significant animal findings in the human brain, and2) the expansion of models to inc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00333.2015
更新日期:2016-03-01 00:00:00
abstract::1. Depolarization-induced elevations of intracellular calcium concentration ([Ca2+]i) were examined in slice-cultured hippocampal pyramidal and nonpyramidal cells of the CA3 region by combined intracellular and multisite fura-2 recording techniques. 2. In pyramidal cells, spiking activity induced by depolarizing curre...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.3.961
更新日期:1992-09-01 00:00:00
abstract::N-arachidonoyldopamine (NADA) is an endogenous molecule found in the nervous system that is capable of acting as a vanilloid agonist via the TRPV1 receptor and as a cannabinoid agonist via the CB1 receptor. Using anesthetized rats, we investigated the neural correlates of behavioral thermal hyperalgesia produced by NA...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00395.2005
更新日期:2006-02-01 00:00:00
abstract::1. We studied the organization of motor units in the tenuissimus (TEN) muscle of pentobarbital-anesthetized cats. The cat TEN is a long, delicate straplike muscle that spans hip and knee, which has a very flat length-tension curve through 22 mm of length change. 2. The TEN motor nucleus, labeled by retrograde transpor...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.59.4.1128
更新日期:1988-04-01 00:00:00
abstract::Based on the findings of the preceding paper, it is known that auditory and visual signals have been translated into common coordinates at the level of the superior colliculus (SC) and share a motor circuit involved in the generation of saccadic eye movements. It is not known, however, whether the translation of senso...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.1.35
更新日期:1987-01-01 00:00:00
abstract::Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their ...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00948.2014
更新日期:2015-11-01 00:00:00
abstract::1. To examine the effect of disruption of basal ganglia output on limb stability and movement, muscimol was injected into the internal globus pallidus (GPi) of monkeys trained to make arm movements to visible or remembered targets in a two-dimensional workspace. 2. Injections of as little as 0.25 micrograms muscimol a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.3.1087
更新日期:1996-03-01 00:00:00
abstract::1. The effects of dopamine on the slow Ca(2+)-dependent K+ current (IAHP; AHP, afterhyperpolarization) and spike frequency adaptation were studied by whole cell voltage-clamp and sharp microelectrode current-clamp recordings in rat CA1 pyramidal neurons in rat hippocampal slices. 2. Dopamine suppressed IAHP in a dose-...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.6.2749
更新日期:1995-12-01 00:00:00
abstract::1. Whole cell patch-clamp techniques, combined with direct visualization of neurons, were used to study voltage-dependent potassium currents in layer 1 neurons and layer II/III pyramidal cells. 2. In the presence of tetrodotoxin, step depolarizations evoked an outward current. This current had a complex waveform and a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.2.668
更新日期:1996-08-01 00:00:00
abstract::The preceding study demonstrated that normal subjects compensate for the additional interaction torques generated when a reaching movement is made during voluntary trunk rotation. The present paper assesses the influence of trunk rotation on finger trajectories and on interjoint coordination and determines whether sim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00160.2001
更新日期:2003-01-01 00:00:00
abstract::Recent physiological studies have suggested that there are several sites of interaction between the neural pathways that control saccadic eye movements and those that control visual pursuit movements. To address the question of saccade/pursuit interaction from a neuroanatomical point of view, we have studied the conne...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.6.3056
更新日期:2001-12-01 00:00:00
abstract::1. Visual attention is often profoundly disturbed in humans after damage to the cortex of the posterior parietal lobe, particularly of the minor hemisphere, with some patients being totally unaware of visual stimuli in the hemifield of extrapersonal space contralateral to the cortical damage. This severe form of visua...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.61.1.74
更新日期:1989-01-01 00:00:00
abstract::1. Intracellular recordings were made from layer VI pyramidal cells in in vitro slice preparations of the cat motor cortex (area 4 gamma). Layer VI pyramidal cells were identified morphologically by intracellular injection of biocytin. 2. Of 22 layer VI pyramidal cells examined, single action potentials were followed ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.2.578
更新日期:1994-08-01 00:00:00
abstract::We have used electrophysiological techniques to document segmental differences in the pathways between the giant, escape command axons, lateral giants (LG) and medial giants (MG), and the nongiant, fast flexor (FF) motoneurons. We found no difference in the input from LG and MG axons to FF motoneurons in the posterior...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.53.1.252
更新日期:1985-01-01 00:00:00
abstract::Altered activity of the entopeduncular nucleus, the rodent homologue of the globus pallidus internal segment in primates, is thought to mediate behavioral consequences of midbrain dopamine depletion in rodents. Few studies, however, have examined dopaminergic modulation of spiking activity in this nucleus. This study ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00844.2001
更新日期:2002-07-01 00:00:00
abstract::1. Discharges of neurons in the peripheral auditory system contain information about the temporal features of acoustic stimuli. Phase-locking of neurons in the anteroventral cochlear nucleus (AVCN) is usually reported to be less robust than in auditory nerve (AN) fibers, which provide their major input. In a companion...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.3.1037
更新日期:1994-03-01 00:00:00
abstract::In reaching to grasp an object, the arm transports the hand to the intended location as the hand shapes to grasp the object. Prior studies that tracked arm endpoint and grip aperture have shown that reaching and grasping, while proceeding in parallel, are interdependent to some degree. Other studies of reaching and gr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00686.2015
更新日期:2015-12-01 00:00:00
abstract::1. The influence of prior metabotropic glutamate receptor (mGluR) activation on subsequent long-term potentiation (LTP) induction was investigated with the use of the mGluR agonist 1-amino-cyclopentane-1S,3R-dicarboxylic acid (ACPD, 20 microM). Field potential recordings were made in the stratum radiatum of CA1 slices...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.2.953
更新日期:1996-08-01 00:00:00
abstract::Primary auditory cortex (A1) neurons are believed not to carry much information about tonal offsets because A1 neurons in barbiturate-anesthetized animals are usually described as having only onset responses. We investigated tonal offset responses in comparison with onset responses in the caudal part of A1 of awake ca...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00184.2007
更新日期:2007-05-01 00:00:00
abstract::Memory for past events may be based on retrieval accompanied by specific contextual details (recollection) or on the feeling that an item is old (familiarity) or new (novelty) in the absence of contextual details. There are indications that recollection, familiarity, and novelty involve different medial temporal lobe ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01029.2005
更新日期:2006-10-01 00:00:00
abstract::We elicited repetitive discharge in hypoglossal motoneurons recorded in slices of rat brain stem using a combination of a suprathreshold injected current step with superimposed noise to mimic the synaptic drive likely to occur during physiological activation. The effects of repetitive en mass stimulation of afferent n...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.2.829
更新日期:1999-08-01 00:00:00
abstract::We constantly make eye movements to bring objects of interest onto the fovea for more detailed processing. Activity in area V4, a prestriate visual area, is enhanced at the location corresponding to the target of an eye movement. However, the precise role of activity in V4 in relation to these saccades and the modulat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00898.2009
更新日期:2010-10-01 00:00:00
abstract::1. The simplicity of the jellyfish nervous system makes it an ideal preparation to assess the contributions of different ion channels to behavior. In the giant motor axons of the jellyfish Aglantha digitale, low-threshold spikes elicit slow swimming, whereas escape swimming depends on a higher-threshold, overshooting ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.3.894
更新日期:1993-03-01 00:00:00
abstract::1. Serotonergic modulation of a hyperpolarization-activated inward current, Ih, and a calcium-dependent outward current, Io(Ca), was examined in the dorsal gastric (DG) motor neuron, with the use of intracellular recording techniques in an isolated preparation of the crab stomatogastric ganglion (STG). 2. Hyperpolariz...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.2.496
更新日期:1992-08-01 00:00:00
abstract::Retinotopy is a fundamental organizing principle of the visual cortex. Over the years, a variety of techniques have been used to examine it. None of these techniques, however, provides a way to rapidly characterize retinotopy, at the submillimeter range, in alert, behaving subjects. Voltage-sensitive dye imaging (VSDI...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00417.2007
更新日期:2007-08-01 00:00:00
abstract::Group I metabotropic glutamate receptor (mGluR) agonists increase the excitability of hippocampal CAl pyramidal neurons via depression of the postspike afterhyperpolarization. In adult rats, this is mediated by both mGluR1 and -5, but the signal transduction processes involved are unknown. In this study, we investigat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01236.2003
更新日期:2004-11-01 00:00:00
abstract::Regional blood oxygenation in the cerebellum and posterior cerebral cortices was monitored with functional magnetic resonance imaging (fMRI) at four Tesla while 16 normal subjects performed three tasks with identical visual stimulation: fixation; attention focused upon either stimulus shape or color and sustained duri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.3.1535
更新日期:1998-03-01 00:00:00
abstract::It is an essential feature for the visual system to keep track of self-motion to maintain space constancy. Therefore the saccadic system uses extraretinal information about previous saccades to update the internal representation of memorized targets, an ability that has been identified in behavioral and electrophysiol...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00543.2004
更新日期:2005-03-01 00:00:00