Comparison between offset and onset responses of primary auditory cortex ON-OFF neurons in awake cats.

Abstract:

:Primary auditory cortex (A1) neurons are believed not to carry much information about tonal offsets because A1 neurons in barbiturate-anesthetized animals are usually described as having only onset responses. We investigated tonal offset responses in comparison with onset responses in the caudal part of A1 of awake cats. Cells responding to both onsets and offsets were commonly found (59.2% of recorded cells). Offset responses usually co-occurred with phasic onset responses or phasic components of sustained responses. These ON-OFF cells had diverse combinations of offset- and onset-frequency-receptive field (FRF): offset-FRF was similar to onset-FRF, or narrower, wider, lower, or higher than onset-FRF. The distribution of FRF patterns was diffuse with no boundaries between the different FRF-pattern groups. The onset- versus offset-FRF pattern of each cell remained unchanged across multiple stimulus intensities. Mean offset response showed similar peak latency (19.5 vs. 21.5 ms), longer half-decay time (74.5 vs. 48.5 ms), and lower peak amplitude (20.4 vs. 35.9 spikes/s) compared with the mean onset response. Although offset responses were facilitated when preceded by the suppression of spike activity, they were still elicited without preceding spike suppression. It is concluded that neurons showing paired onset and offset responses are predominant in the caudal A1. Their frequency-filtering property is usually not static but dynamic, changing between sound onsets and offsets. Offset responses are similarly precise and salient as onset responses for effectively encoding sound offsets. They may be elicited as active spike responses to sound offset rather than simple rebound facilitation.

journal_name

J Neurophysiol

authors

Qin L,Chimoto S,Sakai M,Wang J,Sato Y

doi

10.1152/jn.00184.2007

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

3421-31

issue

5

eissn

0022-3077

issn

1522-1598

pii

00184.2007

journal_volume

97

pub_type

杂志文章
  • Responses of medullary reticulospinal neurons to sinusoidal stimulation of labyrinth receptors in decerebrate cat.

    abstract::The electrical activity of 168 individual neurons located in the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis, and ventralis, has been recorded in precollicular decerebrate cats during sinusoidal tilt about the longitudinal axis of the whole...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.5.1059

    authors: Manzoni D,Pompeiano O,Stampacchia G,Srivastava UC

    更新日期:1983-11-01 00:00:00

  • Spatially selective enhancement of proprioceptive acuity following motor learning.

    abstract::It is well recognized that the brain uses sensory information to accurately produce motor commands. Indeed, most research into the relationship between sensory and motor systems has focused on how sensory information modulates motor function. In contrast, recent studies have begun to investigate the reverse: how senso...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00949.2010

    authors: Wong JD,Wilson ET,Gribble PL

    更新日期:2011-05-01 00:00:00

  • Reorganization in awake rat auditory cortex by local microstimulation and its effect on frequency-discrimination behavior.

    abstract::In common with other sensory cortices, the mammalian primary auditory cortex (AI) demonstrates the capacity for large-scale reorganization following many experimental situations. For example, training animals in frequency-discrimination tasks has been shown to result in an increase in cortical frequency representation...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.4.1555

    authors: Talwar SK,Gerstein GL

    更新日期:2001-10-01 00:00:00

  • Motion selectivity in macaque visual cortex. I. Mechanisms of direction and speed selectivity in extrastriate area MT.

    abstract::Mechanisms of direction selectivity and speed selectivity were studied in single neurons of the middle temporal visual area (MT) of behaving macaque monkeys. Visual stimuli were presented in both smooth and stroboscopic motion within a neuron's receptive field as the monkey fixated a stationary point of light. Directi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.55.6.1308

    authors: Mikami A,Newsome WT,Wurtz RH

    更新日期:1986-06-01 00:00:00

  • Rhythmicity of spinal neurons activated during each form of fictive scratching in spinal turtles.

    abstract::Are behaviors that rely on common muscles and motoneurons generated by separate or overlapping groups of pattern-generating neurons? This question was investigated for the three forms of scratching in immobilized, spinal turtles. Individual neurons were recorded extracellularly from the gray matter through most of the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.2.1026

    authors: Berkowitz A

    更新日期:2001-08-01 00:00:00

  • Single-unit stability using chronically implanted multielectrode arrays.

    abstract::The use of chronic intracortical multielectrode arrays has become increasingly prevalent in neurophysiological experiments. However, it is not obvious whether neuronal signals obtained over multiple recording sessions come from the same or different neurons. Here, we develop a criterion to assess single-unit stability...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90920.2008

    authors: Dickey AS,Suminski A,Amit Y,Hatsopoulos NG

    更新日期:2009-08-01 00:00:00

  • Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter.

    abstract::We have demonstrated that 4-aminopyridine-3-methanol (4-AP-3-MeOH), a 4-aminopyridine derivative, significantly restores axonal conduction in stretched spinal cord white-matter strips and shows no preference in restoring large and small axons. This compound is 10 times more potent when compared with 4-AP and other der...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00154.2009

    authors: Sun W,Smith D,Fu Y,Cheng JX,Bryn S,Borgens R,Shi R

    更新日期:2010-01-01 00:00:00

  • Wide dynamic range but not nociceptive-specific neurons encode multidimensional features of prolonged repetitive heat pain.

    abstract::1. To better characterize temporal and spatial mechanisms involved in the coding of prolonged nociceptive stimuli in the spinal cord, the responses of dorsal horn wide dynamic range (WDR) and nociceptive-specific (NS) neurons to prolonged, repetitive noxious heat stimuli (45-49 degrees C) were examined in unanesthetiz...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.3.703

    authors: Coghill RC,Mayer DJ,Price DD

    更新日期:1993-03-01 00:00:00

  • Metabotropic glutamate receptor-mediated depression of the slow afterhyperpolarization is gated by tyrosine phosphatases in hippocampal CA1 pyramidal neurons.

    abstract::Group I metabotropic glutamate receptor (mGluR) agonists increase the excitability of hippocampal CAl pyramidal neurons via depression of the postspike afterhyperpolarization. In adult rats, this is mediated by both mGluR1 and -5, but the signal transduction processes involved are unknown. In this study, we investigat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01236.2003

    authors: Ireland DR,Guevremont D,Williams JM,Abraham WC

    更新日期:2004-11-01 00:00:00

  • Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization.

    abstract::Alphabetagamma GABA(A) receptor currents are phasic and desensitizing, whereas alphabetadelta GABA(A) receptor currents are tonic and have no fast desensitization. alphabetagamma receptors are subsynaptic and mediate phasic inhibition, whereas alphabetadelta receptors are extra- or perisynaptic and mediate tonic inhib...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00285.2004

    authors: Feng HJ,Macdonald RL

    更新日期:2004-09-01 00:00:00

  • Control of multiple impulse-initiation sites in a leech interneuron.

    abstract::1. Several heart interneurons (HN cells) of the leech nerve cord have impulse-initiation sites in every segmental ganglion through which their single axons pass. All these initiation sites are capable of producing rhythmic impulse bursts. However, under normal conditions a dominant primary initiation site in the gangl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1980.44.5.878

    authors: Calabrese RL

    更新日期:1980-11-01 00:00:00

  • The motor repertoire of older adult fallers may constrain their response to balance perturbations.

    abstract::Older adults are at a high risk of falls, and most falls occur during locomotor activities like walking. This study aimed to improve our understanding of changes in neuromuscular control associated with increased risk of falls in older adults in the presence of dynamic balance challenges during walking. Motor module (...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00302.2018

    authors: Allen JL,Franz JR

    更新日期:2018-11-01 00:00:00

  • Ca2+-induced uncoupling of Aplysia bag cell neurons.

    abstract::Electrical transmission is a dynamically regulated form of communication and key to synchronizing neuronal activity. The bag cell neurons of Aplysia are a group of electrically coupled neuroendocrine cells that initiate ovulation by secreting egg-laying hormone during a prolonged period of synchronous firing called th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00603.2014

    authors: Dargaei Z,Standage D,Groten CJ,Blohm G,Magoski NS

    更新日期:2015-02-01 00:00:00

  • Triple dissociation in the medial temporal lobes: recollection, familiarity, and novelty.

    abstract::Memory for past events may be based on retrieval accompanied by specific contextual details (recollection) or on the feeling that an item is old (familiarity) or new (novelty) in the absence of contextual details. There are indications that recollection, familiarity, and novelty involve different medial temporal lobe ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01029.2005

    authors: Daselaar SM,Fleck MS,Cabeza R

    更新日期:2006-10-01 00:00:00

  • Functional plasticity in the respiratory drive to thoracic motoneurons in the segment above a chronic lateral spinal cord lesion.

    abstract::A previous neurophysiological investigation demonstrated an increase in functional projections of expiratory bulbospinal neurons (EBSNs) in the segment above a chronic lateral thoracic spinal cord lesion that severed their axons. We have now investigated how this plasticity might be manifested in thoracic motoneurons ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00614.2015

    authors: Ford TW,Anissimova NP,Meehan CF,Kirkwood PA

    更新日期:2016-01-01 00:00:00

  • Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity.

    abstract::1. Voltage-dependent Na+ conductances were studied in small (18-25 microns diam) adult rat dorsal root ganglion (DRG) neurons with the use of the whole cell patch-clamp technique. Na+ currents were also recorded from larger (44-50 microns diam) neurons and compared with those of the small neurons. 2. The predominant N...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.6.2796

    authors: Rizzo MA,Kocsis JD,Waxman SG

    更新日期:1994-12-01 00:00:00

  • Central peptidergic neurons regulate gut motility in Aplysia.

    abstract::1. The small cardioactive peptides (SCPs) are potent modulatory neuropeptides in Aplysia. Buccal ganglia neurons B1 and B2 are the largest neurons that exhibit SCP-like immunoreactivity. High-pressure liquid chromatography (HPLC)-bioassay and in vivo radiolabeling procedures confirm that these neurons contain and synt...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.59.5.1613

    authors: Lloyd PE,Kupfermann I,Weiss KR

    更新日期:1988-05-01 00:00:00

  • Activity of hindlimb motor units during locomotion in the conscious rat.

    abstract::This paper compares the activity of hindlimb motor units from muscles mainly composed of fast-twitch muscle fibers (medial and lateral gastrocnemius: MG/LG, tibialis anterior: TA) to motor units from a muscle mainly composed of slow-twitch muscle fibers (soleus: SOL) during unrestrained walking in the conscious rat. S...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2002

    authors: Gorassini M,Eken T,Bennett DJ,Kiehn O,Hultborn H

    更新日期:2000-04-01 00:00:00

  • Mechanisms underlying fictive feeding in aplysia: coupling between a large neuron with plateau potentials activity and a spiking neuron.

    abstract::The buccal ganglia of Aplysia contain a central pattern generator (CPG) that organizes the rhythmic movements of the radula and buccal mass during feeding. Many of the cellular and synaptic elements of this CPG have been identified and characterized. However, the roles that specific cellular and synaptic properties pl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.87.5.2307

    authors: Susswein AJ,Hurwitz I,Thorne R,Byrne JH,Baxter DA

    更新日期:2002-05-01 00:00:00

  • Noise-induced transition to bursting in responses of paddlefish electroreceptor afferents.

    abstract::The response properties of ampullary electroreceptors of paddlefish, Polyodon spathula, were studied in vivo, as single-unit afferent responses to external electrical stimulation with varied intensities of several types of noise waveforms, all Gaussian and zero-mean. They included broadband white noise, Ornstein-Uhlen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01289.2006

    authors: Neiman AB,Yakusheva TA,Russell DF

    更新日期:2007-11-01 00:00:00

  • Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy.

    abstract::1. Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques. The purposes of this study were to characterize the bursts evoked in immature ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.5.1759

    authors: Kim YI,Peacock WJ,Dudek FE

    更新日期:1993-11-01 00:00:00

  • Neural processing of stereopsis as a function of viewing distance in primate visual cortical area V1.

    abstract::1. The influence of viewing distance on disparity selectivity was investigated in area V1 of behaving monkeys. While the animals performed a fixation task, cortical cells were recorded extracellularly in the foveal representation of the visual field. Disparity selectivity was assessed by using static random dot stereo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.5.2872

    authors: Trotter Y,Celebrini S,Stricanne B,Thorpe S,Imbert M

    更新日期:1996-11-01 00:00:00

  • Differential modulation of nucleus accumbens synapses.

    abstract::The nucleus accumbens (NAcc) is a brain region involved in functions ranging from motivation and reward to feeding and drug addiction. The NAcc is typically divided into two major subdivisions, the shell and the core. The primary output neurons of both of these areas are medium spiny neurons (MSNs), which are quiescen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00766.2001

    authors: Brundege JM,Williams JT

    更新日期:2002-07-01 00:00:00

  • Proprioceptive modulation of hip flexor activity during the swing phase of locomotion in decerebrate cats.

    abstract::This study examined the influence of proprioceptive input from hip flexor muscles on the activity in hip flexors during the swing phase of walking in the decerebrate cat. One hindlimb was partially denervated to remove cutaneous input and afferent input from most other hindlimb muscles. Perturbations to hip movement w...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.3.1321

    authors: Lam T,Pearson KG

    更新日期:2001-09-01 00:00:00

  • Spatial localization in cats reared with strabismus.

    abstract::1. The capacity for judging the location of an object relative to the body (egocentric localization) was assessed in cats by measuring the landing position attained when the cat jumped toward a platform viewed from a known distance. 2. Normal cats and kittens land at center of the platform when using one eye or both. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1980.43.3.792

    authors: Olson CR

    更新日期:1980-03-01 00:00:00

  • Synaptic transmission from the supratrigeminal region to jaw-closing and jaw-opening motoneurons in developing rats.

    abstract::The supratrigeminal region (SupV) receives abundant orofacial sensory inputs and descending inputs from the cortical masticatory area and contains premotor neurons that target the trigeminal motor nucleus (MoV). Thus it is possible that the SupV is involved in controlling jaw muscle activity via sensory inputs during ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01145.2007

    authors: Nakamura S,Inoue T,Nakajima K,Moritani M,Nakayama K,Tokita K,Yoshida A,Maki K

    更新日期:2008-10-01 00:00:00

  • Analysis of LFP phase predicts sensory response of barrel cortex.

    abstract::Several previous studies have shown the existence of Up and Down states and have linked their magnitude (e.g., depolarization level) to the size of sensory-evoked responses. Here, we studied how the temporal dynamics of such states influence the sensory-evoked response to vibrissa deflection. Under alpha-chloralose an...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01288.2005

    authors: Haslinger R,Ulbert I,Moore CI,Brown EN,Devor A

    更新日期:2006-09-01 00:00:00

  • Locomotor-activated neurons of the cat. I. Serotonergic innervation and co-localization of 5-HT7, 5-HT2A, and 5-HT1A receptors in the thoraco-lumbar spinal cord.

    abstract::Monoamines are strong modulators and/or activators of spinal locomotor networks. Thus monoaminergic fibers likely contact neurons involved in generating locomotion. The aim of the present study was to investigate the serotonergic innervation of locomotor-activated neurons within the thoraco-lumbar spinal cord followin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91179.2008

    authors: Noga BR,Johnson DM,Riesgo MI,Pinzon A

    更新日期:2009-09-01 00:00:00

  • Kinematic strategies in newly walking toddlers stepping over different support surfaces.

    abstract::In adults, locomotor movements are accommodated to various support surface conditions by means of specific anticipatory locomotor adjustments and changes in the intersegmental coordination. Here we studied the kinematic strategies of toddlers at the onset of independent walking when negotiating various support surface...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00945.2009

    authors: Dominici N,Ivanenko YP,Cappellini G,Zampagni ML,Lacquaniti F

    更新日期:2010-03-01 00:00:00

  • γ Oscillations are involved in the sensorimotor transformation of pain.

    abstract::Pain signals threat and initiates motor responses to avoid harm. The transformation of pain into a motor response is thus an essential part of pain. Here, we investigated the neural mechanisms subserving the sensorimotor transformation of pain at the cortical level by using electroencephalography. In a simple reaction...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00186.2012

    authors: Schulz E,Tiemann L,Witkovsky V,Schmidt P,Ploner M

    更新日期:2012-08-01 00:00:00