Facilitation of long-term potentiation by prior activation of metabotropic glutamate receptors.

abstract：:Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative r...

journal_title：Journal of neurophysiology

authors： Schaefer AT,Larkum ME,Sakmann B,Roth A

更新日期：2003-06-01 00:00:00

abstract：:1. Simultaneous, whole-cell recordings were obtained from synaptically coupled photoreceptor/bipolar cell pairs, by the use of direct visualization in a superfused, mudpuppy retinal slice preparation. 2. OFF-bipolar cells (BPs) generated sign-conserving responses when extrinsic current was injected into rods and cones...

journal_title：Journal of neurophysiology

authors： Kim HG,Miller RF

更新日期：1993-02-01 00:00:00

abstract：:1. We have previously shown that Xenopus spinal motoneurons make both chemical and electrical synapses with neighboring motoneurons. Because motoneurons are active during swimming, these synapses would be expected to contribute excitation to their neighbors. The significance of central motoneuron to motoneuron synapse...

journal_title：Journal of neurophysiology

authors： Perrins R,Roberts A

更新日期：1995-03-01 00:00:00

abstract：:We examined which motor areas would participate in the coding of a simple opposition of the thumb triggered by auditory, somatosensory and visual signals. We tested which motor areas might be active in response to all three modalities, which motor structures would be activated specifically in response to each modality...

journal_title：Journal of neurophysiology

authors： Naito E,Kinomura S,Geyer S,Kawashima R,Roland PE,Zilles K

更新日期：2000-03-01 00:00:00

abstract：:The caudal primate prefrontal cortex (PFC) is involved in target selection and visually guided saccades through both covert attention and overt orienting eye movements. Unilateral damage to the caudal PFC often leads to decreased awareness of a contralesional target alone, referred to as "neglect," or when it is prese...

journal_title：Journal of neurophysiology

authors： Adam R,Johnston K,Everling S

更新日期：2019-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by profound deficits in memory and cognitive function. Neuropathological hallmarks of the disease include a loss of basal forebrain cholinergic neurons and the deposition of beta-amyloid peptide (Abeta) in neuritic plaques. At a cellul...

journal_title：Journal of neurophysiology

authors： Fu W,Jhamandas JH

更新日期：2003-11-01 00:00:00

abstract：:1. We investigated gamma-aminobutyric acid (GABA) receptors using thin slice patch-clamp techniques in the swellings along axons of posterior pituitary nerve terminals. 2. Activation of the nerve terminal GABAA receptor induced a mean conductance change of 1.5 nS. Normalizing to area gave a mean conductance density of...

journal_title：Journal of neurophysiology

authors： Zhang SJ,Jackson MB

更新日期：1995-03-01 00:00:00

abstract：:Cognitive and motor deficits associated with language and speech are seen in humans harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are thought to reside in structural abnormalities distributed across systems important for language and motor learning including the cerebral cortex, basal...

journal_title：Journal of neurophysiology

authors： Miller JE,Spiteri E,Condro MC,Dosumu-Johnson RT,Geschwind DH,White SA

更新日期：2008-10-01 00:00:00

abstract：:During early development neuronal networks express slow oscillating synchronized activity. The activity can be driven by several, not necessarily mutually exclusive, mechanisms. Each mechanism might have distinctive consequences for the phenomenology, formation, or sustainment of the early activity pattern. Here we st...

journal_title：Journal of neurophysiology

authors： Baltz T,Herzog A,Voigt T

更新日期：2011-09-01 00:00:00

abstract：:The cerebral cortex, the neostriatum (Str), and the external segment of the globus pallidus (GPe) form a cortico-Str-GPe disynaptic connection, which is one of the major connections in the basal ganglia circuitries and a target of dopamine modulation. The aim of this study was to examine the actions of D2-like dopamin...

journal_title：Journal of neurophysiology

authors： Watanabe K,Kita T,Kita H

更新日期：2009-02-01 00:00:00

abstract：:1. In the present three-part study electrophysiological techniques were used to characterize responses of afferent fibers in the rat hypogastric nerve to mechanical or chemical stimulation of the uterus, and anatomical techniques were used to identify the spinal segments through which uterine afferent fibers enter the...

journal_title：Journal of neurophysiology

authors： Berkley KJ,Robbins A,Sato Y

更新日期：1988-01-01 00:00:00

abstract：:While it has been well established that optostatic and optokinetic cues contribute to the perception of vertical, it is unclear how the brain processes their combined presence with the nonvisual vestibular cues. Using a psychometric approach, we examined the percept of vertical in human participants (n = 17) with thei...

journal_title：Journal of neurophysiology

authors： Niehof N,Perdreau F,Koppen M,Medendorp WP

更新日期：2019-08-01 00:00:00

abstract：:The small-signal linear characteristics of afferent responses from the isolated semicircular canal were described by the use of white-noise rotational acceleration inputs. The results, based on cross-correlation analysis, showed a striking and systematic variation in linear system impulse response characteristics from...

journal_title：Journal of neurophysiology

authors： O'Leary DP,Dunn RF

更新日期：1976-05-01 00:00:00

abstract：:Corneal-responsive neurons were recorded extracellularly in two regions of the spinal trigeminal nucleus, subnucleus interpolaris/caudalis (Vi/Vc) and subnucleus caudalis/upper cervical cord (Vc/C1) transition regions, from methohexital-anesthetized male rats. Thirty-nine Vi/Vc and 26 Vc/C1 neurons that responded to m...

journal_title：Journal of neurophysiology

authors： Hirata H,Hu JW,Bereiter DA

更新日期：1999-11-01 00:00:00

abstract：:The essential role of calcium in the induction of long-term potentiation (LTP) has been well established. In particular, calcium influx via the N-methyl-D-aspartate (NMDA) receptor (NMDAR) is important for LTP induction in many pathways. However, the specific roles of other calcium sources in hippocampal LTP are less ...

journal_title：Journal of neurophysiology

authors： Raymond CR,Redman SJ

更新日期：2002-07-01 00:00:00

abstract：:The study of quadrupeds has furnished most of our understanding of mammalian locomotion. To allow a more direct comparison of coordination between the four limbs in humans and quadrupeds, we studied crawling in the human, a behavior that is part of normal human development and mechanically more similar to quadrupedal ...

journal_title：Journal of neurophysiology

authors： Patrick SK,Noah JA,Yang JF

更新日期：2009-02-01 00:00:00

abstract：:The increasing use of transgenic mice for the study of pain mechanisms necessitates comprehensive understanding of the murine somatosensory system. Using an in vivo mouse preparation, we studied response properties of tibial nerve afferent fibers innervating glabrous skin. Recordings were obtained from 225 fibers iden...

journal_title：Journal of neurophysiology

authors： Cain DM,Khasabov SG,Simone DA

更新日期：2001-04-01 00:00:00

abstract：:Although T-type Ca(2+) channels in the reticular thalamic nucleus (nRT) have a central function in tuning neuronal excitability and are implicated in sensory processing, sleep, and epilepsy, the mechanisms involved in their regulation are poorly understood. Here we recorded T-type Ca(2+) currents from intact nRT neuro...

journal_title：Journal of neurophysiology

authors： Joksovic PM,Doctor A,Gaston B,Todorovic SM

更新日期：2007-04-01 00:00:00

abstract：:The functional coupling of neural circuits between the upper and lower limbs involving rhythmic movements is of interest to both motor control research and rehabilitation science. This coupling can be detected by examining the effect of remote rhythmic limb movement on the modulation of reflex amplitude in stationary ...

journal_title：Journal of neurophysiology

authors： Sasada S,Tazoe T,Nakajima T,Zehr EP,Komiyama T

更新日期：2010-07-01 00:00:00

abstract：:The mechanical actions of various ankle muscles were changed by surgically crossing or transferring the tendons in kittens. After the kittens grew to adults, both hindlimbs were implanted with multiple electromyogram (EMG) recording and cutaneous nerve stimulation electrodes to compare the activity of altered and norm...

journal_title：Journal of neurophysiology

authors： Loeb GE

更新日期：1999-12-01 00:00:00

abstract：:Ion channel modulation by the peptide myomodulin (MM) has been demonstrated in a wide variety of organisms including Aplysia, Lymnaea, and Pleurobranchaea. This neural and muscular modulation has been shown to be important for shaping and modifying behavior. In this paper, we report that MM modulates several distinct ...

journal_title：Journal of neurophysiology

authors： Wang Y,Strong JA,Sahley CL

更新日期：1999-07-01 00:00:00

abstract：:The goal of this study was to characterize the effects of corticotrophin-releasing factor (CRF) on rat paraventricular nucleus (PVN) putative parvocellular neurons using whole cell patch-clamp recordings and single-cell reverse transcription-multiplex polymerase chain reaction (single-cell RT-mPCR) techniques. Under c...

journal_title：Journal of neurophysiology

authors： Qiu DL,Chu CP,Shirasaka T,Tsukino H,Nakao H,Kato K,Kunitake T,Katoh T,Kannan H

更新日期：2005-07-01 00:00:00

abstract：:1. Neurons in the ventral intraparietal area (VIP) are known to respond to translating random dot patterns. Such responses can be explained on the basis of the input of the middle temporal area (MT) to this area. Anatomic evidence has shown that VIP receives input from the dorsal part of the medial superior temporal a...

journal_title：Journal of neurophysiology

authors： Schaafsma SJ,Duysens J

更新日期：1996-12-01 00:00:00

abstract：:We have used electrophysiological techniques to document segmental differences in the pathways between the giant, escape command axons, lateral giants (LG) and medial giants (MG), and the nongiant, fast flexor (FF) motoneurons. We found no difference in the input from LG and MG axons to FF motoneurons in the posterior...

journal_title：Journal of neurophysiology

authors： Miller LA,Hagiwara G,Wine JJ

更新日期：1985-01-01 00:00:00

abstract：:There is mounting evidence for the idea that performance in a visuomotor rotation task can be supported by both implicit and explicit forms of learning. The implicit component of learning has been well characterized in previous experiments and is thought to arise from the adaptation of an internal model driven by sens...

journal_title：Journal of neurophysiology

authors： Bond KM,Taylor JA

更新日期：2015-06-01 00:00:00

abstract：:Task optimization in the presence of signal-dependent noise (TOPS) has been proposed as a general framework for planning goal-directed movements. Within this framework, the motor command is assumed to be corrupted by signal-dependent noise, which leads to a distribution of possible movements. A task can then be equate...

journal_title：Journal of neurophysiology

authors： Hamilton AF,Wolpert DM

更新日期：2002-05-01 00:00:00

abstract：:Most of what we know about the neural control of gaze comes from experiments in head-fixed animals, but several "head-free" studies have suggested that fixing the head dramatically alters the apparent gaze command. We directly investigated this issue by quantitatively comparing head-fixed and head-free gaze trajectori...

journal_title：Journal of neurophysiology

authors： Martinez-Trujillo JC,Klier EM,Wang H,Crawford JD

更新日期：2003-10-01 00:00:00

abstract：:Metabotropic receptors modulate numerous cellular processes by intracellular Ca2+ signaling, but less is known about their role in regulating mitochondrial metabolic function within the CNS. In this study, we demonstrate in area CA3 of rat organotypic hippocampal slice cultures that glutamatergic, serotonergic, and mu...

journal_title：Journal of neurophysiology

authors： Kann O,Kovács R,Heinemann U

更新日期：2003-08-01 00:00:00

abstract：:With experience, an object can become behaviorally relevant and thereby quickly attract our interest when presented in a visual scene. A likely site of these learning effects is anterior inferior temporal (aIT) cortex, where neurons are thought to participate in the filtering of irrelevant information out of complex v...

journal_title：Journal of neurophysiology

authors： Jagadeesh B,Chelazzi L,Mishkin M,Desimone R

更新日期：2001-07-01 00:00:00

abstract：:Receptive fields of neurons in somatosensory area 3b of monkeys are typically described as restricted to part of a single digit or palm pad. However, such neurons are likely involved in integrating stimulus information from across the hand. To evaluate this possibility, we recorded from area 3b neurons in anesthetized...

journal_title：Journal of neurophysiology

authors： Reed JL,Qi HX,Zhou Z,Bernard MR,Burish MJ,Bonds AB,Kaas JH

更新日期：2010-04-01 00:00:00