Abstract:
:The mechanical actions of various ankle muscles were changed by surgically crossing or transferring the tendons in kittens. After the kittens grew to adults, both hindlimbs were implanted with multiple electromyogram (EMG) recording and cutaneous nerve stimulation electrodes to compare the activity of altered and normal muscles. The tendon transfers showed a remarkable tendency to regrow toward normal or only slightly altered mechanical action. In these animals and in the sham-operation controls, the patterns of muscle activity and reflexes were symmetrical in corresponding muscles of the two legs, although they could differ substantially between animals, particularly for the cutaneous reflexes. Eleven animals had at least some persistent alterations in muscle action. Their cutaneous reflex patterns tended to be asymmetric, in some cases quite markedly. EMG activity during unperturbed locomotion and paw-shaking was more symmetrical, but there were some changes in altered muscles and their synergists. The central pattern generators for locomotion and paw-shaking and particularly for cutaneous reflexes during locomotion appear to be at least partially malleable rather than entirely hardwired. This may provide a tool for studying their development and spinal plasticity in general.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Loeb GEdoi
10.1152/jn.1999.82.6.3392subject
Has Abstractpub_date
1999-12-01 00:00:00pages
3392-405issue
6eissn
0022-3077issn
1522-1598journal_volume
82pub_type
杂志文章abstract::Intracellular Ca2+ is influenced by both Ca2+ influx and release. We examined intracellular Ca2+ following action potential firing in the bag cell neurons of Aplysia californica. Following brief synaptic input, these neuroendocrine cells undergo an afterdischarge, resulting in elevated Ca2+ and the secretion of neurop...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90356.2008
更新日期:2008-07-01 00:00:00
abstract::1. Some scientists reported that the simple spike (SS) activity was transiently depressed after climbing fiber input, but others reported that predominant population of Purkinje cells increased their SS activity after the complex spike (CS). In the present study, SS activity after spontaneous CS was compared before an...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.4.1082
更新日期:1993-04-01 00:00:00
abstract::In neuroendocrine cells, hormone release often requires a collective burst of action potentials synchronized by gap junctions. This is the case for the electrically coupled bag cell neurons in the reproductive system of the marine snail, Aplysia californica. These neuroendocrine cells are found in two clusters, and fi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00494.2014
更新日期:2014-12-01 00:00:00
abstract::Humans with spinal cord injury (SCI) modulate locomotor output in response to limb load. Understanding the neural control mechanisms responsible for locomotor adaptation could provide a framework for selecting effective interventions. We quantified feedback and feedforward locomotor adaptations to limb load modulation...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00604.2009
更新日期:2010-09-01 00:00:00
abstract::Red and green cones of two turtle species (Pseudemys scripta elegans and Chelydra serpentina) retina have been stained with Golgi procedures and examined by light microscopy of whole-mount tissue and by electron microscopy of serial thin sections. By light microscopy, red and green single cones appear indistinguishabl...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.54.2.304
更新日期:1985-08-01 00:00:00
abstract::Rhythm generation by the gastric motor network in the stomatogastric ganglion (STG) of the lobster Homarus gammarus is controlled by modulatory projection neurons from rostral commissural ganglia (CoGs); blocking action potential conduction in these inputs to the STG of a stomatogastric nervous system in vitro rapidly...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.5.2776
更新日期:1998-11-01 00:00:00
abstract::Divergence of the Shaker superfamily of voltage-gated (Kv) ion channels early in metazoan evolution created numerous electrical phenotypes that were presumably selected to produce a wide range of excitability characteristics in neurons, myocytes, and other cells. A comparative approach that emphasizes this early radia...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00858.2005
更新日期:2006-05-01 00:00:00
abstract::1. Buffering of glutamate-induced Ca2+ loads in single rat hippocampal neurons grown in primary culture was studied with ratiometric fluorescent Ca2+ indicators. The hypothesis that mitochondria buffer the large Ca2+ loads elicited by glutamate was tested. 2. The relationship between glutamate concentration and the re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.3.1611
更新日期:1996-09-01 00:00:00
abstract::When identical stimuli are presented in rapid temporal succession, neural responses to the second stimulation are often weaker than those observed for the first. This phenomenon is termed sensory gating and is believed to be an adaptive feature that helps prevent higher-order cortical centers from being flooded with u...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00260.2017
更新日期:2017-10-01 00:00:00
abstract::The way in which input noise perturbs the behavior of a system depends on the internal processing structure of the system. In visual psychophysics, there is a long tradition of using external noise methods (i.e., adding noise to visual stimuli) as tools for system identification. Here, we demonstrate that external noi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01367.2005
更新日期:2006-09-01 00:00:00
abstract::This study was prompted by recent evidence for the existence of positive force feedback in feline locomotor control. Our aim was to establish some basic properties of positive force feedback in relation to load compensation, stability, intrinsic muscle properties, and interaction with displacement feedback. In human s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.6.3226
更新日期:1997-06-01 00:00:00
abstract::To determine whether visual discrimination in macaque frontal eye field (FEF) is contingent on saccade planning, unit activity was recorded in two monkeys during blocked go and no-go visual search trials. The eye movements made by monkeys after correct no-go trials, in addition to an attenuation of the visual response...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.2.1046
更新日期:1997-02-01 00:00:00
abstract::Pyramidal cells and interneurons in rat prefrontal cortical slices exhibit subthreshold oscillations when depolarized by constant current injection. For both types of neurons, the frequencies of these oscillations for current injection just below spike threshold were 2--10 Hz. Above spike threshold, however, the subth...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.4.1782
更新日期:2001-04-01 00:00:00
abstract::The ionic mechanisms underlying the termination of action-potential (AP) bursts and postburst afterhyperpolarization (AHP) in intrinsically bursting (IB) neocortical neurons were investigated by performing intracellular recordings in thin slices of rat sensorimotor cortex. The blockade of Ca(2+)-activated K(+) current...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00695.2002
更新日期:2003-04-01 00:00:00
abstract::Pyramidal cells in the dorsal cochlear nucleus (DCN) show three characteristic discharge patterns in response tones: pauser, buildup, and regular firing. Experimental evidence suggests that a rapidly inactivating K+ current (I(KIF)) plays a critical role in generating these discharge patterns. To explore the role of I...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.2.523
更新日期:2001-02-01 00:00:00
abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00620.2014
更新日期:2015-02-01 00:00:00
abstract::Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable nonhuma...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00327.2017
更新日期:2017-09-01 00:00:00
abstract::After a cortical lesion, cortical areas distant from the site of injury are known to undergo physiological and anatomical changes. However, the mechanisms through which reorganization of distant cortical areas is initiated are poorly understood. In a previous publication, we showed that the ventral premotor cortex (PM...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00792.2006
更新日期:2006-12-01 00:00:00
abstract::We conclude our study of the properties and the functional role of the neuromuscular transform (NMT). The NMT is an input-output relation that formalizes the processes by which patterns of motor neuron firing are transformed to muscle contractions. Because the NMT acts as a dynamic, nonlinear, and modifiable filter, t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.1.260
更新日期:2000-01-01 00:00:00
abstract::Membrane retrieval following exocytosis in synaptic terminals is fast and compensatory, however, little is known about the factors that regulate or contribute to this special form of endocytosis. We used whole-terminal capacitance measurements to examine the effect of hydrostatic pressure on compensatory endocytosis i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00267.2002
更新日期:2002-11-01 00:00:00
abstract::Optogenetic activation of axons is a powerful approach for determining the synaptic properties and impact of long-range projections both in vivo and in vitro. However, because of the difficulty of measuring activity in axons, our knowledge of the reliability of optogenetic axonal stimulation has relied on data from so...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00456.2016
更新日期:2016-11-01 00:00:00
abstract::1. Physiological responses of hippocampal pyramidal neurons in primary culture to prolonged glutamate (GLU) exposure (500 microM in all experiments) were studied with the use of patch electrodes and whole-cell current-clamp recording techniques. In some experiments, perforated patch recordings were employed with elect...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.2.362
更新日期:1992-08-01 00:00:00
abstract::We have previously shown that control subjects use two distinct temporal strategies when stepping on an inclined surface during walking: one for level and 10 degrees surfaces and another for 20 and 30 degrees surfaces. These two temporal strategies were characterized by systematic shifts in the timing of muscle activi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.2.759
更新日期:2001-02-01 00:00:00
abstract::1. This study demonstrates plasticity of the vestibuloocular reflex (VOR) in chickens and compares it to that of other species and to that of newly hatched chicks. Adaptive changes in the VOR were induced by subjecting the animals to combinations of visual and vestibular stimuli that simulated the effect of the VOR be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1982.48.4.952
更新日期:1982-10-01 00:00:00
abstract::The activity of the crayfish abdominal postural motoneurons and their associated neurons (the accessory neuron(s) and the MRO(1)) were examined with the aid of techniques for the analysis of simultaneously recorded spike trains. A means of reliably identifying the spikes of the individual motoneurons based on their re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.2.313
更新日期:1975-03-01 00:00:00
abstract::Several models exist for explaining primary visual cortex (V1) orientation tuning. The modified feedforward model (MFM) and the recurrent model (RM) are major examples. We have implemented these two models, at the same level of detail, alongside a few newer variations, and thoroughly compared their receptive-field str...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00015.2005
更新日期:2006-07-01 00:00:00
abstract::In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00311.2011
更新日期:2011-10-01 00:00:00
abstract::1. Voltage-dependent Na+ conductances were studied in small (18-25 microns diam) adult rat dorsal root ganglion (DRG) neurons with the use of the whole cell patch-clamp technique. Na+ currents were also recorded from larger (44-50 microns diam) neurons and compared with those of the small neurons. 2. The predominant N...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.6.2796
更新日期:1994-12-01 00:00:00
abstract::1. Mechanosensory hairs on the surface of the crayfish telson are dually innervated, one sensory cell responding to headward, the other to tailward deflection of the hair. The average conduction velocity of headward elements was 0.8 m/s (variance 0.08) and of tailward elements 1.2 m/s (variance 0.19). In a frequency r...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.4.816
更新日期:1976-07-01 00:00:00
abstract::1. Several heart interneurons (HN cells) of the leech nerve cord have impulse-initiation sites in every segmental ganglion through which their single axons pass. All these initiation sites are capable of producing rhythmic impulse bursts. However, under normal conditions a dominant primary initiation site in the gangl...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1980.44.5.878
更新日期:1980-11-01 00:00:00