Abstract:
:The caudal primate prefrontal cortex (PFC) is involved in target selection and visually guided saccades through both covert attention and overt orienting eye movements. Unilateral damage to the caudal PFC often leads to decreased awareness of a contralesional target alone, referred to as "neglect," or when it is presented simultaneously with an ipsilesional target, referred to as "extinction." In the current study, we examined whether deficits in contralesional target selection were due to contralesional oculomotor deficits, such as slower reaction times. We experimentally induced a focal ischemic lesion in the right caudal PFC of 4 male macaque monkeys using the vasoconstrictor endothelin-1 and measured saccade choice and reaction times on double-stimulus free-choice tasks and single-stimulus trials before and after the lesion. We found that 1) endothelin-1-induced lesions in the caudal PFC produced contralesional target selection deficits that varied in severity and duration based on lesion volume and location; 2) contralesional neglect-like deficits were transient and recovered by week 4 postlesion; 3) contralesional extinction-like deficits were longer lasting and recovered by weeks 8-16 postlesion; 4) contralesional reaction time returned to baseline well before the contralesional choice deficit had recovered; and 5) neither the mean reaction times nor the reaction time distributions could account for the degree of contralesional extinction on the free-choice task throughout recovery. These findings demonstrate that the saccade choice bias observed after a right caudal PFC lesion is not exclusively due to contralesional motor deficits, but instead reflects a combination of impaired motor and attentional processing.NEW & NOTEWORTHY Unilateral damage to the caudal prefrontal cortex in macaque monkeys results in impaired contralesional target selection during the simultaneous presentation of an ipsilesional target. We show that the recovery of contralesional target selection cannot be explained by the recovery of prolonged contralesional saccadic reaction times alone. This indicates that an impairment in contralesional attentional processing contributes to the magnitude of the saccade choice bias in the weeks following a unilateral caudal prefrontal cortex lesion.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Adam R,Johnston K,Everling Sdoi
10.1152/jn.00078.2019subject
Has Abstractpub_date
2019-08-01 00:00:00pages
672-690issue
2eissn
0022-3077issn
1522-1598journal_volume
122pub_type
杂志文章abstract::We studied the properties of voltage-activated outward currents in two types of spider cuticular mechanoreceptor neurons to learn if these currents contribute to the differences in their adaptation properties. Both types of neurons adapt rapidly to sustained stimuli, but type A neurons usually only fire one or two act...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.6.2937
更新日期:1999-06-01 00:00:00
abstract::In the ventral tegmental area (VTA), interactions between dopamine (DA) and γ-aminobutyric acid (GABA) neurons are critical for regulating DA neuron activity and thus DA efflux. To provide a mechanistic explanation of how GABA neurons influence DA neuron firing, we developed a circuit model of the VTA. The model is ba...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00232.2016
更新日期:2016-10-01 00:00:00
abstract::Humans and songbirds shape learned vocalizations during a sensorimotor sensitive period or "babbling" phase. The brain mechanisms that underlie the shaping of vocalizations by sensory feedback are not known. We examined song behavior and brain activity in zebra finches during singing as they actively shaped their song...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00907.2006
更新日期:2007-01-01 00:00:00
abstract::The musculoskeletal redundancy of the body provides multiple solutions for performing motor tasks. We have proposed that the nervous system solves this unconstrained problem through the recruitment of motor modules or functional muscle synergies that map motor intention to action. Consistent with this hypothesis, we s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00960.2009
更新日期:2010-06-01 00:00:00
abstract::It is well established that orderly patterns of motor neuron activity, muscle recruitment, and limb movement are generated in chicks during motility by embryonic day (E)9, the midpoint in embryonic development. However, our recent work suggests that some attributes of motility, such as the rhythm of repetitive limb mo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00393.2003
更新日期:2003-09-01 00:00:00
abstract::We characterized the electroresponsive and morphological properties of neurons in the bed nucleus of the stria terminalis (BNST). Previously, Rainnie and colleagues distinguished three cell types in the anterolateral region of BNST (BNST-AL): low-threshold bursting cells (LTB; type II) and regular spiking neurons that...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00408.2013
更新日期:2013-11-01 00:00:00
abstract::Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex. J. Neurophysiol. 80: 3392-3397, 1998. We studied movement-related neuronal activity in the dorsolateral prefrontal cortex from the perspective of a general role for the prefrontal cortex in controlling motor behavior to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.6.3392
更新日期:1998-12-01 00:00:00
abstract::We asked if the information about stimulus motion used in a visual working-memory task is localized in space. Monkeys compared the directions of two moving random-dot stimuli, sample and test, separated by a temporal delay and reported whether the stimuli moved in the same or in different directions. By presenting the...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.2.912
更新日期:2001-08-01 00:00:00
abstract::1. The pteropod mollusk Clione limacina swims by rhythmical oscillations of two wings, and its spatial orientation during locomotion is determined by tail movements. The majority of neurons responsible for generation of the wing and tail movements are located in the pedal ganglia. On the other hand, the majority of se...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.5.1912
更新日期:1995-05-01 00:00:00
abstract::Our continuous perception of the world could be the result of discrete sampling, where individual snapshots are seamlessly fused into a coherent stream. It has been argued that endogenous oscillatory brain activity could provide the functional substrate of cortical rhythmic sampling. A new study demonstrates that cort...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00810.2017
更新日期:2018-04-01 00:00:00
abstract::Previous studies have shown that a subset of neurons in the rat anterodorsal thalamus discharge as a function of the animal's head direction (HD) in the horizontal plane, independent of the animal's location and behavior. These cells have consistent firing properties across a wide range of conditions and cell discharg...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00649.2009
更新日期:2010-09-01 00:00:00
abstract::1. The graded, synaptic potentials of first-order visual interneurons (lamina monopolar cells) were examined with intracellular recordings. The spatiotemporal properties were characterized with drifting sine wave gratings and annuli. 2. Annulus-elicited inhibition is maximal for annulus-test pulse intervals of approxi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.6.2168
更新日期:1994-06-01 00:00:00
abstract::Extracellular recordings were made from cold-receptive afferent fibers in the trigeminal ganglion of rats anesthetized with halothane. By applying a standardized series of steady or changing temperatures to the receptive fields, we recorded the static and dynamic responses of the afferents. Comparable recordings were ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.53.2.429
更新日期:1985-02-01 00:00:00
abstract::1. In the European rock lobster, Homarus gammarus, two bilaterally symmetrical pairs of commissural neurons, P and commissural pyloric (CP), evoke excitatory postsynaptic potentials in the neurons of the pyloric motor network. The present paper shows that the two commissural neurons also exert a modulatory control ove...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.6.2490
更新日期:1994-06-01 00:00:00
abstract::The gain of the vertical vestibuloocular reflex (VVOR), defined as eye velocity/head velocity was adapted in squirrel monkeys by employing visual-vestibular mismatch stimuli. VVOR gain, measured in the dark, could be trained to values between 0.4 and 1.5. Single-unit activity of vertical zone Purkinje cells was record...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.5.2267
更新日期:2001-05-01 00:00:00
abstract::The receptive field organization of nociceptive neurons suggests that noxious information may be encoded by population-based mechanisms. Electrophysiological evidence of population coding mechanisms has remained limited. However, psychophysical studies examining interactions between multiple noxious stimuli can provid...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91350.2008
更新日期:2009-12-01 00:00:00
abstract::Eigenmannia, a genus of weakly electric fish, exhibits a specialized behavior known as the jamming avoidance response (JAR). The JAR results in a categorical difference between Eigenmannia that are in groups of conspecifics and those that are alone. Fish in groups exhibit the JAR behavior and thereby experience ongoin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00311.2006
更新日期:2006-11-01 00:00:00
abstract::Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea pigs. J. Neurophysiol. 78: 2269-2279, 1997. Intracellular electrical responses and changes in intracellular calcium concentration ([Ca2+]i) in response to activation of synaptic inputs and to DC injections wer...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2269
更新日期:1997-11-01 00:00:00
abstract::Gonadotropin-releasing hormone (GnRH) controls mammalian reproduction via the hypothalamic-pituitary-gonadal (hpg) axis, acting on gonadotrope cells in the pituitary gland that express the GnRH receptor (GnRHR). Cells expressing the GnRHR have also been identified in the brain. However, the mechanism by which GnRH act...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00357.2015
更新日期:2015-08-01 00:00:00
abstract::The aim of this study was to investigate the contribution of feedback from large-diameter sensory fibers to the adaptation of soleus muscle activity after small ankle trajectory modifications during human walking. Small-amplitude and slow-velocity ankle dorsiflexion enhancements and reductions were applied during the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01071.2004
更新日期:2005-06-01 00:00:00
abstract::We recently reported evidence indicating that selective attention is deployed to a target location in a multi-object display, when the target event (a change of one of the objects) is preceded by subliminal flicker in the gamma range. However, concerns have been raised regarding the stimuli used in this study and the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00357.2010
更新日期:2011-02-01 00:00:00
abstract::1. This study demonstrates plasticity of the vestibuloocular reflex (VOR) in chickens and compares it to that of other species and to that of newly hatched chicks. Adaptive changes in the VOR were induced by subjecting the animals to combinations of visual and vestibular stimuli that simulated the effect of the VOR be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1982.48.4.952
更新日期:1982-10-01 00:00:00
abstract::Group I metabotropic glutamate receptor (mGluR) agonists increase the excitability of hippocampal CAl pyramidal neurons via depression of the postspike afterhyperpolarization. In adult rats, this is mediated by both mGluR1 and -5, but the signal transduction processes involved are unknown. In this study, we investigat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01236.2003
更新日期:2004-11-01 00:00:00
abstract::N-methyl-D-aspartate receptors (NMDARs) play an important role in cell survival versus cell death decisions during neuronal development, ischemia, trauma, and epilepsy. Coupling of neurons by electrical synapses (gap junctions) is high or increases in neuronal networks during all these conditions. In the developing CN...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00656.2010
更新日期:2010-12-01 00:00:00
abstract::Although metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5 are often found to have similar functions, there is considerable evidence that the two receptors also serve distinct functions in neurons. In hippocampal area CA1, mGluR5 has been most strongly implicated in long-term synaptic depression (LTD), where...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00383.2005
更新日期:2006-04-01 00:00:00
abstract::Visual tracking of moving objects requires prediction to compensate for visual delays and minimize mismatches between eye and target position and velocity. In everyday life, objects often disappear behind an occluder, and prediction is required to align eye and target at reappearance. Earlier studies investigating eye...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.00596.2005
更新日期:2006-01-01 00:00:00
abstract::To study the possible role of the cerebellum in the vestibular-ocular reflex, extracellular responses of cerebellar nuclear neurons were recorded in awake monkeys during natural vestibular stimulation; 115 neurons in the fastigial nucleus responded to horizontal sinusoidal accelerations applied to the head by means of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.3.627
更新日期:1975-05-01 00:00:00
abstract::Electrical stimulation has been delivered to the basal ganglia (BG) to treat intractable symptoms of a variety of clinical disorders. However, it is still unknown how such treatments improve behavioral symptoms. A difficulty of this problem is that artificial signals created by electrical stimulation interact with int...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00046.2013
更新日期:2013-07-01 00:00:00
abstract::EEG generator-a model of potentials in a volume conductor. The potential recorded over the cortex electro-corticogram (ECoG) or over the scalp [electroencephalograph (EEG)] derives from the activity of many sources known as "EEG generators." The recorded amplitude is basically a function of the unitary potential of a ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91143.2008
更新日期:2009-11-01 00:00:00
abstract::1. The horizontal eye movements induced by acceleration along the interaural axis were recorded from five monkeys (Macaca mulatta) by the use of the electromagnetic search-coil technique. Animals sat on a sled that was moved briefly in darkness along a linear track (bell-shaped acceleration profile: peak, 400 mm/s2; d...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.66.3.851
更新日期:1991-09-01 00:00:00