Abstract：
:The receptive field organization of nociceptive neurons suggests that noxious information may be encoded by population-based mechanisms. Electrophysiological evidence of population coding mechanisms has remained limited. However, psychophysical studies examining interactions between multiple noxious stimuli can provide indirect evidence that neuron population recruitment can contribute to both spatial and intensity-related percepts of pain. In the present study, pairs of thermal stimuli (35 degrees C/49 degrees C or 49 degrees C/49 degrees C) were delivered at different distances on the leg (0, 5, 10, 20, 40 cm) and abdomen (within and across dermatomes) and subjects evaluated pain intensity and perceived spatial attributes of stimuli. Reports of perceived pain spreading to involve areas that were not stimulated (radiation of pain) were most frequent at 5- and 10-cm distances (chi(2) = 34.107, P < 0.0001). Perceived connectivity between two noxious stimuli (filling-in) was influenced by the distance between stimuli (chi(2) = 16.756, P < 0.01), with the greatest connectivity reported at 5- and 10-cm separation distances. Spatial summation of pain occurred over probe separation distances as large as 40 cm and six dermatomes (P < 0.05), but was maximal at 5- and 10-cm separation distances. Taken together, all three of these phenomena suggest that interactions between recruited populations of neurons may support both spatial and intensity-related dimensions of the pain experience.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Quevedo AS,Coghill RCdoi
10.1152/jn.91350.2008subject
Has Abstractpub_date
2009-12-01 00:00:00pages
3544-53issue
6eissn
0022-3077issn
1522-1598pii
91350.2008journal_volume
102pub_type
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