Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke.

abstract：:Few studies have analyzed activity-induced changes in EMG activity in individual human motor units. We studied the changes in human thenar motor unit EMG that accompany the potentiation of twitch force and fatigue of tetanic force. Single motor unit EMG and force were recorded in healthy subjects in response to select...

journal_title：Journal of neurophysiology

authors： Thomas CK,Johansson RS,Bigland-Ritchie B

更新日期：2006-03-01 00:00:00

abstract：:1. Physiological responses of hippocampal pyramidal neurons in primary culture to prolonged glutamate (GLU) exposure (500 microM in all experiments) were studied with the use of patch electrodes and whole-cell current-clamp recording techniques. In some experiments, perforated patch recordings were employed with elect...

journal_title：Journal of neurophysiology

authors： Coulter DA,Sombati S,DeLorenzo RJ

更新日期：1992-08-01 00:00:00

abstract：:1. The induction of long-term weakening of synaptic transmission in rat hippocampal slices was examined in CA1 synapses during cholinergic modulation. 2. Bath application of the cholinergic agonist carbachol (50 microM) activated an oscillation of the local field potential in the theta-frequency range (5-12 Hz), terme...

journal_title：Journal of neurophysiology

authors： Huerta PT,Lisman JE

更新日期：1996-02-01 00:00:00

abstract：:1. Dopamine-containing neurons of the rat midbrain were recorded intracellularly in vitro. Anoxia (2-5 min) caused reversible membrane hyperpolarization (4-25 mV), which blocked spontaneous firing of action potentials. Under voltage clamp, anoxia produced an outward current (100-1,000 pA) associated with an increase i...

journal_title：Journal of neurophysiology

authors： Mercuri NB,Bonci A,Johnson SW,Stratta F,Calabresi P,Bernardi G

更新日期：1994-03-01 00:00:00

abstract：:Experiments were performed on human elbow flexor and extensor muscles and jaw-opening and -closing muscles to observe the effect on rhythmic movements of sudden loading. The load was provided by an electromagnetic device, which simulated the appearance of a smoothly increasing spring-like load. The responses to this l...

journal_title：Journal of neurophysiology

authors： Abbink JH,van der Bilt A,Bosman F,van der Glas HW,Erkelens CJ,Klaassen MF

更新日期：1999-09-01 00:00:00

abstract：:PSD-95-like, disc-large (DLG) family membrane-associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we show that the protot...

journal_title：Journal of neurophysiology

authors： Liu M,Lewis LD,Shi R,Brown EN,Xu W

更新日期：2014-02-01 00:00:00

abstract：:Event-related potentials (ERPs) have provided crucial data concerning the time course of psychological processes, but the neural mechanisms producing ERP components remain poorly understood. This study continues a program of research in which we investigated the neural basis of attention-related ERP components by simu...

journal_title：Journal of neurophysiology

authors： Purcell BA,Schall JD,Woodman GF

更新日期：2013-01-01 00:00:00

abstract：:The input-output and discharge properties of neurons are shaped by both passive and active electrophysiological membrane properties. Whole cell patch-clamp recordings in lamina I-III neurons in an isolated preparation of the whole spinal cord of juvenile rats with attached dorsal roots and dorsal root ganglia were use...

journal_title：Journal of neurophysiology

authors： Dougherty PM,Chen J

更新日期：2016-09-01 00:00:00

abstract：:In contrast to hand movements, the existence of a neural representation of saccade kinematics is unclear. Saccade kinematics is typically thought to be specified by motor error/desired displacement and generated by brain stem circuits that are not penetrable to voluntary control. We studied the influence of instructed...

journal_title：Journal of neurophysiology

authors： Gopal A,Jana S,Murthy A

更新日期：2017-09-01 00:00:00

abstract：:1. Taste buds in catfish are found not only within the oropharyngeal cavity, as in mammals, but are also located along the external body surface of the animal from the barbels and lips to the caudal fin. Because these taste buds are innervated by the facial (cranial VII) nerve, the extraoral taste system of catfish is...

journal_title：Journal of neurophysiology

authors： Michel W,Caprio J

更新日期：1991-07-01 00:00:00

abstract：:Responses to tones, clicks, and noise were recorded from chinchilla auditory-nerve fibers (ANFs). The responses to noise were analyzed by computing the zeroth-, first-, and second-order Wiener kernels (h0, h1, and h2). The h1s correctly predicted the frequency tuning and phases of responses to tones of ANFs with low c...

journal_title：Journal of neurophysiology

authors： Temchin AN,Recio-Spinoso A,van Dijk P,Ruggero MA

更新日期：2005-06-01 00:00:00

abstract：:1. Effects of deafferentation of the tooth pulps of the posterior mandibular teeth were studied in single neurons recorded in the ipsilateral subnucleus caudalis of the trigeminal (V) spinal tract nucleus of adult cats and kittens. The functional properties of neurons in each anesthetized animal were determined electr...

journal_title：Journal of neurophysiology

authors： Hu JW,Sessle BJ

更新日期：1989-06-01 00:00:00

abstract：:1. In the European rock lobster, Homarus gammarus, two bilaterally symmetrical pairs of commissural neurons, P and commissural pyloric (CP), evoke excitatory postsynaptic potentials in the neurons of the pyloric motor network. The present paper shows that the two commissural neurons also exert a modulatory control ove...

journal_title：Journal of neurophysiology

authors： Nagy F,Cardi P

更新日期：1994-06-01 00:00:00

abstract：:Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neuro...

journal_title：Journal of neurophysiology

authors： Palmer HS

更新日期：2010-10-01 00:00:00

abstract：:The dorsal nucleus of the lateral lemniscus (DNLL) receives afferent inputs from many brain stem nuclei and, in turn, is a major source of inhibitory inputs to the inferior colliculus (IC). The goal of this study was to characterize the monaural and binaural response properties of neurons in the DNLL of unanesthetized...

journal_title：Journal of neurophysiology

authors： Davis KA,Lomakin O,Pesavento MJ

更新日期：2007-09-01 00:00:00

abstract：:The mechanisms underlying the depression of evoked fast excitatory postsynaptic currents (EPSCs) following superfusion with medium deprived of oxygen and glucose (in vitro ischemia) for a 4-min period in hippocampal CA1 neurons were investigated in rat brain slices. The amplitude of evoked fast EPSCs decreased by 85 +...

journal_title：Journal of neurophysiology

authors： Tanaka E,Yasumoto S,Hattori G,Niiyama S,Matsuyama S,Higashi H

更新日期：2001-09-01 00:00:00

abstract：:Recent physiological recording studies in monkeys have suggested that the frontal eye fields (FEFs) are involved in visual scene analysis even when eye movement commands are not required. We examined this proposed function of the human frontal eye fields during performance of visual search tasks in which difficulty wa...

journal_title：Journal of neurophysiology

authors： Muggleton NG,Juan CH,Cowey A,Walsh V

更新日期：2003-06-01 00:00:00

abstract：:Retinal ganglion cells (RGC) transmit visual signals to thalamocortical relay neurons in the lateral geniculate nucleus via retinogeniculate synapses. Relay neuron spike patterns do not simply reflect those of RGCs, but the mechanisms controlling this transformation are not well understood. We therefore examined synap...

journal_title：Journal of neurophysiology

authors： Blitz DM,Regehr WG

更新日期：2003-10-01 00:00:00

abstract：:During object manipulation, grip force is coordinated with load force, which is primarily determined by object kinematics. Proximal arm kinematics may affect grip force control, as proximal segment motion could affect control of distal hand muscles via biomechanical and/or neural pathways. The aim of this study was to...

journal_title：Journal of neurophysiology

authors： Vermillion BC,Lum PS,Lee SW

更新日期：2015-10-01 00:00:00

abstract：:When speed changes during locomotion, both temporal and spatial parameters of the pattern must adjust. Moreover, at slow speeds the step-to-step pattern becomes increasingly variable. The objectives of the present study were to assess if the spinal locomotor network adjusts both temporal and spatial parameters from sl...

journal_title：Journal of neurophysiology

authors： Dambreville C,Labarre A,Thibaudier Y,Hurteau MF,Frigon A

更新日期：2015-08-01 00:00:00

abstract：:Dual whole cell patch-clamp recordings in rat nucleus accumbens, the main component of the ventral striatum, were made to assess the presence of synaptic interconnections between medium-sized spiny neurons, a group of GABAergic and peptidergic neurons that constitute the principal cells of the striatum. Neurons were s...

journal_title：Journal of neurophysiology

authors： Taverna S,van Dongen YC,Groenewegen HJ,Pennartz CM

更新日期：2004-03-01 00:00:00

abstract：:How neurons filter and integrate their complex patterns of synaptic inputs is central to their role in neural information processing. Synaptic filtering and integration are shaped by the frequency-dependent neuronal membrane impedance. Using single and dual dendritic recordings in vivo, pharmacology, and computational...

journal_title：Journal of neurophysiology

authors： Dewell RB,Gabbiani F

更新日期：2019-08-01 00:00:00

abstract：:1. Less than two segments of the cervical spinal cord of the mudpuppy (Necturus maculatus) is sufficient to generate a locomotor rhythm with application of N-methyl-D-aspartic acid (NMDA). We have recorded intracellularly from rhythmically active interneurons in these segments and classified them according to their ph...

journal_title：Journal of neurophysiology

authors： Wheatley M,Jovanović K,Stein RB,Lawson V

更新日期：1994-06-01 00:00:00

abstract：:Glutamate-receptor-mediated synaptic transmission was studied in morphologically identified hippocampal dentate granule cells (DGCs; n = 31) with the use of whole cell patch-clamp recording and intracellular injection of biocytin or Lucifer yellow in slices prepared from surgically removed medial temporal lobe specime...

journal_title：Journal of neurophysiology

authors： Isokawa M,Levesque M,Fried I,Engel J Jr

更新日期：1997-06-01 00:00:00

abstract：:Secondary hyperalgesia is believed to be a key feature of "central sensitization" and is characterized by enhanced pain to mechanical nociceptive stimuli. The aim of the present study was to characterize, using EEG, the effects of pinprick stimulation intensity on the magnitude of pinprick-elicited brain potentials [e...

journal_title：Journal of neurophysiology

authors： van den Broeke EN,Mouraux A,Groneberg AH,Pfau DB,Treede RD,Klein T

更新日期：2015-11-01 00:00:00

abstract：:The group I metabotropic glutamate receptor (mGluR) subtype, mGluR1, is highly expressed on the apical dendrites of olfactory bulb mitral cells and thus may be activated by glutamate released from olfactory nerve (ON) terminals. Previous studies have shown that mGluR1 agonists directly excite mitral cells. In the pres...

journal_title：Journal of neurophysiology

authors： Ennis M,Zhu M,Heinbockel T,Hayar A

更新日期：2006-04-01 00:00:00

abstract：:1. A 16-channel electrode array was used to record simultaneously extracellular laminar field potentials evoked by displacement of contralateral vibrissa from vibrissa/barrel cortex in five rats. Current source-density (CSD) analysis combined with principal component analysis (PCA) was used to determine the time cours...

journal_title：Journal of neurophysiology

authors： Di S,Baumgartner C,Barth DS

更新日期：1990-04-01 00:00:00

abstract：:1. Evoked potentials restricted to the magnocellular portion of the mediodorsal nucleus (MDmc) of the thalamus were recorded after stimulation of the olfactory bulb (OB) and the posterior orbital cortex of the frontal lobe (OFC). Potentials evoked by stimulation of OB were probably trans-synaptically elicited, while p...

journal_title：Journal of neurophysiology

authors： Yarita H,Iino M,Tanabe T,Kogure S,Takagi SF

更新日期：1980-01-01 00:00:00

abstract：:1. Mechanisms of depolarizing synaptic inhibition were investigated at the crayfish giant motor synapse with the use of two-electrode current- and voltage-clamp techniques. Depolarizing inhibitory postsynaptic potentials (d-IPSPs) of between 5 and 15 mV in amplitude are produced there in the motor giant motoneuron (Mo...

journal_title：Journal of neurophysiology

authors： Edwards DH

更新日期：1990-08-01 00:00:00

abstract：:Subjects were asked to track, with their eyes or their hand, the movement of a target that maintained a constant speed and made a single, abrupt change in direction. The tracking speed and direction of motion after the step change in target direction were compared for the eyes and the hand. After removal of the saccad...

journal_title：Journal of neurophysiology

authors： Engel KC,Anderson JH,Soechting JF

更新日期：2000-09-01 00:00:00