Abstract:
:Humans and songbirds shape learned vocalizations during a sensorimotor sensitive period or "babbling" phase. The brain mechanisms that underlie the shaping of vocalizations by sensory feedback are not known. We examined song behavior and brain activity in zebra finches during singing as they actively shaped their song toward a tutor model. We now show that the temporal relationship of behavior and activity in the premotor area HVC changes with the development of song behavior. During sensorimotor learning, HVC bursting activity both preceded and followed learned vocalizations by hundreds of milliseconds. Correspondingly, the duration of bursts that occurred during ongoing song motif behavior was prolonged in juveniles, as compared with adults, and was inversely correlated with song maturation. Multielectrode single-unit recording in juveniles revealed that single fast-spiking neurons were active both before and after vocalization. These same neurons responded to auditory stimuli. Collectively, these data indicate that a key aspect of sensory critical periods--prolonged bursting--also applies to sensorimotor development. In addition, prolonged motor discharge and sensory input coincide in single neurons of the developing song system, providing the necessary cellular elements for sensorimotor shaping through activity-dependent mechanisms.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Crandall SR,Aoki N,Nick TAdoi
10.1152/jn.00907.2006subject
Has Abstractpub_date
2007-01-01 00:00:00pages
806-16issue
1eissn
0022-3077issn
1522-1598pii
00907.2006journal_volume
97pub_type
杂志文章abstract::Annexin I is a local mediator in neural-endocrine feedback control of inflammation. J. Neurophysiol. 80: 3120-3126, 1998. Activation of primary afferent nociceptors induces a neural endocrine-mediated inhibition of the inflammatory response via a circuit that includes ascending spinal pathways and activation of the hy...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.6.3120
更新日期:1998-12-01 00:00:00
abstract::Primate head-free saccade generator implements a desired (post-VOR) eye position command by anticipating intended head motion. J. Neurophysiol. 78: 2811-2816, 1997. When we glance between objects, the brain ultimately controls gaze direction in space. However, it is currently unclear how this is allocated into separat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2811
更新日期:1997-11-01 00:00:00
abstract::Precisely synchronized neuronal activity has been commonly observed in the mammalian visual pathway. Spike timing correlations in the lateral geniculate nucleus (LGN) often take the form of phase synchronized oscillations in the high gamma frequency range. To study the relations between oscillatory activity, synchrony...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01000.2009
更新日期:2010-12-01 00:00:00
abstract::Senosory neurons manifest pronounced changes in excitability during maturation, but the factors contributing to this ubiquitous developmental phenomenon are not well understood. To assess the contribution of intrinsic membrane properties to such changes in excitability, in the present study whole cell patch-clamp reco...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.6.2895
更新日期:1997-12-01 00:00:00
abstract::Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. J. Neurophysiol. 78: 2707-2716, 1997. The relationship between paired-pulse facilitation (PPF) and synaptic potentiation induced by various protocols and their cellular and molecular mechanisms were exam...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2707
更新日期:1997-11-01 00:00:00
abstract::The lability of the responses of mammalian central neurons to gamma-aminobutyric acid (GABA) was studied using neurons acutely dissociated from the CA1 region of the adult guinea pig hippocampus as a model system. GABA was applied to the neuronal somata by pressure ejection and the resulting current (IGABA) recorded u...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.56.1.1
更新日期:1986-07-01 00:00:00
abstract::GABAergic interneurons in the hippocampus express high levels of alpha7 nicotinic acetylcholine receptors, but because of the diverse roles played by hippocampal interneurons, the impact of activation of these receptors on hippocampal output neurons (i.e., CA1 pyramidal cells) is unclear. Activation of hippocampal int...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00316.2001
更新日期:2002-01-01 00:00:00
abstract::The role of potassium channels in regulating spontaneous firing and sound-evoked responses in the central nucleus of the inferior colliculus was studied by recording single-unit activity before and during iontophoretic application of a nonspecific potassium channel blocker, tetraethylammonium (TEA). Tone bursts and si...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00730.2003
更新日期:2004-05-01 00:00:00
abstract::Single-electrode voltage-clamp techniques and bath application of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) were used to study the time course of seizure-induced alterations in NMDA-dependent synaptic currents in granule cells of the dentate gyrus in hippocampal slices f...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.2.564
更新日期:1999-02-01 00:00:00
abstract::Converging inputs to the entorhinal cortex from the piriform cortex and medial septum: facilitation and current source density analysis. J. Neurophysiol. 78: 2602-2615, 1997. The entorhinal cortex receives sensory inputs from the piriform cortex and modulatory inputs from the medial septum. To examine short-term synap...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.5.2602
更新日期:1997-11-01 00:00:00
abstract::Extracellular single-unit recordings were used to characterize responses of thalamic barreloid and cortical barrel neurons to controlled whisker deflections in 2, 3-, and 4-wk-old and adult rats in vivo under fentanyl analgesia. Results indicate that response properties of thalamic and cortical neurons diverge during ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01063.2007
更新日期:2008-01-01 00:00:00
abstract::Here we report on the development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMmicroEs) that practically provide intracellular recordings and stimulation of many individual neurons, while the electrodes maintain an extracellular position. The develo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00265.2010
更新日期:2010-07-01 00:00:00
abstract::Mechanisms that could mitigate the effects of hypoxia on neuronal signaling are incompletely understood. We show that axonal performance of a locust visual interneuron varied depending on oxygen availability. To induce hypoxia, tracheae supplying the thoracic nervous system were surgically lesioned and action potentia...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00354.2016
更新日期:2016-09-01 00:00:00
abstract::1. Properties of 90 lateral cervical nucleus (LCN) neurons responsive to light tactile stimulation of ipsilateral body surfaces were examined in pentobarbital sodium-anesthetized raccoons. Peripheral receptive fields (RFs) of 60 of these lay totally or partially on glabrous skin of the forepaw. There were 71 neurons a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.6.1411
更新日期:1991-06-01 00:00:00
abstract::We have characterized selectivity and sparseness in anterior inferotemporal cortex, using a large data set. Responses were collected from 674 monkey inferotemporal cells, each stimulated by 806 object photographs. This 806 × 674 matrix was examined in two ways: columnwise, looking at responses of a single neuron to al...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00990.2010
更新日期:2011-09-01 00:00:00
abstract::The functional role of sensory input to the motor cortex was studied by interrupting two major input pathways. One was the dorsal column, which sends the input directly through the thalamus to the motor cortex, and the other was the sensory cortex, which transfers its input through association fibers. Removal of the s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.52.2.212
更新日期:1984-08-01 00:00:00
abstract::The lateral hypothalamus (LH), which plays a role in homeostatic functions such as appetite regulation, is also linked to arousal and motivational behavior. However, little is known about how these components are encoded in the LH. Thus cynomolgus monkeys were conditioned with two distinct contexts, i.e., an appetitiv...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00247.2018
更新日期:2019-02-01 00:00:00
abstract::Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable nonhuma...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00327.2017
更新日期:2017-09-01 00:00:00
abstract::Two of the biggest health problems facing us today are addiction to nicotine and the increased prevalence of obesity. Interestingly, nicotine attenuates obesity, but the underlying mechanism is not clear. Here we address the hypothesis that if weight-reducing actions of nicotine are mediated by anorexigenic proopiomel...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00740.2010
更新日期:2011-09-01 00:00:00
abstract::Seconds-scale network states, affecting many neurons within a network, modulate neural activity by complementing fast integration of neuron-specific inputs that arrive in the milliseconds before spiking. Nonrhythmic subthreshold dynamics at intermediate timescales, however, are less well characterized. We found, using...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00116.2017
更新日期:2017-08-01 00:00:00
abstract::The development of modern neuroscience tools is critical for deciphering brain circuit organization and function. An important aspect for technical development is to enhance each technique's advantages and compensate for limitations. We developed a high-precision and fast functional mapping technique in brain slices t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00992.2009
更新日期:2010-04-01 00:00:00
abstract::The purpose of our study was to examine the associations between the performance of older adults on four tests of mobility and the physical capabilities of the lower leg muscles. The assessments included measures of muscle strength, muscle activation, and perceived fatigability. Muscle activation was quantified as the...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00192.2018
更新日期:2018-10-01 00:00:00
abstract::Damage to the cerebellum causes characteristic movement abnormalities but is thought to have minimal impact on somatosensory perception. Traditional clinical assessments of patients with cerebellar lesions reveal no perceptual deficits despite the fact that the cerebellum receives substantial somatosensory information...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00983.2011
更新日期:2012-03-01 00:00:00
abstract::The progenitor cells from the anterior part of the neonatal subventricular zone, the SVZa, are unusual in that, although they undergo division, they have a neuronal phenotype. To characterize the electrophysiological properties of the SVZa precursor cells, recordings were made of potassium and sodium currents from SVZ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.1.95
更新日期:1999-01-01 00:00:00
abstract::1. Cellular properties were studied before and after bath application of the dihydropyridine L-type calcium channel antagonist nimodipine in aging and young rabbit hippocampal CA1 pyramidal cells in vitro. Various concentrations of nimodipine, ranging from 10 nM to 10 microM, were tested to investigate age- and concen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.6.2100
更新日期:1992-12-01 00:00:00
abstract::Mechanoelectric transducer (MET) channels, located near stereocilia tips, are opened by deflecting the hair bundle of sensory hair cells. Defects in this process result in deafness. Despite this critical function, the molecular identity of MET channels remains a mystery. Inherent channel properties, particularly those...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01178.2011
更新日期:2012-05-01 00:00:00
abstract::Group I metabotropic glutamate receptor (mGluR) agonists increase the excitability of hippocampal CAl pyramidal neurons via depression of the postspike afterhyperpolarization. In adult rats, this is mediated by both mGluR1 and -5, but the signal transduction processes involved are unknown. In this study, we investigat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01236.2003
更新日期:2004-11-01 00:00:00
abstract::Directional hearing is crucial for animals depending on acoustic signals to locate a mate. We focused on crickets to explore the reliability of directional information forwarded to the brain by the ascending auditory interneuron AN1, which is crucial for phonotactic behavior. We presented calling song from -45° to +45...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00737.2019
更新日期:2020-03-01 00:00:00
abstract::1. In a brain stem slice preparation, we recorded glutamatergic excitatory postsynaptic currents (EPSCs) in hypoglossal motoneurons (HMs) evoked by extracellular stimulation in the reticular formation just ipsilateral to the hypoglossal motor nucleus (n. XII). Serotonin (5-HT) inhibited glutamatergic synaptic transmis...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.2.799
更新日期:1996-08-01 00:00:00
abstract::The mechanisms and impact of correlated, or synchronous, firing among pairs and groups of neurons are under intense investigation throughout the nervous system. A ubiquitous circuit feature that can give rise to such correlations consists of overlapping, or common, inputs to pairs and populations of cells, leading to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00928.2011
更新日期:2012-09-01 00:00:00