Slow oscillating population activity in developing cortical networks: models and experimental results.

abstract：:1. It has been suggested that passive diffusion is the principal mechanism of the clearance of locally elevated extracellular potassium, K+o, in the cerebral cortex. This concept was based on the assumption that elevated K+ could be modeled as a point source. In the present study, the functional role of passive diffus...

journal_title：Journal of neurophysiology

authors： Vern BA,Schuette WH,Thibault LE

更新日期：1977-09-01 00:00:00

abstract：:Pyramidal cells in the dorsal cochlear nucleus (DCN) show three characteristic discharge patterns in response tones: pauser, buildup, and regular firing. Experimental evidence suggests that a rapidly inactivating K+ current (I(KIF)) plays a critical role in generating these discharge patterns. To explore the role of I...

journal_title：Journal of neurophysiology

authors： Kanold PO,Manis PB

更新日期：2001-02-01 00:00:00

abstract：:In the rodent whisker system, a key model for neural processing and behavioral choices during active sensing, whisker motion is increasingly recognized as only part of a broader motor repertoire employed by rodents during active touch. In particular, recent studies suggest whisker and head motions are tightly coordina...

journal_title：Journal of neurophysiology

authors： Schroeder JB,Ritt JT

更新日期：2016-04-01 00:00:00

abstract：:1. Teased axon recordings were made from 167 spontaneously active A beta- and A delta-afferents that ended in sciatic nerve end neuromas of 6-12 days standing. When challenged with a standard bolus of systemically applied adrenaline, 100 (60%) responded, either with an increase in baseline firing frequency (excitation...

journal_title：Journal of neurophysiology

authors： Chen Y,Michaelis M,Janig W,Devor M

更新日期：1996-12-01 00:00:00

abstract：:The increasing use of transgenic mice for the study of pain mechanisms necessitates comprehensive understanding of the murine somatosensory system. Using an in vivo mouse preparation, we studied response properties of tibial nerve afferent fibers innervating glabrous skin. Recordings were obtained from 225 fibers iden...

journal_title：Journal of neurophysiology

authors： Cain DM,Khasabov SG,Simone DA

更新日期：2001-04-01 00:00:00

abstract：:Magnocellular red nucleus (RNm) is involved in controlling goal-directed limb movements such as reaching to grasp. We tested two hypotheses related to RNm's role in controlling reach-to-grasp movements. One hypothesis is that forelimb RNm neurons are grasp specific, and the other is that they specify the timing of met...

journal_title：Journal of neurophysiology

authors： Van Kan PL,McCurdy ML

更新日期：2002-03-01 00:00:00

abstract：:1. The small cardioactive peptides (SCPs) are potent modulatory neuropeptides in Aplysia. Buccal ganglia neurons B1 and B2 are the largest neurons that exhibit SCP-like immunoreactivity. High-pressure liquid chromatography (HPLC)-bioassay and in vivo radiolabeling procedures confirm that these neurons contain and synt...

journal_title：Journal of neurophysiology

authors： Lloyd PE,Kupfermann I,Weiss KR

更新日期：1988-05-01 00:00:00

abstract：:Neural oscillations are observed ubiquitously in the mammalian brain, but their stability is known to be rather variable. Some oscillations are tonic and last for seconds or even minutes. Other oscillations appear as unstable bursts. Likewise, some oscillations rely on excitatory AMPAergic synapses, but others are GAB...

journal_title：Journal of neurophysiology

authors： Peterson EJ,Voytek B

更新日期：2020-07-01 00:00:00

abstract：:The R6/2 mouse is the most frequently used model for experimental and preclinical drug trials in Huntington's disease (HD). When the R6/2 mouse was first developed, it carried exon 1 of the huntingtin gene with ~150 cytosine-adenine-guanine (CAG) repeats. The model presented with a rapid and aggressive phenotype that ...

journal_title：Journal of neurophysiology

authors： Cummings DM,Alaghband Y,Hickey MA,Joshi PR,Hong SC,Zhu C,Ando TK,André VM,Cepeda C,Watson JB,Levine MS

更新日期：2012-01-01 00:00:00

abstract：:Training rats to perform rapidly and efficiently in an olfactory discrimination task results in robust enhancement of excitatory and inhibitory synaptic connectivity in the rat piriform cortex, which is maintained for days after training. To explore the mechanisms by which such synaptic enhancement occurs, we recorded...

journal_title：Journal of neurophysiology

authors： Saar D,Reuveni I,Barkai E

更新日期：2012-02-01 00:00:00

abstract：:Saccade adaptation is a mechanism that adjusts saccade landing positions if they systematically fail to reach their intended target. In the laboratory, saccades can be shortened or lengthened if the saccade target is displaced during execution of the saccade. In this study, saccades were performed from different posit...

journal_title：Journal of neurophysiology

authors： Zimmermann E

更新日期：2013-04-01 00:00:00

abstract：:Homosynaptic long-term depression (LTD) of synaptic efficacy was induced in field excitatory postsynaptic potentials by administration of 900 pulses at either 1 or 3 Hz in 2- to 3-wk-old Sprague-Dawley rats. The stimulation was administered via a bipolar stimulating electrode placed immediately adjacent to the recordi...

journal_title：Journal of neurophysiology

authors： Christie BR,Schexnayder LK,Johnston D

更新日期：1997-03-01 00:00:00

abstract：:In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...

journal_title：Journal of neurophysiology

authors： Warren TL,Tumer EC,Charlesworth JD,Brainard MS

更新日期：2011-10-01 00:00:00

abstract：:Despite the importance of the thumb to hand function, little is known about the origins of thumb impairment poststroke. Accordingly, the primary purpose of this study was to assess whether thumb flexors have heightened stretch reflexes (SRs) following stroke-induced hand impairment. The secondary purpose was to compar...

journal_title：Journal of neurophysiology

authors： Towles JD,Kamper DG,Rymer WZ

更新日期：2010-10-01 00:00:00

abstract：:Swimming behavior in the marine mollusc Tritonia diomedea is episodic, consisting of a series of alternating dorsal and ventral flexions initiated by a brief sensory stimulus. The swim motor pattern is generated by a network formed of four groups of premotor interneurons: cerebral cell 2 (C2), dorsal swim interneurons...

journal_title：Journal of neurophysiology

authors： Getting PA,Dekin MS

更新日期：1985-02-01 00:00:00

abstract：:Intracellular recordings were performed in Cs-loaded sympathetic preganglionic neurons (SPNs) of the intermediolateral nucleus, identified by antidromic stimulation, in the slice of the T2 or T3 segment of the cat spinal cord. Loading the neurons with Cs resulted in broadening of the action potential, depression of th...

journal_title：Journal of neurophysiology

authors： Yoshimura M,Polosa C,Nishi S

更新日期：1987-05-01 00:00:00

abstract：:1. The electrical responses of nociceptive (N) lateral and N medial neurons of the leech segmental ganglion to mechanical, chemical, and thermal stimulation of the skin were studied in a superfused ganglion-body wall preparation. 2. Mechanical indentation of the skin > 10 mN evoked in both types of cells a sustained d...

journal_title：Journal of neurophysiology

authors： Pastor J,Soria B,Belmonte C

更新日期：1996-06-01 00:00:00

abstract：:The activity of the crayfish abdominal postural motoneurons and their associated neurons (the accessory neuron(s) and the MRO(1)) were examined with the aid of techniques for the analysis of simultaneously recorded spike trains. A means of reliably identifying the spikes of the individual motoneurons based on their re...

journal_title：Journal of neurophysiology

authors： Sokolove PG,Tatton WG

更新日期：1975-03-01 00:00:00

abstract：:1. We investigated the glycine-induced response in ventromedial hypothalamic (VMH) neurons freshly dissociated from 8- to 12-day-old rats using the nystatin and gramicidin perforated patch recording modes. The nystatin-formed pores in the plasma membrane are permeable for both monovalent cations and anions, whereas th...

journal_title：Journal of neurophysiology

authors： Abe Y,Furukawa K,Itoyama Y,Akaike N

更新日期：1994-10-01 00:00:00

abstract：:We used multiunit recording to assess the effect of rotating one eye approximately 90 degrees at about the time of normal eye opening. Rotation of the eye did not alter the topography of the retinal maps onto visual cortex or superior colliculus. The intorted eye drove cells at most recording points in the contralater...

journal_title：Journal of neurophysiology

authors： Gordon B,Moran J,Presson J

更新日期：1983-09-01 00:00:00

abstract：:Long-term depression (LTD) was induced in neocortical layer 5 pyramidal connections by pairing presynaptic firing with subthreshold postsynaptic depolarization (dLTD) or via a spike-timing protocol (tLTD). Like tLTD, dLTD reduced short-term depression and increased the coefficient of variation consistent with a presyn...

journal_title：Journal of neurophysiology

authors： Sjöström PJ,Turrigiano GG,Nelson SB

更新日期：2004-12-01 00:00:00

abstract：:A popular theory is that the cerebellum functions as a timer for clocking motor events (e.g., initiation, termination). Consistent with this idea, cerebellar patients have been reported to show greater deficits during hand movements that repeatedly start and stop (i.e., discontinuous movements) compared with continuou...

journal_title：Journal of neurophysiology

authors： Bo J,Block HJ,Clark JE,Bastian AJ

更新日期：2008-11-01 00:00:00

abstract：:Pain signals threat and initiates motor responses to avoid harm. The transformation of pain into a motor response is thus an essential part of pain. Here, we investigated the neural mechanisms subserving the sensorimotor transformation of pain at the cortical level by using electroencephalography. In a simple reaction...

journal_title：Journal of neurophysiology

authors： Schulz E,Tiemann L,Witkovsky V,Schmidt P,Ploner M

更新日期：2012-08-01 00:00:00

abstract：:We studied the effects of fatigue of the index finger on indices of force variability in discrete and rhythmic accurate force production tasks performed by the index finger and by all four fingers pressing in parallel. An increase in the variance of the force produced by the fatigued index finger was expected. We hypo...

journal_title：Journal of neurophysiology

authors： Singh T,Varadhan SK,Zatsiorsky VM,Latash ML

更新日期：2010-06-01 00:00:00

abstract：:1. Rat dorsal root ganglion (DRG) cell bodies were screened according to action potential (AP) duration, capsaicin sensitivity, expression of IH, IA, and N-, L-, and T-type Ca2+ channel currents. AP duration was measured at half of total amplitude at a membrane potential of -60 mV. Sensitivity to capsaicin was defined...

journal_title：Journal of neurophysiology

authors： Cardenas CG,Del Mar LP,Scroggs RS

更新日期：1995-11-01 00:00:00

abstract：:Previous studies using advanced matrix factorization techniques have shown that the coordination of human voluntary limb movements may be accomplished using combinations of a small number of intermuscular coordination patterns, or muscle synergies. However, the potential use of muscle synergies for isometric force gen...

journal_title：Journal of neurophysiology

authors： Roh J,Rymer WZ,Beer RF

更新日期：2012-04-01 00:00:00

abstract：:Experimental and clinical evidence indicates that pain can affect cognitive processes, but the cortical networks involved in pain-cognition interactions are unclear. In this study, we determined the effect of pain on the activity of cortical areas involved in cognition acting as a whole (i.e., a network). Subjects und...

journal_title：Journal of neurophysiology

authors： Seminowicz DA,Davis KD

更新日期：2007-05-01 00:00:00

abstract：:The spatial arrangement of preferred directions (PDs) in the primary motor cortex has revealed evidence for columnar organization and short-range order. We investigated the large-scale properties of this arrangement. We recorded neural activity at sites on a grid covering a large region of the arm area of the motor co...

journal_title：Journal of neurophysiology

authors： Naselaris T,Merchant H,Amirikian B,Georgopoulos AP

更新日期：2006-12-01 00:00:00

abstract：:We examined the influence of focal cerebellar lesions on working memory (n-back task), gait, and the interaction between working memory and different gait tasks in a dual-task paradigm. The analysis included 17 young patients with chronic focal lesions after cerebellar tumor resection and 17 age-matched controls. Pati...

journal_title：Journal of neurophysiology

authors： Ilg W,Christensen A,Mueller OM,Goericke SL,Giese MA,Timmann D

更新日期：2013-11-01 00:00:00

abstract：:1. Psychophysicists have shown that the intensity and quality of a taste stimulus, as perceived by humans, is modified by including that stimulus in a mixture. Gustatory neurons in the primary taste cortex (anterior insula and frontal operculum) of the cynomolgus macaque are involved with the coding of stimulus intens...

journal_title：Journal of neurophysiology

authors： Plata-Salamán CR,Smith-Swintosky VL,Scott TR

更新日期：1996-06-01 00:00:00