Abstract:
:1. Psychophysicists have shown that the intensity and quality of a taste stimulus, as perceived by humans, is modified by including that stimulus in a mixture. Gustatory neurons in the primary taste cortex (anterior insula and frontal operculum) of the cynomolgus macaque are involved with the coding of stimulus intensity and quality, and so should reflect the impact of these stimulus interactions. 2. We recorded the activity of 48 neurons in primary taste cortex in response to the oral application of each of the four basic stimuli, their six possible dyads, the four triads, and the tetrad of all four. Stimuli were maintained at a constant intensity in all mixtures by increasing their concentrations as the number of components rose. 3. Glucose was the most effective basic stimulus, followed by quinine HCl, NaCl, and HCl. The mean response to dyads was suppressed by 50% from the sum of responses to the two unmixed components. The response to triads was 62% lower than the sum of responses to their three components, and activity evoked by the tetrad was suppressed by 74% from the sum of all four individual responses. Therefore there was nearly total suppression in the sense that the responses to the mixtures were approximately 1/2, 1/3, and 1/4 the sums of responses to two, three, and four components, respectively. 4. Neurons could be divided into four subtypes: those that responded best to each of the basic stimuli. All subtypes except HCl cells were about equally suppressed when their preferred stimulus was included in a mixture. HCl was a particularly ineffective stimulus, such that this subtype responded poorly and so was less susceptible to mixture suppression. 5. Taste quality, as indexed by correlation coefficients among profiles of activity, was quite predictable for dyads. If the mixture included HCl, the profile it generated correlated poorly (about +0.20) with that of HCl and rather well (about +0.60) with that of the other component. If HCl was not included, the mixture's profile correlated about +0.40 with that of each component. 6. The profile generated by the mixture of three stimuli was predictable only if one of the components was HCl. In that case, the triad elicited a profile midway between those of the other two components, i.e., the contribution of HCl was largely ignored. When HCl was not involved, or when all four basic stimuli were combined, the resulting profiles were poorly correlated with those of all basic stimuli. 7. The contribution made by each basic taste to human perception and to the macaque's neurophysiological response was compared for all mixtures. The contribution was often quite similar for human and macaque, but when differences occurred, they were typically due to lower activity from HCl cells in the macaque, a loss that was replaced mainly by larger responses from glucose neurons. 8. The magnitude of responses to mixtures in the macaque taste cortex matches well with expectations from human psychophysical studies. The presumed quality of the response to mixtures is also similar, except that HCl is less effective in monkeys and sugars more so.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Plata-Salamán CR,Smith-Swintosky VL,Scott TRdoi
10.1152/jn.1996.75.6.2369subject
Has Abstractpub_date
1996-06-01 00:00:00pages
2369-79issue
6eissn
0022-3077issn
1522-1598journal_volume
75pub_type
杂志文章abstract::Odor responses of neocortical neurons in rabbits under light pentobarbital anesthesia were studied in a restricted area in the lateral half of the prefrontal cortex close to the frontal pole. A preevent cumulative sum chart provided a visual display of the change in unit discharge rate following each odor stimulation,...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.52.4.638
更新日期:1984-10-01 00:00:00
abstract::N-methyl-d-aspartate receptors (NMDARs) are fundamental coincidence detectors of synaptic activity necessary for the induction of synaptic plasticity and synapse stability. Adjusting NMDAR synaptic content, whether by receptor insertion or lateral diffusion between extrasynaptic and synaptic compartments, could play a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00458.2019
更新日期:2020-03-01 00:00:00
abstract::1. We examined the activity of thermally sensitive trigeminothalamic neurons and nonprojection neurons in the medullary dorsal horn (trigeminal nucleus caudalis) in three monkeys performing thermal and visual detection tasks. 2. An examination of neuronal stimulus-response functions, obtained during thermal-detection ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.62.2.437
更新日期:1989-08-01 00:00:00
abstract::Control of myoelectric prostheses and brain-machine interfaces requires learning abstract neuromotor transformations. To investigate the mechanisms underlying this ability, we trained subjects to move a two-dimensional cursor using a myoelectric-controlled interface. With the upper limb immobilized, an electromyogram ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90614.2008
更新日期:2008-10-01 00:00:00
abstract::The responses of spinothalamic tract neurons were studied by extra- and intracellular recordings from the lumbosacral spinal cord in anesthetized rhesus monkeys (Macaca mulatta). The neurons were identified by antidromic activation from the contralateral diencephalon. They were then classified by the mildest form of m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.1.132
更新日期:1975-01-01 00:00:00
abstract::Intracellular recording from lumbar motoneurons and extracellular recording from ventral roots of the neonatal rat isolated spinal cord were used to study the mechanisms responsible for the excitation mediated by NK3 tachykinin receptors. The selective NK3 agonists senktide or [MePhe7]neurokinin B induced a slow depol...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.6.2939
更新日期:2001-12-01 00:00:00
abstract::To clarify the role of cholinergic inputs to the intermediate layer of the superior colliculus (SC), we examined the effect of microinjection of nicotine into the SC on visually guided saccades in macaque monkeys. After injection of 0.4-2 microl of 1-100 mM nicotine into the SC, frequency of extremely short latency sa...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.3.1642
更新日期:1999-09-01 00:00:00
abstract::1. The aim of this study was to examine the nature of motoneuron firing-rate modulation in type-identified motor units during smoothly graded contractions of the cat medial gastrocnemius (MG) muscle evoked by stimulation of the mesencephalic locomotor region (MLR). Motoneuron discharge patterns, firing rates, and the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.1.38
更新日期:1996-01-01 00:00:00
abstract::Because smooth-pursuit eye movements (SPEM) can be executed only in the presence of a moving target, it has been difficult to attribute the neuronal activity observed during the execution of these eye movements to either sensory processing or to motor preparation or execution. Previously, we showed that rhesus monkeys...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00272.2003
更新日期:2003-09-01 00:00:00
abstract::Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now descr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00174.2016
更新日期:2016-07-01 00:00:00
abstract::1. Whole cell patch-clamp recordings were made of low-voltage-activated (LVA) calcium (Ca2+) currents using 2 mM barium (Ba2+) as charge carrier. Acutely dissociated neurons from medial septum (MS) and the nucleus of the diagonal band (nDB) were examined in young adult (1-3 mo) and aged (24-26 mo) Fischer 344 rats. 2....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.2.876
更新日期:1995-08-01 00:00:00
abstract::The cerebellum was historically considered a brain region dedicated to motor control, but it has become clear that it also contributes to sensory processing, particularly when sensory discrimination is required. Prior work, for example, has demonstrated a cerebellar contribution to sensory discrimination in the visual...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00763.2015
更新日期:2016-05-01 00:00:00
abstract::The neurons in the intermediate layers of the monkey superior colliculus (SC) that discharge before saccadic eye movements can be divided into at least two types, burst and buildup neurons, and the differences in their characteristics are compatible with different functional contributions of the two cell types. It has...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.4.2082
更新日期:1998-04-01 00:00:00
abstract::Action-potential propagation into the axon terminals of olfactory receptor cells was measured with the use of voltage-sensitive dye imaging in the isolated spiny lobster brain. Conditioning shocks to the olfactory nerve, known to cause long-lasting suppression of olfactory lobe neurons, allowed the selective imaging o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.2.1011
更新日期:1998-08-01 00:00:00
abstract::Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K+ current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K+ ions were investigated in vitro with the whole cell patch-cla...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.4.1749
更新日期:1999-04-01 00:00:00
abstract::Astrocyte-derived lactate supports pathologically enhanced neuronal metabolism, but its role under physiological conditions is still a matter of debate. Here, we determined the contribution of astrocytic neuronal lactate shuttle for maintenance of ion homeostasis and energy metabolism. We tested for the effects of α-c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00327.2016
更新日期:2016-11-01 00:00:00
abstract::1. Neuron-specific expression of alternately spliced exons of the gene encoding the Phe-Met-Arg-Phe-NH2 (FMRFamide) family of neuropeptides and the role of encoded peptides in synaptic transmission were examined in an identified cardiorespiratory interneuron, the visceral white interneuron (VWI), in the snail Lymnaea....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.3.915
更新日期:1993-03-01 00:00:00
abstract::Rats typically employ 4- to 12-Hz "whisking" movements of their vibrissae during tactile exploration. The intentional sampling of signals in this frequency range suggests that neural processing of tactile information may be differentially engaged in this bandwidth. We examined action potential responses in rat primary...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01158.2002
更新日期:2003-09-01 00:00:00
abstract::Parkinson's disease is associated with altered neural activity in the motor cortex. Chronic high-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in suppressing parkinsonian motor symptoms and modulates cortical activity. However, the anatomical pathways responsible for STN DBS-medi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00862.2017
更新日期:2018-08-01 00:00:00
abstract::The McGurk illusion is a prominent example of audiovisual speech perception and the influence that visual stimuli can have on auditory perception. In this illusion, a visual speech stimulus influences the perception of an incongruent auditory stimulus, resulting in a fused novel percept. In this high-density electroen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00783.2014
更新日期:2015-04-01 00:00:00
abstract::Histamine is a known secretagogue in adrenal chromaffin cells. Activation of G-protein linked H(1) receptors stimulates phospholipase C, which generates inositol trisphosphate leading to release of intracellular calcium stores and stimulation of calcium influx through store operated and other channels. This calcium le...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.3.1435
更新日期:2000-03-01 00:00:00
abstract::To investigate the nature of the visuomotor transformation, previous studies have used pointing tasks and examined how adaptation to a spatially localized mismatch between vision and proprioception generalizes across the workspace. Whereas some studies found extensive spatial generalization of single-point remapping, ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00507.2007
更新日期:2008-01-01 00:00:00
abstract::1. We have studied the physiology of sensory neurons innervating skin of the rat hindlimb, in three groups of animals: 1) normal animals; 2) animals in which the sural nerve (Sn) had regenerated to its original cutaneous target; and 3) animals in which the gastrocnemius muscle nerve (Gn) had previously been cut and cr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.66.4.1205
更新日期:1991-10-01 00:00:00
abstract::1. The question of whether active uptake limits the duration of action of the inhibitory transmitter glycine has been addressed in vivo at inhibitory synapses on the goldfish Mauthner (M) cell. The kinetics of inhibitory postsynaptic potentials and inhibitory postsynaptic currents (IPSCs) evoked antidromically and by ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.4.1738
更新日期:1996-04-01 00:00:00
abstract::We observed endocytosis in real time in stimulated frog motor nerve terminals by imaging the growth of large membrane infoldings labeled with a low concentration of FM dye. The spatial and temporal information made available by these experiments allowed us to image several new aspects of this synaptic vesicle recyclin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00123.2011
更新日期:2011-08-01 00:00:00
abstract::A series of studies were carried out to investigate the role of the cerebellar flocculus and ventral paraflocculus in the ability to voluntarily cancel the vestibuloocular reflex (VOR). Squirrel monkeys were trained to pursue moving visual targets and to fixate a head stationary or earth stationary target during passi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.3.1599
更新日期:2000-09-01 00:00:00
abstract::1. Whole cell current-clamp recordings show that odors not only depolarize but may also hyperpolarize lobster olfactory receptor cells. Odor-evoked hyperpolarizations occurred in 36% of 178 receptor cells examined. Cell-attached recordings of action potentials followed by current-clamp recordings in the same cell indi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.3.446
更新日期:1991-03-01 00:00:00
abstract::Single, teased fiber recordings were made from the decentralized right cervical vagus nerve (hyponodal) of the rat. A total of 67 afferent fibers that responded to gastric distension (GD) were studied: 9 fibers were stimulated by phasic balloon GD, 58 by more natural fluid GD. All balloon GD-responsive fibers had rest...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.5.2210
更新日期:1999-11-01 00:00:00
abstract::The potassium-chloride cotransporter 2 (KCC2) plays a role in epileptiform synchronization, but it remains unclear how it influences such a process. Here, we used tetrode recordings in the in vitro rat entorhinal cortex (EC) to analyze the effects of the KCC2 antagonist VU0463271 on 4-aminopyridine (4AP)-induced ictal...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00266.2019
更新日期:2019-09-01 00:00:00
abstract::The centre médian-parafascicular (CM-Pf) complex is located at the posterior intralaminar nuclei of the thalamus and forms part of the nonspecific thalamocortical projection system and the internal circuit of the basal ganglia. However, the functional roles of this complex remain to be fully elucidated. Here we have e...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.87.6.3090
更新日期:2002-06-01 00:00:00