Lack of hypertonia in thumb muscles after stroke.

Abstract:

:Despite the importance of the thumb to hand function, little is known about the origins of thumb impairment poststroke. Accordingly, the primary purpose of this study was to assess whether thumb flexors have heightened stretch reflexes (SRs) following stroke-induced hand impairment. The secondary purpose was to compare SR characteristics of thumb flexors in relation to those of finger flexors since it is unclear whether SR properties of both muscle groups are similarly affected poststroke. Stretch reflexes in thumb and finger flexors were assessed at rest on the paretic side in each of 12 individuals with chronic, severe, stroke-induced hand impairment and in the dominant thumb in each of eight control subjects also at rest. Muscle activity and passive joint flexion torques were measured during imposed slow (SS) and fast stretches (FS) of the flexors that span the metacarpophalangeal joints. Putative spasticity was then quantified in terms of the peak difference between FS and SS joint torques and electromyographic changes. For both the hemiparetic and control groups, the mean normalized peak torque differences (PTDs) measured in thumb flexors were statistically indistinguishable (P = 0.57). In both groups, flexor muscles were primarily unresponsive to rapid stretching. For 10 of 12 hemiparetic subjects, PTDs in thumb flexors were less than those in finger flexors (P = 0.03). Paretic finger flexor muscle reflex activity was consistently elicited during rapid stretching. These results may reflect an important difference between thumb and finger flexors relating to properties of the involved muscle afferents and spinal motoneurons.

journal_name

J Neurophysiol

authors

Towles JD,Kamper DG,Rymer WZ

doi

10.1152/jn.00423.2009

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

2139-46

issue

4

eissn

0022-3077

issn

1522-1598

pii

jn.00423.2009

journal_volume

104

pub_type

杂志文章
  • Neurotransmitter inputs to directionally sensitive turtle retinal ganglion cells.

    abstract::Synaptic drugs were superfused into turtle eyecup preparation while recording extracellularly from directionally sensitive (DS) retinal ganglion cells. As in previous experiments in intact rabbit retina, both picrotoxin (a GABA antagonist) and physostigmine [an acetylcholine (ACh) potentiator] reduced or eliminated th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.54.5.1123

    authors: Ariel M,Adolph AR

    更新日期:1985-11-01 00:00:00

  • Effect of stochastic synaptic and dendritic dynamics on synaptic plasticity in visual cortex and hippocampus.

    abstract::Various forms of synaptic plasticity, including spike timing-dependent plasticity, can be accounted for by calcium-dependent models of synaptic plasticity. However, recent results in which synaptic plasticity is induced by multi-spike protocols cannot simply be accounted for by linear superposition of plasticity due t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00895.2006

    authors: Cai Y,Gavornik JP,Cooper LN,Yeung LC,Shouval HZ

    更新日期:2007-01-01 00:00:00

  • Role of visual experience in activating critical period in cat visual cortex.

    abstract::Cats were reared in total darkness from birth until 4-5 mo of age (DR cats, n = 7) or with very brief visual experience (1 or 2 days) during an otherwise similar period of dark rearing [DR(1) cats, n = 3; DR(2) cats, n = 7]. Single-cell recordings were made in area 17 of visual cortex at the end of this rearing period...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.2.572

    authors: Mower GD,Christen WG

    更新日期:1985-02-01 00:00:00

  • Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.

    abstract::The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00067.2017

    authors: Chen LF,Zhou AS,West AE

    更新日期:2017-08-01 00:00:00

  • Avian vestibuloocular reflex: adaptive plasticity and developmental changes.

    abstract::1. This study demonstrates plasticity of the vestibuloocular reflex (VOR) in chickens and compares it to that of other species and to that of newly hatched chicks. Adaptive changes in the VOR were induced by subjecting the animals to combinations of visual and vestibular stimuli that simulated the effect of the VOR be...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.48.4.952

    authors: Wallman J,Velez J,Weinstein B,Green AE

    更新日期:1982-10-01 00:00:00

  • Neural network based on the input organization of an identified neuron signaling impending collision.

    abstract::1. We describe a four-layered neural network (Fig. 1), based on the input organization of a collision signaling neuron in the visual system of the locust, the lobula giant movement detector (LGMD). The 250 photoreceptors ("P" units) in layer 1 are excited by any change in illumination, generated when an image edge pas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.3.967

    authors: Rind FC,Bramwell DI

    更新日期:1996-03-01 00:00:00

  • Spatial attention enhances the selective integration of activity from area MT.

    abstract::Distinguishing which of the many proposed neural mechanisms of spatial attention actually underlies behavioral improvements in visually guided tasks has been difficult. One attractive hypothesis is that attention allows downstream neural circuits to selectively integrate responses from the most informative sensory neu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00949.2011

    authors: Masse NY,Herrington TM,Cook EP

    更新日期:2012-09-01 00:00:00

  • Behavioral inspiratory inhibition: inactivated and activated respiratory cells.

    abstract::1. Eleven adult cats were trained to stop inspiration in response to a conditioning stimulus. The conditioning stimuli were presented at the onset of inspiration at intervals of approximately 20-30 s. Intratracheal pressures, diaphragmatic activity, and the extracellular activity of single medullary respiratory neuron...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.62.5.1069

    authors: Orem J

    更新日期:1989-11-01 00:00:00

  • ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons.

    abstract::The acid-sensing ion channels (ASICs) form cation channels that are transiently activated by extracellular protons. They are expressed in dorsal root ganglia (DRG) neurons and in the periphery where they play a function in nociception and mechanosensation. Previous studies showed that FMRFamide and related peptides po...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00707.2002

    authors: Xie J,Price MP,Wemmie JA,Askwith CC,Welsh MJ

    更新日期:2003-05-01 00:00:00

  • Velocity selectivity in the cat visual system. II. Independence from interactions between different loci.

    abstract::To investigate the dependence of velocity characteristics on spatiotemporal interactions the velocity selectivity of 15 geniculate and 72 cortical cells (areas 17 and 18) was examined with light and dark bars before and after masking all but the most sensitive part of the receptive field. The use of a 0.3 degree windo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.54.4.1050

    authors: Duysens J,Orban GA,Cremieux J

    更新日期:1985-10-01 00:00:00

  • Spatiotemporal distribution of intracellular calcium transients during epileptiform activity in guinea pig hippocampal slices.

    abstract::Calcium ions are known to play an important role in epileptogenesis. Although there is clear evidence for increased neuronal calcium influx during epileptiform potentials, direct measurements of the corresponding intracellular calcium transients are rare and the origin of calcium influx is not known. Therefore the spa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.1.491

    authors: Albowitz B,König P,Kuhnt U

    更新日期:1997-01-01 00:00:00

  • Unilateral electrical stimulation of rat locus coeruleus elicits bilateral response of norepinephrine neurons and sustained activation of medial prefrontal cortex.

    abstract::The brain stem nucleus locus coeruleus (LC) is thought to modulate cortical excitability by norepinephrine (NE) release in LC forebrain targets. The effects of LC burst discharge, typically evoked by a strong excitatory input, on cortical ongoing activity are poorly understood. To address this question, we combined di...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00920.2013

    authors: Marzo A,Totah NK,Neves RM,Logothetis NK,Eschenko O

    更新日期:2014-06-15 00:00:00

  • Neural ensemble coding in inferior temporal cortex.

    abstract::1. Isolated, single-neuron extracellular potentials were recorded sequentially in area TE of the inferior temporal cortex (IT) of two macaque monkeys (n = 58 and n = 41 neurons). Data were obtained while the animals were performing a paired-associate task. The task utilized five stimuli and eight stimulus pairings (4 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.6.2325

    authors: Gochin PM,Colombo M,Dorfman GA,Gerstein GL,Gross CG

    更新日期:1994-06-01 00:00:00

  • The open- and closed-loop gain-characteristics of the cone/horizontal cell synapse in goldfish retina.

    abstract::Under constant light-adapted conditions, vision seems to be rather linear. However, the processes underlying the synaptic transmission between cones and second-order neurons (bipolar cells and horizontal cells) are highly nonlinear. In this paper, the gain-characteristics of the transmission from cones to horizontal c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.3.1256

    authors: Kraaij DA,Spekreijse H,Kamermans M

    更新日期:2000-09-01 00:00:00

  • Frequency organization of delay-sensitive neurons in the auditory cortex of the FM bat, Myotis lucifugus.

    abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.366

    authors: Paschal WG,Wong D

    更新日期:1994-07-01 00:00:00

  • The effects of microstimulation of the dorsomedial frontal cortex on saccade latency.

    abstract::Neural regions in the dorsomedial frontal cortex (DMFC), including the supplementary eye field (SEF) and the presupplementary motor area (pre-SMA), are likely candidates for generating top-down control of saccade target selection. To investigate this, we applied electrical microstimulation to these structures while sa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00119.2007

    authors: Yang SN,Heinen SJ,Missal M

    更新日期:2008-04-01 00:00:00

  • Depolarizing actions of GABA and glycine on amphibian retinal horizontal cells.

    abstract::1. The effects of inhibitory amino acid transmitters on horizontal cells in the superfused amphibian retina were studied by the use of conventional intracellular recording techniques. 2. Gamma-aminobutyric acid (GABA) caused a calcium-independent depolarization of horizontal cells in mud puppy and tiger salamander. Th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.3.680

    authors: Stockton RA,Slaughter MM

    更新日期:1991-03-01 00:00:00

  • Afterdepolarization mechanism in the in vitro, cesium-loaded, sympathetic preganglionic neuron of the cat.

    abstract::Intracellular recordings were performed in Cs-loaded sympathetic preganglionic neurons (SPNs) of the intermediolateral nucleus, identified by antidromic stimulation, in the slice of the T2 or T3 segment of the cat spinal cord. Loading the neurons with Cs resulted in broadening of the action potential, depression of th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.5.1325

    authors: Yoshimura M,Polosa C,Nishi S

    更新日期:1987-05-01 00:00:00

  • Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses.

    abstract::Activation of metabotropic glutamate receptors (mGluRs), which are coupled to G proteins, has important roles in certain forms of synaptic plasticity including corticostriatal long-term depression (LTD). In the present study, extracellular field potential and whole cell voltage-clamp recording techniques were used to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.5.2405

    authors: Sung KW,Choi S,Lovinger DM

    更新日期:2001-11-01 00:00:00

  • Two neuropeptides colocalized in a command-like neuron use distinct mechanisms to enhance its fast synaptic connection.

    abstract::In many neurons more than one peptide is colocalized with a classical neurotransmitter. The functional consequence of such an arrangement has been rarely investigated. Here, within the feeding circuit of Aplysia, we investigate at a single synapse the actions of two modulatory neuropeptides that are present in a choli...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00358.2003

    authors: Koh HY,Vilim FS,Jing J,Weiss KR

    更新日期:2003-09-01 00:00:00

  • Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons.

    abstract::Using whole cell patch-clamp recordings, we examined the effect of colchicine, a microtubule disrupter, on the properties of glycine receptors (GlyRs) in cultured spinal cord neurons. Confocal microscopy revealed that colchicine treatment effectively altered microtubule bundles and neuronal morphology. Application of ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00455.2001

    authors: van Zundert B,Alvarez FJ,Yevenes GE,Cárcamo JG,Vera JC,Aguayo LG

    更新日期:2002-01-01 00:00:00

  • Structural modularity and grid activity in the medial entorhinal cortex.

    abstract::Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question. Fundamental similarities in micro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00574.2017

    authors: Naumann RK,Preston-Ferrer P,Brecht M,Burgalossi A

    更新日期:2018-06-01 00:00:00

  • Conditioned eyelid movement is not a blink.

    abstract::Based on kinematic properties and distinct substrates, there are different classes of eyelid movement described as eyeblinks. We investigate whether the eyelid movements made in response to a conditioned stimulus (CS) are a category of eyelid movements distinct from blinks. Human subjects received 60 trials of classic...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00631.2009

    authors: Schade Powers A,Coburn-Litvak P,Evinger C

    更新日期:2010-02-01 00:00:00

  • Mechanisms of onset responses in octopus cells of the cochlear nucleus: implications of a model.

    abstract::The octopus cells of the posteroventral cochlear nucleus receive inputs from auditory-nerve fibers and form one of the major ascending auditory pathways. They respond to acoustic and electrical stimulation transiently and are believed to carry temporal information in the precise timing of their action potentials. The ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.2.872

    authors: Cai Y,Walsh EJ,McGee J

    更新日期:1997-08-01 00:00:00

  • Potassium currents in octopus cells of the mammalian cochlear nucleus.

    abstract::Octopus cells in the posteroventral cochlear nucleus (PVCN) of mammals are biophysically specialized to detect coincident firing in the population of auditory nerve fibers that provide their synaptic input and to convey its occurrence with temporal precision. The precision in the timing of action potentials depends on...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.5.2299

    authors: Bal R,Oertel D

    更新日期:2001-11-01 00:00:00

  • Facilitation at the lobster neuromuscular junction: a stimulus-dependent mobilization model.

    abstract::Frequency facilitation is a process whereby neurosecretion increases as a function of stimulation frequency during repetitive synaptic activity. To examine the physiological basis underlying facilitation, we have estimated the frequency dependence of the synaptic parameters n (number of units capable of responding to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.1.417

    authors: Worden MK,Bykhovskaia M,Hackett JT

    更新日期:1997-07-01 00:00:00

  • Responses of medullary reticulospinal neurons to sinusoidal stimulation of labyrinth receptors in decerebrate cat.

    abstract::The electrical activity of 168 individual neurons located in the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis, and ventralis, has been recorded in precollicular decerebrate cats during sinusoidal tilt about the longitudinal axis of the whole...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.5.1059

    authors: Manzoni D,Pompeiano O,Stampacchia G,Srivastava UC

    更新日期:1983-11-01 00:00:00

  • Sensory processing in a thermal afferent pathway.

    abstract::Extracellular recordings were made from cold-receptive afferent fibers in the trigeminal ganglion of rats anesthetized with halothane. By applying a standardized series of steady or changing temperatures to the receptive fields, we recorded the static and dynamic responses of the afferents. Comparable recordings were ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.2.429

    authors: Davies SN,Goldsmith GE,Hellon RF,Mitchell D

    更新日期:1985-02-01 00:00:00

  • Adrenoreceptor modulation of oromotor pathways in the rat medulla.

    abstract::Regulation of feeding behavior involves the integration of multiple physiological and neurological pathways that control both nutrient-seeking and consummatory behaviors. The consummatory phase of ingestion includes stereotyped oromotor movements of the tongue and jaw that are controlled through brain stem pathways. T...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00091.2014

    authors: Nasse JS,Travers JB

    更新日期:2014-08-01 00:00:00

  • Flow and thermal responses of aortic baroreceptors.

    abstract::1. The aims of this study were 1) to determine whether the impulse activity in rabbit aortic baroreceptors (BRs) was influenced by changes in nonpulsatile flow through the aortic lumen and 2) to examine the BR and aortic arch responses to changes in temperature. 2. An in vitro aortic arch-aortic nerve preparation was ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2596

    authors: Munch PA

    更新日期:1993-12-01 00:00:00