Effect of stochastic synaptic and dendritic dynamics on synaptic plasticity in visual cortex and hippocampus.

Abstract:

:Various forms of synaptic plasticity, including spike timing-dependent plasticity, can be accounted for by calcium-dependent models of synaptic plasticity. However, recent results in which synaptic plasticity is induced by multi-spike protocols cannot simply be accounted for by linear superposition of plasticity due to spike pairs or by existing calcium-dependent models. In this paper, we show that multi-spike protocols can be accounted for if, in addition to the dynamics of back-propagating action potentials, stochastic synaptic dynamics are taken into account. We show that a stochastic implementation can account for the data better than a deterministic implementation and is also more robust. Our results demonstrate that differences between experimental results obtained in hippocampus and visual cortex can be accounted for by the different synaptic and dendritic dynamics in these two systems.

journal_name

J Neurophysiol

authors

Cai Y,Gavornik JP,Cooper LN,Yeung LC,Shouval HZ

doi

10.1152/jn.00895.2006

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

375-86

issue

1

eissn

0022-3077

issn

1522-1598

pii

00895.2006

journal_volume

97

pub_type

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