Abstract:
:Under constant light-adapted conditions, vision seems to be rather linear. However, the processes underlying the synaptic transmission between cones and second-order neurons (bipolar cells and horizontal cells) are highly nonlinear. In this paper, the gain-characteristics of the transmission from cones to horizontal cells and from horizontal cells to cones are determined with and without negative feedback from horizontal cells to cones. It is shown that 1) the gain-characteristic from cones to horizontal cells is strongly nonlinear without feedback from horizontal cells, 2) the gain-characteristic between cones and horizontal cells becomes linear when feedback is active, and 3) horizontal cells feed back to cones via a linear mechanism. In a quantitative analysis, it will be shown that negative feedback linearizes the synaptic transmission between cones and horizontal cells. The physiological consequences are discussed.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Kraaij DA,Spekreijse H,Kamermans Mdoi
10.1152/jn.2000.84.3.1256subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1256-65issue
3eissn
0022-3077issn
1522-1598journal_volume
84pub_type
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