Abstract:
:Metabotropic receptors modulate numerous cellular processes by intracellular Ca2+ signaling, but less is known about their role in regulating mitochondrial metabolic function within the CNS. In this study, we demonstrate in area CA3 of rat organotypic hippocampal slice cultures that glutamatergic, serotonergic, and muscarinic metabotropic receptor ligands, namely trans-azetidine-2,4-dicarboxylic acid, alpha-methyl-5-hydroxytryptamine, and carbachol, transiently increase mitochondrial Ca2+ concentration ([Ca2+]m) as recorded by changes in Rhod-2 fluorescence, stimulate mitochondrial oxidative metabolism as revealed by elevations in NAD(P)H fluorescence, and induce K+ outward currents as monitored by rapid increases in extracellular K+ concentration ([K+]o). Carbachol (1-1,000 microM) elevated NAD(P)H fluorescence by journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract::Synchronous neural oscillations are found throughout the brain and are thought to contribute to neural coding and the propagation of activity. Several proposed mechanisms of synchronization have gained support through combined theoretical and experimental investigation, including mechanisms based on coupling and corre...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00362.2012
更新日期:2012-10-01 00:00:00
abstract::It is well established that orderly patterns of motor neuron activity, muscle recruitment, and limb movement are generated in chicks during motility by embryonic day (E)9, the midpoint in embryonic development. However, our recent work suggests that some attributes of motility, such as the rhythm of repetitive limb mo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00393.2003
更新日期:2003-09-01 00:00:00
abstract::To gain further insight into the neural mechanisms for different forms of quadrupedal walking, data on postural orientation, hindlimb kinematics, and motor patterns were assessed for four grades of downslope walking, from 25% (14 degrees slope) to 100% (45 degrees), and compared with data from level and downslope walk...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.4.1702
更新日期:1998-04-01 00:00:00
abstract::1. Red rod photoreceptors in the toad retina, which are known to be physiologically coupled, were examined for interreceptor contacts. 2. A dense network of large gap junctions was found between the inner segments of red rods, this being the only specialized site of contact that was observed between rods. Each red rod...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1979.42.1.292
更新日期:1979-01-01 00:00:00
abstract::Fast-spiking (FS) interneurons provide the main route of feedforward inhibition from cortex to spiny projection neurons in the striatum. A steep current-firing frequency curve and a dense local axonal arbor suggest that even small excitatory inputs could translate into powerful feedforward inhibition, although such an...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00063.2005
更新日期:2006-01-01 00:00:00
abstract::N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing schizophrenia-like symptoms. Here we show that the amino acid homocysteine (HCY), which is increased in the blood of schizophrenia patients, reduces ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00809.2012
更新日期:2013-10-01 00:00:00
abstract::1. We recorded local field potentials in the parafoveal representation in the primary visual cortex of anesthetized and paralyzed macaque monkeys with a multicontact electrode that provided for sampling of neural activity at 16 sites along a vertical penetration. Differential recordings at adjacent contacts were trans...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.5.2151
更新日期:1994-11-01 00:00:00
abstract::1. Visual attention is often profoundly disturbed in humans after damage to the cortex of the posterior parietal lobe, particularly of the minor hemisphere, with some patients being totally unaware of visual stimuli in the hemifield of extrapersonal space contralateral to the cortical damage. This severe form of visua...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.61.1.74
更新日期:1989-01-01 00:00:00
abstract::1. We investigated gamma-aminobutyric acid (GABA) receptors using thin slice patch-clamp techniques in the swellings along axons of posterior pituitary nerve terminals. 2. Activation of the nerve terminal GABAA receptor induced a mean conductance change of 1.5 nS. Normalizing to area gave a mean conductance density of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.3.1135
更新日期:1995-03-01 00:00:00
abstract::Electrophysiological properties of the ventral giant axon in the abdominal nerve cord of the cockroach were studied by recording intracellular potentials following partial or complete block of the K+ conductance. When the K+ conductance was completely blocked by tetraethylammonium (TEA) and 3,4-diaminopyridine, the in...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.54.5.1087
更新日期:1985-11-01 00:00:00
abstract::When sudden environmental stimuli signaling threat occur in the portion of space surrounding the body (defensive peripersonal space), defensive responses are enhanced. Recently Bisio et al. (Bisio A, Garbarini F, Biggio M, Fossataro C, Ruggeri P, Bove M. J Neurosci 37: 2415-2424, 2017) showed that a marker of defensiv...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00316.2017
更新日期:2017-10-01 00:00:00
abstract::1. The functional organization of interneurons in spinal laminae III-V was studied in an isolated preparation of hamster dorsal horn with sensory innervation from an excised skin patch. Morphological details of 40 neurons were visualized by intracellular injection of horseradish peroxidase. Active and passive membrane...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.5.1746
更新日期:1992-11-01 00:00:00
abstract::1. We present a new mathematical description of the complete distribution of electrical responses to stochastic synaptic activity (quantal analysis) that is intended as a model of experiments on central neuronal synapses. Unlike previous treatments, this distribution is calculated for each instant after the release of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.3.1395
更新日期:1994-09-01 00:00:00
abstract::Action observation activates brain regions involved in sensory-motor control. Recent research has shown that action observation can also facilitate motor learning; observing a tutor undergoing motor learning results in functional plasticity within the motor system and gains in subsequent motor performance. However, th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00313.2018
更新日期:2018-12-01 00:00:00
abstract::We have addressed the source and nature of the persistent neural activity that bridges the stimulus-free gap between the conditioned stimulus (CS) and unconditioned stimulus (US) during trace eyelid conditioning. Previous work has demonstrated that this persistent activity is necessary for trace eyelid conditioning: C...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00689.2011
更新日期:2012-01-01 00:00:00
abstract::The nucleus tractus solitarii (nTS) is the initial central termination site for visceral afferents and is important for modulation and integration of multiple reflexes including cardiorespiratory reflexes. Glutamate is the primary excitatory neurotransmitter in the nTS and is removed from the extracellular milieu by e...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01054.2015
更新日期:2016-03-01 00:00:00
abstract::1. Nonlinearity of spatial summation in areas 17 and 18 of cat visual cortex was compared with the type of spatial nonlinearity that differentiates X and Y cells in the lateral geniculate nucleus (LGN) and retina. The comparisons were made to examine to what extent the information from X and Y cells may remain separat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.66.5.1667
更新日期:1991-11-01 00:00:00
abstract::1. Responses to innocuous and noxious mechanical and thermal stimuli were recorded from 90 neurons in the gracile nucleus of anesthetized cats. Cells were tested by antidromic activation for projections to the contralateral ventrobasal thalamus. 2. Cells were characterized broadly by their responses to mechanical stim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.3.818
更新日期:1992-09-01 00:00:00
abstract::We recently reported evidence indicating that selective attention is deployed to a target location in a multi-object display, when the target event (a change of one of the objects) is preceded by subliminal flicker in the gamma range. However, concerns have been raised regarding the stimuli used in this study and the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00357.2010
更新日期:2011-02-01 00:00:00
abstract::If a laterally displacing prism is placed in front of one eye of a person or monkey with the other eye occluded, they initially will point to one side of a target that is located directly in front of them. Normally, people and monkeys adapt easily to the displaced vision and correct their aim after a few trials. If th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.4.1960
更新日期:1999-04-01 00:00:00
abstract::The group I metabotropic glutamate receptor (mGluR) subtype, mGluR1, is highly expressed on the apical dendrites of olfactory bulb mitral cells and thus may be activated by glutamate released from olfactory nerve (ON) terminals. Previous studies have shown that mGluR1 agonists directly excite mitral cells. In the pres...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01150.2005
更新日期:2006-04-01 00:00:00
abstract::Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists block...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01228.2004
更新日期:2005-06-01 00:00:00
abstract::Neuroimaging studies in stroke survivors have suggested that adaptive plasticity occurs following stroke. However, the complex temporal dynamics of neural reorganization after injury make the interpretation of functional imaging studies equivocal. In the present study in adult squirrel monkeys, intracortical microstim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90447.2008
更新日期:2008-09-01 00:00:00
abstract::The responses of low-frequency, primary-like neurons of the ventral cochlear nucleus were measured as a function of signal-to-noise ratio for gated tonal signals and noise maskers that were varied in bandwidth and duration. For a given signal-to-noise ratio, each of the maskers is known to produce the same amount of m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.6.1516
更新日期:1983-12-01 00:00:00
abstract::Motor networks such as the pyloric network of the stomatogastric ganglion often require descending neuromodulatory inputs to initiate, regulate, and modulate their activity and their synaptic connectivity to manifest physiologically appropriate output. Prolonged removal of these descending inputs often results in a co...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00183.2012
更新日期:2012-08-01 00:00:00
abstract::Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00047.2015
更新日期:2015-08-01 00:00:00
abstract::1. The sensorimotor synapse of Aplysia expresses various shortlasting changes in synaptic efficacy including homosynaptic depression (HSD) and heterosynaptic facilitation by serotonin (5-HT) either at nondepressed sensory neuron (SN) synaptic connections or at SN synaptic connections first depressed by HSD. We examine...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.4.2250
更新日期:1996-10-01 00:00:00
abstract::In the cochlear nucleus (CN) of awake mustached bats, single- and two-tone stimuli were used to examine how responses in major CN subdivisions contribute to spectrotemporal integrative features in the inferior colliculus (IC). Across CN subdivisions, the proportional representation of frequencies differed. A striking ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00634.2005
更新日期:2006-01-01 00:00:00
abstract::The human visual system is remarkably sensitive to environmental regularities, which can facilitate behavioral performance when sensory events conform to past experience. The point at which prior knowledge is integrated during visual perception is unclear, particularly for incidentally learned associations. One possib...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00733.2017
更新日期:2018-04-01 00:00:00
abstract::In this study we present further evidence supporting the reciprocal nature of output effects on forearm flexor and extensor muscles from single corticomotoneuronal (CM) cells. Spike-triggered averaging of rectified EMG activity was used to test the output effects of 105 motor cortex cells in two rhesus monkeys (Macaca...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.53.4.959
更新日期:1985-04-01 00:00:00