Metabotropic receptor-mediated Ca2+ signaling elevates mitochondrial Ca2+ and stimulates oxidative metabolism in hippocampal slice cultures.

Abstract:

:Metabotropic receptors modulate numerous cellular processes by intracellular Ca2+ signaling, but less is known about their role in regulating mitochondrial metabolic function within the CNS. In this study, we demonstrate in area CA3 of rat organotypic hippocampal slice cultures that glutamatergic, serotonergic, and muscarinic metabotropic receptor ligands, namely trans-azetidine-2,4-dicarboxylic acid, alpha-methyl-5-hydroxytryptamine, and carbachol, transiently increase mitochondrial Ca2+ concentration ([Ca2+]m) as recorded by changes in Rhod-2 fluorescence, stimulate mitochondrial oxidative metabolism as revealed by elevations in NAD(P)H fluorescence, and induce K+ outward currents as monitored by rapid increases in extracellular K+ concentration ([K+]o). Carbachol (1-1,000 microM) elevated NAD(P)H fluorescence by

journal_name

J Neurophysiol

authors

Kann O,Kovács R,Heinemann U

doi

10.1152/jn.00042.2003

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

613-21

issue

2

eissn

0022-3077

issn

1522-1598

pii

00042.2003

journal_volume

90

pub_type

杂志文章
  • Intrinsic heterogeneity in oscillatory dynamics limits correlation-induced neural synchronization.

    abstract::Synchronous neural oscillations are found throughout the brain and are thought to contribute to neural coding and the propagation of activity. Several proposed mechanisms of synchronization have gained support through combined theoretical and experimental investigation, including mechanisms based on coupling and corre...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00362.2012

    authors: Burton SD,Ermentrout GB,Urban NN

    更新日期:2012-10-01 00:00:00

  • Selective effects of light exposure on distribution of motility in the chick embryo at E18.

    abstract::It is well established that orderly patterns of motor neuron activity, muscle recruitment, and limb movement are generated in chicks during motility by embryonic day (E)9, the midpoint in embryonic development. However, our recent work suggests that some attributes of motility, such as the rhythm of repetitive limb mo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00393.2003

    authors: Bradley NS,Jahng DY

    更新日期:2003-09-01 00:00:00

  • Forms of forward quadrupedal locomotion. III. A comparison of posture, hindlimb kinematics, and motor patterns for downslope and level walking.

    abstract::To gain further insight into the neural mechanisms for different forms of quadrupedal walking, data on postural orientation, hindlimb kinematics, and motor patterns were assessed for four grades of downslope walking, from 25% (14 degrees slope) to 100% (45 degrees), and compared with data from level and downslope walk...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.4.1702

    authors: Smith JL,Carlson-Kuhta P,Trank TV

    更新日期:1998-04-01 00:00:00

  • Photoreceptor coupling in retina of the toad, Bufo marinus. I. Anatomy.

    abstract::1. Red rod photoreceptors in the toad retina, which are known to be physiologically coupled, were examined for interreceptor contacts. 2. A dense network of large gap junctions was found between the inner segments of red rods, this being the only specialized site of contact that was observed between rods. Each red rod...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1979.42.1.292

    authors: Gold GH,Dowling JE

    更新日期:1979-01-01 00:00:00

  • Using potassium currents to solve signal-to-noise problems in inhibitory feedforward networks of the striatum.

    abstract::Fast-spiking (FS) interneurons provide the main route of feedforward inhibition from cortex to spiny projection neurons in the striatum. A steep current-firing frequency curve and a dense local axonal arbor suggest that even small excitatory inputs could translate into powerful feedforward inhibition, although such an...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00063.2005

    authors: Kotaleski JH,Plenz D,Blackwell KT

    更新日期:2006-01-01 00:00:00

  • Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition.

    abstract::N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing schizophrenia-like symptoms. Here we show that the amino acid homocysteine (HCY), which is increased in the blood of schizophrenia patients, reduces ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00809.2012

    authors: Bolton AD,Phillips MA,Constantine-Paton M

    更新日期:2013-10-01 00:00:00

  • Population encoding of spatial frequency, orientation, and color in macaque V1.

    abstract::1. We recorded local field potentials in the parafoveal representation in the primary visual cortex of anesthetized and paralyzed macaque monkeys with a multicontact electrode that provided for sampling of neural activity at 16 sites along a vertical penetration. Differential recordings at adjacent contacts were trans...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.5.2151

    authors: Victor JD,Purpura K,Katz E,Mao B

    更新日期:1994-11-01 00:00:00

  • Deficits of visual attention and saccadic eye movements after lesions of parietooccipital cortex in monkeys.

    abstract::1. Visual attention is often profoundly disturbed in humans after damage to the cortex of the posterior parietal lobe, particularly of the minor hemisphere, with some patients being totally unaware of visual stimuli in the hemifield of extrapersonal space contralateral to the cortical damage. This severe form of visua...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.61.1.74

    authors: Lynch JC,McLaren JW

    更新日期:1989-01-01 00:00:00

  • Properties of the GABAA receptor of rat posterior pituitary nerve terminals.

    abstract::1. We investigated gamma-aminobutyric acid (GABA) receptors using thin slice patch-clamp techniques in the swellings along axons of posterior pituitary nerve terminals. 2. Activation of the nerve terminal GABAA receptor induced a mean conductance change of 1.5 nS. Normalizing to area gave a mean conductance density of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.3.1135

    authors: Zhang SJ,Jackson MB

    更新日期:1995-03-01 00:00:00

  • Low-threshold, slow-inactivating Na+ potentials in the cockroach giant axon.

    abstract::Electrophysiological properties of the ventral giant axon in the abdominal nerve cord of the cockroach were studied by recording intracellular potentials following partial or complete block of the K+ conductance. When the K+ conductance was completely blocked by tetraethylammonium (TEA) and 3,4-diaminopyridine, the in...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.54.5.1087

    authors: Yawo H,Kojima H,Kuno M

    更新日期:1985-11-01 00:00:00

  • Approaching threatening stimuli cause an expansion of defensive peripersonal space.

    abstract::When sudden environmental stimuli signaling threat occur in the portion of space surrounding the body (defensive peripersonal space), defensive responses are enhanced. Recently Bisio et al. (Bisio A, Garbarini F, Biggio M, Fossataro C, Ruggeri P, Bove M. J Neurosci 37: 2415-2424, 2017) showed that a marker of defensiv...

    journal_title:Journal of neurophysiology

    pub_type: 评论,杂志文章

    doi:10.1152/jn.00316.2017

    authors: Bufacchi RJ

    更新日期:2017-10-01 00:00:00

  • Functional properties and axon terminations of interneurons in laminae III-V of the mammalian spinal dorsal horn in vitro.

    abstract::1. The functional organization of interneurons in spinal laminae III-V was studied in an isolated preparation of hamster dorsal horn with sensory innervation from an excised skin patch. Morphological details of 40 neurons were visualized by intracellular injection of horseradish peroxidase. Active and passive membrane...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.5.1746

    authors: Schneider SP

    更新日期:1992-11-01 00:00:00

  • A theoretical framework for quantal analysis and its application to long-term potentiation.

    abstract::1. We present a new mathematical description of the complete distribution of electrical responses to stochastic synaptic activity (quantal analysis) that is intended as a model of experiments on central neuronal synapses. Unlike previous treatments, this distribution is calculated for each instant after the release of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.3.1395

    authors: Blum KI,Idiart MA

    更新日期:1994-09-01 00:00:00

  • Somatosensory perceptual training enhances motor learning by observing.

    abstract::Action observation activates brain regions involved in sensory-motor control. Recent research has shown that action observation can also facilitate motor learning; observing a tutor undergoing motor learning results in functional plasticity within the motor system and gains in subsequent motor performance. However, th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00313.2018

    authors: McGregor HR,Cashaback JGA,Gribble PL

    更新日期:2018-12-01 00:00:00

  • Persistent activity in a cortical-to-subcortical circuit: bridging the temporal gap in trace eyelid conditioning.

    abstract::We have addressed the source and nature of the persistent neural activity that bridges the stimulus-free gap between the conditioned stimulus (CS) and unconditioned stimulus (US) during trace eyelid conditioning. Previous work has demonstrated that this persistent activity is necessary for trace eyelid conditioning: C...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00689.2011

    authors: Siegel JJ,Kalmbach B,Chitwood RA,Mauk MD

    更新日期:2012-01-01 00:00:00

  • Excitatory amino acid transporters tonically restrain nTS synaptic and neuronal activity to modulate cardiorespiratory function.

    abstract::The nucleus tractus solitarii (nTS) is the initial central termination site for visceral afferents and is important for modulation and integration of multiple reflexes including cardiorespiratory reflexes. Glutamate is the primary excitatory neurotransmitter in the nTS and is removed from the extracellular milieu by e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01054.2015

    authors: Matott MP,Ruyle BC,Hasser EM,Kline DD

    更新日期:2016-03-01 00:00:00

  • Nonlinearity of spatial summation in simple cells of areas 17 and 18 of cat visual cortex.

    abstract::1. Nonlinearity of spatial summation in areas 17 and 18 of cat visual cortex was compared with the type of spatial nonlinearity that differentiates X and Y cells in the lateral geniculate nucleus (LGN) and retina. The comparisons were made to examine to what extent the information from X and Y cells may remain separat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.5.1667

    authors: Ferster D,Jagadeesh B

    更新日期:1991-11-01 00:00:00

  • Responses of neurons in the gracile nucleus of cats to innocuous and noxious stimuli: basic characterization and antidromic activation from the thalamus.

    abstract::1. Responses to innocuous and noxious mechanical and thermal stimuli were recorded from 90 neurons in the gracile nucleus of anesthetized cats. Cells were tested by antidromic activation for projections to the contralateral ventrobasal thalamus. 2. Cells were characterized broadly by their responses to mechanical stim...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.3.818

    authors: Cliffer KD,Hasegawa T,Willis WD

    更新日期:1992-09-01 00:00:00

  • Subliminal gamma flicker draws attention even in the absence of transition-flash cues.

    abstract::We recently reported evidence indicating that selective attention is deployed to a target location in a multi-object display, when the target event (a change of one of the objects) is preceded by subliminal flicker in the gamma range. However, concerns have been raised regarding the stimuli used in this study and the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00357.2010

    authors: Cheadle SW,Parton A,Müller HJ,Usher M

    更新日期:2011-02-01 00:00:00

  • Cerebellar lesions and prism adaptation in macaque monkeys.

    abstract::If a laterally displacing prism is placed in front of one eye of a person or monkey with the other eye occluded, they initially will point to one side of a target that is located directly in front of them. Normally, people and monkeys adapt easily to the displaced vision and correct their aim after a few trials. If th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.4.1960

    authors: Baizer JS,Kralj-Hans I,Glickstein M

    更新日期:1999-04-01 00:00:00

  • Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells.

    abstract::The group I metabotropic glutamate receptor (mGluR) subtype, mGluR1, is highly expressed on the apical dendrites of olfactory bulb mitral cells and thus may be activated by glutamate released from olfactory nerve (ON) terminals. Previous studies have shown that mGluR1 agonists directly excite mitral cells. In the pres...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01150.2005

    authors: Ennis M,Zhu M,Heinbockel T,Hayar A

    更新日期:2006-04-01 00:00:00

  • Effects of GABA receptor antagonists on retinal glycine receptors and on homomeric glycine receptor alpha subunits.

    abstract::Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists block...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01228.2004

    authors: Wang P,Slaughter MM

    更新日期:2005-06-01 00:00:00

  • Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey.

    abstract::Neuroimaging studies in stroke survivors have suggested that adaptive plasticity occurs following stroke. However, the complex temporal dynamics of neural reorganization after injury make the interpretation of functional imaging studies equivocal. In the present study in adult squirrel monkeys, intracortical microstim...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90447.2008

    authors: Eisner-Janowicz I,Barbay S,Hoover E,Stowe AM,Frost SB,Plautz EJ,Nudo RJ

    更新日期:2008-09-01 00:00:00

  • Neural responses elicited by stimuli associated with masking of low-frequency, monaural tonal signals by noise.

    abstract::The responses of low-frequency, primary-like neurons of the ventral cochlear nucleus were measured as a function of signal-to-noise ratio for gated tonal signals and noise maskers that were varied in bandwidth and duration. For a given signal-to-noise ratio, each of the maskers is known to produce the same amount of m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.6.1516

    authors: Langford TL

    更新日期:1983-12-01 00:00:00

  • Restoration of descending inputs fails to rescue activity following deafferentation of a motor network.

    abstract::Motor networks such as the pyloric network of the stomatogastric ganglion often require descending neuromodulatory inputs to initiate, regulate, and modulate their activity and their synaptic connectivity to manifest physiologically appropriate output. Prolonged removal of these descending inputs often results in a co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00183.2012

    authors: Nahar J,Lett KM,Schulz DJ

    更新日期:2012-08-01 00:00:00

  • Linking express saccade occurance to stimulus properties and sensorimotor integration in the superior colliculus.

    abstract::Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00047.2015

    authors: Marino RA,Levy R,Munoz DP

    更新日期:2015-08-01 00:00:00

  • Development of short-term heterosynaptic facilitation at aplysia sensorimotor synapses in vitro is accompanied by changes in the functional expression of presynaptic serotonin receptors.

    abstract::1. The sensorimotor synapse of Aplysia expresses various shortlasting changes in synaptic efficacy including homosynaptic depression (HSD) and heterosynaptic facilitation by serotonin (5-HT) either at nondepressed sensory neuron (SN) synaptic connections or at SN synaptic connections first depressed by HSD. We examine...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.4.2250

    authors: Sun ZY,Schacher S

    更新日期:1996-10-01 00:00:00

  • Auditory responses in the cochlear nucleus of awake mustached bats: precursors to spectral integration in the auditory midbrain.

    abstract::In the cochlear nucleus (CN) of awake mustached bats, single- and two-tone stimuli were used to examine how responses in major CN subdivisions contribute to spectrotemporal integrative features in the inferior colliculus (IC). Across CN subdivisions, the proportional representation of frequencies differed. A striking ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00634.2005

    authors: Marsh RA,Nataraj K,Gans D,Portfors CV,Wenstrup JJ

    更新日期:2006-01-01 00:00:00

  • Electrophysiological correlates of incidentally learned expectations in human vision.

    abstract::The human visual system is remarkably sensitive to environmental regularities, which can facilitate behavioral performance when sensory events conform to past experience. The point at which prior knowledge is integrated during visual perception is unclear, particularly for incidentally learned associations. One possib...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00733.2017

    authors: Hall MG,Mattingley JB,Dux PE

    更新日期:2018-04-01 00:00:00

  • Characteristics of corticomotoneuronal postspike facilitation and reciprocal suppression of EMG activity in the monkey.

    abstract::In this study we present further evidence supporting the reciprocal nature of output effects on forearm flexor and extensor muscles from single corticomotoneuronal (CM) cells. Spike-triggered averaging of rectified EMG activity was used to test the output effects of 105 motor cortex cells in two rhesus monkeys (Macaca...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.4.959

    authors: Kasser RJ,Cheney PD

    更新日期:1985-04-01 00:00:00