Restoration of descending inputs fails to rescue activity following deafferentation of a motor network.

Abstract:

:Motor networks such as the pyloric network of the stomatogastric ganglion often require descending neuromodulatory inputs to initiate, regulate, and modulate their activity and their synaptic connectivity to manifest physiologically appropriate output. Prolonged removal of these descending inputs often results in a compensatory response that alters the inputs themselves, their targets, or both. Using the pyloric network of the crab, Cancer borealis, we investigated whether isolation of motor networks would result in alterations that change the responses of these networks to restored modulatory input. We used a reversible block with isotonic sucrose to transiently alter descending inputs into the pyloric network of the crab stomatogastric ganglion. Using this method, we found that blocking neuromodulatory inputs caused a reduced ability for subsequently restored modulatory projections to appropriately generate network output. Our results suggest that this could be due to changes in activity of descending projection neurons as well as changes in sensitivity to neuromodulators of the target neurons that develop over the time course of the blockade. These findings suggest that although homeostatic plasticity may play a critical role in recovery of functional output in a deafferented motor network, the results of these compensatory changes may alter the network such that restored inputs no longer function appropriately.

journal_name

J Neurophysiol

authors

Nahar J,Lett KM,Schulz DJ

doi

10.1152/jn.00183.2012

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

871-81

issue

3

eissn

0022-3077

issn

1522-1598

pii

jn.00183.2012

journal_volume

108

pub_type

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