Vestibular short-latency evoked potential abolished by low-frequency noise exposure in rats.

Abstract:

:The vestibular system plays a critical role in detection of head movements and is essential for normal postural control. Because of their anatomical proximity to the cochlea, the otolith organs are selectively exposed to sound pressure and are at risk for noise overstimulation. Clinical reports suggest a link between noise exposure and balance problems, but the structural and physiological basis for this linkage is not well understood. The goal of this study was to determine the effects of low-frequency noise (LFN) on the otolith organs by correlating changes in vestibular short-latency evoked potentials (VsEPs) with changes in saccular afferent endings following noise exposure. LFN exposure transiently abolished the VsEP and reduced the number of stained calyces within the sacculus. Although some recovery of the VsEP waveform could be observed within 3 days after noise, at 3 wk recovery was only partial in most animals, consistent with a reduced number of afferents with calyceal endings. These data show that a single intense noise exposure is capable of causing a vestibular deficit that appears to mirror the synaptic deficit associated with hidden hearing loss after noise-induced cochlear injury. NEW & NOTEWORTHY This is the first study to explore the effects of low-frequency high-intensity noise on vestibular short-latency evoked potential (VsEP) responses, which shows a linkage between attenuated noise-induced VsEPs and pathological changes to otolith organ afferents. This finding suggests a potential limitation of the VsEP for evaluation of vestibular dysfunction, since the VsEP measurement may assess the activity of a specific class rather than all afferents.

journal_name

J Neurophysiol

authors

Stewart CE,Kanicki AC,Altschuler RA,King WM

doi

10.1152/jn.00668.2017

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

662-667

issue

2

eissn

0022-3077

issn

1522-1598

pii

jn.00668.2017

journal_volume

119

pub_type

杂志文章
  • Neural substrates of graphomotor sequence learning: a combined FMRI and kinematic study.

    abstract::The goal of this study was to characterize the dynamics and functional connectivity of brain networks associated with fast (short-term) learning of handwriting using functional magnetic resonance imaging. Participants (n = 12) performed a graphomotor sequence learning task (naïve subjects learning to draw simple, 3-st...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00449.2009

    authors: Swett BA,Contreras-Vidal JL,Birn R,Braun A

    更新日期:2010-06-01 00:00:00

  • Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.

    abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00620.2014

    authors: Wall MJ,Richardson MJ

    更新日期:2015-02-01 00:00:00

  • Suppression of epileptiform activity by a single short-duration electric field in rat hippocampus in vitro.

    abstract::The mechanisms behind the therapeutic effects of electrical stimulation of the brain in epilepsy and other disorders are poorly understood. Previous studies in vitro have shown that uniform electric fields can suppress epileptiform activity through a direct polarizing effect on neuronal membranes. Such an effect depen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00887.2012

    authors: Mikkelsen R,Andreasen M,Nedergaard S

    更新日期:2013-06-01 00:00:00

  • Intracellular analysis of the innervation of a crayfish sensory interneuron by regenerating afferents.

    abstract::Mechanoreceptors of the crayfish tail fan have peripheral somata and send their axons to the last (sixth) abdominal ganglion via five bilateral pairs of nerve roots (R1-R5). Comparisons were made between normal crayfish and regenerate preparations in which R4 had been cut and directed back to an extensively denervated...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.54.2.385

    authors: Strandburg RJ,Krasne FB

    更新日期:1985-08-01 00:00:00

  • Morphological identification of physiologically characterized afferents innervating the turtle posterior crista.

    abstract::The turtle posterior crista consists of two hemicristae. Each hemicrista extends from the planum semilunatum to the nonsensory torus and includes a central zone (CZ) surrounded by a peripheral zone (PZ). Type I and type II hair cells are found in the CZ and are innervated by calyx, dimorphic and bouton afferents. Only...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1202

    authors: Brichta AM,Goldberg JM

    更新日期:2000-03-01 00:00:00

  • Neural correlates of attention and distractibility in the lateral intraparietal area.

    abstract::We examined the activity of neurons in the lateral intraparietal area (LIP) during a task in which we measured attention in the monkey, using an advantage in contrast sensitivity as our definition of attention. The animals planned a memory-guided saccade but made or canceled it depending on the orientation of a briefl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00848.2005

    authors: Bisley JW,Goldberg ME

    更新日期:2006-03-01 00:00:00

  • Forward versus backward walking: transfer of podokinetic adaptation.

    abstract::We asked whether podokinetic adaptation to walking on a circular treadmill transfers to different forms of locomotion. Subjects were blindfolded and asked to walk straight across the floor, in the forward and backward directions, following podokinetic (PK) stimulation that consisted of 30 min of forward walking-in-pla...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.4.1666

    authors: Earhart GM,Jones GM,Horak FB,Block EW,Weber KD,Fletcher WA

    更新日期:2001-10-01 00:00:00

  • Sleep-like states modulate functional connectivity in the rat olfactory system.

    abstract::The present study was an examination of state-dependent functional connectivity during spontaneous activity between the piriform cortex and its upstream and downstream connections. Rats were anesthetized with urethan and allowed to spontaneously cycle between fast- and slow-wave states similar to fast- and slow-wave s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00711.2010

    authors: Wilson DA,Yan X

    更新日期:2010-12-01 00:00:00

  • Effects of tooth pulp deafferentation on nociceptive and nonnociceptive neurons of the feline trigeminal subnucleus caudalis (medullary dorsal horn).

    abstract::1. Effects of deafferentation of the tooth pulps of the posterior mandibular teeth were studied in single neurons recorded in the ipsilateral subnucleus caudalis of the trigeminal (V) spinal tract nucleus of adult cats and kittens. The functional properties of neurons in each anesthetized animal were determined electr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.61.6.1197

    authors: Hu JW,Sessle BJ

    更新日期:1989-06-01 00:00:00

  • Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro.

    abstract::Numerous models of the oculomotor neuronal integrator located in the prepositus hypoglossi nucleus (PHN) involve both highly tuned recurrent networks and intrinsic neuronal properties; however, there is little experimental evidence for the relative role of these two mechanisms. The experiments reported here show that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01355.2005

    authors: Idoux E,Serafin M,Fort P,Vidal PP,Beraneck M,Vibert N,Mühlethaler M,Moore LE

    更新日期:2006-07-01 00:00:00

  • Delaying the onset of treadmill exercise following peripheral nerve injury has different effects on axon regeneration and motoneuron synaptic plasticity.

    abstract::Transection of a peripheral nerve results in withdrawal of synapses from motoneurons. Some of the withdrawn synapses are restored spontaneously, but those containing the vesicular glutamate transporter 1 (VGLUT1), and arising mainly from primary afferent neurons, are withdrawn permanently. If animals are exercised imm...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00892.2014

    authors: Brandt J,Evans JT,Mildenhall T,Mulligan A,Konieczny A,Rose SJ,English AW

    更新日期:2015-04-01 00:00:00

  • Spatiotemporal organization of cat lateral geniculate receptive fields.

    abstract::Spatial and temporal properties of LGN receptive fields were studied by flashing a small bar of light across the field in 28 discrete steps. The flashes at each of the spatial positions were used to produce 28 PST histograms. These histograms were in turn displayed as a plane, with space on the chi axis, time on the p...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1976.39.2.213

    authors: Stevens JK,Gerstein GL

    更新日期:1976-03-01 00:00:00

  • Quantifying the magnitude of changes in synaptic level parameters with long-term potentiation.

    abstract::Experimental evidence supports a number of mechanisms for the synaptic change that occurs with long-term potentiation (LTP) including insertion of AMPA receptors, an increase in AMPA receptor single channel conductance, unmasking silent synapses, and increases in vesicle release probability. Here we combine experiment...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00248.2006

    authors: Holmes WR,Grover LM

    更新日期:2006-09-01 00:00:00

  • Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spiking.

    abstract::Long-term depression (LTD) was induced in neocortical layer 5 pyramidal connections by pairing presynaptic firing with subthreshold postsynaptic depolarization (dLTD) or via a spike-timing protocol (tLTD). Like tLTD, dLTD reduced short-term depression and increased the coefficient of variation consistent with a presyn...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00376.2004

    authors: Sjöström PJ,Turrigiano GG,Nelson SB

    更新日期:2004-12-01 00:00:00

  • GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons.

    abstract::GSG1L is an AMPA receptor (AMPAR) auxiliary subunit that regulates AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its physiological roles in other types of neurons remain to be characterized. Here, we investigated the role of GSG1L in hippocampal dentate granule cells and found that GSG1...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00307.2016

    authors: Mao X,Gu X,Lu W

    更新日期:2017-01-01 00:00:00

  • Mechanisms of electrical coupling between pyramidal cells.

    abstract::Direct electrical coupling between neurons can be the result of both electrotonic current transfer through gap junctions and extracellular fields. Intracellular recordings from CA1 pyramidal neurons of rat hippocampal slices showed two different types of small-amplitude coupling potentials: short-duration (5 ms) bipha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.6.3107

    authors: Vigmond EJ,Perez Velazquez JL,Valiante TA,Bardakjian BL,Carlen PL

    更新日期:1997-12-01 00:00:00

  • Premotor cortex of monkeys: set- and movement-related activity reflecting amplitude and direction of wrist movements.

    abstract::1. Neuronal activity was recorded from the premotor cortex (PM) of Japanese monkeys while they performed hand movements with different amplitudes and directions. On each behavioral trial, two instructions were given sequentially: 1) an amplitude instruction (large or small) and 2) a direction instruction (flexion or e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.1.187

    authors: Kurata K

    更新日期:1993-01-01 00:00:00

  • Mg2+-malate co-transport, a mechanism for Na+-independent Mg2+ transport in neurons of the leech Hirudo medicinalis.

    abstract::Mg2+-extrusion from Mg2+-loaded neurons of the leech, Hirudo medicinalis, is mediated mainly by Na+/Mg2+ antiport. However, in a number of leech neurons, Mg2+ is extruded in the nominal absence of extracellular Na+, indicating the existence of an additional, Na+-independent Mg2+ transport mechanism. This mechanism was...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01221.2004

    authors: Günzel D,Hintz K,Durry S,Schlue WR

    更新日期:2005-07-01 00:00:00

  • Macaque V1 representations in natural and reduced visual contexts: spatial and temporal properties and influence of saccadic eye movements.

    abstract::Vision in natural situations is different from the paradigms generally used to study vision in the laboratory. In natural vision, stimuli usually appear in a receptive field as the result of saccadic eye movements rather than suddenly flashing into view. The stimuli themselves are rich with meaningful and recognizable...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00733.2011

    authors: Ruiz O,Paradiso MA

    更新日期:2012-07-01 00:00:00

  • Spermine mediates inward rectification in potassium channels of turtle retinal Müller cells.

    abstract::Retinal Müller cells are highly permeable to potassium as a consequence of their intrinsic membrane properties. Therefore these cells are able to play an important role in maintaining potassium homeostasis in the vertebrate retina during light-induced neuronal activity. Polyamines and other factors present in Müller c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.4.1357

    authors: Solessio E,Rapp K,Perlman I,Lasater EM

    更新日期:2001-04-01 00:00:00

  • Recovery of thumb and finger extension and its relation to grasp performance after stroke.

    abstract::This study investigated how the ability to extend the fingers and thumb recovers early after stroke and how the ability to extend all of the digits affects grasping performance. We studied 24 hemiparetic patients at 3 and 13 wk post stroke. At each visit, we tested the subjects' ability to actively extend all five dig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91310.2008

    authors: Lang CE,DeJong SL,Beebe JA

    更新日期:2009-07-01 00:00:00

  • Serotonin transduction cascades mediate variable changes in pyloric network cycle frequency in response to the same modulatory challenge.

    abstract::A fundamental question in systems biology addresses the issue of how flexibility is built into modulatory networks such that they can produce context-dependent responses. Here we examine flexibility in the serotonin (5-HT) response system that modulates the cycle frequency (cf) of a rhythmic motor output. We found tha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00986.2007

    authors: Spitzer N,Cymbalyuk G,Zhang H,Edwards DH,Baro DJ

    更新日期:2008-06-01 00:00:00

  • Muscarinic depression of synaptic transmission in the epileptogenic GABA withdrawal syndrome focus.

    abstract::The GABA withdrawal syndrome (GWS) is a model of local status epilepticus consecutive to the interruption of a prolonged GABA infusion into the rat somatomotor cortex. Bursting patterns in slices from GWS rats include intrinsic bursts of action potentials (APs) induced by intracellular depolarizing current injection a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.5.2159

    authors: Silva-Barrat C,Szente M,Menini C,Velluti JC,Champagnat J

    更新日期:2001-05-01 00:00:00

  • Stimulus-evoked modulation of sensorimotor pyramidal neuron EPSPs.

    abstract::Sensory cortical neurons display substantial receptive field dynamics during and after persistent sensory drive. Because a cell's response properties are determined by the inputs it receives, receptive field dynamics are likely to involve changes in the relative efficacy of different inputs to the cell. To test this h...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01012.2001

    authors: Kohn A,Metz C,Tommerdahl MA,Whitsel BL

    更新日期:2002-12-01 00:00:00

  • Intersegmental coordination: influence of a single walking leg on the neighboring segments in the stick insect walking system.

    abstract::A key element of walking is the coordinated interplay of multiple limbs to achieve a stable locomotor pattern that is adapted to the environment. We investigated intersegmental coordination of walking in the stick insect, Carausius morosus by examining the influence a single stepping leg has on the motoneural activity...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00291.2007

    authors: Borgmann A,Scharstein H,Büschges A

    更新日期:2007-09-01 00:00:00

  • Evidence against perfect integration of sensory information during perceptual decision making.

    abstract::Perceptual decision making is often modeled as perfect integration of sequential sensory samples until the accumulated total reaches a fixed decision bound. In that view, the buildup of neural activity during perceptual decision making is attributed to temporal integration. However, an alternative explanation is that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00264.2015

    authors: Carland MA,Marcos E,Thura D,Cisek P

    更新日期:2016-02-01 00:00:00

  • Controlling the statistics of action: obstacle avoidance.

    abstract::Task optimization in the presence of signal-dependent noise (TOPS) has been proposed as a general framework for planning goal-directed movements. Within this framework, the motor command is assumed to be corrupted by signal-dependent noise, which leads to a distribution of possible movements. A task can then be equate...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.87.5.2434

    authors: Hamilton AF,Wolpert DM

    更新日期:2002-05-01 00:00:00

  • Zinc downmodulates thf GABAc receptor current in cone horizontal cells acutely isolated from the catfish retina.

    abstract::1. We studied the effect of zinc on the gamma-aminobutyric acid-C (GABAC) receptor in acutely isolated catfish cone horizontal cells using the whole cell patch-clamp technique. 2. GABA activates the GABAC receptor with a half-activation concentration (EC50) of 2.99 microM. The Hill coefficient is 1.32. Desensitization...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.2.916

    authors: Dong CJ,Werblin FS

    更新日期:1995-02-01 00:00:00

  • Multiple patterns and components of persistent inward current with serotonergic modulation in locomotor activity-related neurons in Cfos-EGFP mice.

    abstract::Using CFos-EGFP transgenic mice (P6-P12), we targeted persistent inward current (PIC) in the spinal interneurons activated by locomotion. Following a locomotor task, whole cell patch-clamp recordings were obtained from ventral EGFP+ neurons in spinal cord slices (200-250 μm from T₁₃-L₄). PIC was recorded by a family o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01111.2009

    authors: Dai Y,Jordan LM

    更新日期:2010-04-01 00:00:00

  • Selectivity of inferior temporal neurons for realistic pictures predicted by algorithms for image database navigation.

    abstract::Primates have a remarkable ability to perceive, recognize, and discriminate among the plethora of people, places, and things that they see, and neural selectivity in the primate inferotemporal (IT) cortex is thought to underlie this ability. Here we investigated the relationship between neural response and perception ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00130.2005

    authors: Allred S,Liu Y,Jagadeesh B

    更新日期:2005-12-01 00:00:00