Abstract:
:The cerebrospinal fluid (CSF) of patients with demyelinating neurological disease, such as Guillain-Barré syndrome or multiple sclerosis, contains factors that inhibit the excitatory Na+ current. Such antiexcitatory factors are occasionally also detectable in CSF from patients with other neurological diseases but were absent from an artificial CSF containing all major CSF constituents (electrolytes, amino acids, vitamins, metabolites, albumin). In an attempt to characterize these factors, unphysiological pCa or pH values were excluded by the application of the Ca2+ chelator EGTA and the use of buffers. Heating the CSF for 10 min to 95 degrees C or digesting it with proteases did not destroy the antiexcitatory potency. Fractionation of the CSF contents according to molecular weight showed that the factors have a molecular weight < 3 kD. This excludes proteins, such as antibodies or cytokines, as candidates. Small peptides are known to be resistant to some proteases and heating.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Brinkmeier H,Seewald MJ,Wollinsky KH,Rüdel Rdoi
10.1002/(SICI)1097-4598(199601)19:1<54::AID-MUS7>3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
54-62issue
1eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199601)19:1<54::AID-MUS7>3journal_volume
19pub_type
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