Abstract:
INTRODUCTION:Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA. METHODS:We measured the levels of urinary 8-OHdG in 33 genetically confirmed SBMA patients and 32 age-matched controls over a 24-month period at 6-month intervals. RESULTS:Urinary 8-OHdG levels in SBMA patients were significantly elevated compared with those of controls and correlated well with motor function scores. During the follow-up period, urinary 8-OHdG levels increased and correlated with motor function at each time-point. In addition, urinary 8-OHdG levels at baseline were correlated with changes in the 6-minute walk test during 24 months. CONCLUSIONS:Urinary 8-OHdG is a biomarker for SBMA, reflecting the severity and possibly predicting the deterioration of motor function.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Mano T,Katsuno M,Banno H,Suzuki K,Suga N,Hashizume A,Tanaka F,Sobue Gdoi
10.1002/mus.23413subject
Has Abstractpub_date
2012-11-01 00:00:00pages
692-7issue
5eissn
0148-639Xissn
1097-4598journal_volume
46pub_type
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