Abstract:
INTRODUCTION:Similar to magnetic resonance imaging (MRI), electrical impedance myography (EIM) is dependent on the presence and location of water in muscle to assess neuromuscular diseases. We compared the 2 technologies in mdx mice to better understand their relationship. METHODS:EIM and MRI, using T2 relaxation and diffusion-weighted imaging (DWI), were performed on the gastrocnemius of 10 mdx and 10 wild-type mice. Muscle function and tissue composition measurements were compared with the EIM and MRI data. RESULTS:EIM reactance and T2 relaxation mapping can discriminate healthy from diseased mice (P < .001 for both), but DWI could not. Both T2 relaxation and EIM reactance also correlated closely with muscle function/composition and with each other. CONCLUSION:Given the low cost of EIM and the simplicity of application, it may be a valuable alternative to muscle MRI in Duchenne muscular dystrophy, where simple cumulative indices of muscle health are being sought.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Wu JS,Li J,Greenman RL,Bennett D,Geisbush T,Rutkove SBdoi
10.1002/mus.24573subject
Has Abstractpub_date
2015-10-01 00:00:00pages
598-604issue
4eissn
0148-639Xissn
1097-4598journal_volume
52pub_type
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