Soleus-specific myopathy induced by passive stretching under local tetanus.

Abstract:

:Twenty-four adult albino rats were injected with tetanus toxin into the right gastrocnemius muscle and then subjected to sustained dorsiflexion of the right ankle joint for 2 to 14 days. Histologic examinations of the soleus after this procedure showed myopathic changes, characterized by variations in fiber diameters, myonecrosis with opaque fibers, interstitial fibrosis, and small groups of regenerated fibers. Electron microscopy revealed derangement of T-tubules immediately adjacent to the sarcolemma in the early degenerative stage. The size and wet weight of soleus increased compared to that of the control side between 2 and 5 days post-tetanus. Serum GOT, LDH, and creatine kinase (CK) levels were elevated especially in the early degenerative stages. Peri- and endomysial fibrosis developed gradually from about 3 days post-tetanus. Pathomechanisms inducing these changes were discussed.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Mizuno Y,Chou SM

doi

10.1002/mus.880131007

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

923-32

issue

10

eissn

0148-639X

issn

1097-4598

journal_volume

13

pub_type

杂志文章
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    pub_type: 杂志文章

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    更新日期:2013-11-01 00:00:00

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    pub_type: 临床试验,杂志文章

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  • Axonal transport in neuropathy.

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    pub_type: 杂志文章

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  • Differential involvement of myelinated and unmyelinated nerve fibers in painful diabetic polyneuropathy.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1002/mus.26356

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    更新日期:2002-05-01 00:00:00

  • Preparation of cell-free extracellular matrix from human peripheral nerve.

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  • Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy.

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