Abstract:
:Electrodiagnostic studies were analyzed in patients with neuropathy associated with IgM monoclonal proteins, 7 with anti-myelin associated glycoprotein reactivity (MAG) and 7 nonreactive to MAG. The findings were distinctly different in the two groups. The electrodiagnostic studies of all the MAG-reactive patients had demyelinating features with slowing of conduction and prolonged distal latencies while only one of the MAG-nonreactive patients had a demyelinating pattern. In fact, the MAG-nonreactive patients were a heterogeneous group, both electrodiagnostically and clinically. This study supports the concept that MAG-reactive polyneuropathy is demyelinating in type, and is caused by the activity of the IgM M-protein directed at an antigen in the myelin sheath.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Kelly JJ Jrdoi
10.1002/mus.880131205subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1113-7issue
12eissn
0148-639Xissn
1097-4598journal_volume
13pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::Abnormalities of GM2 ganglioside metabolism owing to hexosaminidase A (Hex A) deficiency have been associated with ALS phenotypes. The clinical features described in these ALS patients with Hex A deficiency include early onset, positive family history, and/or long disease duration. In an attempt to determine prospecti...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110307
更新日期:1988-03-01 00:00:00
abstract:INTRODUCTION:Contradictory reports of the myosin heavy chain (MHC) composition of adult human suprahyoid muscles leave unresolved the extent to which these muscles express developmental and unconventional MHC. METHODS:By immunohistochemistry, separation sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PA...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23946
更新日期:2014-04-01 00:00:00
abstract::This study compared the force output produced by variable frequency, short-duration trains (VFTs) of electrical pulses with the forces produced by constant frequency, short-duration trains (CFTs). Human quadriceps femoris muscle was stimulated with a 300-msec train of pulses once every second for 180 seconds. Each sub...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.880140909
更新日期:1991-09-01 00:00:00
abstract::In a reported patient with myopathic carnitine deficiency, addition of exogenous carnitine to muscle homogenates failed to correct palmitate oxidation, and oral carnitine was of no clinical benefit. In a muscle biopsy from this patient, we found that, in contrast to the marked deficiency of free carnitine (3% of norma...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880080809
更新日期:1985-10-01 00:00:00
abstract:INTRODUCTION:Muscle weakness and functional disability have not been evaluated in a population-based study of patients with myasthenia gravis (MG). METHODS:All patients with MG in a well-defined catchment area were identified in the Danish National Patient Registry. Of the 175 eligible patients, 90 participated and we...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26356
更新日期:2019-02-01 00:00:00
abstract::The aim of this investigation was to define the boundaries of compound motor action potential (CMAP) dispersion, amplitude decay, and area decay in a control population and determine their dependence on external variables such as age and interelectrode distance. Measurements were made from median, ulnar, and common pe...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880161107
更新日期:1993-11-01 00:00:00
abstract:INTRODUCTION:In this study we compare the ultrasound features in the median nerve in patients with different types of Charcot-Marie-Tooth (CMT) disease and hereditary neuropathies with liability to pressure palsies (HNPP) as a typical entrapment neuropathy. METHODS:Median nerve ultrasound and conduction studies were p...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23681
更新日期:2013-03-01 00:00:00
abstract::A link between the cardioprotective benefits of pharmacological preconditioning and natural mammalian hibernation is considered to involve the cellular activation of opioid receptors and subsequent opening of K(ATP) channels. In previous studies, we have demonstrated the protective effects of specific delta-opioid ago...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20354
更新日期:2005-08-01 00:00:00
abstract::Ultrasound has been used for visualizing peripheral nerve pathology. Our goal was to use ultrasound to quantitate the sizes of upper extremity nerves along their length in control subjects and patients with neuropathy. We measured median and ulnar nerve cross-sectional areas (NCSA) in the arms of 190 subjects, includi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21431
更新日期:2009-12-01 00:00:00
abstract::An enzyme- and immunohistochemical study has been performed on human masseter muscle spindles. Antibodies selective for different myosin heavy chain (MHC) isoforms and M-band proteins (M-protein, myomesin, and MM-CK) were used. The expression of these proteins was determined in the different intrafusal fiber types. Nu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880170105
更新日期:1994-01-01 00:00:00
abstract::Calmodulin levels have been assessed in whole muscle and primary culture extracts in order to examine the relationship between calmodulin and the accumulation of calcium in dystrophic hamster muscle tissues. Significant decreases in both normal and dystrophic skeletal muscle, tongue, and heart calmodulin levels were o...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100113
更新日期:1987-01-01 00:00:00
abstract::We have previously demonstrated that patients with mitochondrial myopathies can benefit from short-term aerobic exercise training. In this study, we compared the responses to short-term aerobic training of patients with mitochondrial myopathies, patients with nonmetabolic myopathies, and sedentary normal subjects. Tra...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-4598(199909)22:9<1239::aid-mus1
更新日期:1999-09-01 00:00:00
abstract::We investigated whether the modulatory effects of segmental and descending inputs on the soleus H reflex are modified by postural conditions. Fourteen healthy volunteers received a transcranial magnetic stimulus (TMS) or percutaneous electrical stimulation of the posterior tibial nerve (PTN), preceding by 0 to 400 ms ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200006)23:6<925::aid-mus13
更新日期:2000-06-01 00:00:00
abstract::Six members originating from two families with hereditary motor and sensory neuropathy (hypertrophic and neuronal types) were noted to have enlarged calf muscles. Muscle computed tomography revealed that muscle enlargement in the propositus of the family with the hypertrophic type of HMSN was due to an increase in mus...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880130109
更新日期:1990-01-01 00:00:00
abstract::To determine if short TI (time to inversion) recovery (STIR) magnetic resonance imaging (MRI) is useful in assessing lower extremity (LE) denervation in subacute lumbar radiculopathy (LR), 25 subjects underwent lumbar spine MRI, LE STIR MRI and needle electromyography (EMG). In 23 (92%) subjects there was a positive c...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199709)20:9<1191::aid-mus1
更新日期:1997-09-01 00:00:00
abstract::Peripheral nerve disorders are commonly encountered in clinical practice. Electrodiagnostic studies remain the cornerstone of the evaluation of nerve disorders. More recently, ultrasound has played an increasing complementary role in the neuromuscular clinic. Ultrasound elastography is a technique that measures the el...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26624
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:Immune-mediated myopathies are a heterogeneous group of chronic autoimmune disorders. Autoantibodies associated with this disease complex are classified into myositis-associated and myositis-specific. Anti-tRNA synthetase antibodies are the most well known of the myositis-specific antibodies. Previous repo...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23383
更新日期:2012-08-01 00:00:00
abstract::A common misconception attributes sparing of the flexor carpi ulnaris (FCU) in ulnar neuropathy at the elbow (UNE) to its innervating branch arising "at or above the elbow." We examined the relationship of FCU branches to the medial epicondyle (ME) and humeroulnar aponeurotic arcade (HUA) in 30 cadaver elbows. In only...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880121203
更新日期:1989-12-01 00:00:00
abstract::Loss of skeletal muscle mass (sarcopenia) is a major contributor to disability in old age. We used two-dimensional gel electrophoresis and mass spectrometry to screen for changes in proteins, and cDNA profiling to assess transcriptional regulations in the gastrocnemius muscle of adult (4 months) and aged (30 months) m...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20808
更新日期:2007-08-01 00:00:00
abstract::A chronic high alcohol intake was induced in rats through the use of two procedures: the schedule-induced polydipsia technique and the liquid diet technique. Rats consumed 11-12 g of ethanol per kilogram body weight per day for 16 to 18 weeks. Morphologic evidence of a mild distal axonal neuropathy in the ventral caud...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880020208
更新日期:1979-03-01 00:00:00
abstract:INTRODUCTION:The neuropathy in patients with neurofibromatosis type 2 (NF2) is difficult to quantify and follow up. In this study we compared 3 methods that may help assess motor axon pathology in NF2 patients. METHODS:Nerve conduction studies in median nerves were supplemented by deriving motor unit number estimates ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25256
更新日期:2017-03-01 00:00:00
abstract::We prospectively evaluated thalidomide-induced neuropathy using electrodiagnostic studies. Sixty-seven men with metastatic androgen-independent prostate cancer in an open-label trial of oral thalidomide underwent neurologic examinations and nerve conduction studies (NCS) prior to and at 3-month intervals during treatm...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.1109
更新日期:2001-08-01 00:00:00
abstract::Single-fiber electromyography (SFEMG) demonstrates abnormal jitter in virtually all (99%) patients with myasthenia gravis (MG). One muscle, the extensor digitorum communis, is abnormal in most patients with this disease, but to obtain the maximum diagnostic sensitivity, it may be necessary to examine other muscles, es...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090904
更新日期:1986-11-01 00:00:00
abstract:INTRODUCTION:The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). METHODS:Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. The...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25373
更新日期:2017-04-01 00:00:00
abstract::Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV-infected patients are classified as follows: (1) HIV-associated myopathies and related conditions, including HIV polymyositis, inclusion-body ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.20338
更新日期:2005-09-01 00:00:00
abstract::The aim of this study was to investigate the fasciculation potentials (FPs) in the small-peripheral muscles of the foot and hand and the possible associated factors, in a healthy population. One hundred-twenty-two normal individuals (65 men and 57 women), aged 17-67 years (mean 39.96, SD=12.76) participated in the stu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199804)21:4<533::aid-mus14
更新日期:1998-04-01 00:00:00
abstract:INTRODUCTION:Myelinating Schwann cells compartmentalize their outermost layer to form actin-rich channels known as Cajal bands. Herein we investigate changes in Schwann cell architecture and cytoplasmic morphology in a novel mouse model of carpal tunnel syndrome. METHODS:Chronic nerve compression (CNC) injury was crea...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22276
更新日期:2012-02-01 00:00:00
abstract::There is evidence that growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12-month controlled trial of mazindol, a putative growth hormone secretion inhibitor, in 83 boys with Duchenne dystrophy. Muscle strength, contractures, functional ability and pulmonary function we...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.880131212
更新日期:1990-12-01 00:00:00
abstract::Beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine recept...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20294
更新日期:2005-05-01 00:00:00
abstract::Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by autoantibodies against presynaptic voltage-gated calcium channels that impair neuromuscular transmission. Malignancies, especially small cell lung cancer (SCLC), have been associated with LEMS and account for approximately 60% of cases...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24122
更新日期:2014-03-01 00:00:00