Median and ulnar nerve injuries reduce volitional forelimb strength in rats.

Abstract:

INTRODUCTION:Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function after PNI. METHODS:We developed an automated behavioral assay that provides quantitative measurements of volitional forelimb strength in rats. Multiple forelimb PNI models involving the median and ulnar nerves were used to assess forelimb function for up to 13 weeks postinjury. RESULTS:Despite multiple weeks of task-oriented training following injury, rats exhibit significant reductions in multiple quantitative parameters of forelimb function, including maximal pull force and speed of force generation. DISCUSSION:This study demonstrates that the isometric pull task is an effective method of evaluating forelimb function following PNI and may aid in development of therapeutic interventions to restore function. Muscle Nerve 56: 1149-1154, 2017.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Meyers EC,Granja R,Solorzano BR,Romero-Ortega M,Kilgard MP,Rennaker RL 2nd,Hays S

doi

10.1002/mus.25590

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1149-1154

issue

6

eissn

0148-639X

issn

1097-4598

journal_volume

56

pub_type

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