Abstract:
:Mutations in the myelin protein zero gene (MPZ) are associated with certain demyelinating neuropathies, and in particular with Charcot-Marie-Tooth disease type 1B (CMT1B), Dejerine-Sottas syndrome, and congenital hypomyelination. MPZ mutations affecting the protein's transmembrane domain are generally associated with more severe phenotypes. We describe a family with mild CMT1B associated with a transmembrane MPZ mutation. Sequence analysis identified a G-to-C transversion at nucleotide 1064, predicting a glycine-to-arginine substitution in codon 163 (G163R) of MPZ. This report furthers the understanding of the clinical and electrophysiological manifestations of MPZ mutations.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Eggers SD,Keswani SC,Melli G,Cornblath DRdoi
10.1002/mus.20034subject
Has Abstractpub_date
2004-06-01 00:00:00pages
867-9issue
6eissn
0148-639Xissn
1097-4598journal_volume
29pub_type
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