Sural nerve water in vivo in normal humans measured by magnetic resonance spectroscopy: relation to age, height, gender, and neurological profile.

Abstract:

:To enable the quantitative assessment of peripheral nerve structure and function, we determined the normal values for sural nerve hydration structure as measured by magnetic resonance proton imaging, and for neurological function with scores for neuropathic symptoms, signs, and nerve conduction properties. Normal human sural nerves contain 24.8 +/- 3.4% water. The structural water content of the nerves did not vary systematically in relation to age, height, gender, sural nerve conduction, neurologic symptoms, or examination deficits. In contrast, the neurological function scores were significantly influenced by age and selectively by height. Both nerve structure and function were stable over a 1-year interval. Measurement of human sural nerve water content in vivo by magnetic resonance proton imaging, and quantitation of the neurological profile of symptoms, signs, and conduction velocity are useful, noninvasive tools for the investigation of diseases in which changes in nerve structure may be related to alterations in nerve function.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Eaton RP,Sibbitt WL Jr,Bicknell JM,King MK,Griffey RH,Sibbitt RR

doi

10.1002/mus.880160311

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

307-11

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

16

pub_type

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