Abstract:
:The objective of this study was to examine the contribution of lower motor neuron (LMN) and upper motor neuron (UMN) dysfunction to weakness and impaired motor control in 27 patients with amyotrophic lateral sclerosis (ALS). Isometric strength was measured by dorsiflexor maximum voluntary contraction force (MVC). LMN function was measured by tetanic force, twitch force, and the amplitude of the compound muscle action potential. UMN function was measured by the speed of rapid foot taps, the maximum rate of rise of voluntary force, and the central activation ratio [CAR = MVC/(MVC + superimposed tetanic force)]. The results suggest that (1) LMN loss appears to be the primary cause of progressive weakness in ALS; while (2) UMN impairment in ALS leads to slowing of contraction speed and rapid movements, and modest decreases in central activation; and (3) during 6 months of progression, LMN changes were greater than UMN changes.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Kent-Braun JA,Walker CH,Weiner MW,Miller RGdoi
10.1002/(sici)1097-4598(199806)21:6<762::aid-mus8>subject
Has Abstractpub_date
1998-06-01 00:00:00pages
762-8issue
6eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199806)21:6<762::AID-MUS8>journal_volume
21pub_type
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