Abstract:
:The axonal distribution of voltage-dependent Na+ channels was determined during inflammatory demyelinating disease of the peripheral nervous system. Experimental allergic neuritis was induced in Lewis rats by active immunization. In diseased spinal roots Na+ channel immunofluorescence at many nodes of Ranvier changed from a highly focal ring to a more diffuse pattern and, as the disease progressed, eventually became undetectable. The loss of nodal channels corresponded closely with the development of clinical signs. Electrophysiological measurements and computations showed that a lateral spread of nodal Na+ channels could contribute significantly to temperature sensitivity and conduction block. During recovery new clusters of Na+ channels were seen. In fibers with large-scale demyelination, the new aggregates formed at the edges of adhering Schwann cells and appeared to fuse to form new nodes. At nodes with demyelination limited to paranodal retraction, Na+ channels were often found divided into two symmetric highly focal clusters. These results suggest that reorganization of Na+ channels plays an important role in the pathogenesis of demyelinating neuropathies.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Novakovic SD,Levinson SR,Schachner M,Shrager Pdoi
10.1002/(sici)1097-4598(199808)21:8<1019::aid-mus6subject
Has Abstractpub_date
1998-08-01 00:00:00pages
1019-32issue
8eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199808)21:8<1019::AID-MUS6journal_volume
21pub_type
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