Abstract:
:The F-wave was used to estimate motor nerve conduction velocity (MNCV) along the proximal segment of the fastest axons of the deep peroneal nerve (anterior-horn cells to knee) in 13 patients with amyotrophic lateral sclerosis (ALS) and in 21 age- and sex-matched control subjects. Measurements were based on the shortest latency of 100 F-waves obtained after supramaximal stimulation at the ankle and knee. The MNCV was estimated with the F-wave and conventional M-response methods in the distal segment (knee to ankle) of the nerve. Our results showed that proximal-nerve conduction is faster than distal conduction both in control subjects and in ALS patients. In ALS, there was a moderate reduction of MNCV, which was of equal degree in both the proximal and distal segments of the deep peroneal nerve. In control subjects and in ALS patients, no statistically significant difference was found between the MNCV estimated for the knee-to-ankle segment by conventional means and that obtained by the F-wave method. This indicates that the F-wave of shortest latency is conducted by the fastest surviving motor fibers, as in the initial components of the M-response--demonstrating that it is legitimate to make direct comparison of F- and M-latencies in estimating the proximal MNCV.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Argyropoulos CJ,Panayiotopoulos CP,Scarpalezos Sdoi
10.1002/mus.880010607subject
Has Abstractpub_date
1978-11-01 00:00:00pages
479-85issue
6eissn
0148-639Xissn
1097-4598journal_volume
1pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract:INTRODUCTION:Skeletal muscle oxidative capacity decreases and fatigability increases after spinal cord injury. Transcription factor peroxisome proliferator-activated receptor δ (PPARδ) promotes a more oxidative phenotype. METHODS:We asked whether PPARδ overexpression could ameliorate these deficits in the medial gastr...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24723
更新日期:2016-02-01 00:00:00
abstract::In order to further characterize and provide a possible mechanism for the asymmetrical involvement of forearm muscles in inclusion body myositis (IBM), we measured isometric hand and pinch grip strength, and forearm muscle girth on 15 IBM patients. Forearm muscle strength and girth were significantly greater on the do...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199805)21:5<659::aid-mus17
更新日期:1998-05-01 00:00:00
abstract::Mutations in the myelin protein zero gene (MPZ) are associated with certain demyelinating neuropathies, and in particular with Charcot-Marie-Tooth disease type 1B (CMT1B), Dejerine-Sottas syndrome, and congenital hypomyelination. MPZ mutations affecting the protein's transmembrane domain are generally associated with ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20034
更新日期:2004-06-01 00:00:00
abstract:INTRODUCTION:Glucocorticosteroids (GC) are effective in slowing weakness in boys with Duchenne muscular dystrophy (DMD). METHODS:This is a multisite, 1-year, open-label trial of twice-weekly prednisolone (5 mg/kg/dose) in infants/young boys (0.4-2.4 years) with DMD. We compared changes in Bayley III Scales of Infant D...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26441
更新日期:2019-06-01 00:00:00
abstract:INTRODUCTION:Nerve enlargement (NE) is described in inflammatory and inherited neuropathies. It is commonly multifocal and moderate in the former and homogeneous and generalized in the latter. We describe 4 cases of massive NE in inflammatory neuropathies. METHODS:Patients presented with symptoms of polyneuropathy tha...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25272
更新日期:2017-02-01 00:00:00
abstract::The double-step technique of repetitive nerve stimulation was compared with repetitive nerve stimulation to a distal and a proximal muscle and with single fiber needle electromyography in 10 patients with myasthenia gravis. We conclude that the double-step technique is slightly more sensitive than repetitive nerve sti...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100306
更新日期:1987-03-01 00:00:00
abstract::A 30-year-old man with essential cryoglobulinemia presented with an axonal neuropathy and was found to have vasculitis at nerve biopsy. After 44 months, in accord with clinical deterioration, motor conduction studies showed excessive temporal dispersion multifocally, with partial conduction block persisting for 3 year...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20778
更新日期:2007-10-01 00:00:00
abstract::We report a family with familial amyloid polyneuropathy (FAP), showing an early-onset and a fatal outcome before age 30. Transthyretin (TTR) gene analysis showed one point mutation (T-->C change) in the second base of codon 55, and the corresponding amino acid substitution of proline (Pro) for leucine (Leu) was confir...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880170611
更新日期:1994-06-01 00:00:00
abstract::Clinical testing for neuromuscular dysfunction is supported by an extensive amount of excellent basic information about normal and abnormal subcellular physiology and ultrastructure. This information provides an essential frame of reference for describing the rationale of single-fiber electromyography (SFEMG). SFEMG i...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880120802
更新日期:1989-08-01 00:00:00
abstract::Reinnervation of a free muscle graft by nerves from an adjacent intact muscle is called muscular neurotization. This paper investigates the mechanisms and stimuli responsible for muscular neurotization in the rat. Sternohyoid or sternomastoid muscles were transplanted as free muscle grafts to the ventral surface of an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100607
更新日期:1987-07-01 00:00:00
abstract::Electrical stimulation was applied daily for 20 minutes to denervated rabbit extensor digitorum longus muscle. One group was stimulated with short tetani, another with 1-Hz frequency, using isometric contractions for both. Tetanic stimulation induced severe fibrosis and is harmful to denervated muscle. One Hertz stimu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100206
更新日期:1987-02-01 00:00:00
abstract::In this pilot study we use T2-weighted magnetic resonance imaging (MRI) to identify possible peripheral nerve inflammation in 4 patients with diffuse chronic pain. In all 4 patients, there was an increase in median and ulnar nerve T2 signal intensity at the wrist (P < 0.05 vs. controls). Positive clinical signs of per...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22221
更新日期:2011-12-01 00:00:00
abstract::Recent years have seen steady progress in the identification of genetic muscle diseases as well as efforts to develop treatment for these diseases. Consequently, sensitive and objective new methods are required to identify and monitor muscle pathology. Magnetic resonance imaging offers multiple potential biomarkers of...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.26497
更新日期:2019-10-01 00:00:00
abstract::Normal motor units (MUs) were simulated and their architecture altered to simulate the changes produced by myopathy. The concentric needle electromyographic recordings of motor unit action potentials (MUAPs) from the MUs were then also simulated. These simulated MUAPs showed features that are seen in myopathy: normal ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880120306
更新日期:1989-03-01 00:00:00
abstract::We describe a patient with a clinical disorder that resembled vasculitic neuropathy in which peripheral nerves were successively affected over several months, but without systemic involvement. An initial muscle biopsy near the involved nerves showed signs of nonspecific inflammation around the muscle and nerve fibers....
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/1097-4598(200010)23:10<1604::aid-mus21>3.0
更新日期:2000-10-01 00:00:00
abstract::The objective of this study was to determine the self-reported prevalence of needlestick injuries among practicing electromyographers. In January 2008, an anonymous electronic survey was sent to all active members of the American Association for Neuromuscular and Electrodiagnostic Medicine (AANEM) who provided e-mail ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21118
更新日期:2008-12-01 00:00:00
abstract::In acquired polyneuropathies, symptoms and signs are typically distal and symmetrical, more prominent in the lower limbs than the upper limbs. This study was undertaken to measure the extent of the decrease in excitability produced by single impulses and by impulse trains in cutaneous afferents in the median and sural...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200005)23:5<763::aid-mus14
更新日期:2000-05-01 00:00:00
abstract::Repetitive nerve stimulation (RNS) of the median nerve is rarely studied in myasthenia gravis (MG). We performed a retrospective analysis of RNS studies performed on 448 patients at our center between 2010 and 2016. Among 95 patients with MG, an abnormal decrement of the compound muscle action potential amplitude was ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26713
更新日期:2019-12-01 00:00:00
abstract::Genetic testing is rapidly becoming an increasingly significant part of the diagnostic armamentarium of neuromuscular clinicians. Although technically easy to order, the results of such testing, whether positive or negative, have potentially enormous consequences for the individual tested and for family members. As a ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.25400
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:Sarcopenia likely comprises muscle fiber denervation and re-innervation, resulting in clustering of muscle fibers of the same type (classified by myosin heavy chain isoform composition). Development of methodology to quantitatively evaluate clustering of muscle fibers according to fiber type is necessary. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24641
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:To collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in a phase 2 double-blind randomized controlled trial. METHODS:Twenty ALS subjects were randomized to placebo and mexiletine 300 or 600 mg daily for 4 wk and asse...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.27146
更新日期:2020-12-19 00:00:00
abstract::The utilization of viable biological nerve graft substitutes and nerve allografts raises the problem of nerve storage. To clarify this, rat sciatic nerve segments were harvested and stored in Dulbecco's modified eagle medium. The segments were divided into three groups. In the first group, no cryoprotectant was added,...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/1097-4598(200008)23:8<1227::aid-mus11>3.0.
更新日期:2000-08-01 00:00:00
abstract::Ultrastructural, biochemical, and electrophysiological analyses were done on 12-14-month-old mice deficient for myelin-associated glycoprotein (MAG) to further characterize the neuropathy that develops as they age. Electron microscopy demonstrated normal myelin compaction and axonal degeneration in a large number of m...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1159
更新日期:2001-10-01 00:00:00
abstract::We used peristimulus time histograms (PSTHs) to estimate characteristics of the composite excitatory postsynaptic potentials (EPSPs) generated at the anterior horn cell by a descending cortical volley induced by subthreshold transcranial magnetic stimuli in 11 normal subjects, 9 patients with DNA-confirmed Kennedy's d...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199903)22:3<299::aid-mus2>
更新日期:1999-03-01 00:00:00
abstract:INTRODUCTION:Documentation of peripheral nerve demyelination is an important part of the chronic inflammatory demyelinating polyneuropathy (CIDP) diagnostic process. METHODS:We performed a retrospective analysis of patients referred with a diagnosis of CIDP who were found to have a different condition. Electrodiagnost...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25997
更新日期:2018-04-01 00:00:00
abstract::A review of our current knowledge of the etiology and pathogenesis of myasthenia gravis is presented, with particular emphasis on the immunological aspects of the disease. Part 1, published in this issue, deals with the clinical and genetic features of myasthenia gravis which led to the autoimmune theory of the etiolo...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880010107
更新日期:1978-01-01 00:00:00
abstract:INTRODUCTION:Surface electromyography (SEMG) allows objective assessment and guides selection of appropriate treatment in focal hand dystonia (FHD). METHODS:Sixteen-channel SEMG obtained during different phases of a writing task was used to study timing, activation patterns, and spread of muscle contractions in FHD co...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23762
更新日期:2013-09-01 00:00:00
abstract::A treatment has been developed to alleviate muscle weakness in murine dystrophy. Cultured myoblasts from genetically normal mouse embryos were injected into the right soleus of 20-day-old normal or dystrophic mice. Hosts and donors were immunocompatible but exhibited different genotype markers. Donor cells produced GP...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110602
更新日期:1988-06-01 00:00:00
abstract::Inhibitory reflex responses to electrical stimulation of the mental nerve were studied in recordings from single motor units (SMU) in the human masseter muscle. A new analytical technique for spike train data was used. Electrical stimuli were delivered to the mental nerve when the SMU fired with two consecutive inter-...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-4598(200002)23:2<259::aid-mus18
更新日期:2000-02-01 00:00:00
abstract::The effects of altering (cross-reinnervation, CR) and/or eliminating (spinal isolation, SI) the activation-dependent neural input to the cat soleus for 8 months on its mechanical and biochemical properties were determined. The percent fast fibers was 0, 27, 38, and 54% for normal control (NC), NC-CR, SI, and SI-CR cat...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199606)19:6<707::AID-MUS4>
更新日期:1996-06-01 00:00:00