Abstract:
INTRODUCTION:Sarcopenia likely comprises muscle fiber denervation and re-innervation, resulting in clustering of muscle fibers of the same type (classified by myosin heavy chain isoform composition). Development of methodology to quantitatively evaluate clustering of muscle fibers according to fiber type is necessary. METHODS:Fiber type specific immunofluorescence histology was used to quantify fiber clustering in murine diaphragm muscle (n = 15) at ages 6 and 24 months. RESULTS:With age, fiber type clustering is evidenced by fiber type specific changes in distances between fibers, specifically a 14% decrease to the closest fiber for type I and 24% increase for type IIx and/or IIb fibers (P < 0.001). Additionally, a 34% increase to the 3 closest type IIx and/or IIb fibers was found (P < 0.001). CONCLUSIONS:This novel method of analyzing fiber type clustering may be useful in examining pathophysiological conditions of motor unit loss in neuromuscular disorders, myopathies, dystrophies, injuries, or amyotrophic lateral sclerosis.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Greising SM,Medina-Martínez JS,Vasdev AK,Sieck GC,Mantilla CBdoi
10.1002/mus.24641subject
Has Abstractpub_date
2015-07-01 00:00:00pages
76-82issue
1eissn
0148-639Xissn
1097-4598journal_volume
52pub_type
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