Abstract:
:The effects of altering (cross-reinnervation, CR) and/or eliminating (spinal isolation, SI) the activation-dependent neural input to the cat soleus for 8 months on its mechanical and biochemical properties were determined. The percent fast fibers was 0, 27, 38, and 54% for normal control (NC), NC-CR, SI, and SI-CR cats. Calcium-activated whole muscle myofibrillar adenosine triphosphatase activity was higher in SI-CR and NC cats. Isometric twitch speed properties and frequency of stimulation:tension response were faster in all experimental groups compared to NC. Maximum twitch and tetanic (Po) force, physiological cross-sectional area (PCSA), and specific tension (Po/PCSA) were unaffected in NC-CR cats, but reduced in SI and SI-CR cats. The soleus was more fatigable in SI-CR compared to NC cats. Alpha-glycerophosphate dehydrogenase activity was higher in all experimental groups compared to NC. All eight parameters reflecting the type of muscle were shifted toward those observed in a "faster" muscle in SI-CR vs. SI cats. These data suggest that electrically silent motoneurons can influence type-related skeletal muscle properties.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Roy RR,Eldridge L,Baldwin KM,Edgerton VRdoi
10.1002/(SICI)1097-4598(199606)19:6<707::AID-MUS4>subject
Has Abstractpub_date
1996-06-01 00:00:00pages
707-14issue
6eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199606)19:6<707::AID-MUS4>journal_volume
19pub_type
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