Abstract:
:Human normal (RCMH) and Duchenne muscular dystrophy (RCDMD) cell lines, as well as newly developed normal and dystrophic murine cell lines, were used for the study of both changes in inositol 1,4,5-trisphosphate (IP3) mass and IP3 binding to receptors. Basal levels of IP3 were increased two- to threefold in dystrophic human and murine cell lines compared to normal cell lines. Potassium depolarization induced a time-dependent IP3 rise in normal human cells and cells of the myogenic mouse cell line (129CB3), which returned to their basal levels after 60 s. However, in the human dystrophic cell line (RCDMD), IP3 levels remained high up to 200 s after potassium depolarization. Expression of IP3 receptors was studied measuring specific binding of 3H-IP3 in the murine cell lines (normal 129CB3 and dystrophic mdx XLT 4-2). All the cell lines bind 3H-IP3 with relatively high affinity (Kd: between 40 and 100 nmol/L). IP3 receptors are concentrated in the nuclear fraction, and their density is significantly higher in dystrophic cells compared to normal. These findings together with high basal levels of IP3 mass suggest a possible role for this system in the deficiency of intracellular calcium regulation in Duchenne muscular dystrophy.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Liberona JL,Powell JA,Shenoi S,Petherbridge L,Caviedes R,Jaimovich Edoi
10.1002/(sici)1097-4598(199807)21:7<902::aid-mus8>subject
Has Abstractpub_date
1998-07-01 00:00:00pages
902-9issue
7eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199807)21:7<902::AID-MUS8>journal_volume
21pub_type
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