Abstract:
INTRODUCTION:In Duchenne muscular dystrophy (DMD), fat replacement of muscle may be a useful endpoint in trials of therapy, although progression in different muscle groups is uneven. In this study we assessed the progression of fat replacement with T(1) -weighted imaging over 2 9-month periods. METHODS:Eight ambulant, corticosteroid-treated boys with DMD were imaged at 3 Tesla at 3 time-points (baseline and 9 and 18 months) with T(1) -weighted imaging to measure fat replacement. RESULTS:The greatest increase in fat content was measured in the biceps femoris long head, vastus lateralis, and rectus femoris, whereas the biceps femoris short head and gluteus maximus progressed more slowly. None of the lower leg muscles studied changed significantly. CONCLUSIONS:MRI can measure specific changes in fat replacement of muscle over time, demonstrating the variability in rates of natural progression between muscle groups and identifying those muscles suitable for use as biomarkers in clinical trials.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Hollingsworth KG,Garrood P,Eagle M,Bushby K,Straub Vdoi
10.1002/mus.23879subject
Has Abstractpub_date
2013-10-01 00:00:00pages
586-8issue
4eissn
0148-639Xissn
1097-4598journal_volume
48pub_type
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